selected publications
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academic article
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Fonseka PLiem MOzcitti CAdda CGAng C-SMathivanan S. Exosomes from N-Myc amplified neuroblastoma cells induce migration and confer chemoresistance to non-N-Myc amplified cells: implications of intra-tumour heterogeneity.
Journal of Extracellular Vesicles.
8.
2019
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Kalra HGangoda LFonseka PChitti SLiem MKeerthikumar SSamuel MBoukouris SAl Saffar HCollins CAdda CGAng C-SMathivanan S. Extracellular vesicles containing oncogenic mutant beta-catenin activate Wnt signalling pathway in the recipient cells.
Journal of Extracellular Vesicles.
8.
2019
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Zhao KBleackley MChisanga DGangoda LFonseka PLiem MKalra HAl Saffar HKeerthikumar SAng C-SAdda CGJiang LYap KPoon IKLock PBulone VAnderson MMathivanan S. Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling.
Communications Biology.
2.
2019
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Zhao KBleackley MChisanga DGangoda LFonseka HPLiem MKalra HAl Saffar HKeerthikumar SAng C-SAdda CGJiang LYap KPoon IKLock PBulone VAnderson MMathivanan S. Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling..
Communications Biology.
2.
2019
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Anand SFoot NAng C-SGembus KMKeerthikumar SAdda CGMathivanan SKumar S. Arrestin-domain Containing Protein 1 (Arrdc1) Regulates the Protein Cargo and Release of Extracellular Vesicles..
Proteomics.
18.
2018
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Samuel MChisanga DLiem MKeerthikumar SAnand SAng C-SAdda CGVersteegen EJois MMathivanan S. Bovine milk-derived exosomes from colostrum are enriched with proteins implicated in immune response and growth.
Scientific Reports.
7:1-10.
2017
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Brown TLTucci JDyson ZALock PAdda CGPetrovski S. Dynamic interactions between prophages induce lysis in Propionibacterium acnes.
Research in Microbiology.
168:103-112.
2017
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Gangoda LLiem MAng C-SKeerthikumar SAdda CGParker BSMathivanan S. Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics.
17:1-5.
2017
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Kvansakul MLay FTAdda CGVeneer PKBaxter AAPhan TKPoon IKHHulett MD. Binding of phosphatidic acid by NsD7 mediates the formation of helical defensin-lipid oligomeric assemblies and membrane permeabilization.
Proceedings of the National Academy of Sciences of USA.
113:11202-11207.
2016
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Shahmiri MEnciso MAdda CGSmith BJPerugini MAMechler A. Membrane core-specific antimicrobial action of Cathelicidin LL-37 peptide switches between pore and nanofibre formation.
Scientific Reports.
6.
2016
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Darmanin CStrachan JAdda CGVe TKobe BAbbey B. Protein crystal screening and characterization for serial femtosecond nanocrystallography.
Scientific Reports.
6.
2016
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Seoudi RSHinds MGWilson DJDAdda CGDel Borgo MAguilar M-IPerlmutter PMechler A. Self-assembled nanomaterials based on beta (beta(3)) tetrapeptides.
Nanotechnology.
27.
2016
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Keerthikumar SGangoda LLiem MFonseka PAtukorala IOzcitti CMechler AAdda CGAng C-SMathivanan S. Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes.
Oncotarget.
6:15375-15396.
2015
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Lydic TATownsend SAdda CGCollins CMathivanan SReid GE. Rapid and comprehensive 'shotgun' lipidome profiling of colorectal cancer cell derived exosomes.
Methods.
87:83-95.
2015
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Baxter AARichter VLay FTPoon IKHAdda CGVeneer PKPhan TBleackley MRAnderson MAKvansakul MHulett MD. The Tomato Defensin TPP3 Binds Phosphatidylinositol (4,5)-Bisphosphate via a Conserved Dimeric Cationic Grip Conformation To Mediate Cell Lysis.
Molecular and Cellular Biology.
35:1964-1978.
2015
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Poon IKHBaxter AALay FTMills GDAdda CGPayne JAEPhan TKRyan GFWhite JAVeneer PKvan der Weerden NLAnderson MAKvansakul MHulett MD. Author response: Phosphoinositide-mediated oligomerization of a defensin induces cell lysis.
eLife.
2014.
2014
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Poon IKHBaxter AALay FTMills GDAdda CGPayne JAEPhan TKRyan GFWhite JAVeneer PKvan der Weerden NLAnderson MAKvansakul MHulett MD. Phosphoinositide-mediated oligomerization of a defensin induces cell lysis.
eLife.
