selected publications
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academic article
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Parakh SKing DGan HKScott AM. Current Development of Monoclonal Antibodies in Cancer Therapy.
Recent Results in Cancer Research.
214:1-70.
2020
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Barthel FPJohnson KCVarn FSMoskalik ADTanner GKocakavuk EAnderson KJAbiola OAldape KAlfaro KDAlpar DAmin SBAshley DMBandopadhayay PBarnholtz-Sloan JSBeroukhim RBock CBrastianos PKBrat DJBrodbelt ARBruns AFBulsara KRChakrabarty AChakravarti AChuang JHClaus EBCochran EJConnelly JCostello JFFinocchiaro GFletcher MNFrench PJGan HKGilbert MRGould PVGrimmer MRIavarone AIsmail AJenkinson MDKhasraw MKim HKouwenhoven MCMLaViolette PSLi MLichter PLigon KLLowman AKMalta TMMazor TMcDonald KLMolinaro AMNam D-HNayyar NNg HKNgan CYNiclou SPNiers JMNoushmehr HNoorbakhsh JOrmond DRPark C-KPoisson LMRabadan RRadlwimmer BRao GReifenberger GSa JKSchuster MShaw BLShort SCSmitt PASSloan AESmits MSuzuki HTabatabai GVan Meir EGWatts CWeller MWesseling PWesterman BAWidhalm GWoehrer AYung WKAZadeh GHuse JTDe Groot JFStead LFVerhaak RGW. Longitudinal molecular trajectories of diffuse glioma in adults.
Nature.
576:112-120.
2019
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Burtness BHarrington KJGreil RSoulières DTahara Mde Castro GPsyrri ABasté NNeupane PBratland ÅFuereder THughes BGMMesía RNgamphaiboon NRordorf TWan Ishak WZHong R-LGonzález Mendoza RRoy AZhang YGumuscu BCheng JDJin FRischin DLerzo GTatangelo MVarela MZarba JJBoyer MGan HGao BHughes BMallesara GRischin DTaylor ABurian MFuereder TGreil RBarrios CHde Castro Junior DOCastro GFranke FAGirotto GLima IPFNicolau URPinto GDJSantos LVictorino A-PChua NCouture FGregg RHansen AHilton JMcCarthy JSoulieres DAscui RGonzalez PVillanueva LTorregroza MZambrano AHoleckova PKral ZMelichar BPrausova JVosmik MAndersen MGyldenkerne NJurgens HPutnik KReinikainen PGruenwald VLaban SAravantinos GBoukovinas IGeorgoulias VPsyrri AKwong DAl-Farhat YCsoszi TErfan JHorvai GLandherr LRemenar ERuzsa ASzota JBillan SGluck IGutfeld OPopovtzer ABenasso MBui SFerrari VLicitra LNole FFujii TFujimoto YHanai NHara HMatsumoto KMitsugi KMonden NNakayama MOkami KOridate NShiga KShimizu YSugasawa MTahara MTakahashi MTakahashi STanaka KUeda TYamaguchi HYamazaki TYasumatsu RYokota TYoshizaki TKudaba IStara ZWan Ishak WZCheah SKAguilar Ponce JGonzalez Mendoza RHernandez Hernandez CMedina Soto FButer JHoeben AOosting SSuijkerbuijk KBratland ABrydoey MAlvarez RMas LCaguioa PQuerol JRegala EETamayo MBVillegas EMKawecki AKarpenko AKlochikhin ASmolin AZarubenkov OGoh BCCohen Gdu Toit JJordaan CLanders GRuff PSzpak WTabane NBrana IIglesias Docampo LLavernia JMesia RAbel EMuratidu VNielsen NCristina VRordorf TRothschild SHong R-LWang H-MYang M-HYeh S-PYen C-JNgamphaiboon NSoparattanapaisarn NSriuranpong VAksoy SCicin IEkenel MHarputluoglu HOzyilkan OHarrington KAgarwala SAli HAlter RAnderson DBruce JBurtness BCampbell NConde MDeeken JEdenfield WFeldman LGaughan EGoueli BHalmos BHegde UHunis BJotte RKarnad AKhan SLaudi NLaux DMartincic DMcCune SMcGaughey DMisiukiewicz KMulford DNadler ENeupane PNunnink JOhr JO'Malley MPatson BPaul DPopa EPowell SRedman RRella VRocha Lima CSivapiragasam ASu YSukari AWong SYilmaz EYorio J. Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study.
Lancet.
394:1915-1928.
2019
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Arnaud-Coffin PMaillet DGan HKStelmes JJYou BDalle SPéron J. A systematic review of adverse events in randomized trials assessing immune checkpoint inhibitors.
International Journal of Cancer.
145:639-648.
2019
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Le Saux OFalandry CGan HKYou BFreyer GPéron J. Changes in the use of comprehensive geriatric assessment in clinical trials for older patients with cancer over time.
The Oncologist.
24:1089-1094.
2019
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Lassman ABRoberts-Rapp LSokolova ISong MPestova EKular RMullen CZha ZLu XGomez EBhathena AMaag DKumthekar PGan HKScott AMGuseva MHolen KDAnsell PJvan den Bent MJ. Comparison of Biomarker Assays for EGFR: Implications for Precision Medicine in Patients with Glioblastoma.
Clinical Cancer Research.
25:3259-3265.
