Jarrod Church

La Trobe Co-author Network

Jarrod obtained his PhD in the Dept of Pharmacology at Monash University in 2002 and worked as a researcher at the University of Cambridge (UK), Augusta University (USA), Monash University and the University of Melbourne before joining the Department of PAM as a Lecturer in 2011. He has a long-standing interest in cell and molecular physiology and intracellular signalling pathways, and currently investigates ways that these pathways can be manipulated to enhance regeneration after injury in a number of tissues, particularly skeletal muscle. Routine techniques include cell culture, molecular biology, RT-PCR, Western blotting, ELISA, immunohistochemistry/cytochemistry and cell imaging.

Positions

Physiology Anatomy and Microbiology , School of Life Sciences
Lecturer in Physiology, Dept of Physiology, Anatomy & Microbiology , (La Trobe University) 2011 -

Research Areas

Sport, Exercise & Rehabilitation (Research Areas)
Understanding Disease (Research Areas)

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selected publications

academic article
- Pham LShultz SRKim HABrady RDWortman RCGenders SGHale MWO'Shea RDDjouma Evan den Buuse MChurch JEChristie BRDrummond GRSobey CGMcDonald SJ. Mild Closed-Head Injury in Conscious Rats Causes Transient Neurobehavioral and Glial Disturbances: A Novel Experimental Model of Concussion. Journal of Neurotrauma. 2019
- Johnstone MRBrady RDSchuijers JAChurch JEOrr DQuinn JMWMcDonald SJGrills BL. The selective TrkA agonist, gambogic amide, promotes osteoblastic differentiation and improves fracture healing in mice. The Journal of Musculoskeletal and Neuronal Interactions. 19:94-103. 2019
- Sun MBrady RDVan Der Poel CApted DSemple BDChurch JEO'Brien TJMcDonald SJShultz SR. A Concomitant Muscle Injury Does Not Worsen Traumatic Brain Injury Outcomes in Mice. Frontiers in Neurology. 9:1-11. 2018
- Johnstone MRSun MTaylor CJBrady RDGrills BLChurch JEShultz SRMcDonald SJ. Gambogic amide, a selective TrkA agonist, does not improve outcomes from traumatic brain injury in mice. Brain Injury. 32:257-268. 2018
- Taylor CChurch JWilliams MDGerrand Y-WKeramidaris EPalmer JAGalea LAPenington AJMorrison WAMitchell GM. Hypoxic preconditioning of myoblasts implanted in a tissue engineering chamber significantly increases local angiogenesis via upregulation of myoblast vascular endothelial growth factor-A expression and downregulation of miRNA-1, miRNA-206 and angiopoietin-1. Journal of Tissue Engineering and Regenerative Medicine. 12:e408-e421. 2018
- Brady RDGrills BLChurch JEWalsh NCMcDonald ACAgoston DVSun MO'Brien TJShultz SRMcDonald SJ. Closed head experimental traumatic brain injury increases size and bone volume of callus in mice with concomitant tibial fracture. Scientific Reports. 6. 2016
- Church JETrieu JChee ANaim TGehrig SMLamon SAngelini CRussell APLynch GS. Alterations in Notch signalling in skeletal muscles from mdx and dko dystrophic mice and patients with Duchenne muscular dystrophy. Experimental Physiology. 99:675-687. 2014
- Church JETrieu JSheorey RChee AY-MNaim TBaum DMRyall JGGregorevic PLynch GS. Functional beta-Adrenoceptors Are Important for Early Muscle Regeneration in Mice through Effects on Myoblast Proliferation and Differentiation. PLoS ONE. 9. 2014
- Murphy KTHam DJChurch JENaim TTrieu JWilliams DALynch GS. Parvalbumin Gene Transfer Impairs Skeletal Muscle Contractility in Old Mice. Human Gene Therapy. 23:824-836. 2012
- Gehrig SMvan der Poel CSayer TASchertzer JDHenstridge DCChurch JELamon SRussell APDavies KEFebbraio MALynch GS. Hsp72 preserves muscle function and slows progression of severe muscular dystrophy. Nature. 484:394-398. 2012
- Church JEGehrig SMChee ANaim TTrieu JMcConell GKLynch GS. Early functional muscle regeneration after myotoxic injury in mice is unaffected by nNOS absence. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 301:R1358-R1366. 2011
- Church JEQian JKumar SBlack SMVenema RCPapapetropoulos AFulton DJR. Inhibition of endothelial nitric oxide synthase by the lipid phosphatase PTEN. Vascular Pharmacology. 52:191-198. 2010
