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Professor Graham Lamb Adjunct Professor, Physiology Anatomy & Microbiology
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- +61 3 9479 2249
Professor Graham Lamb Adjunct Professor, Physiology Anatomy & Microbiology
Positions
Research Areas
- Muscle diseases (Expertise)
- Muscle fatigue (Expertise)
- Muscle function (Expertise)
- Myotonia (Expertise)
- Overview
- Publications
- Research
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Overview
Publications
selected publications
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academic article
- Xu HLamb GDMurphy RM. Changes in contractile and metabolic parameters of skeletal muscle as rats age from 3 to 12 months. Journal of Muscle Research and Cell Motility. 38:405-420. 2018
- Lamboley CXu HYDutka THanson EDHayes AViolet JAMurphy RLamb G. Effect of androgen deprivation therapy on the contractile properties of type I and type II skeletal muscle fibres in men with non-metastatic prostate cancer. Clinical and Experimental Pharmacology and Physiology. 45:146-154. 2018
- Lamb GDStephenson DG. Measurement of force and calcium release using mechanically skinned fibers from mammalian skeletal muscle. Journal of Applied Physiology. 125:1105-1127. 2018
- Xu HRen XLamb GDMurphy RM. Physiological and biochemical characteristics of skeletal muscles in sedentary and active rats. Journal of Muscle Research and Cell Motility. 39:1-16. 2018
- Wette SGSmith HKLamb GDMurphy RM. Characterization of muscle ankyrin repeat proteins in human skeletal muscle. American Journal of Physiology: Cell Physiology. 313:C327-C339. 2017
- Dutka TLMollica JPLamboley CRWeerakkody VCGreening DWPosterino GSMurphy RMLamb GD. S-nitrosylation and S-glutathionylation of Cys134 on troponin I have opposing competitive actions on Ca2+ sensitivity in rat fast-twitch muscle fibers. American Journal of Physiology: Cell Physiology. 312:C316-C327. 2017
- Lamboley CRWyckelsma VLMcKenna MJMurphy RMLamb GD. Ca2+ leakage out of the sarcoplasmic reticulum is increased in type I skeletal muscle fibres in aged humans. The Journal of Physiology. 594:469-481. 2016
- Lamboley CRWyckelsma VLPerry BDMcKenna MJLamb GD. Effect of 23-day muscle disuse on sarcoplasmic reticulum Ca2+ properties and contractility in human type I and type II skeletal muscle fibers. Journal of Applied Physiology. 121:483-492. 2016
- Xu HFrankenberg NTLamb GDGooley PRStapleton DIMurphy RM. When phosphorylated at Thr(148), the beta(2)-subunit of AMP-activated kinase does not associate with glycogen in skeletal muscle. American Journal of Physiology: Cell Physiology. 311:C35-C42. 2016
- Lamboley CRWyckelsma VLDutka TLMcKenna MJMurphy RMLamb GD. Contractile properties and sarcoplasmic reticulum calcium content in typeI and typeII skeletal muscle fibres in active aged humans. The Journal of Physiology. 593:2499-2514. 2015
- Frankenberg NTLamb GDVissing KMurphy RM. Subcellular fractionation reveals HSP72 does not associate with SERCA in human skeletal muscle following damaging eccentric and concentric exercise. Journal of Applied Physiology. 116:1503-1511. 2014
- Dutka TLLamboley CRMurphy RMLamb GD. Acute effects of taurine on sarcoplasmic reticulum Ca2+ accumulation and contractility in human type I and type II skeletal muscle fibers. Journal of Applied Physiology. 117:797-805. 2014
- Lamboley CMurphy RMcKenna MLamb G. Sarcoplasmic reticulum Ca2+ uptake and leak properties, and SERCA isoform expression, in type I and type II fibres of human skeletal muscle. The Journal of Physiology. 592:1381-1395. 2014
- Frankenberg NLamb GOvergaard KMurphy RVissing K. Small heat shock proteins translocate to the cytoskeleton in human skeletal muscle following eccentric exercise independently of phosphorylation. Journal of Applied Physiology. 116:1463-1472. 2014
- Lamboley CRMurphy RMMcKenna MJLamb GD. Endogenous and maximal sarcoplasmic reticulum calcium content and calsequestrin expression in type I and type II human skeletal muscle fibres. The Journal of Physiology. 591:6053-6068. 2013
