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Professor Graham Lamb Adjunct Professor, Physiology Anatomy & Microbiology
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Professor Graham Lamb Adjunct Professor, Physiology Anatomy & Microbiology
Positions
Research Areas
- Muscle diseases (Expertise)
- Muscle fatigue (Expertise)
- Muscle function (Expertise)
- Myotonia (Expertise)
- Overview
- Publications
- Research
- Background
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- Identity
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Overview
Publications
selected publications
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academic article
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Ren XLamb GDMurphy RM. Distribution and activation of matrix metalloproteinase-2 in skeletal muscle fibers.
American Journal of Physiology: Cell Physiology.
317:C613-C625.
2019
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Watanabe DDutka TLLamboley CRLamb GD. Skeletal muscle fibre swelling contributes to force depression in rats and humans: a mechanically-skinned fibre study.
Journal of Muscle Research and Cell Motility.
2019
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Xu HLamb GDMurphy RM. Changes in contractile and metabolic parameters of skeletal muscle as rats age from 3 to 12 months.
Journal of Muscle Research and Cell Motility.
38:405-420.
2018
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Lamboley CXu HYDutka THanson EDHayes AViolet JAMurphy RLamb G. Effect of androgen deprivation therapy on the contractile properties of type I and type II skeletal muscle fibres in men with non-metastatic prostate cancer.
Clinical and Experimental Pharmacology and Physiology.
45:146-154.
2018
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Lamb GDStephenson DG. Measurement of force and calcium release using mechanically skinned fibers from mammalian skeletal muscle.
Journal of Applied Physiology.
125:1105-1127.
2018
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Xu HRen XLamb GDMurphy RM. Physiological and biochemical characteristics of skeletal muscles in sedentary and active rats.
Journal of Muscle Research and Cell Motility.
39:1-16.
2018
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Wette SGSmith HKLamb GDMurphy RM. Characterization of muscle ankyrin repeat proteins in human skeletal muscle.
American Journal of Physiology: Cell Physiology.
313:C327-C339.
2017
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Dutka TLMollica JPLamboley CRWeerakkody VCGreening DWPosterino GSMurphy RMLamb GD. S-nitrosylation and S-glutathionylation of Cys134 on troponin I have opposing competitive actions on Ca2+ sensitivity in rat fast-twitch muscle fibers.
American Journal of Physiology: Cell Physiology.
312:C316-C327.
2017
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Lamboley CRWyckelsma VLMcKenna MJMurphy RMLamb GD. Ca2+ leakage out of the sarcoplasmic reticulum is increased in type I skeletal muscle fibres in aged humans.
The Journal of Physiology.
594:469-481.
2016
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Lamboley CRWyckelsma VLPerry BDMcKenna MJLamb GD. Effect of 23-day muscle disuse on sarcoplasmic reticulum Ca2+ properties and contractility in human type I and type II skeletal muscle fibers.
Journal of Applied Physiology.
121:483-492.
2016
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Xu HFrankenberg NTLamb GDGooley PRStapleton DIMurphy RM. When phosphorylated at Thr(148), the beta(2)-subunit of AMP-activated kinase does not associate with glycogen in skeletal muscle.
American Journal of Physiology: Cell Physiology.
311:C35-C42.
2016
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Lamboley CRWyckelsma VLDutka TLMcKenna MJMurphy RMLamb GD. Contractile properties and sarcoplasmic reticulum calcium content in typeI and typeII skeletal muscle fibres in active aged humans.
The Journal of Physiology.
593:2499-2514.
2015
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Frankenberg NTLamb GDVissing KMurphy RM. Subcellular fractionation reveals HSP72 does not associate with SERCA in human skeletal muscle following damaging eccentric and concentric exercise.
Journal of Applied Physiology.
116:1503-1511.
2014
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Dutka TLLamboley CRMurphy RMLamb GD. Acute effects of taurine on sarcoplasmic reticulum Ca2+ accumulation and contractility in human type I and type II skeletal muscle fibers.
Journal of Applied Physiology.
117:797-805.
2014
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Lamboley CMurphy RMcKenna MLamb G. Sarcoplasmic reticulum Ca2+ uptake and leak properties, and SERCA isoform expression, in type I and type II fibres of human skeletal muscle.
The Journal of Physiology.
592:1381-1395.
2014
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Frankenberg NLamb GOvergaard KMurphy RVissing K. Small heat shock proteins translocate to the cytoskeleton in human skeletal muscle following eccentric exercise independently of phosphorylation.
Journal of Applied Physiology.
116:1463-1472.
2014
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Lamboley CRMurphy RMMcKenna MJLamb GD. Endogenous and maximal sarcoplasmic reticulum calcium content and calsequestrin expression in type I and type II human skeletal muscle fibres.
The Journal of Physiology.
591:6053-6068.
2013
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Murphy RMLamb GD. Important considerations for protein analyses using antibody based techniques: down-sizing Western blotting up-sizes outcomes.