3:1-27.
2014
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Harris KSAdda CGKhore MDrew DRValentini-Gatt AFowkes FJIBeeson JGDutta SAnders RFFoley M. Use of Immunodampening To Overcome Diversity in the Malarial Vaccine Candidate Apical Membrane Antigen 1.
Infection and Immunity.
82:4707-4717.
2014
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Kalra HAdda CGLiem MAng C-SMechler ASimpson RJHulett MDMathivanan S. Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma.
Proteomics.
13:3354-3364.
2013
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Ji HGreening DWBarnes TWLim JWTauro BJRai AXu RAdda CMathivanan SZhao WXue YXu TZhu H-JSimpson RJ. Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components.
Proteomics.
13:1672-1686.
2013
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Adda CGMacRaild CAReiling LWycherley KBoyle MJKienzle VMasendycz PFoley MBeeson JGNorton RSAnders RF. Antigenic Characterization of an Intrinsically Unstructured Protein, Plasmodium falciparum Merozoite Surface Protein 2.
Infection and Immunity.
80:4177-4185.
2012
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Zhang XAdda CGLow AZhang JZhang WSun HTu XAnders RFNorton RS. Role of the Helical Structure of the N-Terminal Region ofPlasmodium falciparumMerozoite Surface Protein 2 in Fibril Formation and Membrane Interaction.
Biochemistry.
51:1380-1387.
2012
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McCarthy JSMarjason JElliott SFahey PBang GMalkin ETierney EAked-Hurditch HAdda CCross NRichards JSFowkes FJIBoyle MJLong CDruilhe PBeeson JGAnders RF. A Phase 1 Trial of MSP2-C1, a Blood-Stage Malaria Vaccine Containing 2 Isoforms of MSP2 Formulated with Montanide® ISA 720.
PLoS ONE.
6:e24413-e24413.
2011
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Chandrashekaran IRAdda CGMacRaild CAAnders RFNorton RS. EGCG disaggregates amyloid-like fibrils formed by Plasmodium falciparum merozoite surface protein 2.
Archives of Biochemistry and Biophysics.
513:153-157.
2011
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Yang XAdda CGMacRaild CALow AZhang XZeng WJackson DCAnders RFNorton RS. Identification of key residues involved in fibril formation by the conserved N-terminal region of Plasmodium falciparum merozoite surface protein 2 (MSP2).
Biochimie.
92:1287-1295.
2010
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Chandrashekaran IRAdda CGMacRaild CAAnders RFNorton RS. Inhibition by Flavonoids of Amyloid-like Fibril Formation byPlasmodium falciparumMerozoite Surface Protein 2.
Biochemistry.
49:5899-5908.
2010
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Anders RFAdda CGFoley MNorton RS. Recombinant protein vaccines against the asexual blood-stages ofPlasmodium falciparum.
Human Vaccines.
6:39-53.
2010
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Schloegel JLAdda CGDurand FMurphy VJVingas KCiccotosto GDCappai RKevin BJFoley MAnders RF. MEROZOITE SURFACE PROTEIN 2 HAS A POTENTIAL ROLE IN THE ATTACHMENT OF PLASMODIUM FALCIPARUM MEROZOITES TO ERYTHROCYTES DURING INVASION.
American Journal of Tropical Medicine and Hygiene.
81:244-244.
2009
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Adda CGMurphy VJSunde MWaddington LJSchloegel JTalbo GHVingas KKienzle VMasciantonio RHowlett GJHodder ANFoley MAnders RF. Plasmodium falciparum merozoite surface protein 2 is unstructured and forms amyloid-like fibrils.
Molecular and Biochemical Parasitology.
166:159-171.
2009
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Zhang XPerugini MAYao SAdda CGMurphy VJLow AAnders RFNorton RS. Solution Conformation, Backbone Dynamics and Lipid Interactions of the Intrinsically Unstructured Malaria Surface Protein MSP2.
Journal of Molecular Biology.
379:105-121.
2008
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Yang XAdda CGKeizer DWMurphy VJRizkalla MMPerugini MAJackson DCAnders RFNorton RS. A partially structured region of a largely unstructured protein,Plasmodium falciparummerozoite surface protein 2 (MSP2), forms amyloid-like fibrils.
Journal of Peptide Science.
13:839-848.
2007
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Low AChandrashekaran IRAdda CGYao SSabo JKZhang XSoetopo AAnders RFNorton RS. Merozoite surface protein 2 ofPlasmodium falciparum: Expression, structure, dynamics, and fibril formation of the conserved N-terminal domain.
