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Associate Professor Adam Mechler Associate Professor, Chemistry
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Associate Professor Adam Mechler Associate Professor, Chemistry
Positions
- Chemistry , School of Molecular Sciences/LIMS
- Associate Professor, Chemistry and Physics , .La Trobe University 2016 -
Research Areas
- Biophysics (Expertise)
- Nanomaterials (Expertise)
- Physical Chemistry of Materials (Expertise)
- Overview
- Publications
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Overview
Publications
selected publications
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academic article
- Vo QVNam PCBay MVThong NMCuong NDMechler A. Density functional theory study of the role of benzylic hydrogen atoms in the antioxidant properties of lignans. Scientific Reports. 8. 2018
- Zhi ZHasan IYMechler A. Formation of alkanethiol supported hybrid membranes revisited. Biotechnology Journal. 1800101-1800101. 2018
- Del Borgo MPKulkarni KTonta MARatcliffe JLSeoudi RMechler AIPerlmutter PParkington HCAguilar M-I. β 3 -tripeptides act as sticky ends to self-assemble into a bioscaffold. APL Bioengineering. 2:026104-026104. 2018
- Flavel MRMechler AShahmiri MMathews ERFranks AEChen WZanker DXian BGao SLuo JTegegne SDoneski CJois M. Growth of Caenorhabditis elegans in Defined Media Is Dependent on Presence of Particulate Matter . G3 (Bethesda, Md.). 8:567-575. 2018
- Marandi ATangestaninejad SMoghadam MMirkhani VMechler AMohammadpoor-Baltork IZadehahmadi F. Dodecatungstocobaltate heteropolyanion encapsulation into MIL-101(Cr) metal-organic framework scaffold provides a highly efficient heterogeneous catalyst for methanolysis of epoxides. Applied Organometallic Chemistry. 32:1-10. 2018
- Afzali NTangestaninejad SMoghadam MMirkhani VMechler AMohammadpoor-Baltork IKardanpour RZadehahmadi F. Oxidation reactions catalysed by molybdenum(VI) complexes grafted on UiO-66 metal-organic framework as an elegant nanoreactor. Applied Organometallic Chemistry. 32:1-11. 2018
- Vo QVRochfort SNam PCNguyen TLNguyen TTMechler A. Synthesis of aromatic and indole alpha-glucosinolates. Carbohydrate Research. 455:45-53. 2018
- Tajik-Ahmadabad BMechler AMuir BWMcLean KHinton TMSeparovic FPolyzos A. A QCM-D and SAXS Study of the Interaction of Functionalised Lyotropic Liquid Crystalline Lipid Nanoparticles with siRNA. ChemBioChem: a European journal of chemical biology. 18:921-930. 2017
- Hasan IYMechler A. Analytical approaches to study domain formation in biomimetic membranes. The Analyst. 142:3062-3078. 2017
- Buchanan CGarvey CPerlmutter PMechler A. Co-assembly of helical β3-peptides: a self-assembled analogue of a statistical copolymer. Pure and Applied Chemistry. 89:1809-1816. 2017
- Bahadori MTangestaninejad SMoghadam MMirkhani VMechler AMohammadpoor-Baltork IZadehahmadi F. Metal organic framework-supported N -heterocyclic carbene palladium complex: A highly efficient and reusable heterogeneous catalyst for Suzuki-Miyaura C-C coupling reaction. Microporous and Mesoporous Materials. 253:102-111. 2017
- Hasan IYMechler A. Nanoviscosity measurements revealing domain formation in biomimetic membranes. Analytical Chemistry. 89:1855-1862. 2017
- Shahmiri MCornell BMechler A. Phenylalanine residues act as membrane anchors in the antimicrobial action of Aurein 1.2. Biointerphases: an open access journal for the biomaterials interface community. 12:1-8. 2017
- Hasan IYMechler A. Cholesterol Rich Domains Identified in Unilamellar Supported Biomimetic Membranes via Nano-Viscosity Measurements. Analytical Chemistry. 88:5037-5041. 2016
- Hasan IYMechler A. Formation of planar unilamellar phospholipid membranes on oxidized gold substrate. Biointerphases: an open access journal for the biomaterials interface community. 11:1-10. 2016
- Shahmiri MEnciso MAdda CGSmith BJPerugini MAMechler A. Membrane core-specific antimicrobial action of Cathelicidin LL-37 peptide switches between pore and nanofibre formation. Scientific Reports. 6. 2016