The Journal of Physiology.
591:5823-5831.
2013
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Fajardo VAMcMeekin LBasic ALamb GDMurphy RMLeBlanc PJ. Isolation of Sarcolemmal Plasma Membranes by Mechanically Skinning Rat Skeletal Muscle Fibers for Phospholipid Analysis.
Lipids.
48:421-430.
2013
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Murphy RDutka THorvath DBell JDelbridge LLamb G. Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle.
The Journal of Physiology.
591:719-729.
2013
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Frankenberg NLarkins NTMurphy RMLamb GD. Influences of temperature, oxidative stress, and phosphorylation on binding of heat shock proteins in skeletal muscle fibers.
American Journal of Physiology: Cell Physiology.
303:C654-C665.
2012
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Dutka TLLamboley CRMcKenna MJMurphy RMLamb GD. Effects of carnosine on contractile apparatus Ca2+ sensitivity and sarcoplasmic reticulum Ca2+ release in human skeletal muscle fibers.
Journal of Applied Physiology.
112:728-736.
2012
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Mollica JPDutka TLMerry TLLamboley CRMcConell GKMcKenna MJMurphy RMLamb GD. S-Glutathionylation of troponin I (fast) increases contractile apparatus Ca2+sensitivity in fast-twitch muscle fibres of rats and humans.
The Journal of Physiology.
590:1443-1463.
2012
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Frankenberg NLarkins NTMurphy RMLamb GD. Absolute amounts and diffusibility of HSP72, HSP25, and αB-crystallin in fast- and slow-twitch skeletal muscle fibers of rat.
American Journal of Physiology: Cell Physiology.
302:C228-C239.
2012
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Frankenberg NDutka TLVerburg ELarkins NHortemo KHLunde PKSejersted OMLamb GD. ROS-Mediated Decline in Maximum Ca2+-Activated Force in Rat Skeletal Muscle Fibers following In Vitro and In Vivo Stimulation.
PLoS ONE.
7.
2012
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Murphy RMVissing KLatchman HLamboley CMcKenna MJOvergaard KLamb GD. Activation of skeletal muscle calpain-3 by eccentric exercise in humans does not result in its translocation to the nucleus or cytosol.
Journal of Applied Physiology.
111:1448-1458.
2011
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Lamb GDWesterblad H. Acute effects of reactive oxygen and nitrogen species on the contractile function of skeletal muscle.
The Journal of Physiology.
589:2119-2127.
2011
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Dutka TLMollica JPPosterino GSLamb GD. Modulation of contractile apparatus Ca2+sensitivity and disruption of excitation-contraction coupling byS-nitrosoglutathione in rat muscle fibres.
The Journal of Physiology.
589:2181-2196.
2011
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Dutka TLMollica JPLamb GD. Differential effects of peroxynitrite on contractile protein properties in fast- and slow-twitch skeletal muscle fibers of rat.
Journal of Applied Physiology.
110:705-716.
2011
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Murphy RMMollica JPBeard NAKnollmann BCLamb GD. Quantification of calsequestrin 2 (CSQ2) in sheep cardiac muscle and Ca2+-binding protein changes in CSQ2 knockout mice.
American Journal of Physiology: Heart and Circulatory Physiology.
300:H595-H604.
2011
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Lamb GD. Mechanisms of excitation-contraction uncoupling relevant to activity-induced muscle fatigueThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process..
Applied Physiology, Nutrition and Metabolism.
34:368-372.
2009
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Verburg EMurphy RMRichard ILamb GD. Involvement of calpains in Ca2+-induced disruption of excitation-contraction coupling in mammalian skeletal muscle fibers.
American Journal of Physiology: Cell Physiology.
296:C1115-C1122.
2009
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Murphy RMMollica JPLamb GD. Plasma membrane removal in rat skeletal muscle fibers reveals caveolin-3 hot-spots at the necks of transverse tubules.
Experimental Cell Research.
315:1015-1028.
2009
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Murphy RMLamb GD. Endogenous Calpain-3 Activation Is Primarily Governed by Small Increases in Resting Cytoplasmic [Ca2+] and Is Not Dependent on Stretch.
Journal of Biological Chemistry.
284:7811-7819.
2009
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Mollica JPOakhill JSLamb GDMurphy RM. Are genuine changes in protein expression being overlooked? Reassessing Western blotting.
Analytical Biochemistry.
386:270-275.
2009
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Murphy RMLarkins NTMollica JPBeard NALamb GD. Calsequestrin content and SERCA determine normal and maximal Ca2+storage levels in sarcoplasmic reticulum of fast- and slow-twitch fibres of rat.
The Journal of Physiology.
587:443-460.
2009
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Murphy RLamb G. Calpain-3 is activated following eccentric exercise..
Journal of Applied Physiology.
106:2068-2068.