- Murphy RMLamb GD. Important considerations for protein analyses using antibody based techniques: down-sizing Western blotting up-sizes outcomes. The Journal of Physiology. 591:5823-5831. 2013
- Fajardo VAMcMeekin LBasic ALamb GDMurphy RMLeBlanc PJ. Isolation of Sarcolemmal Plasma Membranes by Mechanically Skinning Rat Skeletal Muscle Fibers for Phospholipid Analysis. Lipids. 48:421-430. 2013
- Murphy RDutka THorvath DBell JDelbridge LLamb G. Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle. The Journal of Physiology. 591:719-729. 2013
- Larkins NTMurphy RMLamb GD. Influences of temperature, oxidative stress, and phosphorylation on binding of heat shock proteins in skeletal muscle fibers. American Journal of Physiology: Cell Physiology. 303:C654-C665. 2012
- Dutka TLLamboley CRMcKenna MJMurphy RMLamb GD. Effects of carnosine on contractile apparatus Ca 2+ sensitivity and sarcoplasmic reticulum Ca 2+ release in human skeletal muscle fibers. Journal of Applied Physiology. 112:728-736. 2012
- Mollica JPDutka TLMerry TLLamboley CRMcConell GKMcKenna MJMurphy RMLamb GD. S -Glutathionylation of troponin I (fast) increases contractile apparatus Ca 2+ sensitivity in fast-twitch muscle fibres of rats and humans. The Journal of Physiology. 590:1443-1463. 2012
- Larkins NTMurphy RMLamb GD. Absolute amounts and diffusibility of HSP72, HSP25, and αB-crystallin in fast- and slow-twitch skeletal muscle fibers of rat. American Journal of Physiology: Cell Physiology. 302:C228-C239. 2012
- Dutka TLVerburg ELarkins NHortemo KHLunde PKSejersted OMLamb GD. ROS-Mediated Decline in Maximum Ca2+-Activated Force in Rat Skeletal Muscle Fibers following In Vitro and In Vivo Stimulation. PLoS ONE. 7. 2012
- Murphy RMVissing KLatchman HLamboley CMcKenna MJOvergaard KLamb GD. Activation of skeletal muscle calpain-3 by eccentric exercise in humans does not result in its translocation to the nucleus or cytosol. Journal of Applied Physiology. 111:1448-1458. 2011
- Lamb GDWesterblad H. Acute effects of reactive oxygen and nitrogen species on the contractile function of skeletal muscle. The Journal of Physiology. 589:2119-2127. 2011
- Dutka TLMollica JPPosterino GSLamb GD. Modulation of contractile apparatus Ca 2+ sensitivity and disruption of excitation-contraction coupling by S -nitrosoglutathione in rat muscle fibres. The Journal of Physiology. 589:2181-2196. 2011
- Dutka TLMollica JPLamb GD. Differential effects of peroxynitrite on contractile protein properties in fast- and slow-twitch skeletal muscle fibers of rat. Journal of Applied Physiology. 110:705-716. 2011
- Murphy RMMollica JPBeard NAKnollmann BCLamb GD. Quantification of calsequestrin 2 (CSQ2) in sheep cardiac muscle and Ca 2+ -binding protein changes in CSQ2 knockout mice. American Journal of Physiology: Heart and Circulatory Physiology. 300:H595-H604. 2011
- Lamb GD. Mechanisms of excitation-contraction uncoupling relevant to activity-induced muscle fatigue. Applied Physiology, Nutrition and Metabolism. 34:368-372. 2009
- Verburg EMurphy RMRichard ILamb GD. Involvement of calpains in Ca 2+ -induced disruption of excitation-contraction coupling in mammalian skeletal muscle fibers. American Journal of Physiology: Cell Physiology. 296:C1115-C1122. 2009
- Murphy RMMollica JPLamb GD. Plasma membrane removal in rat skeletal muscle fibers reveals caveolin-3 hot-spots at the necks of transverse tubules. Experimental Cell Research. 315:1015-1028. 2009
- Murphy RMLamb GD. Endogenous Calpain-3 Activation Is Primarily Governed by Small Increases in Resting Cytoplasmic [Ca 2+ ] and Is Not Dependent on Stretch. Journal of Biological Chemistry. 284:7811-7819. 2009
- Mollica JPOakhill JSLamb GDMurphy RM. Are genuine changes in protein expression being overlooked? Reassessing Western blotting. Analytical Biochemistry. 386:270-275. 2009
- Murphy RMLarkins NTMollica JPBeard NALamb GD. Calsequestrin content and SERCA determine normal and maximal Ca 2+ storage levels in sarcoplasmic reticulum of fast- and slow-twitch fibres of rat. The Journal of Physiology. 587:443-460. 2009
- Murphy RLamb G. Calpain-3 is activated following eccentric exercise.. Journal of Applied Physiology. 106:2068-2068. 2009