- Seoudi RSHinds MGWilson DJDAdda CGDel Borgo MAguilar M-IPerlmutter PMechler A. Self-assembled nanomaterials based on beta (beta(3)) tetrapeptides. Nanotechnology. 27. 2016
- Seoudi RSDowd ASmith BJMechler A. Structural analysis of bioinspired nano materials with synchrotron far IR spectroscopy. Physical Chemistry Chemical Physics. 18:11467-11473. 2016
- Seoudi RSDowd ADel Borgo MKulkarni KPerlmutter PAguilar M-IMechler A. Amino acid sequence controls the self-assembled superstructure morphology of N-acetylated tri-beta(3)-peptides. Pure and Applied Chemistry. 87:1021-1028. 2015
- Shahmiri MEnciso MMechler AI. Controls and constrains of the membrane disrupting action of Aurein 1.2. Scientific Reports. 5. 2015
- Gopalan RDDel Borgo MPMechler AIPerlmutter PAguilar M-I. Geometrically Precise Building Blocks: the Self-Assembly of beta-Peptides. Chemistry and Biology. 22:1417-1423. 2015
- Keerthikumar SGangoda LLiem MFonseka PAtukorala IOzcitti CMechler AAdda CGAng C-SMathivanan S. Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes. Oncotarget. 6:15375-15396. 2015
- Praporski SMechler ASeparovic FMartin LL. Subtle Differences in Initial Membrane Interactions Underpin the Selectivity of Small Antimicrobial Peptides. ChemPlusChem. 80:91-96. 2015
- Seoudi RSDel Borgo MPKulkarni KPerlmutter PAguilar M-IMechler A. Supramolecular self-assembly of 14-helical nanorods with tunable linear and dendritic hierarchical morphologies. New Journal of Chemistry. 39:3280-3287. 2015
- Hasan IYMechler A. Viscoelastic changes measured in partially suspended single bilayer membranes. Soft Matter. 11:5571-5579. 2015
- Mechler AStringer BMubin MDoeven EPhillips NRudd-Schmidt JHogan C. Labeling phospholipid membranes with lipid mimetic luminescent metal complexes. BBA: Biomembranes. 1838:2939-2946. 2014
- Hall KLee T-HMechler AISwann MJAguilar M-I. Real-time Measurement of Membrane Conformational States Induced by Antimicrobial Peptides: Balance Between Recovery and Lysis. Scientific Reports. 4:1-9. 2014
- Kalra HAdda CGLiem MAng C-SMechler ASimpson RJHulett MDMathivanan S. Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma. Proteomics. 13:3354-3364. 2013
- Del Borgo MPMechler AITraore DForsyth CWilce JAWilce MCJAguilar M-IPerlmutter P. Supramolecular Self-Assembly of N -Acetyl-Capped β-Peptides Leads to Nano- to Macroscale Fiber Formation. Angewandte Chemie International Edition. 52:8266-8270. 2013
- Asghari-Khiavi MWood BRHojati-Talemi PDownes AMcNaughton DMechler A. Exploring the origin of tip-enhanced Raman scattering; preparation of efficient TERS probes with high yield. Journal of Raman Spectroscopy. 43:173-180. 2012
- Fraser SJMulet XMartin LPraporski SMechler AHartley PGPolyzos ASeparovic F. Surface Immobilization of Bio-Functionalized Cubosomes: Sensing of Proteins by Quartz Crystal Microbalance. Langmuir: the ACS journal of surfaces and colloids. 28:620-627. 2012
- Asghari-Khiavi MVongsvivut JPerepichka IMechler AWood BRMcNaughton DBohle DS. Interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX, a solid state spectroscopy study. Journal of Inorganic Biochemistry. 105:1662-1669. 2011
- Mechler MKukhlevsky SVMechler AMcNaughton D. Near-field diffraction in a two-dimensional V-groove and its role in SERS. Physical Chemistry Chemical Physics. 13:20772-20772. 2011
- SirajuddinMechler ATorriero AANafady ALee C-YBond AMO’Mullane APBhargava SK. The formation of gold nanoparticles using hydroquinone as a reducing agent through a localized pH change upon addition of NaOH to a solution of HAuCl4. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 370:35-41. 2010
- Hoffmann DKnappe DHansen APiantavigna SMechler ABinas ANolte OMartin LHoffmann R. In vitro characterization of a novel designer peptide to treat systemic infections caused by Gram-negative human pathogens.. Journal of Peptide Science. 16:119-119. 2010
- Knappe DPiantavigna SHansen AMechler ABinas ANolte OMartin LLHoffmann R. Oncocin (VDKPPYLPRPRPPRRIYNR-NH 2 ): A Novel Antibacterial Peptide Optimized against Gram-Negative Human Pathogens. Journal of Medicinal Chemistry. 53:5240-5247. 2010