2009
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Murphy RMDutka TLLamb GD. Hydroxyl radical and glutathione interactions alter calcium sensitivity and maximum force of the contractile apparatus in rat skeletal muscle fibres.
The Journal of Physiology.
586:2203-2216.
2008
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Laver DRHonen BNLamb GDIkemoto N. A domain peptide of the cardiac ryanodine receptor regulates channel sensitivity to luminal Ca2+ via cytoplasmic Ca2+ sites.
European Biophysics Journal.
37:455-467.
2008
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Dutka TLMurphy RMStephenson DGLamb GD. Chloride conductance in the transverse tubular system of rat skeletal muscle fibres: importance in excitation-contraction coupling and fatigue.
The Journal of Physiology.
586:875-887.
2008
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Allen DGLamb GDWesterblad H. Impaired calcium release during fatigue.
Journal of Applied Physiology.
104:296-305.
2008
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Allen DGLamb GDWesterblad H. Skeletal Muscle Fatigue: Cellular Mechanisms.
Physiological Reviews.
88:287-332.
2008
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Murphy RMGoodman CAMcKenna MJBennie JLeikis MLamb GD. Calpain-3 is autolyzed and hence activated in human skeletal muscle 24 h following a single bout of eccentric exercise.
Journal of Applied Physiology.
103:926-931.
2007
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Dutka TLLamb GD. Na+-K+ pumps in the transverse tubular system of skeletal muscle fibers preferentially use ATP from glycolysis.
American Journal of Physiology: Cell Physiology.
293:C967-C977.
2007
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Dutka TLLamb GD. Transverse tubular system depolarization reduces tetanic force in rat skeletal muscle fibers by impairing action potential repriming.
American Journal of Physiology: Cell Physiology.
292:C2112-C2121.
2007
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Murphy RMVerburg ELamb GD. Ca2+activation of diffusible and bound pools of μ-calpain in rat skeletal muscle.
The Journal of Physiology.
576:595-612.
2006
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YANG ZIKEMOTO NLAMB GSTEELE D. Corrigendum to: The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes [Cardiovascular Research 70 (2006) 475–485].
Cardiovascular Research.
71:606-606.
2006
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Trinh HHLamb GD. MATCHING OF SARCOPLASMIC RETICULUM AND CONTRACTILE PROPERTIES IN RAT FAST- AND SLOW-TWITCH MUSCLE FIBRES.
Clinical and Experimental Pharmacology and Physiology.
33:591-600.
2006
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Lamb GDStephenson DG. The Last Word: Point:Counterpoint authors respond to commentaries on “Lactic acid accumulation is an advantage/disadvantage during muscle activity”.
Journal of Applied Physiology.
101:369-369.
2006
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YANG ZIKEMOTO NLAMB GSTEELE D. The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes.
Cardiovascular Research.
70:475-485.
2006
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Verburg EDutka TLLamb GD. Long-lasting muscle fatigue: partial disruption of excitation-contraction coupling by elevated cytosolic Ca2+ concentration during contractions.
American Journal of Physiology: Cell Physiology.
290:C1199-C1208.
2006
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Lamb GDStephenson DG. Point:Counterpoint: Lactic acid accumulation is an advantage/disadvantage during muscle activity.
Journal of Applied Physiology.
100:1410-1412.
2006
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Murphy RMSnow RJLamb GD. μ-Calpain and calpain-3 are not autolyzed with exhaustive exercise in humans.
American Journal of Physiology: Cell Physiology.
290:C116-C122.
2006
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Dutka TLCole LLamb GD. Calcium phosphate precipitation in the sarcoplasmic reticulum reduces action potential-mediated Ca2+ release in mammalian skeletal muscle.
American Journal of Physiology: Cell Physiology.
289:C1502-C1512.
2005
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Verburg EMurphy RMStephenson DGLamb GD. Disruption of excitation-contraction coupling and titin by endogenous Ca2+-activated proteases in toad muscle fibres.
The Journal of Physiology.
564:775-790.
2005
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Lamb GD. Rippling muscle disease may be caused by ?silent? action potentials in the tubular system of skeletal muscle fibers.
Muscle and Nerve.
31:652-658.
2005
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Dulhunty AFCengia LYoung JPace SMHarvey PJLamb GDChan Y-NWimmer NToth ICasarotto MG. Functional implications of modifying RyR-activating peptides for membrane permeability.
British Journal of Pharmacology.
144:743-754.
2005
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Murphy RMStephenson DGLamb GD. Effect of creatine on contractile force and sensitivity in mechanically skinned single fibers from rat skeletal muscle.
American Journal of Physiology: Cell Physiology.
287:C1589-C1595.
2004
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Laver DRO'Neill ERLamb GD. Luminal Ca2+–regulated Mg2+Inhibition of Skeletal RyRs Reconstituted as Isolated Channels or Coupled Clusters.
Journal of General Physiology.
124:741-758.
