selected publications
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academic article
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Thilakasiri PHuynh JPoh ARTan CWNero TLTran KParslow ACAfshar-Sterle SBaloyan DHannan NJBuchert MScott AMGriffin MDWHollande FParker MWPutoczki TLErnst MChand AL. Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.
EMBO Molecular Medicine.
11.
2019
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Huynh JChand AGough DErnst M. Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map.
Nature Reviews: Cancer.
19:82-96.
2019
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Schmidt SSchumacher NSchwarz JTangermann SKenner LSchlederer MSibilia MLinder MAltendorf-Hofmann AKnösel TGruber ESOberhuber GBolik JRehman ASinha ALokau JArnold PCabron ASZunke FBecker-Pauly CPreaudet ANguyen PHuynh JAfshar-Sterle SChand ALWestermann JDempsey PJGarbers CSchmidt-Arras DRosenstiel PPutoczki TErnst MRose-John S. ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.
Journal of Experimental Medicine.
215:1205-1225.
2018
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Kaitu’u-Lino TUJBrownfoot FCHastie RChand ACannon PDeo MTuohey LWhitehead CHannan NJTong S. Activating Transcription Factor 3 Is Reduced in Preeclamptic Placentas and Negatively Regulates sFlt-1 (Soluble fms-Like Tyrosine Kinase 1), Soluble Endoglin, and Proinflammatory Cytokines in Placenta.
Hypertension.
70:1014-1024.
2017
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Pang J-MBMolania RChand AKnower KTakano EAByrne DJMikeska TMillar EKALee CSO'Toole SAClyne CGorringe KLDobrovic AFox SB. LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness.
Oncotarget.
8:83626-83636.
2017
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Coulson RLiew SHConnelly AAYee NSDeb SKumar BVargas ACO’Toole SAParslow ACPoh APutoczki TMorrow RJAlorro MLazarus KAYeap EFWWalton KLHarrison CAHannan NJGeorge AJClyne CDErnst MAllen AMChand AL. The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma.
Oncotarget.
8:18640-18656.
2017
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Johnstone CNChand APutoczki TLErnst M. Emerging roles for IL-11 signaling in cancer development and progression: Focus on breast cancer.
Cytokine and Growth Factor Reviews.
26:489-498.
2015
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Aesoy RClyne CDChand AL. Insights into orphan nuclear receptors as prognostic markers and novel therapeutic targets for breast cancer.
Frontiers in Endocrinology.
6.
2015
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Lazarus KABrown KAYoung MJZhao ZCoulson RSChand ALClyne CD. Conditional Overexpression of Liver Receptor Homolog-1 in Female Mouse Mammary Epithelium Results in Altered Mammary Morphogenesis via the Induction of TGF-β.
Endocrinology.
155:1606-1617.
2014
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Knower KCChand ALEriksson NTakagi KMiki YSasano HVisvader JELindeman GJFunder JWFuller PJSimpson ERTilley WDLeedman PJGraham JDMuscat GEOClarke CLClyne CD. Distinct nuclear receptor expression in stroma adjacent to breast tumors.
Breast Cancer Research and Treatment.
142:211-223.
2013
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Chand ALPathirage NLazarus KChu SDrummond AEFuller PJClyne CD. Liver receptor homologue-1 expression in ovarian epithelial and granulosa cell tumours.
Steroids.
78:700-706.
2013
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Lazarus KAZhao ZKnower KCTo SQChand ALClyne CD. Oestradiol reduces Liver Receptor Homolog-1 mRNA transcript stability in breast cancer cell lines.
Biochemical and Biophysical Research Communications.
438:533-539.
2013
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Chand ALWijayakumara DDKnower KCHerridge KAHoward TLLazarus KAClyne CD. The orphan nuclear receptor LRH-1 and ERα activate GREB1 expression to induce breast cancer cell proliferation.
PLoS ONE.
7.
2012
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Lazarus KAWijayakumara DChand ALSimpson ERClyne CD. Therapeutic potential of Liver Receptor Homolog-1 modulators.
The Journal of Steroid Biochemistry and Molecular Biology.
130:138-146.
2012
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Chand ALLegge M. Amino acid transport system L activity in developing mouse ovarian follicles.
Human Reproduction.
26:3102-3108.
2011
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Chand ALegge M. Stereological Assessment of Developing Mouse Ovarian Follicles in an in vitro Culture System.
Anatomical Record.
294:379-383.
2011
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Chand ALHerridge KAHoward TLSimpson ERClyne CD. Tissue-specific regulation of aromatase promoter II by the orphan nuclear receptor LRH-1 in breast adipose stromal fibroblasts.
Steroids.
76:741-744.
2011
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Chand ALHerridge KAThompson EWClyne CD. The orphan nuclear receptor LRH-1 promotes breast cancer motility and invasion.
Endocrine-Related Cancer.
