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Professor Chris Handley Emeritus Professor, Office of Molecular Sci
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Professor Chris Handley Emeritus Professor, Office of Molecular Sci
Positions
Research Areas
- Arthritis (Expertise)
- Cartilage (Expertise)
- Connective tissues (Expertise)
- Tendon (Expertise)
- Overview
- Publications
- Background
- Contact
- Identity
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Overview
Publications
selected publications
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academic article
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Gibbon AHobbs Hvan der Merwe WRaleigh SMCook JHandley CJPosthumus MCollins MSeptember AV. The MMP3 gene in musculoskeletal soft tissue injury risk profiling: A study in two independent sample groups.
Journal of Sports Sciences.
35:655-662.
2017
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El Khoury LPosthumus MCollins Mvan der Merwe WHandley CCook JRaleigh SM. ELN and FBN2 Gene Variants as Risk Factors for Two Sports-related Musculoskeletal Injuries.
International Journal of Sports Medicine.
36:333-337.
2015
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Saunders CJvan der Merwe LCook JHandley CJCollins MSeptember AV. Extracellular Matrix Proteins Interact With Cell-Signaling Pathways in Modifying Risk of Achilles Tendinopathy.
Journal of Orthopaedic Research.
33:898-903.
2015
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Cook JLSaunders CJVan der Merwe LHandley CJCollins MSeptember AV. Variants within the COMP and THBS2 genes are not associated with Achilles tendinopathy in a case-control study of South African and Australian populations.
Journal of Sports Sciences.
32:92-100.
2014
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El Khoury LPosthumus MCollins MHandley CJCook JRaleigh SM. Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: A genetic association study.
Journal of Science and Medicine in Sport.
16:493-498.
2013
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Hay MPatricios JCollins RBranfield ACook JHandley CJSeptember AVPosthumus MCollins M. Association of type XI collagen genes with chronic Achilles tendinopathy in independent populations from South Africa and Australia.
British Journal of Sports Medicine.
47:569-574.
2013
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Saunders CJvan der Merwe LPosthumus MCook JHandley CJCollins MSeptember AV. Investigation of variants within theCOL27A1andTNCgenes and Achilles tendinopathy in two populations.
Journal of Orthopaedic Research.
31:632-637.
2013
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Nell E-Mvan der Merwe LCook JHandley CJCollins MSeptember AV. The apoptosis pathway and the genetic predisposition to Achilles tendinopathy.
Journal of Orthopaedic Research.
30:1719-1724.
2012
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Lay ESamiric THandley CJIlic MZ. Short- and long-term exposure of articular cartilage to curcumin or quercetin inhibits aggrecan loss.
Journal of Nutritional Biochemistry.
23:106-112.
2012
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September AVNell E-MO'Connell KCook JHandley CJvan der Merwe LSchwellnus MCollins M. A pathway-based approach investigating the genes encoding interleukin-1 , interleukin-6 and the interleukin-1 receptor antagonist provides new insight into the genetic susceptibility of Achilles tendinopathy.
British Journal of Sports Medicine.
45:1040-1047.
2011
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Munteanu SEZammit GVMenz HBLandorf KBHandley CJElzarka ADeLuca J. Effectiveness of intra-articular hyaluronan (Synvisc, hylan G-F 20) for the treatment of first metatarsophalangeal joint osteoarthritis: a randomised placebo-controlled trial.
Annals of the Rheumatic Diseases.
70:1838-1841.
2011
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Parkinson JSamiric TIlic MZCook JHandley CJ. Involvement of proteoglycans in tendinopathy.
The Journal of Musculoskeletal and Neuronal Interactions.
11:86-93.
2011
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September ANell EO'Connell KCook JHandley Cvan der Merwe Lschwellnus MCollins M. A pathway-based approach investigating the genes encoding interleukin-1ß, interleukin-6 and the interleukin-1 receptor antagonist provides new insight into the genetic susceptibility of Achilles tendinopathy.
British Journal of Sports Medicine.
45:1040-1047.
