selected publications
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academic article
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Sobey CGJudkins CPRivera JLewis CVDiep HLee HWKemp-Harper BKBroughton BRSSelemidis SGaspari TASamuel CSDrummond GR. NOX1 deficiency in apolipoprotein E-knockout mice is associated with elevated plasma lipids and enhanced atherosclerosis.
Free Radical Research.
49:186-198.
2015
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Sobey CJudkins CSundararajan VPhan TDrummond GSrikanth V. Risk of major cardiovascular events in patients with down syndrome.
International Journal of Stroke.
9:215-215.
2014
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Miller AADe Silva TMJudkins CPDiep HDrummond GRSobey CG. Augmented Superoxide Production By Nox2-Containing NADPH Oxidase Causes Cerebral Artery Dysfunction During Hypercholesterolemia.
Stroke.
41:784-789.
2010
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Judkins CPDiep HBroughton BRSMast AEHooker EUMiller AASelemidis SDusting GJSobey CGDrummond GR. Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE−/− mice.
American Journal of Physiology: Heart and Circulatory Physiology.
298:H24-H32.
2010
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Miller ADrummond GDe Silva TMJudkins CSobey C. Excessive Superoxide Production And Endothelial Dysfunction In Cerebral Arteries Of Atherosclerotic Mice Occur In The Absence Of Lesions And Are Due To The Activity Of Nox2-Containing NADPH Oxidase.
The FASEB Journal.
23.
2009
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Drummond GRDiep HMast AESelemidis SDusting GJSobey CGJudkins CP. Nox2-dependent NADPH oxidase activity contributes to atherogenesis in Apolipoprotein E-Null (ApoE-/-) mice.
The FASEB Journal.
22.
2008
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Judkins CPSobey CGDang TTMiller AADusting GJDrummond GR. NADPH-Induced Contractions of Mouse Aorta Do Not Involve NADPH Oxidase: A Role for P2X Receptors.
Journal of Pharmacology and Experimental Therapeutics.
317:644-650.
2006
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HALLS MICHELLELBATHGATE ROSSASUDO SATOKOKUMAGAI JINBOND COURTNEYPSUMMERS ROGERJ. Identification of Binding Sites with Differing Affinity and Potency for Relaxin Analogues on LGR7 and LGR8 Receptors.
Annals of the New York Academy of Sciences.
1041:17-21.
2005
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BOND COURTNEYPPARRY LAURAJSAMUEL CHRISHANSGEHRING HELENMLEDERMAN FIONALROGERS PETERAWSUMMERS ROGERJ. Increased Expression of the Relaxin Receptor (LGR7) in Human Endometrium during the Secretory Phase of the Menstrual Cycle.
Annals of the New York Academy of Sciences.
1041:136-143.
2005
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Judkins CPHalls MLBond CPSudo SKumagai JFerraro TLayfield SBathgate RADSummers RJ. Multiple Binding Sites Revealed by Interaction of Relaxin Family Peptides with Native and Chimeric Relaxin Family Peptide Receptors 1 and 2 (LGR7 and LGR8).
Journal of Pharmacology and Experimental Therapeutics.
313:677-687.
2005
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Judkins CPBond CPParry LJSamuel CSGehring HMLederman FLRogers PAWSummers RJ. Increased Expression of the Relaxin Receptor (LGR7) in Human Endometrium during the Secretory Phase of the Menstrual Cycle.
Journal of Clinical Endocrinology and Metabolism.
89:3477-3485.
2004
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Samuel CSZhao CBond CPHewitson TDAmento EPSummers RJ. Relaxin-1–deficient mice develop an age-related progression of renal fibrosis.
Kidney International.
65:2054-2064.
2004
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Samuel CSZhao CBathgate RADBond CPBurton MDParry LJSummers RJTang MLKAmento EPTregear GW. Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis..
The FASEB Journal.
17:121-123.
2003
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Samuel CSZhao CBathgate RADBond CPBurton MDParry LJSummers RJTang MLKAmento EPTregear GW. Relaxin deficiency in mice is associated with an age‐related progression of pulmonary fibrosis.
The FASEB Journal.
17:121-123.
2003
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Claasz AABond CPBathgate RAOtvos LDawson NFSummers RJTregear GWWade JD. Relaxin-like bioactivity of ovine Insulin 3 (INSL3) analogues.
The Federation of European Biochemical Societies (FEBS) Journal.
269:6287-6293.
