selected publications
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academic article
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Molania RGagnon-Bartsch JADobrovic ASpeed TP. A new normalization for Nanostring nCounter gene expression data.
Nucleic Acids Research.
47:6073-6083.
2019
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Stringer BWDay BWD’Souza RCJJamieson PREnsbey KSBruce ZCLim YCGoasdoué KOffenhäuser CAkgül SAllan SRobertson TLucas PTollesson GCampbell SWinter CDo HDobrovic AInglis P-LJeffree RLJohns TGBoyd AW. A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma.
Scientific Reports.
9.
2019
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Lee EFHarris TJTran SEvangelista MArulananda SJohn TRamnac CHobbs CZhu HGunasingh GSegal DBehren ACebon JDobrovic AMariadason JMStrasser ARohrbeck LHaass NKHerold MJFairlie WD. BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival.
Cell Death and Disease.
10.
2019
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Kondrashova OHo G-YAu-Yeung GLeas LBoughtwood TAlsop KZapparoli GDobrovic AKo Y-AHsu ALLove CJLunke SWakefield MJMcNally OQuinn MAnanda SNeesham DHamilton AGrossi MFreimund AKanjanapan YRischin DTraficante NBowtell DScott CLChristie MTaylor GRMileshkin LWaring PM. Clinical Utility of Real-Time Targeted Molecular Profiling in the Clinical Management of Ovarian Cancer: The ALLOCATE Study.
JCO Precision Oncology.
3.
2019
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Gray ESWitkowski TPereira MCalapre LHerron KIrwin DChapman BKhattak MARaleigh JHatzimihalis ACebon JSandhu SMcArthur GAMillward MZiman MDobrovic AWong SQ. Genomic analysis of circulating tumor DNA using a melanoma-specific UltraSEEK oncogene panel.
The Journal of Molecular Diagnostics.
21:418-426.
2019
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Li AGeyer FCBlecua PLee JYSelenica PBrown DNPareja FLee SSKKumar RRivera BBi RPiscuoglio SWen HYLozada JRGularte-Merida RCavallone LRezoug ZNguyen-Dumont TPeterlongo PTondini CTerkelsen TRonlund KBoonen SEMannerma AWinqvist RJanatova MRajadurai PXia BNorton LRobson MENg P-SLooi L-MSouthey MCWeigelt BSoo-Hwang TTischkowitz MFoulkes WDReis-Filho JSAghmesheh MAmor DAndrews LAntill YBalleine RBeesley JBlackburn ABogwitz MBrown MBurgess MBurke JButow PCaldon LCampbell IChristian AClarke CCohen PCrook ACui JCummings MDawson S-JDe Fazio ADelatycki MDobrovic ADudding TDuijf PEdkins EEdwards SFarshid GFellows AField MFlanagan JFong PForbes JForrest LFox SFrench JFriedlander MOrtega DGGattas MGiles GGill GGleeson MGreening SHaan EHarris MHayward NHickie IHopper JHunt CJames PJenkins MKefford RKentwell MKirk JKollias JLakhani SLindeman GLipton LLobb LLok SMacrea FMane GMarsh DMclachlan S-AMeiser BMilne RNightingale SO'Connell SPachter NPatterson BPhillips KSaleh MSalisbury ESaunders CSaunus JScott CScott RSexton AShelling ASimpson PSpigelman ASpurdle MStone JTaylor JThorne HTrainer ATrench GTucker KVisvader JWalker LWallis MWilliams RWinship IWu KYoung MA. Homologous recombination DNA repair defects in PALB2-associated breast cancers.
npj Breast Cancer.
5.
2019
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Tachtsidis ALe AV-PBlick TGunasinghe DDe Sousa EWaltham MDobrovic AThompson EW. Human-specific RNA analysis shows uncoupled epithelial-mesenchymal plasticity in circulating and disseminated tumour cells from human breast cancer xenografts.
Clinical and Experimental Metastasis.
36:393-409.
2019
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Colebatch AJFerguson PNewell FKazakoff SHWitkowski TDobrovic AJohansson PASaw RPMStretch JRMcArthur GALong GVThompson JFPearson JVMann GJHayward NKWaddell NScolyer RAWilmott JS. Molecular Genomic Profiling of Melanocytic Nevi.
Journal of Investigative Dermatology.
139.
2019
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Arulananda SDo HRivalland GLoh ZMusafer ALau EMitchell PDobrovic AJohn T. Standard dose osimertinib for erlotinib refractory T790M-negative EGFR-mutant non-small cell lung cancer with leptomeningeal disease.
Journal of Thoracic Disease.
11:1756-1764.
2019
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Colebatch AJDobrovic ACooper WA. TERT gene: Its function and dysregulation in cancer.
Journal of Clinical Pathology.
72:281-284.
2019
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Goh SKDo HTestro APavlovic JVago ALokan JJones RMChristophi CDobrovic AMuralidhara V. The Measurement of Donor-Specific Cell-Free DNA Identifies Recipients With Biopsy-Proven Acute Rejection Requiring Treatment After Liver Transplantation.
Transplantation Direct.
5.
2019
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Moujaber TEtemadmoghadam DKennedy CJChiew Y-EBalleine RLSaunders CWain GGao BHogg RSrirangan SKan CFereday STraficante NPatch A-MPearson JWaddell NGrimmond SMDobrovic ABowtell DDLHarnett PRDeFazio ABowtell DChenevix-Trench GGreen AWebb PDeFazio AGertig DTraficante NFereday SMoore SHarrap KSadkowsky TPandeya NHung JMalt MAlexander BAshover EBrown SCorrish TGreen LJackman LFerguson KMartin KMartyn ARanieri BMellon ARobertson RVanden Bergh TJones MMackenzie PMaidens JNattress KChiew YEStenlake ASullivan HWhite JJayde VMamers PBowes LGalletta LGiles DHendley JAlsop KBall CYoung CSchmidt TShirley HViduka SBrooks JStuart-Harris RKirsten RRutovitz JClingan PGlasgow AProietto ABraye SOtton GShannon JBonaventura TStewart JBegbie SBell DBaron-Hay SFerrier AGard GNevell DPavialds NValmadre SYoung BCamaris CCrouch REdwards LHacker NMarsden DRobertson GBeale PBeith JCarter JDalrymple CHoughton RRussell PLinks MGrygiel JHill JBrand AByth KJaworski RSharma RHarnett PWain GFriedlander MWard BPapadimos DCrandon ACummings MHorwood KObermair APerrin LWyld DNicklin JDavy MOehler MKHall CDodd THealy TPittman KHenderson DMiller JPierdes JBlomfield PChallis DMcIntosh RParker ABrown BRome RAllen DGrant PHyde SLaurie RRobbie MHealy DJobling TManolitsas TMcNealage JRogers PSusil BSumithran ESimpson LPhillips KRischin DFax SJohnson DLade SLoughrey MO'Callaghan NMurray WWaring PBillson VPyman JNeesham DQuinn MUnderhill CBell RNg LFBlum RGanju VHammond LLeung YMcCartney ABuck MHaviv IPurdie DWhiteman DZeps N. BRAF mutations in low-grade serous ovarian cancer and response to BRAF inhibition.
JCO Precision Oncology.
2:1-14.
2018
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Le AVPSzaumkessel MTan TZThiery JPThompson EWDobrovic A. DNA Methylation Profiling of Breast Cancer Cell Lines along the Epithelial Mesenchymal Spectrum—Implications for the Choice of Circulating Tumour DNA Methylation Markers.
International Journal of Molecular Sciences.
19:1-20.
2018
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Shepshelovich DTownsend AREspin-Garcia OLatifovic LO Callaghan CJJonker DJTu DChen EMorgen EPrice TJShapiro JSiu LLKubo MDobrovic ARatain MJXu WMushiroda TLiu G. Fc‐gamma receptor polymorphisms, cetuximab therapy, and overall survival in the CCTG CO.20 trial of metastatic colorectal cancer.
Cancer Medicine.
7:5478-5487.
2018
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Garsed DWAlsop KFereday SEmmanuel CKennedy CEtemadmoghadam DGao BGebski VGarès VChristie ELWouters MCAMilne KGeorge JPatch A-MLi JMir Arnau GSemple TGadipally SRChiew Y-EHendley JMikeska TZapparoli GVAmarasinghe KGrimmond SPearson JVWaddell NHung JStewart CJRSharma RAllan PERambau PFTraficante NMcNally OMileshkin LHamilton ALAnanda SGrossi MCohen PALeung YCRome RMBeale PJBlomfield PFriedlander MBrand ADobrovic AKöbel MHarnett PNelson BHBowtell DDLDeFazio A. Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer.
Clinical Cancer Research.