2004
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Dutka TLLamb GD. Effect of low cytoplasmic [ATP] on excitation-contraction coupling in fast-twitch muscle fibres of the rat.
The Journal of Physiology.
560:451-468.
2004
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Stephenson DGLamb GDPedersen TH. Intracellular Acidosis Enhances the Excitability of Working Muscle.
Science.
305:1144-1147.
2004
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Nielsen OBØrtenblad NLamb GDStephenson DG. Excitability of the T-tubular system in rat skeletal muscle: roles of K+and Na+gradients and Na+-K+pump activity.
The Journal of Physiology.
557:133-146.
2004
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Dutka TLLamb GD. Effect of Carnosine on Excitation–Contraction Coupling in Mechanically-Skinned Rat Skeletal Muscle.
Journal of Muscle Research and Cell Motility.
25:203-213.
2004
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Posterino GSLamb GD. Effect of sarcoplasmic reticulum Ca2+ content on action potential-induced Ca2+ release in rat skeletal muscle fibres.
The Journal of Physiology.
551:219-237.
2003
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Posterino GSCellini MALamb GD. Effects of oxidation and cytosolic redox conditions on excitation-contraction coupling in rat skeletal muscle.
The Journal of Physiology.
547:807-823.
2003
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GREEN DPACE SCURTIS SMSAKOWSKA MLAMB GDDULHUNTY AFCASAROTTO MG. The three-dimensional structural surface of two beta-sheet scorpion toxins mimics that of an alpha-helical dihydropyridine receptor segment.
Biochemical Journal.
370:517-527.
2003
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Lamb GDPosterino GS. Effects of oxidation and reduction on contractile function in skeletal muscle fibres of the rat.
The Journal of Physiology.
546:149-163.
2003
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Lamb GD. Excitation-contraction coupling and fatigue mechanisms in skeletal muscle: Studies with mechanically skinned fibres.
Journal of Muscle Research and Cell Motility.
23:81-91.
2002
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Lamb GD. Voltage-sensor control of Ca2+ release in skeletal muscle: insights from skinned fibers.
Frontiers in Bioscience.
7:d834-d834.
2002
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Laver DRLenz GKELamb GD. Regulation of the calcium release channel from rabbit skeletal muscle by the nucleotides ATP, AMP, IMP and adenosine.
The Journal of Physiology.
537:763-778.
2001
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Laver DRLenz GKELamb GD. Regulation of the calcium release channel from rabbit skeletal muscle by the nucleotides ATP, AMP, IMP and adenosine.
The Journal of Physiology.
537:763-778.
2001
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Lamb GDPosterino GSYamamoto TIkemoto N. Effects of a domain peptide of the ryanodine receptor on Ca2+ release in skinned skeletal muscle fibers.
American Journal of Physiology: Cell Physiology.
281:C207-C214.
2001
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Lamb GDPosterino GSYamamoto TIkemoto N. Effects of a domain peptide of the ryanodine receptor on Ca2+ release in skinned skeletal muscle fibers.
American Journal of Physiology: Cell Physiology.
281:C207-C214.
2001
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Posterino GDutka TLamb G. L (+)-lactate does not affect twitch and tetanic responses in mechanically skinned mammalian muscle fibres.
Pfluegers Archiv: European journal of physiology.
442:197-203.
2001
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Lamb GDCellini MAStephenson DG. Different Ca2+releasing action of caffeine and depolarisation in skeletal muscle fibres of the rat.
The Journal of Physiology.
531:715-728.
2001
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Blazev RHussain MBakker AJHead SILamb GD. Effects of the PKA inhibitor H-89 on excitation-contraction coupling in skinned and intact skeletal muscle fibres.
Journal of Muscle Research and Cell Motility.
22:277-286.
2001
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Lamb GDLaver DRStephenson DG. Questions about Adaptation in Ryanodine Receptors: Figure 1.
Journal of General Physiology.
116:883-890.
2000
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Lamb GDEl-Hayek RIkemoto NStephenson DG. Effects of dihydropyridine receptor II-III loop peptides on Ca2+ release in skinned skeletal muscle fibers.
American Journal of Physiology: Cell Physiology.
279:C891-C905.
2000
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Lamb GDEl-Hayek RIkemoto NStephenson DG. Effects of dihydropyridine receptor II-III loop peptides on Ca2+ release in skinned skeletal muscle fibers.
American Journal of Physiology: Cell Physiology.
279:C891-C905.
2000
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Posterino GSLamb GDStephenson DG. Twitch and tetanic force responses and longitudinal propagation of action potentials in skinned skeletal muscle fibres of the rat.
The Journal of Physiology.
527:131-137.
2000
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Laver DREager KRTaoube LLamb GD. Effects of Cytoplasmic and Luminal pH on Ca2+ Release Channels from Rabbit Skeletal Muscle.
Biophysical Journal.
78:1835-1851.
