selected publications
-
academic article
-
Migotto M-AMardon KOrian JWeckbecker GKneuer RBhalla RReutens DC. Efficient Distribution of a Novel Zirconium-89 Labeled Anti-cd20 Antibody Following Subcutaneous and Intravenous Administration in Control and Experimental Autoimmune Encephalomyelitis-Variant Mice.
Frontiers in Immunology.
10.
2019
Full text if available -
Baker DNutma EO'Shea HCooke AOrian JMAmor S. Autoimmune encephalomyelitis in NOD mice is not initially a progressive multiple sclerosis model.
Annals of Clinical and Translational Neurology.
6:1362-1372.
2019
Full text if available -
Kocovski PJiang XD'Souza CLi ZDang PWang XChen WPeter KHale MOrian J. Platelet depletion is effective in ameloirating anxiety-like behavior and reducing the pro-inflammatory environment in the hippocampus in murine experimental autoimmune encephalomyelitis.
Journal of Clinical Medicine.
8.
2019
Full text if available -
Kocovski PDang PTD Souza CSStamper CEHale MWOrian JM. Differential anxiety-like responses in NOD/ShiLtJ and C57BL/6J mice following experimental autoimmune encephalomyelitis induction and oral gavage.
Laboratory Animals.
52:470-478.
2018
Full text if available -
Kyran ELRobinson CKocovski PLi ZDang PTHale MWOrian JM. Multiple pathological mechanisms contribute to hippocampal damage in the experimental autoimmune encephalomyelitis model of multiple sclerosis.
NeuroReport.
29:19-24.
2018
Full text if available -
D'Souza CSLi ZMaxwell DLTrusler OMurphy MCrewther SPeter KOrian JM. Platelets drive neuroinflammation and target grey matter and the retina in autoimmune-mediated encephalomyelitis.
Journal of Neuropathology and Experimental Neurology.
77:567-576.
2018
Full text if available -
Orian JMKeating PDowns LLHale MWJiang XPham HLaFlamme AC. Deletion of IL-4R alpha in the BALB/c mouse is associated with altered lesion topography and susceptibility to experimental autoimmune encephalomyelitis.
Autoimmunity.
48:208-221.
2015
Full text if available -
Dagley LFWhite CALiao YShi WSmyth GKOrian JMEmili APurcell AW. Quantitative proteomic profiling reveals novel region-specific markers in the adult mouse brain.
Proteomics.
14:241-261.
2014
Full text if available -
Gangoda LDoerflinger MSrivastava RNarayan NEdgington LEOrian JHawkins CO'Reilly LAGu HBogyo MEkert PStrasser APuthalakath H. Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice.
Cell Death and Differentiation.
21:1815-1824.
2014
Full text if available -
Bernardes DOliveira-Lima OCda Silva TVFaraco CCFLeite HRJuliano MAdos Santos DMBethea JRBrambilla ROrian JMArantes RMECarvalho-Tavares J. Differential brain and spinal cord cytokine and BDNF levels in experimental autoimmune encephalomyelitis are modulated by prior and regular exercise.
Journal of Neuroimmunology.
264:24-34.
2013
Full text if available -
Farg MASoo KYWalker AKPham HOrian JHorne MKWarraich STWilliams KLBlair IPAtkin JD. Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase.
Neurobiology of Aging.
33:2855-2868.
2012
Full text if available -
Boyd SENair BNg SWKeith JMOrian JM. Computational Characterization of 3′ Splice Variants in the GFAP Isoform Family.
PLoS ONE.
7:e33565-e33565.
2012
Full text if available -
Pham HDoerrbecker JRamp AAD'Souza CSGorasia DGPurcell AWAyers MMOrian JM. Experimental autoimmune encephalomyelitis (EAE) IN C57Bl/6 mice is not associated with astrogliosis.
Journal of Neuroimmunology.
232:51-62.