24:569-580.
2018
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Kondrashova OTopp MNesic KLieschke EHo G-YHarrell MZapparoli GHadley AHolian RBoehm EHeong VSanij EPearson RBKrais JJJohnson NMcNally OAnanda SAlsop KHutt KJKaufmann SHLin KKHarding TCTraficante NdeFazio AMcNeish LABowtell DDSwisher EMDobrovic AWakefield MJScott CLChenevix-Trench GGreen AWebb PGertig DFereday SMoore SHung JHarrap KSadkowsky TPandeya NMalt MMellon ARobertson RVanden Bergh TJones MMackenzie PMaidens JNattress KChiew YEStenlake ASullivan HAlexander BAshover PBrown SCorrish TGreen LJackman LFerguson KMartin KMartyn ARanieri BWhite JJayde VMamers PBowes LGalletta LGiles DHendley JSchmidt TShirley HBall CYoung CViduka STran HBilic SGlavinas LBrooks JStuart-Harris RKirsten FRutovitz JClingan PGlasgow AProietto ABraye SOtton GShannon JBonaventura TStewart JBegbie SFriedlander MBell DBaron-Hay SFerrier AGard GNevell DPavlakis NValmadre SYoung BCamaris CCrouch REdwards LHacker NMarsden DRobertson GBeale PBeith JCarter JDalrymple CHoughton RRussell PLinks MGrygiel JHill JBrand AByth KJaworski RHarnett PSharma RWain GWard BPapadimos DCrandon ACummings MHorwood KObermair APerrin LWyld DNicklin JDavy MOehler MKHall CDodd THealy TPittman KHenderson DMiller JPierdes JBlomfield PChallis DMclntosh RParker ABrown BRome RAllen DGrant PHyde SLaurie RRobbie MHealy DJobling TManolitsas TMcNealage JRogers PSusil BSumithran ESimpson IPhillips KRischin DFox SJohnson DLade SLoughrey MO'Callaghan NMurray WWaring PBillson VPyman JNeesham DQuinn MUnderhill CBell RNg LFBlum RGanju VHammond ILeung YMcCartney ABuck MHaviv IPurdie DWhiteman DZeps N. Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma.
Nature Communications.
9:1-16.
2018
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Arulananda SThapa BWalkiewicz MZapparoli GVWilliams DSDobrovic AJohn T. Mismatch Repair Protein Defects and Microsatellite Instability in Malignant Pleural Mesothelioma.
Journal of Thoracic Oncology.
13:1588-1594.
2018
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Hildebrand MSHarvey ASMalone SDamiano JADo HYe ZMcQuillan LMaixner WKalnins RNolan BWood MOzturk EJones NCGillies GPope KLockhart PJDobrovic ALeventer RJScheffer IEBerkovic SF. Somatic GNAQ mutation in the forme fruste of Sturge-Weber syndrome.
Neurology Genetics.
4.
2018
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Dwight TFlynn AAmarasinghe KBenn DELupat RLi JCameron DLHogg ABalachander SCandiloro ILMWong SQRobinson BGPapenfuss ATGill AJDobrovic AHicks RJClifton-Bligh RJTothill RW. TERT structural rearrangements in metastatic pheochromocytomas.
Endocrine-Related Cancer.
25:1-9.
2018
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Cameron DLSchroeder JPenington JSDo HMolania RDobrovic ASpeed TPPapenfuss AT. GRIDSS: sensitive and specific genomic rearrangement detection using positional de Bruijn graph assembly
2017
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Candiloro ILMMikeska TDobrovic A. Assessing alternative base substitutions at primer CpG sites to optimise unbiased PCR amplification of methylated sequences.
Clinical Epigenetics.
9:1-9.
2017
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Deb SGorringe KLPang J-MBByrne DJTakano EAInvestigators KDobrovic AFox SB. BRCA2 carriers with male breast cancer show elevated tumour methylation.
BMC Cancer.
17:1-11.
2017
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Pang J-MBSavas PFellowes APMir Arnau GKader TVedururu RHewitt CTakano EAByrne DJChoong DYHMillar EKALee CSO'Toole SALakhani SRCummings MCMann GBCampbell IGDobrovic ALoi SGorringe KLFox SB. Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer.
Modern Pathology.
30:952-963.
2017
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Arulananda SDo HMusafer AMitchell PDobrovic AJohn T. Combination osimertinib and gefitinib in C797S and T790M EGFR- mutated non–small cell lung cancer.
Journal of Thoracic Oncology.
12:1728-1732.
2017
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Clay TDRussell PADo HSundararajan VConron MWright GMSolomon BDobrovic AMcLachlan S-AMoore MM. EGFR and KRAS mutations do not enrich for the activation of IL-6, JAK1 or phosphorylated STAT3 in resected lung adenocarcinoma.
Medical Oncology.
34:1-11.
2017
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Lu JRu KCandiloro IDobrovic AKorbie DTrau M. Evaluation of Different Oligonucleotide Base Substitutions at CpG Binding sites in Multiplex Bisulfite-PCR sequencing.
Scientific Reports.
7:1-10.
2017
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Cameron DLSchröder JPenington JSDo HMolania RDobrovic ASpeed TPPapenfuss AT. GRIDSS: sensitive and specific genomic rearrangement detection using positional de Bruijn graph assembly.
Genome Research.
27:2050-2060.
2017
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Morgen EKLenz HJJonker DJTu DMilano GGraziano FZalcberg JKarapetis CSDobrovic AO Callaghan CJLiu G. Germline polymorphisms as biomarkers of tumor response in colorectal cancer patients treated with anti-EGFR monoclonal antibodies: a systematic review and meta-analysis.
Pharmacogenomics Journal.
17:535-542.
2017
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Pang J-MBMolania RChand AKnower KTakano EAByrne DJMikeska TMillar EKALee CSO'Toole SAClyne CGorringe KLDobrovic AFox SB. LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness.
Oncotarget.
8:83626-83636.
2017
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Goh SKMuralidharan VChristophi CDo HDobrovic A. Probe-Free Digital PCR Quantitative Methodology to Measure Donor-Specific Cell-Free DNA after Solid-Organ Transplantation.
Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine.
63:742-750.
2017
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Gamell CGulati TLevav-Cohen YYoung RJDo HPilling PTakano EWatkins NFox SBRussell PGinsberg DMonahan BJWright GDobrovic AHaupt SSolomon BHaupt Y. Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non–small cell lung cancer.
Science Signaling.
10:1-10.
2017
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Do HMolania RMitchell PVaiskunaite RMurdoch JDDobrovic A. Reducing Artifactual EGFR T790M Mutations in DNA from Formalin-Fixed Paraffin-Embedded Tissue by Use of Thymine-DNA Glycosylase.
Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine.
63:1506-1514.
2017
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Damiano JADo HOzturk EBurgess RKalnins RJones NCDobrovic ABerkovic SFHildebrand MS. Sensitive quantitative detection of somatic mosaic mutation in "double cortex" syndrome.
Epileptic Disorders: international epilepsy journal with videotape.
19:450-455.
2017
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Wong NCPope BJCandiloro ILKorbie DTrau MWong SQMikeska TZhang XPitman MEggers SDoyle SRDobrovic A. MethPat: a tool for the analysis and visualisation of complex methylation patterns obtained by massively parallel sequencing.
BMC Bioinformatics.
17:1-14.
2016
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Colebatch AJdi Stefano LWong SQWaring PJDobrovic AMcArthur GAPapenfuss AT. Clustered somatic mutations are frequent in transcription factor binding sites in melanoma and other cutaneous malignancies.
Pathology.
48:S94-S94.
2016
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Clay TDRussell PADo HSundararajan VConron MWright GMDobrovic AMoore MMMcLachlan SA. Associations between the IASLC/ATS/ERS lung adenocarcinoma classification and EGFR and KRAS mutations.
Pathology.
48:17-24.
2016
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Colebatch AJDi Stefano LWong SQHannan RDWaring PMDobrovic AMcArthur GAPapenfuss AT. Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies.
Oncotarget.
7:66569-66585.
2016
Full text if available -
Goh SKMusafer AWitkowski TMuralidharan VChristophi CDo HDobrovic A. Comparison of 3 Methodologies for Genotyping of Small Deletion and Insertion Polymorphisms.
Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine.
62:1012-1019.
2016
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Lorgelly PKDoble BRowen DBrazier JThomas DMFox SBThorne HParisot JPDoig KFellowes ADobrovic AJames PALipton LAshley DHayes TMcMurrick PRichardson GLorgelly PLucas MMcNeil JJJohn T. Condition-specific or generic preference-based measures in oncology? A comparison of the EORTC-8D and the EQ-5D-3L.