- Ryall JGChurch JELynch GS. Novel role for β-adrenergic signalling in skeletal muscle growth, development and regeneration. Clinical and Experimental Pharmacology and Physiology. 37:397-401. 2010
- Qian JZhang QChurch JEStepp DWRudic RDFulton DJR. Role of local production of endothelium-derived nitric oxide on cGMP signaling and S -nitrosylation. American Journal of Physiology: Heart and Circulatory Physiology. 298:H112-H118. 2010
- Koopman RRyall JGChurch JELynch GS. The role of β-adrenoceptor signaling in skeletal muscle: therapeutic implications for muscle wasting disorders. Current Opinion in Clinical Nutrition and Metabolic Care. 12:601-606. 2009
- Urmaliya VBChurch JECoupar IMRoseʼMeyer RBPouton CWWhite PJ. Cardioprotection Induced by Adenosine A1 Receptor Agonists in a Cardiac Cell Ischemia Model Involves Cooperative Activation of Adenosine A2A and A2B Receptors by Endogenous Adenosine. Journal of Cardiovascular Pharmacology. 53:424-433. 2009
- White PJAnastasopoulos FChurch JEKuo C-YBoyd BJHickey PLCTu LSBurns PLew AMHeath WRDavey GMPouton CW. Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants. Vaccine. 26:6824-6831. 2008
- Tovey SCDedos SGTaylor EJAChurch JETaylor CW. Selective coupling of type 6 adenylyl cyclase with type 2 IP 3 receptors mediates direct sensitization of IP 3 receptors by cAMP. The Journal of Cell Biology. 183:297-311. 2008
- Jagnandan DChurch JEBanfi BStuehr DJMarrero MBFulton DJR. Novel Mechanism of Activation of NADPH Oxidase 5. Journal of Biological Chemistry. 282:6494-6507. 2007
- Church JEZhang Q. Functional Relevance of Golgi- and Plasma Membrane-Localized Endothelial NO Synthase in Reconstituted Endothelial Cells. Arteriosclerosis, Thrombosis and Vascular Biology. 26:1015-1021. 2006
- Church JEFulton D. Differences in eNOS Activity Because of Subcellular Localization Are Dictated by Phosphorylation State Rather than the Local Calcium Environment. Journal of Biological Chemistry. 281:1477-1488. 2006
- Fulton DChurch JERuan LLi CSood SGKemp BEJennings IGVenema RC. Src Kinase Activates Endothelial Nitric-oxide Synthase by Phosphorylating Tyr-83. Journal of Biological Chemistry. 280:35943-35952. 2005
- Church JEMoldrich RXBeart PMHodgson WC. Modulation of intracellular Ca2+ levels by Scorpaenidae venoms. Toxicon. 41:679-689. 2003
- Church JEHodgson WC. Stonefish ( Synanceia trachynis ) Antivenom: In Vitro Efficacy and Clinical Use. Toxin Reviews. 22:69-76. 2003
- Church JEHodgson WC. The pharmacological activity of fish venoms. Toxicon. 40:1083-1093. 2002
- Church JEHodgson WC. Adrenergic and cholinergic activity contributes to the cardiovascular effects of lionfish (Pterois volitans) venom. Toxicon. 40:787-796. 2002
- Church JEHodgson WC. Stonefish (Synanceia spp.) antivenom neutralises the in vitro and in vivo cardiovascular activity of soldierfish (Gymnapistes marmoratus) venom. Toxicon. 39:319-324. 2001
- Church JHodgson W. Dose-dependent cardiovascular and neuromuscular effects of stonefish (Synanceja trachynis) venom. Toxicon. 38:391-407. 2000
conference paper
- Sun MBrady RDVan der Poel CSemple BDChurch JEO'Brien TJMcdonald SJShultz SR. A CONCOMITANT MUSCLE INJURY DOES NOT WORSEN TRAUMATIC BRAIN INJURY OUTCOMES IN A MOUSE MODEL OF MULTITRAUMA. Journal of Neurotrauma. A69-A69. 2018
- Brady RGrills BChurch JSun MO'Brien TShultz SMcDonald S. CLOSED-HEAD EXPERIMENTAL TRAUMATIC BRAIN INJURY PROMOTES FRACTURE HEALING IN MICE. Journal of Neurotrauma. A59-A60. 2016
- Torrent AMontell EVerges JDalmau PRuhi RSwiderski KChurch JEBaum DMLynch GS. Novel Natural Compounds with Potential to Prevent and Treat Skeletal Muscle Atrophy. The FASEB Journal. 2015
- Zhang QChurch JEJagnandan DCatravas JDSessa WCFulton D. Functional relevance of golgi and plasma membrane localized endothelial nitric oxide synthase (eNOS) in reconstituted endothelial cells. The FASEB Journal. A721-A721. 2006
- Fulton DChurch JELi CYRuan LVenema RC. Src family kinases mediate the tyrosine phosphorylation of endothelial nitric oxide synthase in response to oxidant stress. The FASEB Journal. A1044-A1044. 2005
- Church JFulton D. The contribution of calcium to functional differences between plasma-membrane and cytosolic targeted eNOS. The FASEB Journal. A1555-A1555. 2005