- Murphy RMDutka TLLamb GD. Hydroxyl radical and glutathione interactions alter calcium sensitivity and maximum force of the contractile apparatus in rat skeletal muscle fibres. The Journal of Physiology. 586:2203-2216. 2008
- Laver DRHonen BNLamb GDIkemoto N. A domain peptide of the cardiac ryanodine receptor regulates channel sensitivity to luminal Ca2+ via cytoplasmic Ca2+ sites. European Biophysics Journal. 37:455-467. 2008
- Dutka TLMurphy RMStephenson DGLamb GD. Chloride conductance in the transverse tubular system of rat skeletal muscle fibres: importance in excitation-contraction coupling and fatigue. The Journal of Physiology. 586:875-887. 2008
- Allen DGLamb GDWesterblad H. Impaired calcium release during fatigue. Journal of Applied Physiology. 104:296-305. 2008
- Allen DGLamb GDWesterblad H. Skeletal Muscle Fatigue: Cellular Mechanisms. Physiological Reviews. 88:287-332. 2008
- Murphy RMGoodman CAMcKenna MJBennie JLeikis MLamb GD. Calpain-3 is autolyzed and hence activated in human skeletal muscle 24 h following a single bout of eccentric exercise. Journal of Applied Physiology. 103:926-931. 2007
- Dutka TLLamb GD. Na + -K + pumps in the transverse tubular system of skeletal muscle fibers preferentially use ATP from glycolysis. American Journal of Physiology: Cell Physiology. 293:C967-C977. 2007
- Dutka TLLamb GD. Transverse tubular system depolarization reduces tetanic force in rat skeletal muscle fibers by impairing action potential repriming. American Journal of Physiology: Cell Physiology. 292:C2112-C2121. 2007
- Murphy RMVerburg ELamb GD. Ca 2+ activation of diffusible and bound pools of μ-calpain in rat skeletal muscle. The Journal of Physiology. 576:595-612. 2006
- YANG ZIKEMOTO NLAMB GSTEELE D. Corrigendum to: The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes [Cardiovascular Research 70 (2006) 475–485]. Cardiovascular Research. 71:606-606. 2006
- Trinh HHLamb GD. MATCHING OF SARCOPLASMIC RETICULUM AND CONTRACTILE PROPERTIES IN RAT FAST- AND SLOW-TWITCH MUSCLE FIBRES. Clinical and Experimental Pharmacology and Physiology. 33:591-600. 2006
- Lamb GDStephenson DG. The Last Word: Point:Counterpoint authors respond to commentaries on “Lactic acid accumulation is an advantage/disadvantage during muscle activity”. Journal of Applied Physiology. 101:369-369. 2006
- YANG ZIKEMOTO NLAMB GSTEELE D. The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes. Cardiovascular Research. 70:475-485. 2006
- Verburg EDutka TLLamb GD. Long-lasting muscle fatigue: partial disruption of excitation-contraction coupling by elevated cytosolic Ca 2+ concentration during contractions. American Journal of Physiology: Cell Physiology. 290:C1199-C1208. 2006
- Lamb GDStephenson DG. Point:Counterpoint: Lactic acid accumulation is an advantage/disadvantage during muscle activity. Journal of Applied Physiology. 100:1410-1412. 2006
- Murphy RMSnow RJLamb GD. μ-Calpain and calpain-3 are not autolyzed with exhaustive exercise in humans. American Journal of Physiology: Cell Physiology. 290:C116-C122. 2006
- Dutka TLCole LLamb GD. Calcium phosphate precipitation in the sarcoplasmic reticulum reduces action potential-mediated Ca 2+ release in mammalian skeletal muscle. American Journal of Physiology: Cell Physiology. 289:C1502-C1512. 2005
- Verburg EMurphy RMStephenson DGLamb GD. Disruption of excitation-contraction coupling and titin by endogenous Ca 2+ -activated proteases in toad muscle fibres. The Journal of Physiology. 564:775-790. 2005
- Lamb GD. Rippling muscle disease may be caused by ?silent? action potentials in the tubular system of skeletal muscle fibers. Muscle and Nerve. 31:652-658. 2005
- Dulhunty AFCengia LYoung JPace SMHarvey PJLamb GDChan Y-NWimmer NToth ICasarotto MG. Functional implications of modifying RyR-activating peptides for membrane permeability. British Journal of Pharmacology. 144:743-754. 2005
- Murphy RMStephenson DGLamb GD. Effect of creatine on contractile force and sensitivity in mechanically skinned single fibers from rat skeletal muscle. American Journal of Physiology: Cell Physiology. 287:C1589-C1595. 2004