Biopolymers.
87:12-22.
2007
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Rekas AAdda CGAquilina JABarnham KJSunde MGalatis DWilliamson NAMasters CLAnders RFRobinson CVCappai RCarver JA. Interaction of the molecular chaperone alpha B-crystallin with alpha-synuclein: Effects on amyloid fibril formation and chaperone activity.
Journal of Molecular Biology.
340:1167-1183.
2004
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Rekas AAdda CGAndrew Aquilina JBarnham KJSunde MGalatis DWilliamson NAMasters CLAnders RFRobinson CVCappai RCarver JA. Interaction of the Molecular Chaperone αB-Crystallin with α-Synuclein: Effects on Amyloid Fibril Formation and Chaperone Activity.
Journal of Molecular Biology.
340:1167-1183.
2004
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Adda CAnders RTilley LFoley M. Random Sequence Libraries Displayed on Phage: Identification of Biologically Important Molecules.
Combinatorial Chemistry and High Throughput Screening.
5:1-14.
2002
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Adda CGTilley LAnders RFFoley M. Isolation of peptides that mimic epitopes on a malarial antigen from random peptide libraries displayed on phage.
Infection and Immunity.
67:4679-4688.
1999
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Fonseka PLiem MOzcitti CAdda CGAng C-SMathivanan S. Exosomes from N-Myc amplified neuroblastoma cells induce migration and confer chemoresistance to non-N-Myc amplified cells: implications of intra-tumour heterogeneity.
Journal of Extracellular Vesicles.
8.
2019
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conference paper
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Baxter ARichter VPoon IKLay FTAdda CKvansakul MHulett MD. The tomato defensin TPP3 induces tumour cell lysis through a conserved mechanism involving PIP2 binding and oligomerization..
Molecular Biology of the Cell.
2014
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Fahey PHobba GDElmer HRegester GOMurphy VJAdda CGMcCarthy JSAnders RF. Development of a malaria vaccine containing two forms of Plasmodium falciparum merozoite surface protein 2..
International Journal for Parasitology.
S87-S87.
2008
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Norton RSLow AYang XAdda CGZhang XYao SChandrashekaran IRSabo JAnders RF. Merozoite surface protein 2 (MSP2): structure, dynamics and amyloid formation of the N-terminal region..
International Journal for Parasitology.
S64-S64.
2008
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Adda CWaddington LHodder AMurphy VAnders R. Fibril Formation by Merozoite Surface Protein 2..
28th Annual Lorne Conference on Protein Structure & Function .
239-239.
2003
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Adda CWaddington LHodder AMurphy VAnders R. Fibril Formation by Plasmodium Falciparum Merozoite Surface Protein 2.
93-93.
2003
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Adda CMurphy VVingas KAbdulnour SWaddington LSunde MHodder AMasciantonio RAnders R. Plasmodium Falciparum Merozoite Surface Protein 2 is Instrinsically Unstructured and Forms Amyloid-like Fibrils in vitro.
2004-2004.
2003
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Anders RAdda CMasciantonio RVingas KAbdulnour SMurphy V. Progress Towards a Recombinant Protein Malaria Vaccine.
17-17.
2003
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Masciantonio RMurphy VCasey JAdda CAnders R. Antigenic characterization of polymorphic forms of Plasmodium falciparum AMA1..
Twenty Seventh Annual Lorne Conference on Protein Structure and Function.
1-1.
2002
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Adda CMurphy VAnders R. Development of a 2-site ELISA to Quantify AMA1 Expression Levels..
Twenty Seventh Annual Lorne Conference on Protein Structure and Function.
31-31.
2002
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Murphy VAdda CElliott SGould AMoscou FAndrews JBertram KIrving DAnders R. Optimisation of Fermentation Conditions for Production of Recombinant Plasmodium Falciparum (3D7) AMA1 for Clinical Trials..
Twenty Seventh Annual Lorne Conference on Protein Structure and Function.
46-46.
2002
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Adda CTilley LAnders RFoley M. Isolation of peptides that mimic epitopes on malarial antigens from phage-displayed random peptide libraries
2000
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Adda CTilley LAnders RFoley M. Peptides that mimic epitopes on malarial antigens isolated form random peptide libraries displayed on phage
2000
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Baxter ARichter VPoon IKLay FTAdda CKvansakul MHulett MD. The tomato defensin TPP3 induces tumour cell lysis through a conserved mechanism involving PIP2 binding and oligomerization..
Molecular Biology of the Cell.
2014