2002
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Tan YYDawson NFKompa ARBond CPClaasz AWade JDTregear GWSummers RJ. Structural requirements for the interaction of sheep insulin-like factor 3 with relaxin receptors in rat atria.
Behavioural Processes.
457:153-160.
2002
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Bathgate RADSamuel CSBurazin TCDLayfield SClaasz AAReytomas IGTDawson NFZhao CBond CSummers RJParry LJWade JDTregear GW. Human Relaxin Gene 3 (H3) and the Equivalent Mouse Relaxin (M3) Gene.
Journal of Biological Chemistry.
277:1148-1157.
2002
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Bathgate RAScott DSamuel CSBurazin TCDLayfield SClaasz AADawson NFMa SBond CSummers RJWade JDTregear GW. Relaxin 3, a novel member of the insulin/relaxin superfamily of peptide hormones..
Biology of Reproduction.
66:249-249.
2002
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Mathieu MNWade JDTregear GWBond CPSummers RJCatimel BNice ECOtvos L. Synthesis, conformational studies and biological activity of Nualpha-mono-biotinylated rat relaxin*.
Chemical Biology and Drug Design.
57:374-382.
2001
Full text if available
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Sobey CGJudkins CPRivera JLewis CVDiep HLee HWKemp-Harper BKBroughton BRSSelemidis SGaspari TASamuel CSDrummond GR. NOX1 deficiency in apolipoprotein E-knockout mice is associated with elevated plasma lipids and enhanced atherosclerosis.
Free Radical Research.
49:186-198.
2015
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conference paper
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Sobev CGJudkins CPPhan TGSundararajan VDrummond GRSrikanth VK. Increased Incidence of Cerebrovascular Events and Decreased Incidence of Coronary Events in Down Syndrome Individuals.
Circulation.
2013
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Drummond GRJudkins CPPhan TGSundararajan VSobey CGSrikanth V. Increased Risk of Ischemic Coronary and Cerebrovascular Events in Patients With Chronic Granulomatous Disease.
Circulation.
2013
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Judkins CPDiep HBroughton BRMast AEHooker EUMiller AASelemidis SDusting GJSobey CGDrummond GR. Dual Effects of Nox2-NADPH Oxidase During Atherosclerotic Plaque Development in Apolipoprotein E-Null Mice.
Circulation.
S1096-S1096.
2009
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Miller AADeSilva MJudkins CPDiep HDrummond GRSobey CG. Excessive Superoxide Production and Endothelial Dysfunction in Cerebral Arteries of Atherosclerotic Mice Are Due to Enhanced Activity of Nox2-containing NADPH-oxidase.
Circulation.
S1085-S1085.
2009
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De Silva TMDrummond GRBroughton BRJudkins CSobey CGMiller AA. Defining the Role(s) of Nox2-Containing NADPH Oxidase in the Cerebral Circulation.
Hypertension.
E32-E32.
2009
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Miller AADe Silva TMJudkins CPDiep HDrummond GRSobey CG. Excessive superoxide production and endothelial dysfunction in cerebral arteries of atherosclerotic mice are due to enhanced activity of Nox2-containing NADPH-Oxidase.
Journal of Cerebral Blood Flow and Metabolism.
S73-S73.
2009
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Miller AADe Silva TMJudkins CPDiep HDrummond GRSobey CG. CEREBROVASCULAR DYSFUNCTION DURING HYPERCHOLESTEROLEMIA: ROLE OF NOX2-DERIVED SUPEROXIDE.
Journal of Vascular Research.
5-5.
2009
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Judkins CPDiep HBroughton BRSMast AEHooker EUMiller AASelemidis SDusting GJSobey CGDrummond G. DUAL EFFECTS OF NOX2-NADPH OXIDASE DURING ATHEROSCLEROTIC PLAQUE DEVELOPMENT IN APOLIPOPROTEIN E-NULL MICE.
Journal of Vascular Research.
8-8.
2009
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Judkins CPDusting GJDrummond GR. The effects of chronic tempol treatment on athersclerosis vary from attenuation to exacerbation depending on treatment duration..
Journal of Hypertension.
326-326.
2006
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Drummond GRJudkins CPDang TTMiller AADusting GJSobey CG. NADPH-induced contractions of mouse aorta do not involve NADPH oxidase: A role for P2X receptors.
The FASEB Journal.
A664-A664.
2006
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Sobev CGJudkins CPPhan TGSundararajan VDrummond GRSrikanth VK. Increased Incidence of Cerebrovascular Events and Decreased Incidence of Coronary Events in Down Syndrome Individuals.
Circulation.
2013
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abstract