- Laver DRO'Neill ERLamb GD. Luminal Ca 2+ –regulated Mg 2+ Inhibition of Skeletal RyRs Reconstituted as Isolated Channels or Coupled Clusters. Journal of General Physiology. 124:741-758. 2004
- Dutka TLLamb GD. Effect of low cytoplasmic [ATP] on excitation-contraction coupling in fast-twitch muscle fibres of the rat. The Journal of Physiology. 560:451-468. 2004
- Stephenson DGLamb GDPedersen TH. Intracellular Acidosis Enhances the Excitability of Working Muscle. Science. 305:1144-1147. 2004
- Nielsen OBØrtenblad NLamb GDStephenson DG. Excitability of the T-tubular system in rat skeletal muscle: roles of K + and Na + gradients and Na + -K + pump activity. The Journal of Physiology. 557:133-146. 2004
- Dutka TLLamb GD. Effect of Carnosine on Excitation–Contraction Coupling in Mechanically-Skinned Rat Skeletal Muscle. Journal of Muscle Research and Cell Motility. 25:203-213. 2004
- Posterino GSLamb GD. Effect of sarcoplasmic reticulum Ca2+ content on action potential-induced Ca2+ release in rat skeletal muscle fibres. The Journal of Physiology. 551:219-237. 2003
- Posterino GSCellini MALamb GD. Effects of oxidation and cytosolic redox conditions on excitation-contraction coupling in rat skeletal muscle. The Journal of Physiology. 547:807-823. 2003
- GREEN DPACE SCURTIS SMSAKOWSKA MLAMB GDDULHUNTY AFCASAROTTO MG. The three-dimensional structural surface of two beta-sheet scorpion toxins mimics that of an alpha-helical dihydropyridine receptor segment. Biochemical Journal. 370:517-527. 2003
- Lamb GDPosterino GS. Effects of oxidation and reduction on contractile function in skeletal muscle fibres of the rat. The Journal of Physiology. 546:149-163. 2003
- Lamb GD. Excitation-contraction coupling and fatigue mechanisms in skeletal muscle: Studies with mechanically skinned fibres. Journal of Muscle Research and Cell Motility. 23:81-91. 2002
- Lamb GD. Voltage-sensor control of Ca2+ release in skeletal muscle: insights from skinned fibers. Frontiers in Bioscience. 7:d834-d834. 2002
- Laver DRLenz GKELamb GD. Regulation of the calcium release channel from rabbit skeletal muscle by the nucleotides ATP, AMP, IMP and adenosine. The Journal of Physiology. 537:763-778. 2001
- Laver DRLenz GKELamb GD. Regulation of the calcium release channel from rabbit skeletal muscle by the nucleotides ATP, AMP, IMP and adenosine. The Journal of Physiology. 537:763-778. 2001
- Blazev RHussain MBakker AJHead SILamb GD. Effects of the PKA inhibitor H-89 on excitation-contraction coupling in skinned and intact skeletal muscle fibres. Journal of Muscle Research and Cell Motility. 22:277-286. 2001
- Lamb GDPosterino GSYamamoto TIkemoto N. Effects of a domain peptide of the ryanodine receptor on Ca 2+ release in skinned skeletal muscle fibers. American Journal of Physiology: Cell Physiology. 281:C207-C214. 2001
- Lamb GDPosterino GSYamamoto TIkemoto N. Effects of a domain peptide of the ryanodine receptor on Ca2+ release in skinned skeletal muscle fibers. American Journal of Physiology: Cell Physiology. 281:C207-C214. 2001
- Posterino GDutka TLamb G. L (+)-lactate does not affect twitch and tetanic responses in mechanically skinned mammalian muscle fibres. Pfluegers Archiv: European journal of physiology. 442:197-203. 2001
- Lamb GDCellini MAStephenson DG. Different Ca 2+ releasing action of caffeine and depolarisation in skeletal muscle fibres of the rat. The Journal of Physiology. 531:715-728. 2001
- Lamb GDLaver DRStephenson DG. Questions about Adaptation in Ryanodine Receptors: Figure 1. Journal of General Physiology. 116:883-890. 2000
- Lamb GDEl-Hayek RIkemoto NStephenson DG. Effects of dihydropyridine receptor II-III loop peptides on Ca 2+ release in skinned skeletal muscle fibers. American Journal of Physiology: Cell Physiology. 279:C891-C905. 2000
- Lamb GDEl-Hayek RIkemoto NStephenson DG. Effects of dihydropyridine receptor II-III loop peptides on Ca2+ release in skinned skeletal muscle fibers. American Journal of Physiology: Cell Physiology. 279:C891-C905. 2000