Quality of Life Research.
18:562-572.
2016
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Liu GTu DLewis MCheng DSullivan LAChen ZMorgen ESimes JPrice TJTebbutt NCShapiro JDJeffery GMMellor JDMikeska TVirk SShepherd LEJonker DJO'Callaghan CJZalcberg JRKarapetis CSDobrovic A. Fc-gamma Receptor Polymorphisms, Cetuximab Therapy, and Survival in the NCIC CTG CO.17 Trial of Colorectal Cancer.
Clinical Cancer Research.
22:2435-2444.
2016
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Lim AMWong NCPidsley RZotenko ECorry JDobrovic AClark SJRischin DSolomon B. Genome-scale methylation assessment did not identify prognostic biomarkers in oral tongue carcinomas.
Clinical Epigenetics.
8.
2016
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Lorgelly PKDoble BKnott RJThomas DMFox BThorne HParisot JPDoig KFellowes ADobrovic AJames PALipton LAshley DHayes TMcMurrick PRichardson GLorgelly PLucas MMcNeil JJJohn T. Realising the Value of Linked Data to Health Economic Analyses of Cancer Care: A Case Study of Cancer 2015.
PharmacoEconomics.
34:139-154.
2016
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Chia PLDo HMorey AMitchell PDobrovic AJohn T. Temporal changes of EGFR mutations and T790M levels in tumour and plasma DNA following AZD9291 treatment.
Lung Cancer.
98:29-32.
2016
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Thompson EWAnh V-PLTachtsidis ABlick TGunasinghe DWaltham MDobrovic A. EPITHELIAL-MESENCHYMAL PLASTICITY STATUS IN CIRCULATING TUMOUR CELLS OF BREAST CANCER XENOGRAFT MODELS.
Asia Pacific Journal of Clinical Oncology.
11:72-72.
2015
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Thompson EWMcLaren SADissanayake VRedfern AChan ADobrovic ASoon LSaunders CM. PREDICTIVE VALUE OF DE NOVO AND INDUCED EPITHELIAL-MESENCHYMAL TRANSITION IN LOCALLY ADVANCED BREAST CANCER TREATED WITH NEOADJUVANT CHEMOTHERAPY.
Asia Pacific Journal of Clinical Oncology.
11:115-116.
2015
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Dobrovic A. High-Resolution Assessment of Copy Number Variation.
Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine.
61:684-685.
2015
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Do HParisot JPThorne HFellowes ADoig KLucas MMcNeil JJDoble BDobrovic AJohn TJames PALipton LAshley DHayes TMcMurrick PRichardson GLorgelly PFox SBThomas DM. "Cancer 2015": A Prospective, Population-Based Cancer Cohort-Phase 1: Feasibility of Genomics-Guided Precision Medicine in the Clinic.
Journal of Personalized Medicine.
5:354-369.
2015
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Anh V-PLHuang DBlick TThompson EWDobrovic A. An optimised direct lysis method for gene expression studies on low cell numbers.
Scientific Reports.
5.
2015
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Sobral-Leite MWesseling JSmit VTHBMNevanlinna Hvan Miltenburg MHSanders JHofland IBlows FMCoulson PPatrycja GSchellens JHMFagerholm RHeikkilä PAittomäki KBlomqvist CProvenzano EAli HRFigueroa JSherman MLissowska JMannermaa AKataja VKosma V-MHartikainen JMPhillips K-ACouch FJOlson JEVachon CVisscher DBrenner HButterbach KArndt VHolleczek BHooning MJHollestelle AMartens JWMvan Deurzen CHMvan de Water BBroeks AChang-Claude JChenevix-Trench GEaston DFPharoah PDPGarcía-Closas Mde Graauw MSchmidt MKAghmesheh MAmor DAndrews LAntill YArmitage SArnold LBalleine RBankier ABastick PBeesley JBeilby JBennett BBennett IBerry GBlackburn ABogwitz MBrennan MBrown MBuckley MBurgess MBurke JButow PByron KCallen DCampbell IChauhan DChauhan MChenevix-Trench GChristian AClarke CColley ACotton DCrook ACui JCulling BCummings MDawson S-JdeFazio ADelatycki MDickson RDixon JDobrovic ADudding TEdkins TEdwards SEisenbruch MFarshid GFawcett SFellows AFenton GField MFirgaira FFlanagan JFleming JFong PForbes JFox SFrench JFriedlander MGaff CGardner MGattas MGeorge PGiles GGill GGoldblatt JGreening SGrist SHaan EHardie KHarris MHart SHayward NHealey SHeiniger LHopper JHumphrey EHunt CJames PJenkins MJones AKefford RKidd AKiely BKirk JKoehler JKollias JKovalenko SLakhani SLeaming ALeary JLim JLindeman GLipton LLobb LMann GMarsh DMcLachlan SAMeiser BMeldrum CMilne RMitchell GNewman BNiedermayr EO’Connell SO’Loughlin IOsborne RPachter NPatterson BPeters LPhillips KPrice MPurser LReeve TRichards RRickard ERobinson BRudzki BSaleh MSalisbury ESambrook JSaunders CSaunus JSayer RScott EScott RScott CSeshadri RSexton ASharma RShelling ASimpson PSouthey MSpurdle ASuthers GSykes PTassell MTaylor DTaylor JThierry BThomas SThompson EThorne HTownshend STrainer ATran LTucker KTyler JVisvader JWalker LWalpole IWard RWaring PWarner BWarren GWilliams RWilson JWinship IWu KYoung MABowtell DGreen AWebb PGertig G. Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis.
BMC Medicine.
13.
2015
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Pang JMBGorringe KLWong SQDobrovic ACampbell IGFox SB. Appraisal of the technologies and review of the genomic landscape of ductal carcinoma in situ of the breast.
Breast Cancer Research.
17.
2015
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Wong SQFellowes ADoig KEllul JBosma TJIrwin DVedururu RTan AYCWeiss JChan KSLucas MThomas DMDobrovic AParisot JPFox SB. Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients.
British Journal of Cancer.
112:1411-1420.
2015
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Do HHuang KTMikeska TLi JTakano EAMillar EKAGraham PHBoyle SECampbell IGSpeed TPDobrovic AFox SB. Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour.
BMC Cancer.
15.
2015
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Gorringe KLHunter SMPang J-MOpeskin KHill PRowley SMChoong DYHThompson ERDobrovic AFox SBMann GBCampbell IG. Copy number analysis of ductal carcinoma in situ with and without recurrence.
Modern Pathology.
28:1174-1184.
2015
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Wee EJHRauf SShiddiky MJADobrovic ATrau M. DNA ligase-based strategy for quantifying heterogeneous DNA methylation without sequencing.
Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine.
61:163-171.
2015
Full text if available -
Wong NCPope BJCandiloro IKorbie DTrau MWong SQMikeska Tvan Denderen BJWThompson EWEggers SDoyle SRDobrovic A. Exemplary multiplex bisulfite amplicon data used to demonstrate the utility of Methpat.
GigaScience.
4.
2015
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House IGThia KBrennan AJTothill RDobrovic AYeh WZSaffery RChatterton ZTrapani JAVoskoboinik I. Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals.
Immunology and Cell Biology.
93:575-580.
2015
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Stirzaker CZotenko ESong JZQu WNair SSLocke WJStone AArmstong NJRobinson MDDobrovic AAvery-Kiejda KAPeters KMFrench JDStein SKorbie DJTrau MForbes JFScott RJBrown MAFrancis GDClark SJ. Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value.
Nature Communications.
6.
2015
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Tsao SC-HWeiss JHudson CChristophi CCebon JBehren ADobrovic A. Monitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations.
Scientific Reports.
5.
2015
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Michael MWhite SCAbdi ENott LClingan PZimet AButton PGregory DSolomon BDobrovic ADo HClarke S. Multicenter randomized, open-label phase II trial of sequential erlotinib and gemcitabine compared with gemcitabine monotherapy as first-line therapy in elderly or ECOG PS two patients with advanced NSCLC.
Asia Pacific Journal of Clinical Oncology.
11:4-14.
2015
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Do HDobrovic A. Sequence Artifacts in DNA from Formalin-Fixed Tissues: Causes and Strategies for Minimization.
Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine.
61:64-71.
2015
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Mar VJLiu WDevitt BWong SQDobrovic AMcArthur GAWolfe RKelly JW. The role of BRAF mutations in primary melanoma growth rate and survival.
British Journal of Dermatology.
173:76-82.
2015
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Wong SQBehren AMar VJWoods KLi JMartin CSheppard KEWolfe RKelly JCebon JDobrovic AMcArthur GA. Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma.
Oncotarget.
6:1115-1127.