2011
Full text if available -
Ramp AAHall COrian JM. Strain-related effects of fenbendazole treatment on murine experimental autoimmune encephalomyelitis.
Laboratory Animals.
44:271-273.
2010
Full text if available -
Pham HRamp AAKlonis NNg SWKlopstein AAyers MMOrian JM. The astrocytic response in early experimental autoimmune encephalomyelitis occurs across both the grey and white matter compartments.
Journal of Neuroimmunology.
208:30-39.
2009
Full text if available -
Wang DAyers MMCatmull DVHazelwood LJBernard CCAOrian JM. Astrocyte-associated axonal damage in pre-onset stages of experimental autoimmune encephalomyelitis.
Glia.
51:235-240.
2005
Full text if available -
Ayers MMHazelwood LJCatmull DVWang DMcKormack QBernard CCAOrian JM. Early glial responses in murine models of multiple sclerosis.
Neurochemistry International: the journal for the publication of cellular and molecular aspects of neurochemistry.
45:409-419.
2004
Full text if available -
Orian JMAhern AJAyers MMLevine JMTapp LDReynolds R. Disturbed oligodendrocyte development and recovery from hypomyelination in a c-myc transgenic mouse mutant.
Journal of Neuroscience Research.
66:46-58.
2001
Full text if available -
Onuki MAyers MMBernard CCAOrian JM. Axonal degeneration is an early pathological feature in autoimmune-mediated demyelination in mice.
Microscopy Research and Technique.
52:731-739.
2001
Full text if available -
Orian JMSlavin AAyers MMBernard CCA. Delayed and incomplete myelination in a transgenic mouse mutant with abnormal oligodendrocytes.
Journal of Neuroscience Research.
50:809-820.
1997
Full text if available -
Orian JMSlavin AAyers MMBernard CCA. Delayed and incomplete myelination in a transgenic mouse mutant with abnormal oligodendrocytes.
Journal of Neuroscience Research.
50:809-820.
1997
Full text if available -
Slavin AJJohns TGOrian JMBernard CCA. Regulation of Myelin Oligodendrocyte Glycoprotein in Different Species throughout Development.
Developmental Neuroscience.
19:69-78.
1997
Full text if available -
Danks RAOrian JMKaye AHGonzales MFTan SSAlexander BMikoshiba K. Transformation of Astrocytes in Transgenic Mice Expressing SV40 T Antigen under the Transcriptional Control of the Glial Fibrillary Acidic Protein Promoter.
Cancer Research.
55:4302-4310.
1995
-
Danks RAChopra GGonzales MFOrian JMKaye AH. Aberrant p53 Expression Does Not Correlate with the Prognosis in Anaplastic Astrocytoma.
Neurosurgery.
37:246-254.
1995
Full text if available -
Snibson KJWoodcock DOrian JMBrandon MRAdams TE. Methylation and expression of a metallothionein promoter ovine growth hormone fusion gene (MToGH1) in transgenic mice.
Transgenic Research.
4:114-122.
1995
Full text if available -
Orian JMMitchell AWSMarshman WEWebb GCAyers MMGrail DFord JHKaye AHGonzales MF. Insertional mutagenesis inducing hypomyelination in transgenic mice.
Journal of Neuroscience Research.
39:604-612.
1994
Full text if available -
Orian JMVasilopoulos KYoshida SKaye AHChow CWGonzales MF. Overexpression of multiple oncogenes related to histological grade of astrocytic glioma.
British Journal of Cancer.
66:106-112.
1992
Full text if available -
ORIAN JACQUELINEMSNIBSON KENNETHSTEVENSON JANETLBRANDON MALCOLMRHERINGTON ADRIANC. Elevation of Growth Hormone (GH) and Prolactin Receptors in Transgenic Mice Expressing Ovine GH.
Endocrinology.
128:1238-1246.