- Posterino GSLamb GDStephenson DG. Twitch and tetanic force responses and longitudinal propagation of action potentials in skinned skeletal muscle fibres of the rat. The Journal of Physiology. 527:131-137. 2000
- Laver DREager KRTaoube LLamb GD. Effects of Cytoplasmic and Luminal pH on Ca2+ Release Channels from Rabbit Skeletal Muscle. Biophysical Journal. 78:1835-1851. 2000
- Dutka TLLamb GD. Effect of lactate on depolarization-induced Ca 2+ release in mechanically skinned skeletal muscle fibers. American Journal of Physiology: Cell Physiology. 278:C517-C525. 2000
- Dutka TLLamb GD. Effect of lactate on depolarization-induced Ca2+ release in mechanically skinned skeletal muscle fibers. American Journal of Physiology: Cell Physiology. 278:C517-C525. 2000
- Blazev RLamb GD. Adenosine inhibits depolarization-induced Ca2+ release in mammalian skeletal muscle. Muscle and Nerve. 22:1674-1683. 1999
- Blazev RLamb GD. Low [ATP] and elevated [Mg 2+ ] reduce depolarization-induced Ca 2+ release in rat skinned skeletal muscle fibres. The Journal of Physiology. 520:203-215. 1999
- Lamb GDCellini MA. High intracellular [Ca 2+ ] alters sarcoplasmic reticulum function in skinned skeletal muscle fibres of the rat. The Journal of Physiology. 519:815-827. 1999
- Laver DREager KRTaoube LLamb GD. Regulation of the skeletal muscle calcium release channel (RyR1) by luminal and cytosolic pH.. Biophysical Journal. 76:A303-A303. 1999
- Coonan JRLamb GD. Effect of transverse-tubular chloride conductance on excitability in skinned skeletal muscle fibres of rat and toad. The Journal of Physiology. 509:551-564. 1998
- Laver DRLamb GD. Inactivation of Ca2+ Release Channels (Ryanodine Receptors RyR1 and RyR2) with Rapid Steps in [Ca2+] and Voltage. Biophysical Journal. 74:2352-2364. 1998
- Coonan JRLamb GD. Effect of chloride on Ca 2+ release from the sarcoplasmic reticulum of mechanically skinned skeletal muscle fibres. Pfluegers Archiv: European journal of physiology. 435:720-730. 1998
- STEPHENSON DGLAMB GDSTEPHENSON GMM. Events of the excitation-contraction-relaxation (E-C-R) cycle in fast- and slow-twitch mammalian muscle fibres relevant to muscle fatigue. Acta Physiologica. 162:229-245. 1998
- Posterino GSLamb GD. Effect of nifedipine on depolarization-induced force responses in skinned skeletal muscle fibres of rat and toad. Journal of Muscle Research and Cell Motility. 19:53-65. 1998
- Posterino GSLamb GD. Investigation of the effect of inositol trisphosphate in skinned skeletal muscle fibres with functional excitation-contraction coupling. Journal of Muscle Research and Cell Motility. 19:67-74. 1998
- Laver DROwen VJJunankar PRTaske NLDulhunty AFLamb GD. Reduced inhibitory effect of Mg2+ on ryanodine receptor-Ca2+ release channels in malignant hyperthermia. Biophysical Journal. 73:1913-1924. 1997
- Lamb GDStephenson DG. Oxidation effects in fatigue: unphysiological responses to “depolarization” in skinned muscle fibers. Journal of Applied Physiology. 82:2054-2056. 1997
- Owen VJLamb GDStephenson DGFryer MW. Relationship between depolarization-induced force responses and Ca2+ content in skeletal muscle fibres of rat and toad.. The Journal of Physiology. 498:571-586. 1997
- Brotto MAPNosek TMLamb GDStephenson DG. Hydrogen peroxide disrupts Ca2+ release from the sarcoplasmic reticulum of rat skeletal muscle fibers (multiple letters). Journal of Applied Physiology. 82:2054-2056. 1997
- Owen VJTaske NLLamb GD. Reduced Mg2+ inhibition of Ca2+ release in muscle fibers of pigs susceptible to malignant hyperthermia. American Journal of Physiology: Cell Physiology. 272:C203-C211. 1997
- Owen VJTaske NLLamb GD. Reduced Mg2+ inhibition of Ca2+ release in muscle fibers of pigs susceptible to malignant hyperthermia. American Journal of Physiology: Cell Physiology. 272:C203-C211. 1997
- Lamb GD. Ryanodine receptor 'adaptation': A flash in the pan?. Journal of Muscle Research and Cell Motility. 18:611-616. 1997
- Posterino GSLamb GD. Effects of reducing agents and oxidants on excitation-contraction coupling in skeletal muscle fibres of rat and toad.. The Journal of Physiology. 496:809-825. 1996