2011
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Posthumus MCollins MCook JHandley CJRibbans WJSmith RKWSchwellnus MPRaleigh SM. Components of the transforming growth factor- family and the pathogenesis of human Achilles tendon pathology--a genetic association study.
Rheumatology.
49:2090-2097.
2010
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Parkinson JSamiric TIlic MZCook JFeller JAHandley CJ. Change in proteoglycan metabolism is a characteristic of human patellar tendinopathy.
Arthritis and Rheumatism.
62:3028-3035.
2010
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Munteanu SEMenz HBZammit GVLandorf KBHandley CJElZarka ADeLuca J. Efficacy of intra-articular hyaluronan (Synvisc®) for the treatment of osteoarthritis affecting the first metatarsophalangeal joint of the foot (hallux limitus): study protocol for a randomised placebo controlled trial.
Journal of Foot and Ankle Research.
2.
2009
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Samiric TTom SParkinson JIlic MZCook JFeller JAHandley CJ. Changes in the composition of the extracellular matrix in patellar tendinopathy.
Matrix Biology.
28:230-236.
2009
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September AVCook JHandley CJvan der Merwe LSchwellnus MPCollins M. Variants within the COL5A1 gene are associated with Achilles tendinopathy in two populations.
British Journal of Sports Medicine.
43:357-365.
2009
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Ilic MZMartinac BSamiric THandley CJ. Effects of glucosamine on proteoglycan loss by tendon, ligament and joint capsule explant cultures.
Osteoarthritis and Cartilage.
16:1501-1508.
2008
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Scott ALian ØRoberts CRCook JLHandley CJBahr RSamiric TIlic MZParkinson JHart DADuronio VKhan KM. Increased versican content is associated with tendinosis pathology in the patellar tendon of athletes with jumper's knee.
Scandinavian Journal of Medicine and Science in Sports.
18:427-435.
2008
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Ilic MZEast CJRogerson FMFosang AJHandley CJ. Distinguishing Aggrecan Loss from Aggrecan Proteolysis in ADAMTS-4 and ADAMTS-5 Single and Double Deficient Mice.
Journal of Biological Chemistry.
282:37420-37428.
2007
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Samiric TIlic MZHandley CJ. Sulfated polysaccharides inhibit the catabolism and loss of both large and small proteoglycans in explant cultures of tendon.
The Federation of European Biochemical Societies (FEBS) Journal.
273:3479-3488.
2006
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ILIC MZCARTER PTYNDALL ADUDHIA JHANDLEY CJ. Proteoglycans and catabolic products of proteoglycans present in ligament.
Biochemical Journal.
385:381-388.
2005
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Samiric TIlic MZHandley CJ. Large aggregating and small leucine-rich proteoglycans are degraded by different pathways and at different rates in tendon.
The Federation of European Biochemical Societies (FEBS) Journal.
271:3612-3620.
2004
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Samiric TIlic MZHandley CJ. Large aggregating and small leucine-rich proteoglycans are degraded by different pathways and at different rates in tendon.
The Federation of European Biochemical Societies (FEBS) Journal.
271:3612-3620.
2004
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Samiric TIlic MZHandley CJ. Characterisation of proteoglycans and their catabolic products in tendon and explant cultures of tendon.
Matrix Biology.
23:127-140.
2004
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Ilic MZMartinac BHandley CJ. Effects of long-term exposure to glucosamine and mannosamine on aggrecan degradation in articular cartilage.
Osteoarthritis and Cartilage.
11:613-622.
2003
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Vankemmelbeke MNJones GCFowles CIlic MZHandley CJDay AJKnight CGMort JSButtle DJ. Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters.
The Federation of European Biochemical Societies (FEBS) Journal.
270:2394-2403.
2003
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Handley CJWinter GMIlic MZRoss JMAnthony Poole CClem Robinson H. Distribution of newly synthesized aggrecan in explant cultures of bovine cartilage treated with retinoic acid.
Matrix Biology.
21:579-592.