2015
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Do HWong NCMurone CJohn TSolomon BMitchell PLDobrovic A. A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma.
Scientific Reports.
4:1-8.
2014
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Li JDoyle MASaeed IWong SQMar VGoode DLCaramia FDoig KRyland GLThompson ERHunter SMHalgamuge SKEllul JDobrovic ACampbell IGPapenfuss ATMcArthur GATothill RW. Bioinformatics pipelines for targeted resequencing and whole-exome sequencing of human and mouse genomes: a virtual appliance approach for instant deployment.
PLoS ONE.
9:1-8.
2014
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Clemons NJDo HFennell CDeb SFellowes ADobrovic APhillips WA. Characterization of a novel tumorigenic esophageal adenocarcinoma cell line: OANC1.
Digestive Diseases and Sciences.
59:78-88.
2014
Full text if available -
Mar VJWong SQLogan ATrung NCebon JKelly JWWolfe RDobrovic AMcLean CMcArthur GA. Clinical and pathological associations of the activating RAC1 P29S mutation in primary cutaneous melanoma.
Pigment Cell and Melanoma Research.
27:1117-1125.
2014
Full text if available -
Lim AMDo HYoung RJWong SQAngel CCollins MTakano EACorry JWiesenfeld DKleid SSigston ELyons BFox SBRischin DDobrovic ASolomon B. Differential mechanisms of CDKN2A (p16) alteration in oral tongue squamous cell carcinomas and correlation with patient outcome.
International Journal of Cancer.
135:887-895.
2014
Full text if available -
Russell PAYu YDo HClay TDMoore MMWright GMConron MWainer ZDobrovic AMcLachlan SA. EGFR gene copy number alterations are not a useful screening tool for predicting EGFR mutation status in lung adenocarcinoma.
Pathology.
46:32-36.
2014
Full text if available -
Emmanuel CChiew YGeorge JEtemadmoghadam DAnglesio MSharma RRussell PKennedy CFereday SHung JGalletta LHogg RWain GBrand ABalleine RMacConaill LPalescandolo EHunter SCampbell IDobrovic AWong SDo HClarke CHarnett PBowtell DdeFazio A. Genomic Classification of Serous Ovarian Cancer with Adjacent Borderline Differentiates RAS Pathway and TP53-Mutant Tumors and Identifies NRAS as an Oncogenic Driver.
Clinical Cancer Research.
20:6618-6630.
2014
Full text if available -
Young RJWaldeck KMartin CFoo JHCameron DPKirby LDo HMitchell CCullinane CLiu WFox SBDutton-Regester KHayward NKJene NDobrovic APearson RBChristensen JGRandolph SMcarthur GASheppard KE. Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines.
Pigment Cell and Melanoma Research.
27:590-600.
2014
Full text if available -
Wright GMDo HWeiss JAlam NZRathi VWalkiewicz MJohn TRussell PADobrovic A. Mapping of actionable mutations to histological subtype domains in lung adenocarcinoma: implications for precision medicine.
Oncotarget.
5:2107-2115.
2014
Full text if available -
Pang JMBDeb STakano EAByrne DJJene NBoulghourjian AHolliday AMillar ELee CSO'Toole SADobrovic AFox SB. Methylation profiling of ductal carcinoma in situ and its relationship to histopathological features.
Breast Cancer Research.
16:1-11.
2014
Full text if available -
Deb SWong SQLi JDo HWeiss JByrne DChakrabarti ABosma TFellowes ADobrovic AFox SB. Mutational profiling of familial male breast cancers reveals similarities with luminal A female breast cancer with rare TP53 mutations.
British Journal of Cancer.
111:2351-2360.
2014
Full text if available -
Deb SJohansson IByrne DNilsson CConstable LFjällskog MLDobrovic AHedenfalk IFox SB. Nuclear HIF1A expression is strongly prognostic in sporadic but not familial male breast cancer.
Modern Pathology.
27:1223-1230.
2014
Full text if available -
Chia PLMitchell PDobrovic AJohn T. Prevalence and natural history of ALK positive non-small-cell lung cancer and the clinical impact of targeted therapy with ALK inhibitors.
Clinical Epidemiology.
6:423-432.
2014
Full text if available -
Lim AMCandiloro ILMWong NCollins MDo HTakano EAAngel CYoung RJCorry JWiesenfeld DKleid SSigston ELyons BRischin DSolomon BDobrovic A. Quantitative methodology is critical for assessing DNA methylation and impacts on correlation with patient outcome.
Clinical Epigenetics.
6:1-16.
2014
Full text if available -
Busuttil RAZapparoli GVHaupt SFennell CWong SQPang JMBTakeno EAMitchell CDi Costanzo NFox SHaupt YDobrovic ABoussioutas A. Role of p53 in the progression of gastric cancer.
Oncotarget.
5:12016-12026.
2014
Full text if available -
Wong SQLi JTan AYCVedururu RPang JMBDo HEllul JDoig KBell AMacarthur GAFox SBThomas DMFellowes AParisot JPDobrovic A. Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing.
BMC Medical Genomics.
7:1-10.
2014
Full text if available -
Clay TDDo HSundararajan VMoore MMConron MWright GMMcLachlan SADobrovic ARussell PA. The clinical relevance of pathologic subtypes in metastatic lung adenocarcinoma.
Journal of Thoracic Oncology.
9:654-663.
2014
Full text if available -
Mellor JDBrown MPIrving HRZalcberg JRDobrovic A. A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer.
Journal of Hematology and Oncology.
6.
2013
Full text if available -
Richter AGrieu FCarrello AAmanuel BNamdarian KRynska ALucas AMichael VBell AFox SBHewitt CADo HMcArthur GAWong SQDobrovic AIacopetta B. A multisite blinded study for the detection of BRAF mutations in formalin-fixed, paraffin-embedded malignant melanoma.
Scientific Reports.
3.
2013
Full text if available -
Andrews MCBehren AChionh FMariadason JVella LJDo HDobrovic ATebbutt NCebon J. BRAF inhibitor-driven tumor proliferation in akras-mutated colon carcinoma is not overcome by mek1/2 inhibition.
Journal of Clinical Oncology.
31:e448-e451.
2013
Full text if available -
Mar VJWong SQLi JScolyer RAMcLean CPapenfuss ATTothill RWKakavand HMann GJThompson JFBehren ACebon JSWolfe RKelly JWDobrovic AMcArthur GA. BRAF/NRAS wild-type melanomas have a high mutation load correlating with histologic and molecular signatures of UV damage.
Clinical Cancer Research.
19:4589-4598.
2013
Full text if available -
Pang JMBDobrovic AFox SB. DNA methylation in ductal carcinoma in situ of the breast.
Breast Cancer Research.
15.
2013
Full text if available -
Tebbutt NCParry MMZannino DStrickland AHVan Hazel GAPavlakis NGanju VMellor DDobrovic AGebski VJ. Docetaxel plus cetuximab as second-line treatment for docetaxel-refractory oesophagogastric cancer: The AGITG ATTAX2 trial.
British Journal of Cancer.
108:771-774.
2013
Full text if available -
Mitchell GBallinger MLWong SHewitt CJames PYoung MACipponi APang TGoode DLDobrovic AThomas DMPorceddu SGattas MNeuhaus SSuthers GTattersall MTucker KLewis CCarey-Smith R. High Frequency of Germline TP53 Mutations in a Prospective Adult-Onset Sarcoma Cohort.
PLoS ONE.
8.
2013
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Anaka MHudson CLo PHDo HCaballero OLDavis IDDobrovic ACebon JBehren A. Intratumoral genetic heterogeneity in metastatic melanoma is accompanied by variation in malignant behaviors.
BMC Medical Genomics.
6.
2013
Full text if available -
Mikeska TAlsop KMitchell GBowtell DDDobrovic A. No evidence for PALB2 methylation in high-grade serous ovarian cancer.
Journal of Ovarian Research.
6.
2013
Full text if available -
George JAlsop KEtemadmoghadam DHondow HMikeska TDobrovic ADeFazio ASmyth GKLevine DAMitchell GBowtell DD. Nonequivalent gene expression and copy number alterations in high-grade serous ovarian cancers with BRCA1 and BRCA2 mutations.
Clinical Cancer Research.
19:3474-3484.
2013
Full text if available -
Deb SDo HByrne DJene NDobrovic AFox SB. PIK3CA mutations are frequently observed in BRCAX but not BRCA2 -associated male breast cancer.
Breast Cancer Research.
15.
2013
Full text if available -
Zapparoli GVJorissen RNHewitt CAMcBean MWesterman DADobrovic A. Quantitative threefold allele-specific PCR (QuanTAS-PCR) for highly sensitive JAK2 V617F mutant allele detection.