2000
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Dutka TLLamb GD. Effect of lactate on depolarization-induced Ca2+ release in mechanically skinned skeletal muscle fibers.
American Journal of Physiology: Cell Physiology.
278:C517-C525.
2000
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Dutka TLLamb GD. Effect of lactate on depolarization-induced Ca2+ release in mechanically skinned skeletal muscle fibers.
American Journal of Physiology: Cell Physiology.
278:C517-C525.
2000
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Blazev RLamb GD. Adenosine inhibits depolarization-induced Ca2+ release in mammalian skeletal muscle.
Muscle and Nerve.
22:1674-1683.
1999
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Blazev RLamb GD. Low [ATP] and elevated [Mg2+] reduce depolarization-induced Ca2+release in rat skinned skeletal muscle fibres.
The Journal of Physiology.
520:203-215.
1999
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Lamb GDCellini MA. High intracellular [Ca2+] alters sarcoplasmic reticulum function in skinned skeletal muscle fibres of the rat.
The Journal of Physiology.
519:815-827.
1999
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Laver DREager KRTaoube LLamb GD. Regulation of the skeletal muscle calcium release channel (RyR1) by luminal and cytosolic pH..
Biophysical Journal.
76:A303-A303.
1999
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Coonan JRLamb GD. Effect of transverse-tubular chloride conductance on excitability in skinned skeletal muscle fibres of rat and toad.
The Journal of Physiology.
509:551-564.
1998
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Laver DRLamb GD. Inactivation of Ca2+ Release Channels (Ryanodine Receptors RyR1 and RyR2) with Rapid Steps in [Ca2+] and Voltage.
Biophysical Journal.
74:2352-2364.
1998
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Coonan JRLamb GD. Effect of chloride on Ca 2+ release from the sarcoplasmic reticulum of mechanically skinned skeletal muscle fibres.
Pfluegers Archiv: European journal of physiology.
435:720-730.
1998
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STEPHENSON DGLAMB GDSTEPHENSON GMM. Events of the excitation-contraction-relaxation (E-C-R) cycle in fast- and slow-twitch mammalian muscle fibres relevant to muscle fatigue.
Acta Physiologica.
162:229-245.
1998
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Posterino GSLamb GD. Effect of nifedipine on depolarization-induced force responses in skinned skeletal muscle fibres of rat and toad.
Journal of Muscle Research and Cell Motility.
19:53-65.
1998
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Posterino GSLamb GD. Investigation of the effect of inositol trisphosphate in skinned skeletal muscle fibres with functional excitation-contraction coupling.
Journal of Muscle Research and Cell Motility.
19:67-74.
1998
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Laver DROwen VJJunankar PRTaske NLDulhunty AFLamb GD. Reduced inhibitory effect of Mg2+ on ryanodine receptor-Ca2+ release channels in malignant hyperthermia.
Biophysical Journal.
73:1913-1924.
1997
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Lamb GDStephenson DG. Oxidation effects in fatigue: unphysiological responses to “depolarization” in skinned muscle fibers.
Journal of Applied Physiology.
82:2054-2056.
1997
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Owen VJLamb GDStephenson DGFryer MW. Relationship between depolarization-induced force responses and Ca2+ content in skeletal muscle fibres of rat and toad..
The Journal of Physiology.
498:571-586.
1997
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Brotto MAPNosek TMLamb GDStephenson DG. Hydrogen peroxide disrupts Ca2+ release from the sarcoplasmic reticulum of rat skeletal muscle fibers (multiple letters).
Journal of Applied Physiology.
82:2054-2056.
1997
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Owen VJTaske NLLamb GD. Reduced Mg2+ inhibition of Ca2+ release in muscle fibers of pigs susceptible to malignant hyperthermia.
American Journal of Physiology: Cell Physiology.
272:C203-C211.
1997
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Owen VJTaske NLLamb GD. Reduced Mg2+ inhibition of Ca2+ release in muscle fibers of pigs susceptible to malignant hyperthermia.
American Journal of Physiology: Cell Physiology.
272:C203-C211.
1997
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LAMB GD. Ryanodine receptor 'adaptation': A flash in the pan?.
Journal of Muscle Research and Cell Motility.
18:611-616.
1997
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Posterino GSLamb GD. Effects of reducing agents and oxidants on excitation-contraction coupling in skeletal muscle fibres of rat and toad..
The Journal of Physiology.
496:809-825.
1996
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Lamb GDStephenson DG. Effects of FK506 and rapamycin on excitation-contraction coupling in skeletal muscle fibres of the rat..
The Journal of Physiology.
494:569-576.
1996
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Owen VJLamb GDStephenson DG. Effect of low [ATP] on depolarization-induced Ca2+ release in skeletal muscle fibres of the toad..
The Journal of Physiology.
493:309-315.
1996
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Owen VJLamb GDStephenson DG. Low [ATP] reduces depolarization-induced calcium release in skeletal muscle fibers.