2002
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Munteanu SEIlic MZHandley CJ. Highly sulfated glycosaminoglycans inhibit aggrecanase degradation of aggrecan by bovine articular cartilage explant cultures.
Matrix Biology.
21:429-440.
2002
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Handley CJTuck Mok MIlic MZAdcocks CButtle DJRobinson HC. Cathepsin D cleaves aggrecan at unique sites within the interglobular domain and chondroitin sulfate attachment regions that are also cleaved when cartilage is maintained at acid pH.
Matrix Biology.
20:543-553.
2001
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Vankemmelbeke MNHolen IWilson AGIlic MZHandley CJKelner GSClark MLiu CMaki RABurnett DButtle DJ. Expression and activity of ADAMTS-5 in synovium.
The Federation of European Biochemical Societies (FEBS) Journal.
268:1259-1268.
2001
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Munteanu SEIlic MZHandley CJ. Calcium pentosan polysulfate inhibits the catabolism of aggrecan in articular cartilage explant cultures.
Arthritis and Rheumatism.
43:2211-2218.
2000
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Ilic MZVankemmelbeke MNHolen IButtle DJClem Robinson HHandley CJ. Bovine joint capsule and fibroblasts derived from joint capsule express aggrecanase activity.
Matrix Biology.
19:257-265.
2000
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Winter ADCampbell MARobinson HCHandley CJ. Catabolism of newly synthesized decorin by explant cultures of bovine ligament.
Matrix Biology.
19:129-138.
2000
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Vankemmelbeke MNIlic MZHandley CJKnight CGButtle DJ. Coincubation of Bovine Synovial or Capsular Tissue with Cartilage Generates a Soluble “Aggrecanase” Activity.
Biochemical and Biophysical Research Communications.
255:686-691.
1999
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Tester AMIlic MZRobinson HCHandley CJ. Metabolic processing of newly synthesized link protein in bovine articular cartilage explant cultures.
Matrix Biology.
18:65-74.
1999
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Ilic MZRobinson HCHandley CJ. Characterization of Aggrecan Retained and Lost from the Extracellular Matrix of Articular Cartilage.
Journal of Biological Chemistry.
273:17451-17458.
1998
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Winter GMPoole CAIlic MZRoss JMRobinson HCHandley CJ. Identification of Distinct Metabolic Pools of Aggrecan and Their Relationship to Type VI Collagen in the Chondrons of Mature Bovine Articular Cartilage Explants.
Connective Tissue Research.
37:277-293.
1998
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Buttle DJFowles AIlic MZHandley CJ. "Aggrecanase" activity is implicated in tumour necrosis factor alpha mediated cartilage aggrecan breakdown but is not detected by an in vitro assay..
Journal of Clinical Pathology.
50:153-159.
1997
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Karopoulos CRowley MJIlic MZHandley CJ. Presence of antibodies to native G1 domain of aggrecan core protein in synovial fluids from patients with various joint diseases.
Arthritis and Rheumatism.
39:1990-1997.
1996
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Yang ZdeVeer MJGardiner EEDevenish RJHandley CJUnderwood JRRobinson HC. Rabbit Polymorphonuclear Neutrophils Form35S-LabeledS-Sulfo-calgranulin C When Incubated with Inorganic [35S]Sulfate.
Journal of Biological Chemistry.
271:19802-19809.
1996
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Campbell MATester AMHandley CJCheckley GJChow GLCant AEWinter ADCain WE. Characterization of a Large Chondroitin Sulfate Proteoglycan Present in Bovine Collateral Ligament.
Archives of Biochemistry and Biophysics.
329:181-190.
1996
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Campbell MAWinter ADIlic MZHandley CJ. Catabolism and Loss of Proteoglycans from Cultures of Bovine Collateral Ligament.
Archives of Biochemistry and Biophysics.
328:64-72.
1996
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Ilic MZMok MTWilliamson ODCampbell MAHughes CEHandley CJ. Catabolism of Aggrecan by Explant Cultures of Human Articular Cartilage in the Presence of Retinoic Acid.
Archives of Biochemistry and Biophysics.