- Lamb GDStephenson DG. Effects of FK506 and rapamycin on excitation-contraction coupling in skeletal muscle fibres of the rat.. The Journal of Physiology. 494:569-576. 1996
- Owen VJLamb GDStephenson DG. Effect of low [ATP] on depolarization-induced Ca2+ release in skeletal muscle fibres of the toad.. The Journal of Physiology. 493:309-315. 1996
- Owen VJLamb GDStephenson DG. Low [ATP] reduces depolarization-induced calcium release in skeletal muscle fibers. Biophysical Journal. 70:MPO80-MPO80. 1996
- Bakker AJLamb GDStephenson DG. The effect of 2,5-di-(tert-butyl)-1,4-hydroquinone on force responses and the contractile apparatus in mechanically skinned muscle fibres of the rat and toad. Journal of Muscle Research and Cell Motility. 17:55-67. 1996
- Lamb GDJunankar PRStephenson DG. Raised intracellular [Ca2+] abolishes excitation-contraction coupling in skeletal muscle fibres of rat and toad.. The Journal of Physiology. 489:349-362. 1995
- STEPHENSON DGLAMB GDSTEPHENSON GMMFRYER MW. STORAGE OF CA2+ IN THE SARCOPLASMIC-RETICULUM AND ENDOGENOUS MODIFIERS OF E-C COUPLING IN SKELETAL-MUSCLE FIBERS FROM CANE TOAD AND RAT. The Journal of Physiology. 487P:S8-S8. 1995
- Lamb GDStephenson DG. Activation of ryanodine receptors by flash photolysis of caged Ca2+. Biophysical Journal. 68:946-948. 1995
- Fryer MWOwen VJLamb GDStephenson DG. Effects of creatine phosphate and P(i) on Ca2+ movements and tension development in rat skinned skeletal muscle fibres.. The Journal of Physiology. 482:123-140. 1995
- Stephenson DGLamb GDStephenson GMMFryer MW. Mechanisms of excitation-contraction coupling relevant to skeletal muscle fatigue. Advances in Experimental Medicine and Biology. 384:45-56. 1995
- Lamb GDStephenson DG. Effects of intracellular pH and [Mg2+] on excitation-contraction coupling in skeletal muscle fibres of the rat.. The Journal of Physiology. 478:331-339. 1994
- Lamb GFryer MStephenson D. Ca(2+)-induced Ca2+ release in response to flash photolysis. Science. 263:986-988. 1994
- BAKKER AJLAMB GDSTEPHENSON DG. THE EFFECT OF 2,5-DI-(TERT-BUTYL)-1,4-BENZOHYDROQUINONE ON THE CONTRACTILE APPARATUS AND FORCE RESPONSES IN SKINNED MUSCLE-FIBERS OF THE RAT. Biophysical Journal. 66:A90-A90. 1994
- Lamb GDPosterino GSStephenson DG. Effects of heparin on excitation-contraction coupling in skeletal muscle toad and rat.. The Journal of Physiology. 474:319-329. 1994
- Lamb GD. Ca2+ inactivation, Mg2+ inhibition and malignant hyperthermia. Journal of Muscle Research and Cell Motility. 14:554-556. 1993
- Lamb GDStephenson DGStienen GJ. Effects of osmolality and ionic strength on the mechanism of Ca2+ release in skinned skeletal muscle fibres of the toad.. The Journal of Physiology. 464:629-648. 1993
- STEPHENSON DGLAMB GD. VISUALIZATION OF THE TRANSVERSE TUBULAR SYSTEM IN ISOLATED INTACT AND IN MECHANICALLY SKINNED MUSCLE-FIBERS OF THE CANE TOAD BY CONFOCAL LASER SCANNING MICROSCOPY. The Journal of Physiology. 459:P15-P15. 1993
- LAMB GDSTEPHENSON DG. IMPORTANCE OF MG-2+ IN EXCITATION-CONTRACTION COUPLING IN SKELETAL-MUSCLE. Physiology. 7:270-274. 1992
- Lamb GD. DHP receptors and excitation-contraction coupling. Journal of Muscle Research and Cell Motility. 13:394-405. 1992
- Lamb GDRecupero EStephenson DG. Effect of myoplasmic pH on excitation-contraction coupling in skeletal muscle fibres of the toad.. The Journal of Physiology. 448:211-224. 1992
- Lamb GDStephenson DG. Control of calcium release from the sarcoplasmic reticulum. Advances in human genetics. 311:289-303. 1991
- Lamb GDStephenson DG. Excitation-contraction coupling in skeletal muscle fibres of rat and toad in the presence of GTP gamma S.. The Journal of Physiology. 444:65-84. 1991
- Lamb GD. Effect of Bay K8644 on Ca2+ channel gating charge. Biophysical Journal. 60:979-979. 1991
- LAMB GD. Ca2+ channels or voltage sensors?. Nature. 352:113-113. 1991
- Lamb GDStephenson DG. Effect of Mg2+ on the control of Ca2+ release in skeletal muscle fibres of the toad.. The Journal of Physiology. 434:507-528. 1991
- Lamb GDStephenson DG. Calcium release in skinned muscle fibres of the toad by transverse tubule depolarization or by direct stimulation.. The Journal of Physiology. 423:495-517. 1990