2019
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Tiu CLoh ZGan CLGan HJohn THawkes E. Effect of Reasons for Screen Failure on Subsequent Treatment Outcomes in Cancer Patients Assessed for Clinical Trials.
Oncology: international journal of cancer research and treatment.
97:270-276.
2019
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Gan HKMillward MJHua YQi CSai YSu WWang JZhang LFrigault MMMorgan SYang LLickliter JD. First-in-human phase I study of the selective MET inhibitor, Savolitinib, in patients with advanced solid tumors: Safety, pharmacokinetics and anti-tumor activity.
Clinical Cancer Research.
25.
2019
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Lassman ABvan den Bent MJGan HKReardon DKumthekar PButowski NLwin ZMikkelson TNabors LBPapadopoulos KPPenas-Prado MSimes JWheeler HWalbert TScott AMGomez ELee H-JRoberts-Rapp LXiong HAnsell PJBain EHolen KDMagg DMerrell R. Safety and efficacy of depatuxizumab mafodotin +
temozolomide in patients with EGFR-amplified,
recurrent glioblastoma: results from an international
phase I multicenter trial.
Neuro-Oncology.
21:106-114.
2019
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Anderson NJJackson JEWada MSchneider MPoulsen MRolfo MFahandej MGan HKhoo V. The changing landscape of head and neck cancer radiotherapy patients: is high-risk, prolonged feeding tube use indicative of on-treatment weight loss?.
Journal of Medical Radiation Sciences.
2019
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Hafeez UMenon SNguyen BLum CGaughran GPranavan GCher LNowak AKGan HParakh S. Young adults diagnosed with high grade gliomas: Patterns of care, outcomes, and impact on employment.
Journal of Clinical Neuroscience.
68:45-50.
2019
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Ameratunga MMiller DNg WWada MGonzalvo ACher LGan HK. A single-institution prospective evaluation of a neuro-oncology multidisciplinary team meeting.
Journal of Clinical Neuroscience.
56:127-130.
2018
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Zer APond GRRazak ARATirona KGan HKChen EXO’Sullivan BWaldron JGoldstein DPWeinreb IHope AJKim JJChan KKWChan AKSiu LLBernstein LJ. Association of Neurocognitive Deficits With Radiotherapy or Chemoradiotherapy for Patients With Head and Neck Cancer.
JAMA Otolaryngology - Head and Neck Surgery.
144:71-79.
2018
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Phillips ACBoghaert ERVaidya KSFalls HDMitten MJDeVries PJBenatuil LHsieh C-MMeulbroek JAPanchal SCBuchanan FGDurbin KRVoorbach MJReuter DRMudd SRLoberg LIRalston SLCao DGan HKScott AMReilly EB. Characterization of ABBV-221, a Tumor-Selective EGFR-Targeting Antibody Drug Conjugate.
Molecular Cancer Therapeutics.
17:795-805.
2018
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Arulananda SLynam JSem Liew MWada MCher LGan HK. Clinical correlates of severe thrombocytopenia from temozolomide in glioblastoma patients.
Internal Medicine Journal.
48:1206-1214.
2018
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Brastianos PKIppen FMHafeez UGan HK. Emerging Gene Fusion Drivers in Primary and Metastatic Central Nervous System Malignancies: A Review of Available Evidence for Systemic Targeted Therapies.
The Oncologist.
23:1063-1075.
2018
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Aldape KAmin SBAshley DMBarnholtz-Sloan JSBates AJBeroukhim RBock CBrat DJClaus EBCostello JFde Groot JFFinocchiaro GFrench PJGan HKGriffith BHerold-Mende CCHorbinski CIavarone AKalkanis SNKarabatsou KKim HKouwenhoven MCMMcDonald KLMiletic HNam D-HKeung Ng HNiclou SPNoushmehr HOrmond DRPoisson LMReifenberger GRoncaroli FSa JKSillevis Smitt PAESmits MSouza CFTabatabai GVan Meir EGVerhaak RGWWatts CWesseling PWoehrer AYung WKAJungk CHau A-Cvan Dyck EWesterman BAYin JAbiola OZeps NGrimmond SBuckland MKhasraw MSulman EPMuscat AMStead L. Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium.
Neuro-Oncology.
20:873-884.
2018
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Burvenich IJGParakh SLee F-TGuo NLiu ZGan HKRigopoulos AO'Keefe GJGong SJGoh YWTochon-Danguy HScott FEKotsuma MHirotani KSenaldi GScott AM. Molecular imaging of T cell co-regulator factor B7-H3 with Zr-89-DS-5573a.
Theranostics.
8:4199-4209.
2018
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Hafeez UGan HKScott AM. Monoclonal antibodies as immunomodulatory therapy against cancer and autoimmune diseases.
Current Opinion in Pharmacology.
41:114-121.
2018
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Ameratunga MChenard-Poirier MMoreno Candilejo IPedregal MLui ADolling DAversa CGarces AIAng JEBanerji UKaye SGan HDoger BMoreno Vde Bono JLopez J. Neutrophil-lymphocyte ratio kinetics in patients with advanced solid tumours on phase I trials of PD-1/PD-L1 inhibitors.
European Journal of Cancer.
89:56-63.
2018
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Wann ATully PABarnes EHLwin ZJeffree RDrummond KJGan HKhasraw M. Outcomes after second surgery for recurrent glioblastoma: a retrospective case–control study.