322:22-30.
1995
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Karopoulos CRowley MJHandley CJStrugnell RA. Antibody Reactivity to Mycobacterial 65kDa Heat Shock Protein: Relevance to Autoimmunity.
Journal of Autoimmunity.
8:235-248.
1995
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Parker GJHandley CJRobinson HC. An Assay for Galactosyltransferase-I Activity in Articular Cartilage.
Analytical Biochemistry.
226:154-160.
1995
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Ng CKHandley CJPreston BNRobinson HCBolis SParker G. Effect of Exogenous Hyaluronan and Hyaluronan Oligosaccharides on Hyaluronan and Aggrecan Synthesis and Catabolism in Adult Articular Cartilage Explants.
Archives of Biochemistry and Biophysics.
316:596-606.
1995
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Ilic MZHaynes SRWinter GMHandley CJ. Kinetics of release of aggrecan from explant cultures of bovine cartilage from different sources and from animals of different ages.
Acta Orthopaedica.
66:33-37.
1995
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Handley CJButtle DJ. [4] Assay of proteoglycan degradation.
Methods in Enzymology.
248:47-58.
1995
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Kleftogiannis FHandley CJCampbell MA. Characterization of extracellular matrix macromolecules from bovine synovial capsule.
Journal of Orthopaedic Research.
12:365-374.
1994
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GARDINER EEMOK SSSRIRATANA AROBINSON HCVEITCH BJALOWTHER DAHANDLEY CJ. Polymorphonuclear neutrophils release 35S-labelled proteoglycans into cartilage during frustrated phagocytosis.
The Federation of European Biochemical Societies (FEBS) Journal.
221:871-879.
1994
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Vinh TFaine SHandley CJAdler B. Immunochemical studies of opsonic epitopes of the lipopolysaccharide ofLeptospira interrogansserovarhardjo.
FEMS Immunology and Medical Microbiology.
8:99-107.
1994
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Buttle DJHandley CJIlic MZSaklatvala JMurata MBarrett AJ. Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin b and an inhibitor of matrix metalloproteinases. evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation.
Arthritis and Rheumatism.
36:1709-1717.
1993
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Karopoulos CRowley MJHandley CJ. Intrasynovial levels of sulphated glycosaminoglycans and autoantibodies to type II collagen in rheumatoid arthritis: a correlative analysis.
Rheumatology International: clinical and experimental investigations.
13:15-20.
1993
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Curtis AJDevenish RJHandley CJ. Modulation of aggrecan and link-protein synthesis in articular cartilage.
Biochemical Journal.
288:721-726.
1992
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Gardiner EERobinson HCSriratana AMok SSLowther DAHandley CJ. Synthesis of 35S-labelled macromolecules by polymorphonuclear neutrophils. Evidence for the production of [35S]sulphite which can modify both endogenous and exogenous proteins.
Biochemical Journal.
288:577-583.
1992
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Gardiner EERobinson HCSriratana AMok SSLowther DAHandley CJ. Synthesis of 35S-labelled macromolecules by polymorphonuclear neutrophils. Evidence for the production of [35S]sulphite which can modify both endogenous and exogenous proteins..
Biochemical Journal.
288:577-583.
1992
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Ng CKHandley CJPreston BNRobinson HC. The extracellular processing and catabolism of hyaluronan in cultured adult articular cartilage explants.
Archives of Biochemistry and Biophysics.
298:70-79.
1992
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Curtis AJNg CKHandley CJRobinson HC. Effect of insulin-like growth factor-I on the synthesis and distribution of link protein and hyaluronan in explant cultures of articular cartilage.
BBA: Molecular Cell Research.
1135:309-317.
1992
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Ilic MZHandley CJRobinson HCMok MT. Mechanism of catabolism of aggrecan by articular cartilage.
Archives of Biochemistry and Biophysics.
294:115-122.
1992
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Mok MTIlic MZHandley CJRobinson HC. Cleavage of proteoglycan aggregate by leucocyte elastase.