- Asghari-Khiavi MWood BRMechler ABambery KRBuckingham DWCooke BMMcNaughton D. Correlation of atomic force microscopy and Raman micro-spectroscopy to study the effects of ex vivo treatment procedures on human red blood cells. The Analyst. 135:525-525. 2010
- Barbante GJHogan CFMechler AHughes AB. Electrochemiluminescence of surface bound microparticles of ruthenium complexes. Journal of Materials Chemistry. 20:891-899. 2010
- Sherman PJJackway RJGehman JDPraporski SMcCubbin GAMechler AMartin LLSeparovic FBowie JH. Solution Structure and Membrane Interactions of the Antimicrobial Peptide Fallaxidin 4.1a: An NMR and QCM Study. Biochemistry. 48:11892-11901. 2009
- Praporski SNg SMNguyen ADCorbin CJMechler AZheng JConley AJMartin LL. Organization of Cytochrome P450 Enzymes Involved in Sex Steroid Synthesis. Journal of Biological Chemistry. 284:33224-33232. 2009
- Asghari-Khiavi MMechler ABambery KRMcNaughton DWood BR. A resonance Raman spectroscopic investigation into the effects of fixation and dehydration on heme environment of hemoglobin. Journal of Raman Spectroscopy. 40:1668-1674. 2009
- Glover DJNg SMMechler AMartin LLJans DA. Multifunctional protein nanocarriers for targeted nuclear gene delivery in nondividing cells. The FASEB Journal. 23:2996-3006. 2009
- Lee THHall KMechler AMartin LPopplewell JRonan GAguilar MI. Molecular imaging and orientational changes of antimicrobial peptides in membranes.. Advances in Experimental Medicine and Biology. 611:313-315. 2009
- Piantavigna SCzihal PMechler ARichter MHoffmann RMartin LL. Cell Penetrating Apidaecin Peptide Interactions with Biomimetic Phospholipid Membranes. International Journal of Peptide Research and Therapeutics. 15:139-146. 2009
- Mechler APraporski SPiantavigna SHeaton SMHall KNAguilar M-IMartin LL. Structure and homogeneity of pseudo-physiological phospholipid bilayers and their deposition characteristics on carboxylic acid terminated self-assembled monolayers. Biomaterials. 30:682-689. 2009
- Battle ARValenzuela SMMechler ANichols RJPraporski Sdi Maio ILIslam HGirard-Egrot APCornell BAPrashar JCaruso FMartin LLMartin DK. Novel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane. Advanced Functional Materials. 19:201-208. 2009
- Gruber CWČemažar MMechler AMartin LLCraik DJ. Biochemical and biophysical characterization of a novel plant protein disulfide isomerase. Biopolymers. 92:35-43. 2009
- Kokavecz JMechler A. Spring constant of microcantilevers in fundamental and higher eigenmodes. Physical Review B: Condensed Matter and Materials Physics. 78. 2008
- Qu XNafady AMechler AZhang JHarris ARO’Mullane APMartin LLBond AM. AFM study of morphological changes associated with electrochemical solid–solid transformation of three-dimensional crystals of TCNQ to metal derivatives (metal = Cu, Co, Ni; TCNQ = tetracyanoquinodimethane). Journal of Solid State Electrochemistry. 12:739-746. 2008
- Friend JRYeo LYArifin DRMechler A. Evaporative self-assembly assisted synthesis of polymeric nanoparticles by surface acoustic wave atomization. Nanotechnology. 19:145301-145301. 2008
- Hou XMechler AMartin LLAguilar M-ISmall DH. Cholesterol and anionic phospholipids increase the binding of amyloidogenic transthyretin to lipid membranes. BBA: Biomembranes. 1778:198-205. 2008
- Mechler APraporski SAtmuri KBoland MSeparovic FMartin LL. Specific and Selective Peptide-Membrane Interactions Revealed Using Quartz Crystal Microbalance. Biophysical Journal. 93:3907-3916. 2007
- Kokavecz JMechler A. Investigation of fluid cell resonances in intermittent contact mode atomic force microscopy. Applied Physics Letters. 91:023113-023113. 2007
- Bhatt AIMechler DMartin LLBond AM. Synthesis of Ag and Au nanostructures in an ionic liquid: thermodynamic and kinetic effects underlying nanoparticle, cluster and nanowire formation. Journal of Materials Chemistry. 17:2241-2241. 2007
- Hou XParkington HCColeman HAMechler AMartin LLAguilar M-ISmall DH. Transthyretin oligomers induce calcium influx via voltage-gated calcium channels. Journal of Neurochemistry. 100:446-457. 2007