Biophysical Journal.
70:MPO80-MPO80.
1996
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Bakker AJLamb GDStephenson DG. The effect of 2,5-di-(tert-butyl)-1,4-hydroquinone on force responses and the contractile apparatus in mechanically skinned muscle fibres of the rat and toad.
Journal of Muscle Research and Cell Motility.
17:55-67.
1996
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Lamb GDJunankar PRStephenson DG. Raised intracellular [Ca2+] abolishes excitation-contraction coupling in skeletal muscle fibres of rat and toad..
The Journal of Physiology.
489:349-362.
1995
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STEPHENSON DGLAMB GDSTEPHENSON GMMFRYER MW. STORAGE OF CA2+ IN THE SARCOPLASMIC-RETICULUM AND ENDOGENOUS MODIFIERS OF E-C COUPLING IN SKELETAL-MUSCLE FIBERS FROM CANE TOAD AND RAT.
The Journal of Physiology.
487P:S8-S8.
1995
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Lamb GDStephenson DG. Activation of ryanodine receptors by flash photolysis of caged Ca2+.
Biophysical Journal.
68:946-948.
1995
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Fryer MWOwen VJLamb GDStephenson DG. Effects of creatine phosphate and P(i) on Ca2+ movements and tension development in rat skinned skeletal muscle fibres..
The Journal of Physiology.
482:123-140.
1995
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Stephenson DGLamb GDStephenson GMMFryer MW. Mechanisms of Excitation-Contraction Coupling Relevant to Skeletal Muscle Fatigue.
Advances in Experimental Medicine and Biology.
384:45-56.
1995
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Lamb GDStephenson DG. Effects of intracellular pH and [Mg2+] on excitation-contraction coupling in skeletal muscle fibres of the rat..
The Journal of Physiology.
478:331-339.
1994
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Lamb GFryer MStephenson D. Ca(2+)-induced Ca2+ release in response to flash photolysis.
Science.
263:986-988.
1994
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BAKKER AJLAMB GDSTEPHENSON DG. THE EFFECT OF 2,5-DI-(TERT-BUTYL)-1,4-BENZOHYDROQUINONE ON THE CONTRACTILE APPARATUS AND FORCE RESPONSES IN SKINNED MUSCLE-FIBERS OF THE RAT.
Biophysical Journal.
66:A90-A90.
1994
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Lamb GDPosterino GSStephenson DG. Effects of heparin on excitation-contraction coupling in skeletal muscle toad and rat..
The Journal of Physiology.
474:319-329.
1994
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Lamb GD. Ca2+ inactivation, Mg2+ inhibition and malignant hyperthermia.
Journal of Muscle Research and Cell Motility.
14:554-556.
1993
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Lamb GDStephenson DGStienen GJ. Effects of osmolality and ionic strength on the mechanism of Ca2+ release in skinned skeletal muscle fibres of the toad..
The Journal of Physiology.
464:629-648.
1993
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STEPHENSON DGLAMB GD. VISUALIZATION OF THE TRANSVERSE TUBULAR SYSTEM IN ISOLATED INTACT AND IN MECHANICALLY SKINNED MUSCLE-FIBERS OF THE CANE TOAD BY CONFOCAL LASER SCANNING MICROSCOPY.
The Journal of Physiology.
459:P15-P15.
1993
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LAMB GDSTEPHENSON DG. IMPORTANCE OF MG-2+ IN EXCITATION-CONTRACTION COUPLING IN SKELETAL-MUSCLE.
Physiology.
7:270-274.
1992
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Lamb GD. DHP receptors and excitation-contraction coupling.
Journal of Muscle Research and Cell Motility.
13:394-405.
1992
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Lamb GDRecupero EStephenson DG. Effect of myoplasmic pH on excitation-contraction coupling in skeletal muscle fibres of the toad..
The Journal of Physiology.
448:211-224.
1992
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Lamb GDStephenson DG. Control of Calcium Release from the Sarcoplasmic Reticulum.
Advances in human genetics.
311:289-303.
1992
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Lamb GDStephenson DG. Excitation-contraction coupling in skeletal muscle fibres of rat and toad in the presence of GTP gamma S..
The Journal of Physiology.
444:65-84.
1991
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Lamb GD. Effect of Bay K8644 on Ca2+ channel gating charge.
Biophysical Journal.
60:979-979.
1991
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LAMB GD. Ca2+ channels or voltage sensors?.
Nature.
352:113-113.
1991
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Lamb GDStephenson DG. Effect of Mg2+ on the control of Ca2+ release in skeletal muscle fibres of the toad..
The Journal of Physiology.
434:507-528.
1991
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Lamb GDStephenson DG. Calcium release in skinned muscle fibres of the toad by transverse tubule depolarization or by direct stimulation..
The Journal of Physiology.
423:495-517.
1990
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Lamb GDStephenson DG. Control of calcium release and the effect of ryanodine in skinned muscle fibres of the toad..
