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Professor Chris Sobey Professor in Physiology, Physiology Anatomy & Microbiology

Professor Chris Sobey obtained his PhD in 1991 in the Department of Physiology at the University of Melbourne, studying the role of endothelium in the coronary circulation. In 1994 he was awarded an NHMRC CJ Martin Fellowship to conduct postdoctoral research work at the University of Iowa (USA) where he gained expertise in studies of the cerebral circulation.

In 1996 he returned to Australia where he established the Cerebrovascular Reactivity Laboratory in the Department of Pharmacology at the University of Melbourne. In 2002 he was awarded an NHMRC RD Wright Career Development Award, and in 2005 he was appointed an NHMRC Senior Research Fellow. In 2006 he was recruited to the Department of Pharmacology at Monash University where, together with Grant Drummond, he established the Vascular Biology and Immunopharmacology Group (VBIG) which has now published more than 80 research articles. In 2015 Chris was appointed as Program Lead of the Cardiovascular Disease program in the new Monash Biomedicine Discovery Institute. Then in 2017, both he and Grant Drummond were recruited to the School of Life Sciences at La Trobe University where they are now Professors in Physiology. Their VBIG research team comprises approximately 15 members.

Chris is also a Senior Editor of the British Journal of Pharmacology, a current or past member of numerous Editorial Boards of International Journals, and is an elected Fellow of the American Heart Association (FAHA) and British Pharmacological Society (FBPhS). He has served as a member of the Assigner's Academy and several Grant Review Panels for the NHMRC. He has held continuous Fellowship support from the NHMRC since 2002 and has been Chief Investigator on 18 NHMRC-funded Project Grants (including 3 current and a total of 10 as CIA).

He has a career total of more than 200 publications with over 11,000 citations, and his research has examined numerous signalling mechanisms regulating the coronary and cerebral circulations, showing that vascular function is substantially altered in a range of diseases including hypertension, subarachnoid haemorrhage, sepsis, ischaemia-reperfusion and hypercholesterolaemia, and that gender differences often exist. A major part of his current research is investigating the oxidative and inflammatory mechanisms occurring in the brain after stroke in order to identify and develop novel approaches to treat stroke patients. One facet of this work involves his co-leadership of a Phase I Clinical Trial to assess the safety of Amnion Cell Therapy in Ischemic stroke (I-ACT) to provide a platform for a Phase II Trial. The Trial is registered with the Australian & New Zealand Clinical Trials Registry (ACTRN12618000076279p).

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