Archives of Biochemistry and Biophysics.
292:442-447.
1992
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Tesch GHHandley CJCornell HJHerington AC. Effects of free and bound insulin-like growth factors on proteoglycan metabolism in articular cartilage explants.
Journal of Orthopaedic Research.
10:14-22.
1992
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Katrantzis MBaker MSHandley CJLowther DA. The oxidant hypochlorite (OCl−), a product of the myeloperoxidase system, degrades articular cartilage proteoglycan aggregate.
Free Radical Biology and Medicine.
10:101-109.
1991
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Ilic MZHandley CJRobinson HC. The N-terminal sequence of the large proteoglycan of articular cartilage.
Biochemistry International.
21:977-986.
1990
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Hey NJHandley CJChee Keng NgOakes BW. Characterization and synthesis of macromolecules by adult collateral ligament.
BBA: General Subjects.
1034:73-80.
1990
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Bolis SHandley CJCornper WD. Passive loss of proteoglycan from articular cartilage explants.
BBA: General Subjects.
993:157-167.
1989
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Ng CKHandley CJMason RMRobinson HC. Synthesis of hyaluronate in cultured bovine articular cartilage.
Biochemical Journal.
263:761-767.
1989
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Campbell MAHandley CJD'Souza SE. Turnover of proteoglycans in articular-cartilage cultures. Characterization of proteoglycans released into the medium.
Biochemical Journal.
259:21-25.
1989
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Fosang AJHandley CJ. Connective Tissue Remodelling in the Ovine Cervix During Pregnancy and at Term.
Connective Tissue Research.
17:277-285.
1988
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Strugnell RAKent THandley CJFaine S. Experimental syphilitic orchitis. Relationship between Treponema pallidum infection and testis synthesis of proteoglycans.
American Journal of Pathology.
133:110-117.
1988
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Campbell MAHandley CJ. The effect of retinoic acid on proteoglycan turnover in bovine articular cartilage cultures.
Archives of Biochemistry and Biophysics.
258:143-155.
1987
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Campbell MAHandley CJ. The effect of retinoic acid on proteoglycan biosynthesis in bovine articular cartilage cultures.
Archives of Biochemistry and Biophysics.
253:462-474.
1987
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Comper WDPratt LHandley CJHarper GS. Cell transport in model extracellular matrices.
Archives of Biochemistry and Biophysics.
252:60-70.
1987
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Handley CJCampbell MA. [21] Catabolism and turnover of proteoglycans.
Methods in Enzymology.
144:412-419.
1987
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McQuillan DJHandley CJCampbell MABolis SMilway VEHerington AC. Stimulation of proteoglycan biosynthesis by serum and insulin-like growth factor-I in cultured bovine articular cartilage.
Biochemical Journal.
240:423-430.
1986
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McQuillan DJHandley CJRobinson HC. Control of proteoglycan biosynthesis. Further studies on the effect of serum on cultured bovine articular cartilage.
Biochemical Journal.
237:741-747.
1986
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McQuillan DJHandley CJRobinson HCNg KTzaicos C. The relation of RNA synthesis to chondroitin sulphate biosynthesis in cultured bovine cartilage.
Biochemical Journal.
235:499-505.
1986
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Strugnell RAHandley CJDrummond LPFaine S. Characterization of the proteoglycans synthesized by rabbit testis in response to infection by Treponema pallidum.
American Journal of Pathology.
124:216-225.
1986
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HANDLEY CLOWTHER DMCQUILLAN D. Mini-review: The structure and synthesis of proteoglycans of articular cartilage.
Cell Biology International Reports.
9:753-782.
1985
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Byers SHandley CJLowther DASriratana A. Carrageenin-induced arthritis. VI. Alterations in amino acid transport by articular cartilage in acute inflammatory arthritis..
Annals of the Rheumatic Diseases.
44:477-484.
1985
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Bartholomew JSHandley CJLowther DA. The effects of trypsin treatment on proteoglycan biosynthesis by bovine articular cartilage.
Biochemical Journal.
227:429-437.