BMC Cancer.
13.
2013
Full text if available -
Do HWong SQLi JDobrovic A. Reducing sequence artifacts in amplicon-based massively parallel sequencing of formalin-fixed paraffin-embedded DNA by enzymatic depletion of uracil-containing templates.
Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine.
59:1376-1383.
2013
Full text if available -
Wong SQLi JSalemi RSheppard KEHongdo DTothill RWMcArthur GADobrovic A. Targeted-capture massively-parallel sequencing enables robust detection of clinically informative mutations from formalin-fixed tumours.
Scientific Reports.
3.
2013
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Saw JCurtis DJHussey DJDobrovic AAplan PDSlape CI. The fusion partner specifies the oncogenic potential of NUP98 fusion proteins.
Leukemia Research: clinical and laboratory studies.
37:1668-1673.
2013
Full text if available -
Alsop KFereday SMeldrum CDeFazio AEmmanuel CGeorge JDobrovic ABirrer MJWebb PMStewart CFriedlander MFox SBowtell DMitchell G. BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian ovarian cancer study group.
Journal of Clinical Oncology.
30:2654-2663.
2012
Full text if available -
Mikeska TBock CDo HDobrovic A. DNA methylation biomarkers in cancer: Progress towards clinical implementation.
Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare.
12:473-487.
2012
Full text if available -
Blombery PAWong SQHewitt CADobrovic AMaxwell ELJuneja SGrigoriadis GWesterman DA. Detection of BRAF mutations in patients with hairy cell leukemia and related lymphoproliferative disorders.
Haematologica: the hematology journal.
97:780-783.
2012
Full text if available -
Do HDobrovic A. Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase.
Oncotarget.
3:546-558.
2012
Full text if available -
Weickhardt AJPrice TJChong GGebski VPavlakis NJohns TGAzad ASkrinos EFluck KDobrovic ASalemi RScott AMMariadason JMTebbutt NC. Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer.
Journal of Clinical Oncology.
30:1505-1512.
2012
Full text if available -
Wee EJHPeters KNair SSHulf TStein SWagner SBailey PLee SYQu WJBrewster BFrench JDDobrovic AFrancis GDClark SJBrown MA. Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status in advanced breast cancer.
Oncogene.
31:4182-4195.
2012
Full text if available -
Kristensen LSRaynor MCandiloro IDobrovic A. Methylation profiling of normal individuals reveals mosaic: Promoter methylation of cancer-associated genes.
Oncotarget.
3:450-461.
2012
Full text if available -
Mikeska TCarney DASeymour JFDobrovic A. No evidence for DNA methylation of the ATM promoter CpG island in chronic lymphocytic leukemia.
Leukemia and Lymphoma.
53:1420-1422.
2012
Full text if available -
Tan AYCWong SQNyvold CGCarney DAWei ASeymour JFHokland PWestermanDobrovic A. Rapid detection of FLT3 exon 20 tyrosine kinase domain mutations in patients with acute myeloid leukemia by high-resolution melting analysis.
Leukemia and Lymphoma.
53:1225-1229.
2012
Full text if available -
Hopper JLJenkins MADowty JGDite GSApicella CKeogh LWin AKYoung JPBuchanan DWalsh MDRosty CBaglietto LSeveri GPhillips KAWong EMDobrovic AWaring PWinship IRamus SJGiles GGSouthey MC. Using tumour pathology to identify people at high genetic risk of breast and colorectal cancers.
Pathology.
44:89-98.
2012
Full text if available -
Hondow HLFox SBMitchell GScott RJBeshay VWong SQDobrovic A. A high-throughput protocol for mutation scanning of the BRCA1 and BRCA2 genes.
BMC Cancer.
11:1-11.
2011
Full text if available -
Huang KTTakano EAMikeska TByrne DJDobrovic AFox SB. Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer.
Breast Cancer Research and Treatment.
130:319-329.
2011
Full text if available -
Mikeska TFelsberg JHewitt CADobrovic A. Analysing DNA methylation using bisulphite pyrosequencing.
Methods in Molecular Biology.
791:33-53.
2011
Full text if available -
Candiloro ILMMikeska TDobrovic A. Assessing combined methylation-sensitive high resolution melting and pyrosequencing for the analysis of heterogeneous DNA methylation..
Epigenetics.
6:500-507.
2011
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Wong EMDobrovic A. Assessing gene-specific methylation using HRM-based analysis..
Methods in Molecular Biology.
687:207-217.
2011
Full text if available -
Devitt BLiu WSalemi RWolfe RKelly JTzen CYDobrovic AMcarthur G. Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma.
Pigment Cell and Melanoma Research.
24:666-672.
2011
Full text if available -
Candiloro ILMMikeska TDobrovic A. Closed-tube PCR methods for locus-specific DNA methylation analysis.
Methods in Molecular Biology.
791:55-71.
2011
Full text if available -
Wong EMSouthey MCFox SBBrown MADowty JGJenkins MAGiles GGHopper JLDobrovic A. Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer.
Cancer Prevention Research.
4:23-33.
2011
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Newnham GMConron MMcLachlan SDobrovic ADo HLi JOpeskin KThompson NWright GMThomas DM. Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer.
BMC Cancer.
11:1-11.
2011
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Drini MWong NCScott HSCraig JMDobrovic AHewitt CADow CYoung JPJenkins MASaffery RMacrae FA. Investigating the Potential Role of Genetic and Epigenetic Variation of DNA Methyltransferase Genes in Hyperplastic Polyposis Syndrome.
PLoS ONE.
6.
2011
Full text if available -
Hirani RConnolly ARPutral LDobrovic ATrau M. Sensitive quantification of somatic mutations using molecular inversion probes.
Analytical Chemistry.
83:8215-8221.
2011
Full text if available -
Chan PMöller ALiu MCPSceneay JEWong CSFWaddell NHuang KTDobrovic AMillar EKA'Toole SAMcNeil CMSutherland RLBowtell DDFox SB. The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression.
Breast Cancer Research.
13:1-10.
2011
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Huang KTDobrovic AFox SB. No evidence for DNA methylation of von Hippel-Lindau ubiquitin ligase complex genes in breast cancer.
Breast Cancer Research and Treatment.
124:853-856.
2010
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Huang KTDobrovic AYan MKarim RZLee CSLakhani SRFox SB. DNA methylation profiling of phyllodes and fibroadenoma tumours of the breast.
Breast Cancer Research and Treatment.
124:555-565.
2010
Full text if available -
Do HSalemi RMurone CMitchell PLDobrovic A. Rarity ofAKT1andAKT3E17K mutations in squamous cell carcinoma of lung.
Cell Cycle.
9:4411-4412.
2010
Full text if available -
Huang KTMikeska TDobrovic AFox SB. DNA methylation analysis of the HIF-1α prolyl hydroxylase domain genes PHD1, PHD2, PHD3 and the factor inhibiting HIF gene FIH in invasive breast carcinomas.
Histopathology.
57:451-460.
2010
Full text if available -
Da Silva LSimpson PTSmart CECocciardi SWaddell NLane AMorrison BJVargas ACHealey SBeesley JPakkiri PParry SKurniawan NReid LKeith PFaria PPereira ESkalova ABilous MBalleine RLDo HDobrovic AFox SFranco MReynolds BKhanna KKCummings MChenevix-Trench GLakhani SR. HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer.
Breast Cancer Research.
12.
2010
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Mikeska TCandiloro ILMDobrovic A. The implications of heterogeneous DNA methylation for the accurate quantification of methylation.
Epigenomics.
2:561-573.
2010
Full text if available -
Handolias DHamilton ALSalemi RTan AMoodie KKerr LDobrovic AMcArthur GA. Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT.
British Journal of Cancer.
102:1219-1223.
2010
Full text if available -
Handolias DSalemi RMurray WTan ALiu WViros ADobrovic AKelly JMcArthur GA. Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure.
Pigment Cell and Melanoma Research.
23:210-215.
2010
Full text if available -
Takano EAMikeska TDobrovic AByrne DJFox SB. A multiplex endpoint RT-PCR assay for quality assessment of RNA extracted from formalin-fixed paraffin-embedded tissues.
BMC Biotechnology.
10:89-89.
2010
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Whitehall VTran KUmapathy AGrieu FHewitt CEvans T-JIsmail TLi WQCollins PRavetto PLeggett BSalto-Tellez MSoong RFox SScott RJDobrovic AIacopetta B. A Multicenter Blinded Study to Evaluate KRAS Mutation Testing Methodologies in the Clinical Setting.
The Journal of Molecular Diagnostics.
11:543-552.
2009
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Candiloro ILMDobrovic A. Detection of MGMT Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 MGMT Promoter Single Nucleotide Polymorphism.