- Piorek BMechler ÁLal RFreudenthal PMeinhart CBanerjee S. Nanoscale resolution microchannel flow velocimetry by atomic force microscopy. Applied Physics Letters. 89:153123-153123. 2006
- Mechler ANawaratna GAguilar M-IMartin LL. A Study of Protein Electrochemistry on a Supported Membrane Electrode. International Journal of Peptide Research and Therapeutics. 12:217-224. 2006
- Losic DMartin LLMechler AAguilar M-ISmall DH. High resolution scanning tunnelling microscopy of the β-amyloid protein (Aβ1–40) of Alzheimer’s disease suggests a novel mechanism of oligomer assembly. Journal of Structural Biology. 155:104-110. 2006
- Mechler AIKokavecz JTóth ZHorváth ZLHeszler PMechler Á. Novel amplitude and frequency demodulation algorithm for a virtual dynamic atomic force microscope. Nanotechnology. 17:S173-S177. 2006
- Kokavecz JMarti OHeszler PMechler Á. Imaging bandwidth of the tapping mode atomic force microscope probe. Physical Review B: Condensed Matter and Materials Physics. 73. 2006
- Langford SJLatter MJLau V-LMartin LLMechler A. Organogels Derived from Tetranitrated Crown Ethers. Organic Letters. 8:1371-1373. 2006
- Losic DMartin LLMechler ASmall DHAguilar M. High resolution scanning tunnelling microscopy of the beta-amyloid protein (A beta I-40) of Alzheimer's disease suggests a novel mechanism of oligomer assembly. Journal of Peptide Science. 12:93-93. 2006
- Hall KNMechler AIMartin LLAguilar MI. Molecular imaging of membrane lysis by antimicrobial peptides. Journal of Peptide Science. 12:162-162. 2006
- Mechler ÁKopniczky JKokavecz JHoel AGranqvist C-GHeszler P. Anomalies in nanostructure size measurements by AFM. Physical Review B: Condensed Matter and Materials Physics. 72. 2005
- Thimm JMechler ALin HRhee SLal R. Calcium-dependent Open/Closed Conformations and Interfacial Energy Maps of Reconstituted Hemichannels. Journal of Biological Chemistry. 280:10646-10654. 2005
- Mechler ÁPiorek BLal RBanerjee S. Nanoscale velocity–drag force relationship in thin liquid layers measured by atomic force microscopy. Applied Physics Letters. 85:3881-3883. 2004
- Kokavecz JHorváth ZLMechler Á. Dynamical properties of the Q-controlled atomic force microscope. Applied Physics Letters. 85:3232-3234. 2004
- Ionescu-Zanetti CMechler ACarter SALal R. Semiconductive Polymer Blends: Correlating Structure with Transport Properties at the Nanoscale (Adv. Mater. 2004, 16, 385.). Advanced Materials. 16:579-579. 2004
- Ionescu-Zanetti CMechler ACarter SALal R. Semiconductive Polymer Blends: Correlating Structure with Transport Properties at the Nanoscale. Advanced Materials. 16:385-389. 2004
- Mechler ÁKokavecz JHeszler PLal R. Surface energy maps of nanostructures: Atomic force microscopy and numerical simulation study. Applied Physics Letters. 82:3740-3742. 2003
- Kokavecz JHeszler PTóth ZMechler Á. Effect of step function-like perturbation on intermittent contact mode sensors: a response analysis. Applied Surface Science. 210:123-127. 2003
- Mechler AIMechler ÁKokavecz JHeszler P. The observability of poorly bound powder-like material on hard surface by atomic force microscopy. Materials Science and Engineering C: Biomimetic and Supramolecular Systems. 15:29-32. 2001
- Csiszár MSzűcs ÁTölgyesi MMechler ÁNagy JNovák M. Electrochemical reactions of cytochrome c on electrodes modified by fullerene films. Journal of Electroanalytical Chemistry. 497:69-74. 2001
- Mechler AITóth ZMechler ÁHeszler P. Local laser-assisted chemical vapor deposition of diamond. Applied Surface Science. 168:5-8. 2000
- Mechler AIHeszler PRévész KReimann CTMechler ÁBor Z. Enhanced frictive, adhesive and attractive forces imaged at etch-pit edges on highly-oriented pyrolytic graphite by scanning force microscopy. Nanotechnology. 11:37-43. 2000
- Mechler AIMechler ÁHeszler PMárton ZKovács MSzörényi TBor Z. Raman spectroscopic and atomic force microscopic study of graphite ablation at 193 and 248 nm. Applied Surface Science. 154-155:22-28. 2000
- Tóth ZHopp BMechler ABor ZMoustaizis SDAthanassiou AGeorgiou SKalpouzos CFotakis C. Reflectivity transients on solid surfaces induced by 0.5 ps high power excimer laser irradiation. Laser Physics: international journal. 10:241-245. 2000