1985
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Lutjen PJHandley CJde Witt MTTrounson AOMcBain JC. Biochemical changes in cervical mucus-factor infertility.
Gamete Research.
12:265-274.
1985
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McQuillan DJHandley CJRobinson HCNg KTzaicos CBrooks PRLowther DA. The relation of protein synthesis to chondroitin sulphate biosynthesis in cultured bovine cartilage.
Biochemical Journal.
224:977-988.
1984
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Campbell MAHandley CJHascall VCCampbell RALowther DA. Turnover of proteoglycans in cultures of bovine articular cartilage.
Archives of Biochemistry and Biophysics.
234:275-289.
1984
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Bartholomew JSLowther DAHandley CJ. Changes in proteoglycan biosynthesis following leukocyte elastase treatment of bovine articular cartilage in culture.
Arthritis and Rheumatism.
27:905-912.
1984
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Bates EJLowther DAHandley CJ. Oxygen free-radicals mediate an inhibition of proteoglycan synthesis in cultured articular cartilage..
Annals of the Rheumatic Diseases.
43:462-469.
1984
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Fosang AJHandley CJSanter VLowther DAThorburn GD. Pregnancy-Related Changes in the Connective Tissue of the Ovine Cervix.
Biology of Reproduction.
30:1223-1235.
1984
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Strugnell RAHandley CJDrummond LFaine SLowther DAGraves SR. Polyanions in syphilis: evidence that glycoproteins and macromolecules resembling glycosaminoglycans are synthesised by host tissues in response to infection with Treponema pallidum..
British Journal of Venereal Diseases.
60:75-82.
1984
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Strugnell RAHandley CJLowther DAFaine SGraves SR. Treponema pallidum does not synthesise in vitro a capsule containing glycosaminoglycans or proteoglycans..
British Journal of Venereal Diseases.
60:8-13.
1984
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Stevens JWOike YHandley CHascall VCHampton ACaterson B. Characteristics of the core protein of the aggregating proteoglycan from the Swarm rat chondrosarcoma.
Journal of Cellular Biochemistry.
26:247-259.
1984
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De Witt MTHandley CJOakes BWLowther DA. In vitroResponse of Chondrocytes to Mechanical Loading. The Effect of Short Term Mechanical Tension.
Connective Tissue Research.
12:97-109.
1984
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Stow JLGlasgow EFHandley CJHascall VC. Biosynthesis of proteoglycans by isolated rabbit glomeruli.
Archives of Biochemistry and Biophysics.
225:950-957.
1983
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Hascall VCHandley CJMcQuillan DJHascall GKRobinson HCLowther DA. The effect of serum on biosynthesis of proteoglycans by bovine articular cartilage in culture.
Archives of Biochemistry and Biophysics.
224:206-223.
1983
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Ma JHandley CJde Boer WGRM. An ovarian tumour specific mucin antigen—immunohistological and biochemical studies.
Pathology.
15:385-391.
1983
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Byers SHandley CJLowther DA. Transport of Neutral Amino Acids by Adult Articular Cartilage.
Connective Tissue Research.
11:321-330.
1983
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Oakes BWBatty ACHandley CJSandberg LB. The synthesis of elastin, collagen, and glycosaminoglycans by high density primary cultures of neonatal rat aortic smooth muscle. An ultrastructural and biochemical study.
European Journal of Cell Biology.
27:34-46.
1982
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Salem HHKoutts JHandley CVan Der Weyden MBDudley FJFirkin BG. The aggregation of human platelets by ascitic fluid: A possible mechanism for disseminated intravascular coagulation complicating LeVeen shunts.
American Journal of Hematology.
11:153-157.
1981
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Speight GHandley CJLowther DA. Effect of dibutyryl cyclic AMP on the sulphation of proteoglycans by chondrocytes.
BBA: General Subjects.
672:89-97.
1981
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Handley CJSpeight GRobinson HCLowther DA. Molecular size distribution of proteoglycan subunits and glycosaminoglycans synthesized by chondrocytes under conditions of reduced proteoglycan synthesis.