Journal of Neuro-Oncology.
137:409-415.
2018
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Bernstein LJPond GRGan HKTirona KChan KKHope AKim JChen EXSiu LLRazak ARA. Pretreatment neurocognitive function and self-reported symptoms in patients with newly diagnosed head and neck cancer compared with noncancer cohort.
Head and Neck: journal for the sciences and specialities of the head and neck.
40:2029-2042.
2018
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Anderson NJJackson JESmith JGWada MSchneider MPoulsen MRolfo MFahandej MGan HJoon DLKhoo V. Pretreatment risk stratification of feeding tube use in patients treated with intensity-modulated radiotherapy for head and neck cancer.
Head and Neck: journal for the sciences and specialities of the head and neck.
40:2181-2192.
2018
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Burvenich IJGParakh SParslow ACLee STGan HKScott AM. Receptor occupancy imaging studies in oncology drug development.
American Association of Pharmaceutical Scientists (AAPS) Journal.
20:1-16.
2018
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Gan HKReardon DALassman ABMerrell Rvan den Bent MButowski NLwin ZWheeler HFichtel LScott AMGomez EJFischer JMandich HXiong HLee H-JMunasinghe WPRoberts-Rapp LAAnsell PJHolen KDKumthekar P. Safety, pharmacokinetics, and antitumor response of depatuxizumab mafodotin as monotherapy or in combination with temozolomide in patients with glioblastoma.
Neuro-Oncology.
20:838-847.
2018
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Gan HKvan den Bent MLassman ABReardon DAScott AM. Antibody–drug conjugates in glioblastoma therapy: the right drugs to the right cells.
Nature Reviews Clinical Oncology.
14:695-707.
2017
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Le Saux OFalandry CGan HKYou BFreyer GPéron J. Changes in the use of end points in clinical trials for elderly cancer patients over time.
Annals of Oncology.
28:2606-2611.
2017
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Reardon DALassman ABvan den Bent MKumthekar PMerrell RScott AMFichtel LSulman EPGomez EFischer JLee H-JMunasinghe WXiong HMandich HRoberts-Rapp LAnsell PHolen KDGan HK. Efficacy and safety results of ABT-414 in combination with radiation and temozolomide in newly diagnosed glioblastoma..
Neuro-Oncology.
19:965-975.
2017
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van den Bent MGan HKLassman ABKumthekar PMerrell RButowski NLwin ZMikkelsen TNabors LBPapadopoulos KPPenas-Prado MSimes JWheeler HWalbert TScott AMGomez ELee H-JRoberts-Rapp LXiong HBain EAnsell PJHolen KDMaag DReardon DA. Efficacy of depatuxizumab mafodotin (ABT-414) monotherapy in patients with EGFR-amplified, recurrent glioblastoma: results from a multi-center, international study.
Cancer Chemotherapy and Pharmacology.
80:1209-1217.
2017
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Parakh SGan HKParslow ACBurvenich IJGBurgess AWScott AM. Evolution of anti-HER2 therapies for cancer treatment.
Cancer Treatment Reviews.
59:1-21.
2017
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Tamjid BPhan PJohn TMitchell PGan H. Outcomes for patients with synchronous and metachronous primary lung cancer after diagnosis of head and neck cancer.
Head and Neck: journal for the sciences and specialities of the head and neck.
39:1544-1549.
2017
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Soria JCGan HKBlagden SPPlummer RArkenau HTRanson MEvans TRJZalcman GBahleda RHollebecque ALemech CDean EBrown JGibson DPeddareddigari VMurray SNebot NMazumdar JSwartz LAuger KRFleming RASingh RMillward M. A phase I, pharmacokinetic and pharmacodynamic study of GSK2256098, a focal adhesion kinase inhibitor, in patients with advanced solid tumors.
Annals of Oncology.
27:2268-2274.
2016
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Maillet DGan HKBlay JYYou BPéron J. Aggregated adverse-events outcomes in oncology phase III reports: A systematic review.
European Journal of Cancer.
52:26-32.
2016
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Parslow ACParakh SLee F-TGan HKScott AM. Antibody-Drug Conjugates for Cancer Therapy.
Biomedicines.
4:1-17.
2016
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Parakh SParslow ACGan HKScott AM. Antibody-mediated delivery of therapeutics for cancer therapy.
Expert Opinion on Drug Delivery.
13:401-419.
2016
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Gan HKBurgess AWParslow ACScott AM. Dual targeting of EGFR: Ready for prime time?.
Translational Cancer Research.
5:S18-S21.
2016
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Burvenich IJGLee F-TGuo NGan HKRigopoulos AParslow ACO'Keefe GJGong SJTochon-Danguy HRudd SEDormelly PSKotsuma MOhtsuka TSenaldi GScott AM. In vitro and in vivo evaluation of 89Zr-DS-8273a as a theranostic for anti-death receptor 5 therapy.
Theranostics.
6:2225-2234.
2016
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Le Saux OFalandry CGan HKYou BFreyer GPeron J. Inclusion of elderly patients in oncology clinical trials.
Annals of Oncology.
27:1799-1804.
2016
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Lee FTBurvenich IJGGuo NKocovski PTochon-Danguy HAckermann UO'Keefe GJGong SRigopoulos ALiu ZGan HKScott AM. L-Tyrosine Confers Residualizing Properties to a D-Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies.