17:965-975.
2010
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Chand ALHarrison CAShelling AN. Inhibin and premature ovarian failure.
Human Reproduction Update.
16:39-50.
2010
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Chand ALSimpson ERClyne CD. Aromatase expression is increased in BRCA1mutation carriers.
BMC Cancer.
9.
2009
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McInnes KJBrown KAKnower KCChand ALClyne CDSimpson ER. Characterisation of aromatase expression in the human adipocyte cell line SGBS.
Breast Cancer Research and Treatment.
112:429-435.
2008
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Chand ALMurray ASJones RLHannan NJSalamonsen LARombauts L. Laser capture microdissection and cDNA array analysis of endometrium identify CCL16 and CCL21 as epithelial-derived inflammatory mediators associated with endometriosis.
Reproductive Biology and Endocrinology.
5.
2007
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Chand ALOoi GTHarrison CAShelling ANRobertson DM. Functional analysis of the human inhibin subunit variant A257T and its potential role in premature ovarian failure.
Human Reproduction.
22:3241-3248.
2007
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CHAND AROBERTSON DSHELLING AHARRISON C. Mutational analysis of betaglycan/TGF-βRIII in premature ovarian failure.
Fertility and Sterility.
87:210-212.
2007
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CHAND APONNAMPALAM AHARRIS SWINSHIP ISHELLING A. Mutational analysis of BMP15 and GDF9 as candidate genes for premature ovarian failure.
Fertility and Sterility.
86:1009-1012.
2006
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Harris SEChand ALWinship IMGersak KNishi YYanase TNawata HShelling AN. INHA promoter polymorphisms are associated with premature ovarian failure.
Molecular Human Reproduction.
11:779-784.
2005
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Chand ALHarris SE. Identification of novel mutations in FOXL2 associated with premature ovarian failure.
Molecular Human Reproduction.
8:729-733.
2002
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Shelling ANBurton KAChand ALvan Ee CCFrance JTFarquhar CMMilsom SRLove DRGersak KAittomäki KWinship IM. Inhibin: A Candidate Gene for Premature Ovarian Failure.
Obstetrical and Gynecological Survey.
56:279-280.
2001
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Shelling ANBurton KAChand ALvan Ee CCFrance JTFarquhar CMMilsom SRLove DRGersak KAittomäki KWinship IM. Inhibin: a candidate gene for premature ovarian failure.
Human Reproduction.
15:2644-2649.
2000
Full text if available
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Thilakasiri PHuynh JPoh ARTan CWNero TLTran KParslow ACAfshar-Sterle SBaloyan DHannan NJBuchert MScott AMGriffin MDWHollande FParker MWPutoczki TLErnst MChand AL. Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.
EMBO Molecular Medicine.
11.
2019
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conference paper
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Huynh JChand AErnst M. IL-11 as a therapeutic target to treat colorectal cancer.
Cancer Research.
2018
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Coulson RSDeb SErnst MAllen AChand AL. The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma.
Cancer Research.
2016
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Chand AZhao ZClyne CD. Liver Receptor Homolog 1 (LRH-1) Regulates Heterogeneous Nuclear Ribonucleoprotein A1 Expression to Induce Proliferation in Breast Cancer Cells.
Endocrine Reviews.
2014
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Huynh JChand AErnst M. IL-11 as a therapeutic target to treat colorectal cancer.
Cancer Research.
2018
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editorial article
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George AJAllen AChand AL. Repurposing ARBs as treatments for breast cancer.
Aging.
9:1357-1358.
2017
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George AJAllen AChand AL. Repurposing ARBs as treatments for breast cancer.
Aging.
9:1357-1358.
2017
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letter
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Knower KCChand ALClyne CD. Estrogen receptor status of breast stromal cells.
Breast Cancer Research and Treatment.
609-610.
2014
Full text if available
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Knower KCChand ALClyne CD. Estrogen receptor status of breast stromal cells.
Breast Cancer Research and Treatment.
609-610.
2014
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abstract
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Pang J-MChand AKnower KTakano EByrne DSprenkeler EMolania RMillar ELee SO'Toole SClyne CDobrovic AFox S. Abstract 2962: LRH-1 expression in breast cancer tissue and its association with phenotype and DNA methylation [Abstract].
Cancer Research.
2962-2962.
2015
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Lazarus KABrown KYoung MCain JJayasekara SCoulson RWatkins NClyne CChand A. Abstract 76: Liver receptor homologue-1 increases incidence of DMBA-induced mammary tumors.
Cancer Research.
76-76.
2014
Full text if available
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Pang J-MChand AKnower KTakano EByrne DSprenkeler EMolania RMillar ELee SO'Toole SClyne CDobrovic AFox S. Abstract 2962: LRH-1 expression in breast cancer tissue and its association with phenotype and DNA methylation [Abstract].
Cancer Research.
2962-2962.
2015