BBA: General Subjects.
631:124-129.
1980
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Handley CJSpeight GLeyden KMLowther DA. Extracellular matrix metabolism by chondrocytes 7. Evidence that L-glutamine is an essential amino acid for chondrocytes and other connective tissue cells.
BBA: General Subjects.
627:324-331.
1980
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Handley CJBrooks PLowther DA. Suppression of collagen synthesis by chondrocytes by exogenous concentrations of proteoglycan subunit.
Biochemistry International.
1:270-276.
1980
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Cumming GJHandley CJPreston BN. Permeability of composite chondrocyte-culture-millipore membranes to solutes of varying size and shape.
Biochemical Journal.
181:257-266.
1979
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Handley CJLowther DA. Extracellular matrix metabolism by chondrocytes 5. The proteoglycans and glycosaminoglycans synthesized by chondrocytes in high density cultures.
BBA: General Subjects.
582:234-245.
1979
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Handley CJBrooks PRLowther DA. Extracellular matrix metabolism by chondrocytes.
BBA: General Subjects.
544:441-444.
1978
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Speight GHandley CJLowther DA. Extracellular matrix metabolism by chondrocytes 4. Role of glutamine in glycosaminoglycan synthesis in vitro by chondrocytes.
BBA: General Subjects.
540:238-245.
1978
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Lowther DAHandley CJGundalach A. Effect of Salicylic Acid on Articular Cartilage in Organ Culture.
Pharmacology.
17:50-55.
1978
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Handley CJHandley SLowther DA. Extracellular matrix metabolism by chondrocytes III. Modulation of proteoglycan synthesis by extracellular levels of proteoglycan in cartilage cells in culture.
BBA: General Subjects.
500:132-139.
1977
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Carmichael DJGillard GCLowther DAHandley CJSanter VB. Carrageenin-induced arthritis.
Arthritis and Rheumatism.
20:834-840.
1977
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Oakes BWHandley CJLisner FLowther DA. An ultrastructural and biochemical study of high density primary cultures of embryonic chick chondrocytes.
Journal of Embryology and Experimental Morphology.
Vol. 38:239-263.
1977
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Lowther DAGillard GCBaxter EHandley CJRich KA. Carrageenin-induced arthritis. III. Proteolytic enzymes present in rabbit knee joints after a single intraarticular injection of carrageenin.
Arthritis and Rheumatism.
19:1287-1294.
1976
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Handley CJLowther DA. Inhibition of proteoglycan biosynthesis by hyaluronic acid in chondrocytes in cell culture.
BBA: General Subjects.
444:69-74.
1976
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Handley CJBateman JFOakes BWLowther DA. Characterization of the collagen synthesized by cultured cartilage cells.
Biochimica et Biophysica Acta - Protein Structure.
386:444-450.
1975
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Oakes BWHandley CJ. Proceedings: The ultrastructural morphology and biochemistry of chick embryo chondrocytes in culture..
Journal of Anatomy.
118:390-391.
1974
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Handley CJPhelps CF. The biosynthesis in vitro of keratan sulphate in bovine cornea.
Biochemical Journal.
128:205-213.
1972
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Handley CJPhelps CF. The concentrations of sugar nucleotides in bovine corneal epithelium and endothelium.
Biochemical Journal.
127:911-912.
1972
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Handley CJPhelps CF. The biosynthesis in vitro of chondroitin sulphate in neonatal rat epiphysial cartilage.
Biochemical Journal.
126:417-432.
1972
Full text if available
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Gibbon AHobbs Hvan der Merwe WRaleigh SMCook JHandley CJPosthumus MCollins MSeptember AV. The MMP3 gene in musculoskeletal soft tissue injury risk profiling: A study in two independent sample groups.
Journal of Sports Sciences.
35:655-662.
2017
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book
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conference paper
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Samiric THandley CJCook JParkinson J. GENE EXPRESSION OF MATRIX-DEGRADING ENZYMES IN PATELLAR TENDINOPATHY.