Molecular Imaging.
15:1-9.
2016
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Burvenich IJGParakh SGan HKLee F-TGuo NRigopoulos ALee S-TGong SO'Keefe GJTochon-Danguy HKotsuma MHasegawa JSenaldi GScott AM. Molecular Imaging and Quantitation of EphA2 Expression in Xenograft Models with Zr-89-DS-8895a.
Journal of Nuclear Medicine.
57:974-980.
2016
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Parakh SThursfield VCher LDally MDrummond KMurphy MRosenthal MAGan HK. Recurrent glioblastoma: Current patterns of care in an Australian population.
Journal of Clinical Neuroscience.
24:78-82.
2016
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Maillet DBlay JYYou BRachdi AGan HKPeron J. The reporting of adverse events in oncology phase III trials: a comparison of the current status versus the expectations of the EORTC members.
Annals of Oncology.
27:192-198.
2016
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Whittle JRLickliter JDGan HKScott AMSimes JSolomon BJMacDiarmid JABrahmbhatt HRosenthal MA. First in human nanotechnology doxorubicin delivery system to target epidermal growth factor receptors in recurrent glioblastoma.
Journal of Clinical Neuroscience.
22:1889-1894.
2015
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Kao YHGan HKZaheer SLam WWCLoke KSHWong WYNg DCEGoh ASW. Gender, Race, and Age at Diagnosis as Risk Factors for Metastasis or Recurrence among 1,657 Thyroid Cancer Patients Treated with Radioiodine across 40 Years in Singapore.
Oncology Research and Treatment.
38:679-682.
2015
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Lee W-IAmeratunga Mdu Plessis JGan H. Hypopharyngeal large cell neuroendocrine carcinoma.
BMJ Case Reports.
2015:bcr2015211908-bcr2015211908.
2015
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Gan HKRosenthal MACher LDally MDrummond KMurphy MThursfield V. Management of glioblastoma in Victoria, Australia (2006-2008).
Journal of Clinical Neuroscience.
22:1462-1466.
2015
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Ciprotti MTebbutt NCLee F-TLee S-TGan HKMcKee DCO'Keefe GJGong SJChong GHopkins WChappell BScott FEBrechbiel MWTse ANJansen MMatsumura MKotsuma MWatanabe RVenhaus RBeckman RAGreenberg JScott AM. Phase I Imaging and Pharmacodynamic Trial of CS-1008 in Patients With Metastatic Colorectal Cancer.
Journal of Clinical Oncology.
33:2609-2616.
2015
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Bylicki OGan HKJoly FMaillet DYou BPéron J. Poor patient-reported outcomes reporting according to CONSORT guidelines in randomized clinical trials evaluating systemic cancer therapy.
Annals of Oncology.
26:231-237.
2015
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Richter SSeah J-APond GRGan HKMackenzie MJHotte SJMukherjee SDMurray NKollmannsberger CHeng DHaider MAHalford RIvy SPMoore MJSridhar SS. Evaluation of second line and subsequent targeted therapies in metastatic renal cell cancer (mRCC) patients treated with first line cediranib.
Canadian Urological Association Journal.
8:398-402.
2014
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Campbell RNLiew MSGan HKCher L. Mistaken identity: Granular cell astrocytoma masquerading as histiocytosis of the central nervous system.
Journal of Clinical Neuroscience.
21:1457-1459.
2014
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Tamjid BCher LWada MKalnins RGan H. Olfactory Neuroblastoma (Esthesioneuroblastoma) following Retro-Orbital Irradiation for Graves' Ophthalmopathy.
JOURNAL OF CASE REPORTS AND STUDIES.
1:1-5.
2014
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Ciprotti MChong GGan HKChan AMurone CMacGregor DLee FTJohns TGHeath JKErnst MBurgess AWScott AM. Quantitative intratumoural microdistribution and kinetics of 131I-huA33 antibody in patients with colorectal carcinoma.
EJNMMI Research.
4:1-10.
2014
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Péron JMaillet DGan HKChen EXYou B. Adherence to CONSORT adverse event reporting guidelines in randomized clinical trials evaluating systemic cancer therapy: A systematic review.
Journal of Clinical Oncology.
31:3957-3963.
2013
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Chang JHWada MAnderson NJLim Joon DLee STGong SJGunawardana DHSachinidis JO'Keefe GGan HKKhoo VScott AM. Hypoxia-targeted radiotherapy dose painting for head and neck cancer using 18F-FMISO PET: A biological modeling study.
Acta Oncologica.
52:1723-1729.
2013
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Péron JYou BGan HKMaillet DChen EXPond GR. Influence of statistician involvement on reporting of randomized clinical trials in medical oncology.
Anti-Cancer Drugs: international journal on anti-cancer agents.
24:306-309.
2013
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Wong SFMak GRosenthal MACher LGan HK. Local perspective on a rare brain tumour: Adult medulloblastoma.
Internal Medicine Journal.
43:567-572.
2013
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Gan HKCvrljevic ANJohns TG. The epidermal growth factor receptor variant III (EGFRvIII): Where wild things are altered.
The Federation of European Biochemical Societies (FEBS) Journal.
280:5350-5370.
2013
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Boespflug AGan HChen ÉXPond GYou B. Consistency in the analysis and reporting of PEPs in oncology randomized controlled trials from registration to publication: a systematic review.