- Lamb GDStephenson DG. Control of calcium release and the effect of ryanodine in skinned muscle fibres of the toad.. The Journal of Physiology. 423:519-542. 1990
- LAMB GDSTEPHENSON DG. ACTIVATION AND REDUCTION OF CALCIUM RELEASE IN SKINNED MUSCLE-FIBERS FROM THE CANE TOAD. The Journal of Physiology. 418:P70-P70. 1989
- Gage PWLamb GDWakefield BT. Transient and persistent sodium currents in normal and denervated mammalian skeletal muscle.. The Journal of Physiology. 418:427-439. 1989
- Fryer MWLamb GDNeering IR. The action of ryanodine on rat fast and slow intact skeletal muscles.. The Journal of Physiology. 414:399-413. 1989
- Lamb GDHopkinson KCDenborough MA. Calcium currents and asymmetric charge movement in malignant hyperpyrexia. Muscle and Nerve. 12:135-140. 1989
- Gage PWDulhunty AFLamb GDWakefield BT. Effects of denervation on excitation - contraction coupling in mammalian muscle. Fernstrom Foundation Series. 13:405-412. 1989
- Field ACHill CLamb GD. Asymmetric charge movement and calcium currents in ventricular myocytes of neonatal rat.. The Journal of Physiology. 406:277-297. 1988
- Lamb GDWalsh T. Calcium currents, charge movement and dihydropyridine binding in fast- and slow-twitch muscles of rat and rabbit.. The Journal of Physiology. 393:595-617. 1987
- Dulhunty AFGage PWLamb GD. Potassium contractures and asymmetric charge movement in extensor digitorum longus and soleus muscles from thyrotoxic rats. Journal of Muscle Research and Cell Motility. 8:289-296. 1987
- Lamb GD. Asymmetric charge movement in polarized and depolarized muscle fibres of the rabbit.. The Journal of Physiology. 383:349-367. 1987
- Lamb GD. Asymmetric charge movement in contracting muscle fibres in the rabbit.. The Journal of Physiology. 376:63-83. 1986
- Lamb GD. Components of charge movement in rabbit skeletal muscle: the effect of tetracaine and nifedipine.. The Journal of Physiology. 376:85-100. 1986
- Dulhunty AFGage PWLamb GD. Differential effects of thyroid hormone on T-tubules and terminal cisternae in rat muscles: An electrophysiological and morphometric analysis. Journal of Muscle Research and Cell Motility. 7:225-236. 1986
- Lamb GD. Generalization of the three-microelectrode voltage clamp technique to allow unequal electrode spacings. Journal of Electrophysiological Techniques. 13:255-264. 1986
- Lamb GD. Tactile discrimination of textured surfaces: peripheral neural coding in the monkey.. The Journal of Physiology. 338:567-587. 1983
- Lamb GD. Tactile discrimination of textured surfaces: psychophysical performance measurements in humans.. The Journal of Physiology. 338:551-565. 1983
- Johnson KOLamb GD. Neural mechanisms of spatial tactile discrimination: neural patterns evoked by braille-like dot patterns in the monkey.. The Journal of Physiology. 310:117-144. 1981
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conference paper
- Kennedy PMcLean CLamb GMurphy R. Calpain-3 stability following delays in freezing skeletal muscle biopsy samples-stablishing an optimal time frame for accurate interpretation. Neuromuscular Disorders. S144-S144. 2017
- Lamb G. Muscle fatigue. 1-1. 2006
- Pedersen THNielsen OBLamb GDStephenson DG. Intracellular acidosis enhances T-system excitability in depolarized skeletal muscles. The FASEB Journal. A1115-A1115. 2005
- Honen BNLamb GDLaver DRIkemoto N. Aberrant calcium release underlying sudden cardiac death probed with RyR domain peptides. Biophysical Journal. 92A-92A. 2005
- Lamb G. Muscle fatigue and H+ : firend or foe?. Exercise, Muscle and Metabolism Meeting. 1-1. 2005
- Laver DRLamb GD. Regulation of single and coupled RyRs in bilayers by luminal Ca2+. Biophysical Journal. 383A-383A. 2005
- Lamb G. EC coupling in skeletal muscle : implications for fatigue. 2nd Australian Health & Medical Research Congress. 1-1. 2004
- Murphy RStephenson DLamb G. Effect of creatine on contractile force and sensitivity in mechanically-skinned single fibers from rat skeletal muscle.. Proceedings of the Australian Physiological Society, 34. 12-12. 2004