Cancer Prevention Research.
2:862-867.
2009
Full text if available -
Zhang H-HWalker FKiflemariam SWhitehead RHWilliams DPhillips WAMikeska TDobrovic ABurgess AW. Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf.
International Journal of Cancer.
125:297-307.
2009
Full text if available -
Kansara MTsang MKodjabachian LSims NATrivett MKEhrich MDobrovic ASlavin JChoong PFMSimmons PJDawid IBThomas DM. Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice.
Journal of Clinical Investigation.
119:837-851.
2009
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Bianco-Miotto THussey DJDay TKO'Keefe DSDobrovic A. DNA Methylation of the ABO Promoter Underlies Loss of ABO Allelic Expression in a Significant Proportion of Leukemic Patients.
PLoS ONE.
4:e4788-e4788.
2009
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Ashley DMRiffkin CDLovric MMMikeska TDobrovic AMaxwell JAFriedman HSDrummond KJKaye AHGan HKJohns TGHawkins CJ. Erratum: In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.
British Journal of Cancer.
100:1012-1012.
2009
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Dobrovic AKristensen LS. DNA methylation, epimutations and cancer predisposition.
The International Journal of Biochemistry and Cell Biology.
41:34-39.
2009
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Raynor MPStephenson S-APittman KBWalsh DCAHenderson MADobrovic A. Identification of circulating tumour cells in early stage breast cancer patients using multi marker immunobead RT-PCR.
Journal of Hematology and Oncology.
2:24-24.
2009
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Do HDobrovic A. Limited copy number - high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies.
Molecular Cancer.
8:82-82.
2009
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Wojdacz TKDobrovic A. Melting Curve Assays for DNA Methylation Analysis.
Methods in Molecular Biology.
507:229-240.
2009
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Huang KTDobrovic AFox SB. No evidence for promoter region methylation of the succinate dehydrogenase and fumarate hydratase tumour suppressor genes in breast cancer.
BMC Research Notes.
2:194-194.
2009
Full text if available -
Mikeska TDobrovic A. Validation of a primer optimisation matrix to improve the performance of reverse transcription – quantitative real-time PCR assays.
BMC Research Notes.
2:112-112.
2009
Full text if available -
Do HKrypuy MMitchell PLFox SBDobrovic A. High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies.
BMC Cancer.
8.
2008
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Wojdacz TKDobrovic AHansen LL. Methylation-sensitive high-resolution melting.
Nature Protocols.
3:1903-1908.
2008
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Takano EAMitchell GFox SBDobrovic A. Rapid detection of carriers with BRCA1 and BRCA2mutations using high resolution melting analysis.
BMC Cancer.
8.
2008
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Wojdacz TKDobrovic AAlgar EM. Rapid detection of methylation change at H19 in human imprinting disorders using methylation-sensitive high-resolution melting.
Human Mutation.
29:1255-1260.
2008
Full text if available -
Anagnostopoulos TPertesi MKonstantopoulou IArmaou SKamakari SNasioulas GAthanasiou ADobrovic AYoung M-AGoldgar DFountzilas GYannoukakos D. G1738R is a BRCA1 founder mutation in Greek breast/ovarian cancer patients: evaluation of its pathogenicity and inferences on its genealogical history.
Breast Cancer Research and Treatment.
110:377-385.
2008
Full text if available -
Ashley DMRiffkin CDLovric MMMikeska TDobrovic AMaxwell JAFriedman HSDrummond KJKaye AHGan HKJohns TGHawkins CJ. In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.
British Journal of Cancer.
99:294-304.
2008
Full text if available -
Kristensen LSDobrovic A. Direct Genotyping of Single Nucleotide Polymorphisms in Methyl Metabolism Genes Using Probe-Free High-Resolution Melting Analysis.
Cancer Epidemiology, Biomarkers and Prevention.
17:1240-1247.
2008
Full text if available -
Kristensen LSMikeska TKrypuy MDobrovic A. Sensitive Melting Analysis after Real Time- Methylation Specific PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detection.
Nucleic Acids Research.
36:e42-e42.
2008
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Ritchie DSMcBean MWesterman DAKovalenko SSeymour JFDobrovic A. Complete molecular response of e6a2 BCR-ABL–positive acute myeloid leukemia to imatinib then dasatinib.
Blood.
111:2896-2898.
2008
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Snell CKrypuy MWong EMLoughrey MBDobrovic A. BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1tumour phenotype.
Breast Cancer Research.
10.
2008
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Wojdacz TKHansen LDobrovic A. A new approach to primer design for the control of PCR bias in methylation studies.
BMC Research Notes.
1:54-54.
2008
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Tan AYCWesterman DACarney DASeymour JFJuneja SDobrovic A. Detection of NPM1 exon 12 mutations and FLT3 – internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia.
Journal of Hematology and Oncology.
1:10-10.
2008
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Do HSolomon BMitchell PLFox SBDobrovic A. Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting.
BMC Research Notes.
1:14-14.
2008
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Essakali SCarney DWesterman DGambell PSeymour JFDobrovic A. Negative selection of chronic lymphocytic leukaemia cells using a bifunctional rosette-based antibody cocktail.
BMC Biotechnology.
8:6-6.
2008
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Candiloro ILMMikeska THokland PDobrovic A. Rapid analysis of heterogeneously methylated DNA using digital methylation-sensitive high resolution melting: application to the CDKN2B (p15) gene.
Epigenetics and Chromatin.
1:7-7.
2008
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Krypuy MAhmed AAEtemadmoghadam DHyland SJdeFazio AFox SBBrenton JDBowtell DDDobrovic A. High resolution melting for mutation scanning of TP53exons 5–8.
BMC Cancer.
7.
2007
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Loughrey MBWaring PMTan ATrivett MKovalenko SBeshay VYoung M-AMcArthur GBoussioutas ADobrovic A. Incorporation of somatic BRAF mutation testing into an algorithm for the investigation of hereditary non-polyposis colorectal cancer.
Familial Cancer.
6:301-310.
2007
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Tan AYCWesterman DADobrovic A. A Simple, Rapid, and Sensitive Method for the Detection of theJAK2V617F Mutation.
American Journal of Clinical Pathology.
127:977-981.
2007
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Dobrovic AEaston DFPooley KADunning AMPharoah PDPThompson DBallinger DGStruewing JPMorrison JField HLuben RWareham NAhmed SHealey CSBowman RMeyer KBHaiman CAKolonel LKHenderson BELe Marchand LBrennan PSangrajrang SGaborieau VOdefrey FShen C-YWu P-EWang H-CEccles DEvans DGPeto JFletcher OJohnson NSeal SStratton MRRahman NChenevix-Trench GBojesen SENordestgaard BGAxelsson CKGarcia-Closas MBrinton LChanock SLissowska JPeplonska BNevanlinna HFagerholm REerola HKang DYoo K-YNoh D-YAhn S-HHunter DJHankinson SECox DGHall PWedren SLiu JLow Y-LBogdanova NSchürmann PDörk TTollenaar RAEMJacobi CEDevilee PKlijn JGMSigurdson AJDoody MMAlexander BHZhang JCox ABrock IWMacPherson GReed MWRCouch FJGoode ELOlson JEMeijers-Heijboer Hvan den Ouweland AUitterlinden ARivadeneira FMilne RLRibas GGonzalez-Neira ABenitez JHopper JLMcCredie MSouthey MGiles GGSchroen CJustenhoven CBrauch HHamann UKo Y-DSpurdle ABBeesley JChen XMannermaa AKosma V-MKataja VHartikainen JDay NECox DRPonder BAJ. Genome-wide association study identifies novel breast cancer susceptibility loci.
Nature.
447:1087-1093.
2007
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Liu WKelly JWTrivett MMurray WKDowling JPWolfe RMason GMagee JAngel CDobrovic AMcArthur GA. Distinct Clinical and Pathological Features Are Associated with the BRAFT1799A(V600E) Mutation in Primary Melanoma.
Journal of Investigative Dermatology.
127:900-905.
2007
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Wojdacz TKDobrovic A. Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation.
Nucleic Acids Research.
35:e41-e41.
2007
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Krypuy MNewnham GMThomas DMConron MDobrovic A. High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer.
BMC Cancer.
6.
2006
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Hugo HCures ASuraweera NDrabsch YPurcell DMantamadiotis TPhillips WDobrovic AZupi GGonda TJIacopetta BRamsay RG. Mutations in theMYB intron I regulatory sequence increase transcription in colon cancers.
Genes Chromosomes and Cancer.
45:1143-1154.
2006
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Tan AWesterman DMcArthur GALynch KWaring PDobrovic A. Sensitive Detection of KIT D816V in Patients with Mastocytosis.
Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine.
52:2250-2257.
2006
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Loughrey MBWaring PMDobrovic ADemetri GKovalenko SMcArthur G. Polyclonal Resistance in Gastrointestinal Stromal Tumor Treated with Sequential Kinase Inhibitors.
Clinical Cancer Research.
12:6205-6206.
2006
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Loughrey MBTrivett MBeshay VDobrovic AKovalenko SMurray WLade STurner HMcArthur GAZalcberg JWaring PM. KIT immunohistochemistry and mutation status in gastrointestinal stromal tumours (GISTs) evaluated for treatment with imatinib.
Histopathology.
49:52-65.
2006
Full text if available -
Loughrey MBBeshay VDobrovic AZalcberg JWaring PM. Pathological response of gastrointestinal stromal tumour to imatinib treatment correlates with tumourKITmutational status in individual tumour clones.
Histopathology.
49:99-100.
2006
Full text if available -
Dobrovic A. DNA repair gene inactivation in non-Hodgkin's lymphoma.
Leukemia and Lymphoma.
47:1728-1729.
2006
Full text if available -
Ritchie MEDiyagama DNeilson Jvan Laar RDobrovic AHolloway ASmyth GK. Empirical array quality weights in the analysis of microarray data.
BMC Bioinformatics.
7:261-261.
2006
Full text if available -
Thompson EDragovic RLStephenson S-AEccles DMCampbell IGDobrovic A. A novel duplication polymorphism in the FANCApromoter and its association with breast and ovarian cancer.
BMC Cancer.
5.
2005
Full text if available -
Raynor MStephenson S-AWalsh DCAPittman KBDobrovic A. Optimisation of the RT-PCR detection of immunomagnetically enriched carcinoma cells.
BMC Cancer.
2.
2002
Full text if available -
Dobrovic ABianco TTan LWSanders THussey D. Screening for and analysis of methylation differences using methylation-sensitive single-strand conformation analysis.
Methods.
27:134-138.
2002
Full text if available -
Hussey DJDobrovic A. Recurrent coiled-coil motifs in NUP98 fusion partners provide a clue to leukemogenesis.
Blood.
99:1097-1097.
2002
Full text if available -
Tan L-WBianco TDobrovic A. Variable promoter region CpG island methylation of the putative tumor suppressor gene Connexin 26 in breast cancer.
Carcinogenesis.
23:231-236.
2002
Full text if available -
Tan L-WDobrovic A. Methylation Analysis of Formalin-Fixed, Paraffin-Embedded Sections Using a Nontoxic DNA Extraction Protocol.
BioTechniques: the journal of laboratory technology for bioresearch.
31:1354-1357.
2001
Full text if available -
Bianco TFarmer BJSage REDobrovic A. Loss of red cell A, B, and H antigens is frequent in myeloid malignancies.
Blood.
97:3633-3639.
2001
Full text if available -
Varga AEDobrovic AWebb GCHutchinson R. Clustering of 1p36 breakpoints distal to 1p36.2 in hematological malignancies.
Cancer Genetics and Cytogenetics.
125:78-79.
2001
Full text if available -
Hussey DJMoore SNicola MDobrovic A. Fusion of the NUP98 gene with the LEDGF/p52 gene defines a recurrent acute myeloid leukemia translocation.
BMC Genetics.
2:20-20.
2001
Full text if available -
Hussey DJAlbanese NODobrovic A. Nuclear and cytoplasmic localisation of the leukemia associated nup98-rap1gds1 fusion protein.
Blood.
96.
2000
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Dobrovic ABianco T. Tumour-specific distribution of BRCA1 promoter region methylation supports a pathogenetic role in breast and ovarian cancer.
Carcinogenesis.
21:147-151.
2000
Full text if available -
Hardingham JEHewett PJSage REFinch JLNuttall JDKotasek DDobrovic A. Molecular detection of blood-borne epithelial cells in colorectal cancer patients and in patients with benign bowel disease.
International Journal of Cancer.
89:8-13.
2000
Full text if available -
Butler LMDobrovic ABianco TCowled PA. Promoter region methylation does not account for the frequent loss of expression of the Fas gene in colorectal carcinoma.
British Journal of Cancer.
82:131-135.
2000
Full text if available -
Bianco THussey DDobrovic A. Methylation-sensitive, single-strand conformation analysis (MS-SSCA): A rapid method to screen for and analyze methylation.
Human Mutation.
14:289-293.
1999
Full text if available -
Hussey DJNicola MMoore SPeters GBDobrovic A. The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia.
Blood.
94:2072-2079.
1999
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Hardingham JEButler WJRoder DDobrovic ADymock RBSage RERoberts-Thomson IC. Somatic mutations, acetylator status, and prognosis in colorectal cancer.
Gut.
42:669-672.
1998
Full text if available -
Hussey DJParker NJHussey NDLittle PFRDobrovic A. Characterization of a KRAB Family Zinc Finger Gene,ZNF195,Mapping to Chromosome Band 11p15.5.
Genomics.
45:451-455.
1997
Full text if available -
Dobrovic ASimpfendorfer D. Methylation of the BRCA1 gene in sporadic breast cancer.
Cancer Research.
57:3347-3350.
1997
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Eaton MCHardingham JEKotasek DDobrovic A. Immunobead RT-PCR: A Sensitive Method for Detection of Circulating Tumor Cells.
BioTechniques: the journal of laboratory technology for bioresearch.
22:100-105.
1997
Full text if available -
O'Keefe DSDobrovic A. A rapid and reliable PCR method for genotyping the ABO blood group. II: A2 and O2 alleles.
Human Mutation.
8:358-361.
1996
Full text if available -
O'Keefe DSDobrovic A. Decreased stability of the O allele mRNA transcript of the ABO gene [2].
Blood.
87:3061-3062.
1996
-
Hardingham JEKotasek DSage REEaton MCPascoe VHDobrovic A. Detection of Circulating Tumor Cells in Colorectal Cancer by Immunobead-PCR Is a Sensitive Prognostic Marker for Relapse of Disease.
Molecular Medicine.
1:789-794.
1995
Full text if available -
Hardingham JEKotasek DSage REGooley LTMi JXDobrovic ANorman JEBolton AEDale BM. Significance of molecular marker-positive cells after autologous peripheral-blood stem-cell transplantation for non-Hodgkin's lymphoma..
Journal of Clinical Oncology.
13:1073-1079.
1995
Full text if available -
O'Keefe DSDobrovic A. Erratum.
Human Mutation.
3:337-337.
1994
Full text if available -
O'Keefe DSDobrovic A. Erratum: A rapid and reliable PCR method for genotyping the ABO blood group (Human Mutation (1993) 2 (67-70)).
Human Mutation.
3:337.
1994
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Evdokiou AWebb GCPeters GBDobrovic AO'Keefe DSForbes IJCowled PA. Localization of the human growth arrest-specific gene ( GAS1 ) to chromosome bands 9q21.3-q22, a region frequently deleted in myeloid malignancies.
Genomics.
18:731-733.
1993
Full text if available -
Kalatzis VPeters GBDobrovic A. Mapping of the chromosome 11 breakpoint of the t(4;11)(q21;p14–15) translocation.
Cancer Genetics and Cytogenetics.
69:122-125.
1993
Full text if available -
O'Keefe DSDobrovic A. A rapid and reliable PCR method for genotyping the ABO blood group.
Human Mutation.
2:67-70.
1993
Full text if available -
Hardingham JEKotasek DFarmer BButler RNMi JXSage REDobrovic A. Immunobead-PCR: A Technique for the Detection of Circulating Tumor Cells Using Immunomagnetic Beads and the Polymerase Chain Reaction.
Cancer Research.
53:3455-3458.
1993
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Dobrovic AO'Keefe DSage REBatchelder E. Imprinting and loss of ABO antigens in leukemia [5].
Blood.
82:1684-1685.
1993
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Hardingham JEKotasek DSage REDobrovic AGooley TDale BM. Molecular detection of residual lymphoma cells in peripheral blood stem cell harvests and following autologous transplantation.
Bone Marrow Transplantation.
11:15-20.
1993
-
Stein BDobrovic AMills KBenn PBirnie G. Relationship between M-BCR breakpoint position in blast crisis and length of chronic phase in chronic myeloid leukemia [5].
Blood.
79:3097-3098.
1992
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Rockman SBegley CGKannourakis GMann GJDobrovic ANKefford RFMcGrath K. SCL gene in human tumors.
Leukemia.
6:623-625.
1992
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Hardingham JEPeters GBDobrovic ADale BMKotasek DFord HEStory CJSage RE. A rare translocation (4;11)(q21;p14–15) in an acute lymphoblastic leukemia expressing T-cell and myeloid markers.