Bulletin du Cancer.
99:943-952.
2012
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Wong SFGan HKCher L. A single centre study of the treatment of relapsed primary central nervous system lymphoma (PCNSL) with single agent temozolomide.
Journal of Clinical Neuroscience.
19:1501-1505.
2012
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Gan HKYou BPond GRChen EX. Assumptions of expected benefits in randomized phase III trials evaluating systemic treatments for cancer.
Journal of National Cancer Institute.
104:590-598.
2012
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You BGan HKPond GChen EX. Consistency in the analysis and reporting of primary end points in oncology randomized controlled trials from registration to publication: a systematic review.
Journal of Clinical Oncology.
30:210-216.
2012
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Le Tourneau CGan HKRazak ARAPaoletti X. Efficiency of New Dose Escalation Designs in Dose-Finding Phase I Trials of Molecularly Targeted Agents.
PLoS ONE.
7.
2012
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Péron JPond GRGan HKChen EXAlmufti RMaillet DYou B. Quality of reporting of modern randomized controlled trials in medical oncology: A systematic review.
Journal of National Cancer Institute.
104:982-989.
2012
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Gan HKBurgess AWClayton AHAScott AM. Targeting of a conformationally exposed, tumor-specific epitope of EGFR as a strategy for cancer therapy.
Cancer Research.
72:2924-2930.
2012
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Pillay VGan HKScott AM. Antibodies in oncology.
New Biotechnology.
28:518-529.
2011
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Gan HKBernstein LJBrown JRingash JVakilha MWang LGoldstein DKim JHope AO'Sullivan BWaldron JAbdul Razak ARChen EXSiu LL. Cognitive functioning after radiotherapy or chemoradiotherapy for head-and-neck cancer.
International Journal of Radiation: Oncology - Biology - Physics.
81:126-134.
2011
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Le Tourneau CRazak ARAGan HKPop SDiéras VTresca PPaoletti X. Heterogeneity in the definition of dose-limiting toxicity in phase i cancer clinical trials of molecularly targeted agents: A review of the literature.
European Journal of Cancer.
47:1468-1475.
2011
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Le Tourneau CRazak ARALevy CCalugaru VGalatoire ODendale RDesjardins LGan HK. Role of chemotherapy and molecularly targeted agents in the treatment of adenoid cystic carcinoma of the lacrimal gland.
British Journal of Ophthalmology.
95:1483-1489.
2011
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Gan HKPond GRMoore MJSiu LL. Reply to D.J. Stewart.
Journal of Clinical Oncology.
28:e651-e651.
2010
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Johns TGMcKay MJCvrljevic ANGan HKTaylor CXu HSmyth FEScott AM. MAb 806 Enhances the Efficacy of Ionizing Radiation in Glioma Xenografts Expressing the de2-7 Epidermal Growth Factor Receptor.
International Journal of Radiation: Oncology - Biology - Physics.
78:572-578.
2010
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Lee FTO'Keefe GJGan HKMountain AJJones GRSaunder THSagona JRigopoulos ASmyth FEJohns TGGovindan SVGoldenberg DMOld LJScott AM. Immuno-PET Quantitation of de2-7 Epidermal Growth Factor Receptor Expression in Glioma Using 124I-IMP-R4-Labeled Antibody ch806.
Journal of Nuclear Medicine.
51:967-972.
2010
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Gan HKGrothey APond GRMoore MJSiu LLSargent D. Randomized Phase II Trials: Inevitable or Inadvisable?.
Journal of Clinical Oncology.
28:2641-2647.
2010
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Gan HKRosenthal MADowling AKalnins RAlgar EWong NBenson AWoods AMCher L. A phase II trial of primary temozolomide in patients with grade III oligodendroglial brain tumors.
Neuro-Oncology.
12:500-507.
2010
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Gan HKAzad ACher LMitchell PLR. Neurolymphomatosis: diagnosis, management, and outcomes in patients treated with rituximab.
Neuro-Oncology.
12:212-215.
2010
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Arrondeau JGan HKRazak ARAPaoletti XLe Tourneau C. Development of anti-cancer drugs..
Discovery medicine.
10:355-362.
2010
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Le Tourneau CMichiels SGan HKSiu LL. Reporting of Time-to-Event End Points and Tracking of Failures in Randomized Trials of Radiotherapy With or Without Any Concomitant Anticancer Agent for Locally Advanced Head and Neck Cancer.
Journal of Clinical Oncology.
27:5965-5971.
2009
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Lwin ZGan HKMason WP. Low-grade oligodendroglioma: current treatments and future hopes.
Expert Review of Anticancer Therapy: an essential contribution to decision making in cancer care.
9:1651-1661.
2009
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Gan HKLappas MCao DXCvrljevdic AScott AMJohns TG. Targeting a unique EGFR epitope with monoclonal antibody 806 activates NF-κB and initiates tumour vascular normalization.
Journal of Cell and Molecular Medicine.
13:3993-4001.
2009
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Gan HKSeruga BKnox JJ. Sunitinib in solid tumors.
Expert Opinion on Investigational Drugs.
18:821-834.
2009
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Gan HKKaye AHLuwor RB. The EGFRvIII variant in glioblastoma multiforme.
Journal of Clinical Neuroscience.
16:748-754.