- O'Neill ELamb GLaver D. Magnesium inhibition of skeletal RyRs modified by DIDS, ryanodine and ATP. Biophysical Journal. 108A-108A. 2003
- Kobayashi SYamamoto TLaver DRLamb GDIkemoto N. RyR1 and RyR2 seem to share a common mechanism of cytoplasmic domain-mediated channel regulation: peptide probe studies. Biophysical Journal. 427A-427A. 2003
- Lamb G. AP-induced Ca2+ release at different SR Ca2+ content. Gordon Research Conference on Excitation Contraction Coupling in Muscle. 1-1. 2003
- Lamb G. All you ever wanted to know about skinned fibres. Curtin Conference on Muscle. 1-1. 2003
- Nielsen OBOrtenblad NLamb GDStephenson DG. Role of the Na+-K+ pump in maintaining T-tubular excitability in rat skeletal muscle. The Journal of Physiology. 80P-81P. 2002
- Lamb G. EC coupling, oxidation and muscle fatigue : Insights from skinned fibres. European Muscle Society Conference. 1-1. 2002
- Lamb G. Voltage-sensor control of Ca2+ release in skeletal muscle : Insights from MH and RyR DP4. International Union of Physiological Societies Satellite Conference on Excitation-contraction coupling in skeletal and cardiac muscle. 1-1. 2001
- Lamb G. Excitation-Contraction Coupling In Skeletal Muscle: Comparisons With Cardiac Muscle. Clinical and Experimental Pharmacology and Physiology. 216-224. 2000
- Lamb GD. Excitation-contraction coupling and fatigue in skeletal muscle. BIOCHEMISTRY OF EXERCISE X. 99-114. 1999
- Lamb GDRecupero EStephenson DG. Effect of pH on excitation-contraction coupling in isolated skeletal muscle of toad. The Journal of Physiology. P263-P263. 1992
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editorial article
- Lamb GD. Calpains in muscle: selective and protective?. The Journal of Physiology. 582:897-897. 2007
- Lamb GD. Store-operated Ca 2+ release in skeletal muscle: tailored for a specialized system. The Journal of Physiology. 583:1-1. 2007
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letter
- Wette SGSmith HKLamb GDMurphy RM. Reply to “Letter to the editor: Comments on Wette et al. (2017): ‘Characterization of muscle ankyrin repeat proteins in human skeletal muscle’”. American Journal of Physiology: Cell Physiology. C471-C472. 2017
- Dutka TLMollica JPPosterino GSLamb GD. Potential problems and pitfalls with the use of S-nitrosoglutathione and other S-nitrosothiols in physiology-oriented basic science Reply. The Journal of Physiology. 6249-6250. 2012
- Lamb GDMurphy RMStephenson DG. On the localization of ClC-1 in skeletal muscle fibers. Journal of General Physiology. 327-329. 2011
- Murphy RMLamb GD. Calpain-3 is activated following eccentric exercise. Journal of Applied Physiology. 2068-2068. 2009
Research
principal investigator on
- Calcium cycling and heat generation in skeletal muscle fibres awarded by Australian Research Council (ARC) - Discovery Projects 2018 - 2021
- Molecular Basis of Ca2+-Dependent Disruption of EC-coupling and Weakness in Skeletal Muscle awarded by National Health and Medical Research Council (NHMRC) - Project Grants 2015 - 2018
- Physiological and Pathological Effects of Oxidation on Contractile Function in Skeletal Muscle awarded by National Health and Medical Research Council (NHMRC) - Project Grants 2013 - 2016
- Uncoupled Research Fellowship awarded by National Health and Medical Research Council (NHMRC) - Research Fellowships 2009 - 2015
- Calpain regulation in skeletal muscle awarded by National Health and Medical Research Council (NHMRC) - Project Grants 2010 - 2012
- Mechanisms involved in skeletal muscle contraction in health, exercise and disease awarded by National Health and Medical Research Council (NHMRC) - Project Grants 2009 - 2011
- Understanding how chloride channels function and their role in muscle fatigue and disease awarded by National Health and Medical Research Council 2009 - 2011
- Calcium-dependent proteases in muscle damage and disease awarded by National Health and Medical Research Council (NHMRC) - Project Grants 2007 - 2010
investigator on
Background
education and training
- M.Sc., .
- PHD, Melbourne University
Contact
full name
- Professor Graham Lamb