British Journal of Sports Medicine.
e2.3-e2.
2013
Full text if available -
Handley CParkinson JCook JIlic MFeller JSamiric T. Altered proteoglycans metabolism is a feature of human patellar tendinopathy.
The International Scientific Tendinopathy Symposium.
46-46.
2010
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Handley CParkinson JSamiric TIlic MCook JFeller J. Overuse tendinopathy is characterised by changes in the metabolism of proteoglycans present in the extracellular matrix of tendons.
Journal of Science and Medicine in Sport.
35-35.
2010
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Ilic MEast CRogerson FFosang ASamiric THandley C. Comparison between aggrecan loss and aggrecan precessing in explants of cartilage from ADAMTS-4, ADAMTS-5 and ADAMTS- 4/5 deficient mice..
7th Pan Pacific Connective Tissue Societies Symposium.
67-67.
2007
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Parkinson JSamiric TIlic MFeller JHandley CCook J. Patella tendinopathy; can it be explained by changes in themetabolism of matrix molecules?.
7th Pan Pacific Connective Tissue Societies Symposium.
63-63.
2007
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Lay ESamiric TParkinson JIlic MHandley C. The effect of circumin on interleukin - 1a and retinoic acid stimulated aggrecanase activity in bovine articular cartilage explant cultures..
7th Pan Pacific Connective Tissue Societies Symposium.
60-60.
2007
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Samiric TParkinson JIlic MHandley C. Differences in chemical levels of collagen and proteoglycan species between normal and pathological patella tendon in humans.
447-447.
2006
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Samiric TIlic MHandley C. Catabolism of proteoglycans in tendon..
Matrix matters .
29-29.
2003
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Samiric TIlic MHandley C. Characterisation of proteoglycans and their degradation products of bovine tendon.
12-12.
2003
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Dooley PHowgate MHandley CSchuijers JGrills B. Early, Soft tissue fracture callus contracts and relaxes in vitro..
116-116.
2003
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Samiric TIlic MHandley C. The kinetics and catabolic fate of newly synthesized proteoglycans in explant cultures of bovine tendon.
13-13.
2003
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Ilic MMartinac BHandley C. Effects of Glucosamine On The Catabolism of Aggrecan In Articular Cartilage.
Osteoarthritis and Cartilage.
10-10.
2002
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Ilic MMartinac BHandley C. Effects of long term exposure to glucosamine and mannosamine on aggrecan degratatiion in explant cultures of articular cartilage.
27-27.
2002
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Vankemmelbeke MJones GFowles CIlic MHandley CDay A. Inhibition of adamts-1, -4 and 5 by catecin esters.
19-19.
2002
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Munteanu SIlic MHandley C. Short-Term Exposure Of Explant Cultures of Articular Cartilage to Pentosan Polysulfate Results in Long-Term Protection to Aggrecan loss.
45-45.
2002
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Handley CMunteanu SIlic M. Suppression of aggrecanse mediated degradation of aggrecan by highly sulfated polysaccharides.
20-20.
2002
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Handley C. Articular Cartilage, Structure, Function and its Potential for Repair.
7-7.
2001
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Munteanu SIlic MVan Kemmetfeke MHolen IButtle DRobinson HHandley C. Aggrecanases in Joint Capsule
2000
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Handley CMok MAdcocks CIlic MRobinson HButtle D. Antolysis of cartilage
2000
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BRADBEER MBROOKS PRHANDLEY CJROBINSON JAROBINSON HC. GALACTOSYL TRANSFERASE-ACTIVITY OF CHONDROCYTES IN CULTURE.
Connective Tissue Research.
331-331.
1983
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Samiric THandley CJCook JParkinson J. GENE EXPRESSION OF MATRIX-DEGRADING ENZYMES IN PATELLAR TENDINOPATHY.
British Journal of Sports Medicine.
e2.3-e2.
2013
Background
education and training
- BA(Hons), York
- DSc, York
- DipEd, Monash University
- PHD, Bristol
Contact
full name
- Professor Chris Handley