2009
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Garrett TPJBurgess AWGan HKLuwor RBCartwright GWalker FOrchard SGClayton AHANice ECRothacker JCatimel BCavenee WKOld LJStockert ERitter GAdams TEHoyne PAWittrup DChao GCochran JRLuo CLou MHuyton TXu YFairlie WDYao SScott AMJohns TG. Antibodies specifically targeting a locally misfolded region of tumor associated EGFR.
Proceedings of the National Academy of Sciences of USA.
106:5082-5087.
2009
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Ashley DMRiffkin CDLovric MMMikeska TDobrovic AMaxwell JAFriedman HSDrummond KJKaye AHGan HKJohns TGHawkins CJ. Erratum: In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.
British Journal of Cancer.
100:1012-1012.
2009
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Gan HKSeruga BKnox JJ. Management of toxicities and optimal dosing of targeted drugs in advanced kidney cancer.
Current Oncology.
16:S54-S61.
2009
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Gan HKSeruga BKnox JJ. Targeted therapies for renal cell carcinoma: more gains from using them again.
Current Oncology.
16:S47-S53.
2009
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Ashley DMRiffkin CDLovric MMMikeska TDobrovic AMaxwell JAFriedman HSDrummond KJKaye AHGan HKJohns TGHawkins CJ. In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.
British Journal of Cancer.
99:294-304.
2008
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Gan HKWalker FBurgess AWRigopoulos AScott AMJohns TG. The Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor AG1478 Increases the Formation of Inactive Untethered EGFR Dimers.
Journal of Biological Chemistry.
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2007
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Gan HKMitchell PLGalettis PDavis IDCebon Jde Souza PLinks M. A phase 1 and pharmacokinetic study of gemcitabine and oxaliplatin in patients with solid tumors.
Cancer Chemotherapy and Pharmacology.
58:157-164.
2006
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Gan HLoveland BE. Mannan-MUC1-Pulsed Dendritic Cell Immunotherapy: A Phase I Trial in Patients with Adenocarcinoma.
Clinical Cancer Research.
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2006
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Scott AGan HPerera RM. Treatment of Human Tumor Xenografts with Monoclonal Antibody 806 in Combination with a Prototypical Epidermal Growth Factor Receptor-Specific Antibody Generates Enhanced Antitumor Activity.
Clinical Cancer Research.
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Panousis CRayzman VMJohns TGRenner CLiu ZCartwright GLee F-TWang DGan HCao DKypridis ASmyth FEBrechbiel MWBurgess AWOld LJScott AM. Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR.
British Journal of Cancer.
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Parakh SKing DGan HKScott AM. Current Development of Monoclonal Antibodies in Cancer Therapy.
Recent Results in Cancer Research.
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Gan HKLee JJSiu LL. Phase II Trials with Anticancer Agents.
141-161.
2011
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Gan HKLee JJSiu LL. Phase II Trials with Anticancer Agents.
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Lee RCGan HK. BI 853520, a FAK-Simile of Prior FAK Inhibitors?.
Targeted Oncology.
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Lee RCGan HK. BI 853520, a FAK-Simile of Prior FAK Inhibitors?.
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Markman BTran BGan HPrawira ACoward JJin XLi BWang MXia YDesai JMillward M. A Phase 1 study of AK104, a tetrameric bispecific antibody that targets PD-1 and CTLA-4 in patients with advanced solid tumors.
Journal for ImmunoTherapy of Cancer.
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Coward JGan HKuo JMillward MRichardson GDeng WMitra SSchmidt MXiang HHorvath LPrawira A. A phase 1 study of FPT155, a first-in-class CD80 extracellular domain-Fc fusion protein, in patients with advanced solid tumors.
Journal for ImmunoTherapy of Cancer.
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Luo DAbdul-Karim RAzad ABendell JGan HJanku FSen STan TWang JSchechet LBaker LLeveque JMeniawy T. Open-label, multicenter phase 1/2 dose escalation and expansion study of THOR-707 as a single agent and in combination with a PD-1 inhibitor in adult subjects with advanced or metastatic solid tumors.
Journal for ImmunoTherapy of Cancer.
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Gan HCher LInglis PLwin ZLau EWichmann CAckermann UCoombs NRemen KGuo NLee STGong SPalmer JBPathmaraj KO'Keefe GScott FDay BWBoyd AWThomas PDurrant CScott AM. Abstract CT063: Preliminary findings of a Phase I safety and bioimaging trial of KB004 (ifabotuzumab) in patients with glioblastoma.
Cancer Research.
2019
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Goh JGao BMarkman BGan HVoskoboynik MWu Y-LGuo JZhou QZhao JChen CQiu JXu YYang LMillward M. Abstract CT167: A Phase Ib study to assess safety, tolerability, pharmacokinetics, and preliminary antitumor activity of sitravatinib in combination with tislelizumab in patients with advanced solid tumors.
Cancer Research.
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Chia PLCao DGan HKReilly EBPhillips AJohn TScott AM. ABT-806 derived antibody drug conjugates (ADCs) inhibit growth of malignant mesothelioma in-vivo..
Journal of Clinical Oncology.
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Reardon DAKaley TJDietrich JClarke JLDunn GLim MCloughesy TFGan HKPark AJSchwarzenberger PRicciardi TMacri MJRyan AVenhaus RR. Phase II study to evaluate safety and efficacy of MEDI4736 (durvalumab) + radiotherapy in patients with newly diagnosed unmethylated MGMT glioblastoma (new unmeth GBM)..