1991
Full text if available -
Orian JMTamakoshi KMackay IRBrandon MR. New Murine Model for Hepatocellular Carcinoma: Transgenic Mice Expressing Metallothionein--Ovine Growth Hormone Fusion Gene.
Journal of National Cancer Institute.
82:393-398.
1990
Full text if available -
ORIAN JACQUELINEMSEONG LEE CHEEWEISS LINDAMBRANDON MALCOLMR. The Expression of a Metallothionein-Ovine Growth Hormone Fusion Gene in Transgenic Mice Does Not Impair Fertility but Results in Pathological Lesions in the Liver.
Endocrinology.
124:455-463.
1989
Full text if available -
Orian JMO'Mahoney JVBrandon MR. Cloning and sequencing of the ovine growth hormone gene.
Nucleic Acids Research.
16:9046-9046.
1988
Full text if available -
Orian JMHadikusumo RGMarzuki SLinnane AW. Biogenesis of mitochondria: Defective yeast H+-ATPase assembled in the absence of mitochondrial protein synthesis is membrane associated.
Journal of Bioenergetics and Biomembranes.
16:561-581.
1984
Full text if available -
Orian JMMurphy MMarzuki S. Mitochondrially synthesized protein subunits of the yeast mitochondrial adenosine triphosphatase.
Biochimica et Biophysica Acta - Section Nucleic Acids And Protein Synthesis.
652:234-239.
1981
Full text if available -
Orian JMMarzuki S. The largest mitochondrial translation product copurifying with the mitochondrial adenosine triphosphatase of Saccharomyces cerevisiae is not a subunit of the enzyme complex.
Journal of Bacteriology.
146:813-815.
1981
-
Migotto M-AMardon KOrian JWeckbecker GKneuer RBhalla RReutens DC. Efficient Distribution of a Novel Zirconium-89 Labeled Anti-cd20 Antibody Following Subcutaneous and Intravenous Administration in Control and Experimental Autoimmune Encephalomyelitis-Variant Mice.
Frontiers in Immunology.
10.
2019
-
chapter
-
Dang PTBui QD'Souza CSOrian JM. Modelling MS: Chronic-relapsing EAE in the NOD/Lt mouse strain.
Current Topics in Behavioral Neurosciences.
Ed. Orian JM.
143-177.
2015
Full text if available
-
Dang PTBui QD'Souza CSOrian JM. Modelling MS: Chronic-relapsing EAE in the NOD/Lt mouse strain.
Current Topics in Behavioral Neurosciences.
Ed. Orian JM.
143-177.
2015
-
comment
-
conference paper
-
Migotto M-ABhalla RMardon KOrian JWeckbecker GKneuer RReutens D. Effect of Route of Administration on the Biodistribution of a Novel Anti-CD20 Antibody in Experimental Autoimmune Encephalomyelitis-Variant Mice.
Neurology.
2019
-
Murphy MJCrewther SGLi ZConnell FOrian JM. Early Retinal Dysfunction in the Mouse EAE Model of Multiple Sclerosis: An Electrophysiological Characterisation.
Investigative Ophthalmology and Visual Science.
2018
-
Migotto M-ABhalla RMardon KOrian JWeckbecker GKneuer RReutens D. Comparison of biodistribution following subcutaneous and intravenous administration of a novel Zirconium-89 labelled anti-CD20 antibody using imaging.
European Journal of Neurology.
436-436.
2018
-
Migotto M-ABhalla RMardon KOrian JWeckbecker GKneuer RReutens D. Comparison of Biodistribution Following Subcutaneous and Intravenous Administration of a Novel Zirconium-89 Labeled Anti-CD20 Antibody Using Imaging.
Neurology.
P3.406-P3.406.
2018
-
Orian JMDang PTD'Souza C. Distinct cytokine profiles differentially induce white and grey matter inflammation in the experimental autoimmune encephalomyelitis model of multiple scelrosis.
European Journal of Immunology.
162-162.