The Journal of Physiology.
423:519-542.
1990
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LAMB GDSTEPHENSON DG. ACTIVATION AND REDUCTION OF CALCIUM RELEASE IN SKINNED MUSCLE-FIBERS FROM THE CANE TOAD.
The Journal of Physiology.
418:P70-P70.
1989
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Gage PWLamb GDWakefield BT. Transient and persistent sodium currents in normal and denervated mammalian skeletal muscle..
The Journal of Physiology.
418:427-439.
1989
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Fryer MWLamb GDNeering IR. The action of ryanodine on rat fast and slow intact skeletal muscles..
The Journal of Physiology.
414:399-413.
1989
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Lamb GDHopkinson KCDenborough MA. Calcium currents and asymmetric charge movement in malignant hyperpyrexia.
Muscle and Nerve.
12:135-140.
1989
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Gage PWDulhunty AFLamb GDWakefield BT. Effects of denervation on excitation - contraction coupling in mammalian muscle.
Fernstrom Foundation Series.
13:405-412.
1989
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Field ACHill CLamb GD. Asymmetric charge movement and calcium currents in ventricular myocytes of neonatal rat..
The Journal of Physiology.
406:277-297.
1988
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Lamb GDWalsh T. Calcium currents, charge movement and dihydropyridine binding in fast- and slow-twitch muscles of rat and rabbit..
The Journal of Physiology.
393:595-617.
1987
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Dulhunty AFGage PWLamb GD. Potassium contractures and asymmetric charge movement in extensor digitorum longus and soleus muscles from thyrotoxic rats.
Journal of Muscle Research and Cell Motility.
8:289-296.
1987
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Lamb GD. Asymmetric charge movement in polarized and depolarized muscle fibres of the rabbit..
The Journal of Physiology.
383:349-367.
1987
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Lamb GD. Asymmetric charge movement in contracting muscle fibres in the rabbit..
The Journal of Physiology.
376:63-83.
1986
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Lamb GD. Components of charge movement in rabbit skeletal muscle: the effect of tetracaine and nifedipine..
The Journal of Physiology.
376:85-100.
1986
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Dulhunty AFGage PWLamb GD. Differential effects of thyroid hormone on T-tubules and terminal cisternae in rat muscles: An electrophysiological and morphometric analysis.
Journal of Muscle Research and Cell Motility.
7:225-236.
1986
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Lamb GD. Generalization of the three-microelectrode voltage clamp technique to allow unequal electrode spacings.
Journal of Electrophysiological Techniques.
13:255-264.
1986
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Lamb GD. Tactile discrimination of textured surfaces: peripheral neural coding in the monkey..
The Journal of Physiology.
338:567-587.
1983
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Lamb GD. Tactile discrimination of textured surfaces: psychophysical performance measurements in humans..
The Journal of Physiology.
338:551-565.
1983
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Johnson KOLamb GD. Neural mechanisms of spatial tactile discrimination: neural patterns evoked by braille-like dot patterns in the monkey..
The Journal of Physiology.
310:117-144.
1981
Full text if available
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Ren XLamb GDMurphy RM. Distribution and activation of matrix metalloproteinase-2 in skeletal muscle fibers.
American Journal of Physiology: Cell Physiology.
317:C613-C625.
2019
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conference paper
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Kennedy PMcLean CLamb GMurphy R. Calpain-3 stability following delays in freezing skeletal muscle biopsy samples-stablishing an optimal time frame for accurate interpretation.
Neuromuscular Disorders.
S144-S144.
2017
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Lamb G. Muscle fatigue.
1-1.
2006
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Pedersen THNielsen OBLamb GDStephenson DG. Intracellular acidosis enhances T-system excitability in depolarized skeletal muscles.
The FASEB Journal.
A1115-A1115.
2005
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Honen BNLamb GDLaver DRIkemoto N. Aberrant calcium release underlying sudden cardiac death probed with RyR domain peptides.
Biophysical Journal.
92A-92A.
2005
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Lamb G. Muscle fatigue and H+ : firend or foe?.
Exercise, Muscle and Metabolism Meeting.
1-1.
2005
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Laver DRLamb GD. Regulation of single and coupled RyRs in bilayers by luminal Ca2+.
Biophysical Journal.
383A-383A.
2005
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Lamb G. EC coupling in skeletal muscle : implications for fatigue.
2nd Australian Health & Medical Research Congress.
1-1.
2004
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Murphy RStephenson DLamb G. Effect of creatine on contractile force and sensitivity in mechanically-skinned single fibers from rat skeletal muscle..
Proceedings of the Australian Physiological Society, 34.
12-12.
2004
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O'Neill ELamb GLaver D. Magnesium inhibition of skeletal RyRs modified by DIDS, ryanodine and ATP.
Biophysical Journal.
108A-108A.