Journal of Clinical Oncology.
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Millward MGan HKJoshua AMKuo JC-YPrawira ARichardson GEBarbee SDInamdar SPPierce KLQureshi MHorvath L. FPT155-001: A phase Ia/Ib study of FPT155 (CD80-FC) in patients with advanced solid tumors..
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Desai JMarkman BFriedlander MGan HHorvath LTownsend AMillward MJameson MYen C-JHou M-MHou JWu JLiang LDeva S. Long-term exposure (LTE) to Tislelizumab, an investigational anti-PD-1 antibody, in a first-in-human Phase I study.
Cancer Research.
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Annals of Oncology.
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Cancer Science.
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Sandhu SHill AGan HFriedlander MVoskoboynik MBarlow PTownsend ASong JZhang YLiang LDesai J. Tislelizumab, an anti-PD-1 antibody, in patients with urothelial carcinoma (UC): Results from an ongoing phase I/II study.
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Gan HKMurone CWong MFitt GKennedy EMaag DAldape K. Radiologically evident treatment effects in patients with glioblastoma (GBM) and its clinical implications.
Annals of Oncology.
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Lassman ABRoberts-Rapp LHe LLu XZha ZBhathena AAnsell PJGan HKScott AMvan den Bent M. GENOMIC PROFILING IDENTIFIES TUBULIN MUTATIONS THAT MAY PREDICT RESPONSE TO DEPATUXIZUMAB MAFODOTIN IN PATIENTS WITH GLIOBLASTOMA.
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2012
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Gan HNebot NSoria JCArkenau HTBlagden SPlummer RRanson MEvans TRJZalcman GPeddareddigari VGibson DMurray SMazumdar JFleming RAuger KMillward M. 613 Pharmacokinetics/pharmacodynamics (PK/PD) of GSK2256098, a Focal Adhesion Kinase (FAK) Inhibitor, in Patients with Advanced Solid Tumors.
European Journal of Cancer.
189-189.
2012
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Liew MSMurone CWalkiewicz MMitchell PGan HBarnett SRussell PWright GScott AJohn T. CORRELATION OF WTEGFR ACTIVATION ASSESSED BY MAB806 BINDING AND EGFR KINASE MUTATIONS IN STAGE IIIA N2 NSCLC.
Annals of Oncology.
542-542.
2012
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Soria J-CGan HKArkenau H-TBlagden SPPlummer RRanson MEvans TRJZalcman GBahleda RHollebecque ALemech CBrown JPeddareddigari VGRGibson DMurray SCNebot NMazumdar JFleming RAMillward M. Phase I clinical and pharmacologic study of the focal adhesion kinase (FAK) inhibitor GSK2256098 in pts with advanced solid tumors.
Journal of Clinical Oncology.
2012
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Razak ARAGan HKPond GRTirona KMChen EXChan KHope AJKim J-HJSiu LLBernstein LJ. Pretreatment neurocognitive function (NCF) status in head and neck cancer (HNC) patients (pts) with comparison to control cohort.
Journal of Clinical Oncology.
2012
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Peron JPond GGan HGChen EXMaillet DYou B. 1314 POSTER Quality of Reporting of Modern Randomized Controlled Trials in Oncology.
European Journal of Cancer.
S167-S167.
2011
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Richter SGan HKMacKenzie MJHotte SJMukherjee SDKollmannsberger CKIvy SPFernandes KHalford RMassey CWang LMoore MJSridhar SS. Evaluation of second-line response to targeted therapy following progression on first-line cediranib, an oral pan-vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor (TKI), in advanced renal cell carcinoma (RCC)..
Journal of Clinical Oncology.
e15153-e15153.
2011
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Gan HKYou BPond GRChen EX. Expected benefits versus actual outcomes in oncology phase III randomized controlled trials (RCTs)..
Journal of Clinical Oncology.
2562-2562.
2011
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Razak ARASiu LLChan APond GRTirona KMChen EXHope AJRingash JO'Sullivan BWaldron JNChan KGan HKBernstein LJ. Neurocognitive function (NCF) in patients (pts) treated with chemo/bio-radiotherapy (C/B-RT) for head and neck cancers (HNC)..
Journal of Clinical Oncology.
2011
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Le Tourneau CRazak RAGan HKPop SPaoletti X. Definition of dose-limiting toxicity in phase I cancer clinical trials of molecularly targeted agents.
Annals of Oncology.
22-22.
2011
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Tourneau CLRazak ARAGan HKPop SPaoletti X. Abstract 1690: Definition of dose-limiting toxicity in phase I cancer clinical trials of molecularly targeted agents.
Cancer Research.
2011
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Gan HKYou BPond GRChen EX. Adequacy of data provision and analysis in oncology phase III trials over the past 5 years..
Journal of Clinical Oncology.
6122-6122.
2010
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Bernstein LJGan HKAbdul Razak ARTirona KMRingash JO'Sullivan BWaldron JNHope AJGoldstein DPSiu LL. Cognitive functioning pre- and postradiotherapy (RT), chemoradiotherapy (CRT), or bioradiotherapy (BRT) in patients with locally advanced squamous cell cancer of the head and neck (LA-SCCHN)..
Journal of Clinical Oncology.
e19629-e19629.