- Mechler AIHopp BTóth ZGál KMechler ÁBor ZMoustaizis SGeorgiou SFotakis C. Time-resolved investigation of the transient surface reflection changes of subpicosecond excimer laser ablated liquids. Applied Physics A: materials science and processing. 69:S191-S194. 1999
- Mechler AIMárton ZHeszler PMechler ÁHopp BKántor ZBor Z. Time-resolved shock-wave photography above 193-nm excimer laser-ablated graphite surface. Applied Physics A: materials science and processing. 69:S133-S136. 1999
- Mechler ÁHeszler PKántor ZSzörényi TBor Z. Excimer laser irradiation induced formation of diamond-like carbon layer on graphite. Applied Surface Science. 138-139:174-178. 1999
- Mechler AIMechler ÁHeszler PReimann CRévész KBor Z. Cantilever flexure, adhesive\attractive and lateral force measurements on highly-oriented pyrolytic graphite by scanning force microscopy. Vacuum. 50:281-287. 1998
- Mechler AIMechler ÁHeszler PKántor ZSzörényi TBor Z. Diamond-like carbon layer formation on graphite by excimer laser irradiation. Applied Physics A: materials science and processing. 66:659-661. 1998
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chapter
- Seoudi RSMechler A. Design principles of peptide based self-assembled nanomaterials. Advances in Experimental Medicine and Biology. 51-94. 2017
- Aguilar MIHou XLosic DMechler AIMartin LLSmall DH. Single-Molecule Imaging of Amyloidβ Protein (Aβ) of Alzheimer's Disease. From Single-Molecule Structures to Aggregation Mechanisms and Membrane Interactions. 47-56. 2013
- Mechler A. Atomic Force Microscopy of Proteins. 249-276. 2011
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conference paper
- Del Borgo MPMechler AITraore DForsyth CWilce JAWilce MCJPerlmutter PAguilar M-I. Supramolecular Self-Assembly of Unnatural Peptides Yields Nano- and Macroscopic Fibers. Biopolymers. 240-240. 2013
- Mechler AIHopp BTóth ZGál KMechler ÁBor ZMoustaizis SGeorgiou SFotakis C. Time-resolved investigation of the transient surface reflection changes of subpicosecond excimer laser ablated liquids. Applied Physics A: materials science and processing. S191-S194. 1999
- Mechler AIMárton ZHeszler PMechler ÁHopp BKántor ZBor Z. Time-resolved shock-wave photography above 193-nm excimer laser-ablated graphite surface. Applied Physics A: materials science and processing. S133-S136. 1999
- Mechler AHeszler PKantor ZSzorenyi TBor Z. Atomic force microscope study of excimer laser treated graphite surfaces. Proceedings of SPIE - The International Society for Optical Engineering. 96-99. 1998
Research
principal investigator on
- Mechanism of antimicrobial peptide-membrane interactions awarded by Australian Nuclear Science and Technology Organisation - Bragg Institute Neutron Beam Instrument 2018
- Hierarchical supramolecular self-assembly of unnatural peptides awarded by Australian Nuclear Science and Technology Organisation - Bragg Institute Neutron Beam Instrument 2016
- Biophysical surface characterisation facility awarded by Australian Research Council (ARC) - Linkage Infrastructure Equipment and Facilities 2011 - 2013
- Ultra-high frequency non-contact vibrometry equipment for biomicrofluidics metrology awarded by Australian Research Council (ARC) - Linkage Infrastructure Equipment and Facilities 2010
investigator on
- "The Sound of Cancer" Podcast awarded by CommBank Foundation Centenary Grant 2018 - 2019
- Advanced fluorescence characterisation facility awarded by Australian Research Council (ARC) - Linkage Infrastructure Equipment and Facilities 2012
- Laser Facility for Ultra-Sensitive Molecular Characterization� awarded by Australian Research Council (ARC) - Linkage Infrastructure Equipment and Facilities 2010
Background
education and training
- PHD, University of Szeged
Contact
full name
- Associate Professor Adam Mechler
mailing address
-
LIMS1/621
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La Trobe University
Chemistry and Physics, La Trobe Institute for Molecular Science
Melbourne
VIC
3086
Australia