2016
-
Jiang XDuan ELu COrian JChen W. Spatiotemporal dynamics of innate immunity and lung pathogenesis during influenza virus infection.
European Journal of Immunology.
699-700.
2016
-
Dang PTBambery KOrian JM. Neuronal loss results from the extrinsic apoptotic pathway and axonal loss from the intrinsic pathway in EAE.
Multiple Sclerosis.
NP24-NP25.
2015
-
D'Souza CPeter KOrian JM. Platelets drive neuroinflammation in the C57Bl/6 variant of the Experimental Autoimmune Encephalomyelitis (EAE) model of Multiple Sclerosis (MS).
Multiple Sclerosis.
NP9-NP9.
2015
-
Orian JM. Early disease stage in MOG(35-55)-induced EAE is associated with induction of the extrinsic apoptotic pathway in neurons.
Multiple Sclerosis.
422-423.
2015
-
Orian JM. The relationship between neuronal S1P receptor modulation by Fingolimod and neuronal survival.
Multiple Sclerosis.
343-344.
2014
-
Orian J. Conventional and molecular profiling approaches reveal the neuroprotective capacity of fingolimod in the experimental autoimmune encephalomyelitis model.
Multiple Sclerosis.
567-567.
2013
-
Nair BBoyd SDang PWoei NSOrian JM. A Strategy for the Generation and Characterization of Monoclonal Isoform-Specific Antibodies against Glial Fibrillary Acidic Protein.
Multiple Sclerosis.
697-697.
2012
-
D'Souza CSPham HDoerrbecker JRamp AAGorasia DGPurcell AWAyers MMOrian JM. Quantification of GFAP Expression in Two EAE Variants Reveals Contrasting Astrocytic Reactivity.
Multiple Sclerosis.
697-698.
2012
-
Orian JMRamp APham HDang PAyers M. Treatment of experimental autoimmune encephalomyelitis with FTY720 reduces both white and grey matter inflammation, together with neuronal stress.
Multiple Sclerosis.
691-691.
2012
-
Pham HRamp AAAyers MMOrian JM. Astrocyte-T cell interactions are characteristic of early neuroinflammation.
Journal of Neuroimmunology.
68-68.
2010
-
Orian J. Is there a role for astrocytes in early murine experimental autoimmune encephalomyelitis?.
35th annual meeting of the Society for Neuroscience.
2005
-
Ayers MBruggink LHazelwood LBernard COrian J. Astrocytes influence disease expression in murine experimental autoimmune encephalomyelitis (EAE).
Journal of Neuroimmunology.
56-56.
2004
-
Wang DAyers MCatmull DHazelwood LBernard COrian J. Axonal injury at the onset of murine experimental autoimmune encephalomyelitis (EAE): a role for astrocytes.
Journal of Neuroimmunology.
166-166.
2004
-
Reddrop CAyers MBernard COrian J. Axonal Pathology is Evident from Pre-Clinical Stages in a Murine Model of Autoimmune-Mediated Demyelination
2002
-
Migotto M-ABhalla RMardon KOrian JWeckbecker GKneuer RReutens D. Effect of Route of Administration on the Biodistribution of a Novel Anti-CD20 Antibody in Experimental Autoimmune Encephalomyelitis-Variant Mice.
Neurology.
2019
-
conference poster
-
Migotto M-ABhalla RMardon KOrian JMWeckbecker GKneuer RReutens D. Imaging and biodistribution of a novel anti-CD20 antibody following subcutaneous administration in control and experimental autoimmune encephalomyelitis-variant mice.
Multiple Sclerosis.
588-589.
2018
Full text if available
-
Migotto M-ABhalla RMardon KOrian JMWeckbecker GKneuer RReutens D. Imaging and biodistribution of a novel anti-CD20 antibody following subcutaneous administration in control and experimental autoimmune encephalomyelitis-variant mice.
Multiple Sclerosis.
588-589.
2018