2010
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You BGan HKPond GRChen EX. Consistency in reporting of primary endpoints (PEP) from registration to publication for modern randomized oncology phase III trials..
Journal of Clinical Oncology.
6031-6031.
2010
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Gan HKBernstein LJBrown JRingash JVakilha MWang LO'Sullivan BWaldron JChen EXSiu LL. Neurocognitive outcomes of head and neck chemoradiotherapy: A pilot study.
Journal of Clinical Oncology.
2009
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Le Tourneau CMichiels SGan HSiu L. Reporting of endpoints and tracking of failures in randomized trials of radiotherapy or concurrent chemoradiotherapy for locally advanced head and neck squamous cell cancer (LA-HNSCC).
Journal of Clinical Oncology.
2009
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Gan HKCher LBenson ADowling ARosenthal M. A phase II trial of temolozomide in patients with untreated high grade oligodengroglial brain tumours.
Journal of Clinical Oncology.
13005-13005.
2008
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Gan HKBurgess AWWalker FScott AMJohns TG. The epidermal growth factor receptor (EGFR) exists as an inactive dimer conformation that is reactive with mAb 806 and distinct from the "back-to-back" ligated dimer..
Clinical Cancer Research.
8995S-8995S.
2005
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Markman BTran BGan HPrawira ACoward JJin XLi BWang MXia YDesai JMillward M. A Phase 1 study of AK104, a tetrameric bispecific antibody that targets PD-1 and CTLA-4 in patients with advanced solid tumors.
Journal for ImmunoTherapy of Cancer.
2019
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conference poster
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Chia PLCao DGan HReilly EPhillips AJohn TScott A. ABT-806 Derived Antibody Drug Conjugates (ADCs) Inhibit Growth of Malignant Mesothelioma In-Vivo.
Journal of Thoracic Oncology.
S759-S759.
2019
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Lee RCGan HMarhoon NPanagiotopoulos SKhor R. Study evaluating the impact of AI software to identify and validate patients for clinical trials.
Asia Pacific Journal of Clinical Oncology.
166-166.
2019
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Leimgruber AHickson KLee STGan HCher LSachinidis JO'Keefe GScott AM. GLYOXIA: INTEGRATED ANALYSIS OF GLUCOSE METABOLISM AND HYPOXIA WITH F-18-FLUOROMISONIDAZOLE (FMISO) AND 18F-FLUORODEOXYGLUCOSE (FDG) PET IN HIGH GRADE GLIOMA PATIENTS.
Internal Medicine Journal.
26-27.
2012
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Chia PLCao DGan HReilly EPhillips AJohn TScott A. ABT-806 Derived Antibody Drug Conjugates (ADCs) Inhibit Growth of Malignant Mesothelioma In-Vivo.
Journal of Thoracic Oncology.
S759-S759.
2019
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letter
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Parakh SHamid ACher LGan HK. Temozolomide-Associated Liver Fibrosis.
Journal of Clinical Pharmacology.
1448-1449.
2016
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Wong SFMak GRosenthal MACher LGan HK. Author reply.
Internal Medicine Journal.
210-211.
2014
Full text if available
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Parakh SHamid ACher LGan HK. Temozolomide-Associated Liver Fibrosis.
Journal of Clinical Pharmacology.
1448-1449.
2016
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other publication
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Ameratunga MMcArthur GGan HCher L. Prolonged disease control with MEK inhibitor in neurofibromatosis type I-associated glioblastoma.
Journal of Clinical Pharmacy and Therapeutics.
357-359.
2016
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Gan H. Local Perspective On A Rare Brain Tumour: Adult Medulloblastoma – Author Reply.
Internal Medicine Journal.
210-211.
2014
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Ameratunga MMcArthur GGan HCher L. Prolonged disease control with MEK inhibitor in neurofibromatosis type I-associated glioblastoma.
Journal of Clinical Pharmacy and Therapeutics.
357-359.
2016
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abstract
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Gan HSeow ALau ESze-Ting LAmeratunga MPerchyonok YCao DRigopoulos ALee H-JGomez EMaag DScott A. TUMOR VOLUME AS A PREDICTOR OF RESPONSE TO ANTI-EGFR ADC ABT-414.
Neuro-Oncology.
24-24.
2018
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van den Bent MLassman ABGan HKReardon DAKumthekar PButowski NLwin ZMikkelsen TNabors LBPapadopoulos KPPenas-Prado MSimes JWheeler HGomez ELee H-JRoberts-Rapp LXiong HBain EHolen KMerrell R. Efficacy of a novel antibody-drug conjugate (ADC), ABT-414, with temozolomide (TMZ) in recurrent glioblastoma (rGBM).
Annals of Oncology.
2016
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Gong SJO'Keefe GJLee STAkhurst TLee FTDavis IWeickhardt AGan HPathmeraj KHicks RJHudson PJScott AM. DOSIMETRY OF I-124-PEG-AVP0458 DIABODY IN PATIENTS WITH TAG-72 POSITIVE OVARIAN OR PROSTATE CANCER.
Internal Medicine Journal.
40-41.
2015
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Gan HSeow ALau ESze-Ting LAmeratunga MPerchyonok YCao DRigopoulos ALee H-JGomez EMaag DScott A. TUMOR VOLUME AS A PREDICTOR OF RESPONSE TO ANTI-EGFR ADC ABT-414.
Neuro-Oncology.
24-24.
2018