Cancer Genetics and Cytogenetics.
56:255-262.
1991
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Dobrovic APeters GBFord JH. Review: Molecular analysis of the Philadelphia chromosome.
Chromosoma: biology of the nucleus.
100:479-486.
1991
Full text if available -
Dobrovic AMorley AASeshadri RJanuszewicz EH. Molecular diagnosis of Philadelphia negative CML using the polymerase chain reaction and DNA analysis: Clinical features and course of M-bcr negative and M-bcr positive CML.
Leukemia.
5:187-190.
1991
-
Seshadri RMatthews CDobrovic AHorsfall DJ. The significance of oncogene amplification in primary breast cancer.
International Journal of Cancer.
43:270-272.
1989
Full text if available -
Leduc FBrauch HHajj CDobrovic AKaye FGazdar AHarbour JWPettengill OSSorenson GDVan Den Berg AKok KCampling BPaquin FBradley WECZbar BMinna JBuys CAyoub J. Loss of heterozygosity in a gene coding for a thyroid hormone receptor in lung cancers.
American Journal of Human Genetics.
44:282-287.
1989
-
Dobrovic ATrainor KJMorley AA. Detection of the molecular abnormality in chronic myeloid leukemia by use of the polymerase chain reaction.
Blood.
72:2063-2065.
1988
-
Gareau J-LPHoule BLeduc FBradley WECDobrovic A. A frequent HindIII RFLP on chromosome 3p21–25 detected by a genomicerbAβ sequence.
Nucleic Acids Research.
16:1223-1223.
1988
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Dobrovic AGareau JLPOuellette GBradley WEC. DNA methylation and genetic inactivation at thymidine kinase locus: Two different mechanisms for silencing autosomal genes.
Somatic Cell and Molecular Genetics.
14:55-68.
1988
Full text if available -
Dobrovic AHoule BBelouchi ABradley IW. erba-related sequence coding for dna-binding hormone receptor localized to chromosome 3p21-3p25 and deleted in small cell lung carcinoma.
Cancer Research.
48:682-685.
1988
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Dobrovic AGareau PSeifert A-MMessing KBradley WEC. AHindIII RFLP for the HPRT pseudogene on chromosome 3 (HPRTP1).
Nucleic Acids Research.
15:1346-1346.
1987
Full text if available -
Graves JADobrovic AGraves M. Gene mapping in marsupials and monotremes.
Cytogenetic and Genome Research.
41:9-13.
1986
Full text if available -
DOBROVIC AGRAVES JAM. ASSIGNMENTS TO THE X-CHROMOSOME OF DASYURID MARSUPIALS.
Cytogenetic and Genome Research.
40:618-618.
1985
-
COOPER DWMCALLAN BMDONALD JADAWSON GDOBROVIC AGRAVES JAM. STEROID SULFATASE IS NOT DETECTED ON THE X-CHROMOSOME OF AUSTRALIAN MARSUPIALS.
Cytogenetic and Genome Research.
37:439-439.
1984
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Molania RGagnon-Bartsch JADobrovic ASpeed TP. A new normalization for Nanostring nCounter gene expression data.
Nucleic Acids Research.
47:6073-6083.
2019
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chapter
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Mikeska TDobrovic A. Epigenetic Basis of Human Cancer.
83-102.
2017
Full text if available -
Dobrovic A. Analysis of DNA Methylation in Clinical Samples: Methods and Applications.
261-277.
2016
Full text if available -
Dobrovic A. Methods for Analysis of DNA Methylation.
149-160.
2006
Full text if available
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Mikeska TDobrovic A. Epigenetic Basis of Human Cancer.
83-102.
2017
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comment
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Thai AChia PLRussell PADo HDobrovic AMitchell PJohn T. De novo
activating epidermal growth factor mutations (EGFR
) in small-cell lung cancer.
Internal Medicine Journal.
1071-1074.
2017
Full text if available
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Thai AChia PLRussell PADo HDobrovic AMitchell PJohn T. De novo
activating epidermal growth factor mutations (EGFR
) in small-cell lung cancer.
Internal Medicine Journal.
1071-1074.
2017
-
conference paper
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DeFazio AMoujaber TEtemadmoghadam DKennedy CChiew Y-EBalleine RLSaunders CWain GVDobrovic ABowtell DDLHarnett PR. BRAFV600E mutations in serous ovarian cancer and response to the BRAF inhibitor, dabrafenib..
Clinical Cancer Research.
2016
Full text if available -
Do HCameron DMolania RThapa BRivalland GMitchell PLMurone CJohn TPapenfuss ADobrovic A. Digital PCR of genomic rearrangements for monitoring circulating tumour DNA.
Advances in Experimental Medicine and Biology.
139-146.
2016
Full text if available -
Le AVPTachtsidis ABlick TGunasinghe DWaltham MDobrovic AThompson E. Investigating epithelial-mesenchymal plasticity in circulating tumour cells from breast cancer xenograft models.
European Journal of Cancer.
S43-S43.
2016
Full text if available -
Weickhardt AJPrice TJPavlakis NSkrinos EDobrovic ASalemi RScott AMMariadason JChong GTebbutt NC. DUX study: A phase II study of evaluating dual targeting of the EGFR using the combination of cetuximab and erlotinib in patients with chemotherapy refractory metastatic colorectal cancer..
Journal of Clinical Oncology.
3533-3533.
2010
Full text if available -
Graves JADOBROVIC ABRADLEY WEC. MAPPING OF GENES SYNTENIC TO THYMIDINE KINASE ON CHINESE-HAMSTER CHROMOSOME-7 BY RADIATION-INDUCED GENE SEGREGATION.
Cytogenetic and Genome Research.
618-618.
1985
-
DeFazio AMoujaber TEtemadmoghadam DKennedy CChiew Y-EBalleine RLSaunders CWain GVDobrovic ABowtell DDLHarnett PR. BRAFV600E mutations in serous ovarian cancer and response to the BRAF inhibitor, dabrafenib..
Clinical Cancer Research.
2016
-
editorial article
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Dobrovic A. White Blood Cell BRCA1 Promoter Methylation Status and Ovarian Cancer Risk: A Perspective.
Annals of Internal Medicine.
168:365-365.
2018
Full text if available -
Dobrovic A. DNA Breathing Enables Closed-Tube Mutant Allele Enrichment for Circulating Tumor DNA Analysis.
Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine.
63:e1-e3.
2017
Full text if available
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Dobrovic A. White Blood Cell BRCA1 Promoter Methylation Status and Ovarian Cancer Risk: A Perspective.
Annals of Internal Medicine.
168:365-365.
2018
-
letter
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Goh SKWong BKLMuralidharan VChristophi CDo HDobrovic A. Adapting an Established Clinical Chemistry Quality Control Measure for Droplet Generation Performance in Digital PCR.
Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine.
1255-1257.
2018
Full text if available -
Goh SKMuralidharan VChristophi CDobrovic A. Fresh Frozen Plasma Transfusion Can Confound the Analysis of Circulating Cell-Free DNA.
Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine.
749-751.
2018
Full text if available -
Do HArulananda SJohn TDobrovic A. In Reply to Leone.
Journal of Thoracic Oncology.
e22-e23.
2018
Full text if available -
Colebatch AJWitkowski TWaring PMMcArthur GAWong SQDobrovic A. Optimizing Amplification of the GC-Rich TERT Promoter Region Using 7-Deaza-dGTP for Droplet Digital PCR Quantification of TERT Promoter Mutations.
Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine.
745-747.
2018
Full text if available
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Goh SKWong BKLMuralidharan VChristophi CDo HDobrovic A. Adapting an Established Clinical Chemistry Quality Control Measure for Droplet Generation Performance in Digital PCR.
Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine.
1255-1257.
2018
-
working paper
-
Le AV-PSzaumkessel MTan TZThiery J-PThompson EWDobrovic A. DNA methylation profiling of breast cancer cell lines along the epithelial mesenchymal spectrum - implications for the choice of circulating tumour DNA methylation markers
2017
-
Le AV-PSzaumkessel MTan TZThiery J-PThompson EWDobrovic A. DNA methylation profiling of breast cancer cell lines along the epithelial mesenchymal spectrum - implications for the choice of circulating tumour DNA methylation markers
2017
-
abstract
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Dobrovic A. LIQUID BIOPSIES FROM SOLID TUMORS.
Asia Pacific Journal of Clinical Oncology.
77-78.
2016
-
Dobrovic A. LIQUID BIOPSIES FROM SOLID TUMORS.
Asia Pacific Journal of Clinical Oncology.
77-78.
2016