selected publications
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academic article
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Thilakasiri PHuynh JPoh ARTan CWNero TLTran KParslow ACAfshar-Sterle SBaloyan DHannan NJBuchert MScott AMGriffin MDWHollande FParker MWPutoczki TLErnst MChand AL. Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.
EMBO Molecular Medicine.
11.
2019
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Huynh JChand AGough DErnst M. Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map.
Nature Reviews: Cancer.
19:82-96.
2019
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Schmidt SSchumacher NSchwarz JTangermann SKenner LSchlederer MSibilia MLinder MAltendorf-Hofmann AKnösel TGruber ESOberhuber GBolik JRehman ASinha ALokau JArnold PCabron ASZunke FBecker-Pauly CPreaudet ANguyen PHuynh JAfshar-Sterle SChand ALWestermann JDempsey PJGarbers CSchmidt-Arras DRosenstiel PPutoczki TErnst MRose-John S. ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.
Journal of Experimental Medicine.
215:1205-1225.
2018
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Aw JScholz GMHuq NLHuynh JO'Brien-Simpson NMReynolds EC. Interplay between Porphyromonas gingivalis and EGF signalling in the regulation of CXCL14.
Cellular Microbiology.
20:1-13.
2018
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Huynh JScholz GMAw JReynolds EC. Interferon regulatory Factor 6 promotes Keratinocyte differentiation in response to Porphyromonas gingivalis.
Infection and Immunity.
85:1-12.
2017
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Huynh JEtemadi NHollande FErnst MBuchert M. The JAK/STAT3 axis: A comprehensive drug target for solid malignancies.
Seminars in Cancer Biology.
45:13-22.
2017
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Huynh JScholz GMAw JKwa MQAchuthan AHamilton JAReynolds EC. IRF6 regulates the expression of IL-36γ by human oral epithelial cells in response to Porphyromonas gingivalis.
Journal of Immunology.
196:2230-2238.
2016
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Kwa MQHuynh JReynolds ECHamilton JAScholz GM. Disease-associated mutations in IRF6 and RIPK4 dysregulate their signalling functions.
Cellular Signalling.
27:1509-1516.
2015
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Kwa MQNguyen THuynh JRamnath DDe Nardo DLam PYReynolds ECHamilton JASweet MJScholz GM. Interferon regulatory factor 6 differentially regulates toll-like receptor 2-dependent chemokine gene expression in epithelial cells.
Journal of Biological Chemistry.
289:19758-19768.
2014
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Kwa MQHuynh JAw JZhang LNguyen TReynolds ECSweet MJHamilton JAScholz GM. Receptor-interacting protein kinase 4 and interferon regulatory factor 6 function as a signaling axis to regulate keratinocyte differentiation.
Journal of Biological Chemistry.
289:31077-31087.
2014
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Hamilton JALacey DCTurner Ade Kok BHuynh JScholz GM. Hypoxia Enhances the Proliferative Response of Macrophages to CSF-1 and Their Pro-Survival Response to TNF.
PLoS ONE.
7:e45853-e45853.
2012
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Huynh JKwa MQCook ADHamilton JAScholz GM. CSF-1 receptor signalling from endosomes mediates the sustained activation of Erk1/2 and Akt in macrophages.
Cellular Signalling.
24:1753-1761.
2012
Full text if available
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Thilakasiri PHuynh JPoh ARTan CWNero TLTran KParslow ACAfshar-Sterle SBaloyan DHannan NJBuchert MScott AMGriffin MDWHollande FParker MWPutoczki TLErnst MChand AL. Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.
EMBO Molecular Medicine.
11.
2019
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conference paper
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Huynh JChand AErnst M. IL-11 as a therapeutic target to treat colorectal cancer.
Cancer Research.
2018
Full text if available
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Huynh JChand AErnst M. IL-11 as a therapeutic target to treat colorectal cancer.
Cancer Research.
2018