2003
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Kobayashi SYamamoto TLaver DRLamb GDIkemoto N. RyR1 and RyR2 seem to share a common mechanism of cytoplasmic domain-mediated channel regulation: peptide probe studies.
Biophysical Journal.
427A-427A.
2003
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Lamb G. AP-induced Ca2+ release at different SR Ca2+ content.
Gordon Research Conference on Excitation Contraction Coupling in Muscle.
1-1.
2003
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Lamb G. All you ever wanted to know about skinned fibres.
Curtin Conference on Muscle.
1-1.
2003
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Nielsen OBOrtenblad NLamb GDStephenson DG. Role of the Na+-K+ pump in maintaining T-tubular excitability in rat skeletal muscle.
The Journal of Physiology.
80P-81P.
2002
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Lamb G. EC coupling, oxidation and muscle fatigue : Insights from skinned fibres.
European Muscle Society Conference.
1-1.
2002
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Lamb G. Voltage-sensor control of Ca2+ release in skeletal muscle : Insights from MH and RyR DP4.
International Union of Physiological Societies Satellite Conference on Excitation-contraction coupling in skeletal and cardiac muscle.
1-1.
2001
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Lamb G. Excitation-Contraction Coupling In Skeletal Muscle: Comparisons With Cardiac Muscle.
Clinical and Experimental Pharmacology and Physiology.
216-224.
2000
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Lamb GD. Excitation-contraction coupling and fatigue in skeletal muscle.
BIOCHEMISTRY OF EXERCISE X.
99-114.
1999
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Lamb GDRecupero EStephenson DG. Effect of pH on excitation-contraction coupling in isolated skeletal muscle of toad.
The Journal of Physiology.
P263-P263.
1992
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Kennedy PMcLean CLamb GMurphy R. Calpain-3 stability following delays in freezing skeletal muscle biopsy samples-stablishing an optimal time frame for accurate interpretation.
Neuromuscular Disorders.
S144-S144.
2017
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editorial article
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Lamb GD. Calpains in muscle: selective and protective?.
The Journal of Physiology.
582:897-897.
2007
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Lamb GD. Store-operated Ca2+release in skeletal muscle: tailored for a specialized system.
The Journal of Physiology.
583:1-1.
2007
Full text if available
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Lamb GD. Calpains in muscle: selective and protective?.
The Journal of Physiology.
582:897-897.
2007
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letter
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Wette SGSmith HKLamb GDMurphy RM. Reply to “Letter to the editor: Comments on Wette et al. (2017): ‘Characterization of muscle ankyrin repeat proteins in human skeletal muscle’”.
American Journal of Physiology: Cell Physiology.
C471-C472.
2017
Full text if available -
Dutka TLMollica JPPosterino GSLamb GD. Potential problems and pitfalls with the use of S-nitrosoglutathione and other S-nitrosothiols in physiology-oriented basic science Reply.
Journal of Physiology: Paris.
6249-6250.
2012
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Lamb GDMurphy RMStephenson DG. On the localization of ClC-1 in skeletal muscle fibers.
Journal of General Physiology.
327-329.
2011
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Murphy RMLamb GD. Calpain-3 is activated following eccentric exercise.
Journal of Applied Physiology.
2068-2068.
2009
Full text if available
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Wette SGSmith HKLamb GDMurphy RM. Reply to “Letter to the editor: Comments on Wette et al. (2017): ‘Characterization of muscle ankyrin repeat proteins in human skeletal muscle’”.
American Journal of Physiology: Cell Physiology.
C471-C472.
2017
Research
principal investigator on
- Calcium cycling and heat generation in skeletal muscle fibres awarded by Australian Research Council (ARC) - Discovery Projects 2018 - 2021
- Molecular Basis of Ca2+-Dependent Disruption of EC-coupling and Weakness in Skeletal Muscle awarded by National Health and Medical Research Council (NHMRC) - Project Grants 2015 - 2018
- Physiological and Pathological Effects of Oxidation on Contractile Function in Skeletal Muscle awarded by National Health and Medical Research Council (NHMRC) - Project Grants 2013 - 2016
- Uncoupled Research Fellowship awarded by National Health and Medical Research Council (NHMRC) - Research Fellowships 2009 - 2015
- Calpain regulation in skeletal muscle awarded by National Health and Medical Research Council (NHMRC) - Project Grants 2010 - 2012
- Mechanisms involved in skeletal muscle contraction in health, exercise and disease awarded by National Health and Medical Research Council (NHMRC) - Project Grants 2009 - 2011
- Understanding how chloride channels function and their role in muscle fatigue and disease awarded by National Health and Medical Research Council 2009 - 2011
- Calcium-dependent proteases in muscle damage and disease awarded by National Health and Medical Research Council (NHMRC) - Project Grants 2007 - 2010
investigator on
Background
education and training
- M.Sc, .
- PHD, Melbourne University
Contact
full name
- Professor Graham Lamb