Cancer Research

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Activation of canonical BMP4-SMAD7 signaling suppresses breast cancer metastasis. 80. 2020
Frizzled-7 is required for Wnt signalling in gastric tumors with and without Apc mutations. 79:970-981. 2019
Inflammasome adaptor ASC suppresses apoptosis of gastric cancer cells by an IL18-mediated inflammation-independent mechanism. 78:1293-1307. 2018
Tight junction protein claudin-2 promotes self-renewal of human colorectal cancer stem-like cells.. 78:2925-2938. 2018
An Accessible Proteogenomics Informatics Resource for Cancer Researchers. 77:e43-e46. 2017
HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2 + Tumors. 77:2594-2606. 2017
MicroRNA-194 Promotes Prostate Cancer Metastasis by Inhibiting SOCS2. 77:1021-1034. 2017
Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model. 76:2277-2287. 2016
The Biodistribution and Immune Suppressive Effects of Breast Cancer-Derived Exosomes. 76:6816-6827. 2016
Correction: HOXB7, a Homeodomain Protein, Is Overexpressed in Breast Cancer and Confers Epithelial–Mesenchymal Transition. 75:2401-2401. 2015
Emergence of Drug Tolerance in Cancer Cell Populations: An Evolutionary Outcome of Selection, Nongenetic Instability, and Stress-Induced Adaptation. 75:930-939. 2015
BMP4 Inhibits Breast Cancer Metastasis by Blocking Myeloid-Derived Suppressor Cell Activity. 74:5091-5102. 2014
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer. 74:3238-3247. 2014
Metabolic Vulnerabilities in Endometrial Cancer. 74:5832-5845. 2014
Optimal effector functions in human natural killer cells rely upon autocrine bone morphogenetic protein signaling. 74:5019-5031. 2014
Targeting EphA3 inhibits cancer growth by disrupting the tumor stromal microenvironment. 74:4470-4481. 2014
The Emerging Role of Immunosurveillance in Dictating Metastatic Spread in Breast Cancer. 73:5852-5857. 2013
SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer. 73:725-735. 2013
The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. 73:1180-1189. 2013
Abstract P3-10-09: Peptide-based molecular targeting of inflammatory breast cancer.. 72. 2012
Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche. 72:3906-3911. 2012
Abstract 4316: Villin expression is frequently lost in colon cancers with microsatellite instability.. 72. 2012
Abstract LB-308: Combination of CTx-0294945 a highly selective inhibitor of focal adhesion kinase with bevacizumab in pre-clinical models of breast cancer. 72. 2012
Vascular Normalization by Loss of Siah2 Results in Increased Chemotherapeutic Efficacy. 72:1694-1704. 2012
Cathepsin B Inhibition Limits Bone Metastasis in Breast Cancer. 72:1199-1209. 2012
Ovarian Cancer Risk Associated with Inherited Inflammation-Related Variants. 72:1064-1069. 2012
Targeting of a conformationally exposed, tumor-specific epitope of EGFR as a strategy for cancer therapy. 72:2924-2930. 2012
MYB is essential for mammary tumorigenesis. 71:7029-7037. 2011
Abstract 1469: Mechanisms of oncostatin M (OSM)-mediated breast cancer metastasis to bone: Evidence for a role in osteoclastogenesis. 71. 2011
PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis. 71:3709-3719. 2011
Genomic and Biological Characterization of Exon 4 KRAS Mutations in Human Cancer. 70:5901-5911. 2010
Altered Dynamics of Intestinal Cell Maturation in Apc1638N/+ Mice. 70:5348-5357. 2010
Correction: An A13 Repeat within the 3′-Untranslated Region of Epidermal Growth Factor Receptor (EGFR) Is Frequently Mutated in Microsatellite Instability Colon Cancers and Is Associated with Increased EGFR Expression. 70:1275.2-1275. 2010
Apoptotic Sensitivity of Colon Cancer Cells to Histone Deacetylase Inhibitors Is Mediated by an Sp1/Sp3-Activated Transcriptional Program Involving Immediate-Early Gene Induction. 70:609-620. 2010
Correction: PIK3CA Mutation/PTEN Expression Status Predicts Response of Colon Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Cetuximab. 69:9156-9156. 2009
Correction: Parathyroid Hormone-Related Protein Protects against Mammary Tumor Emergence and Is Associated with Monocyte Infiltration in Ductal Carcinoma In situ. 69:8832-8832. 2009
An A13 Repeat within the 3'-Untranslated Region of Epidermal Growth Factor Receptor (EGFR) Is Frequently Mutated in Microsatellite Instability Colon Cancers and Is Associated with Increased EGFR Expression. 69:7811-7818. 2009
Parathyroid Hormone-Related Protein Protects against Mammary Tumor Emergence and Is Associated with Monocyte Infiltration in Ductal Carcinoma In situ. 69:7473-7479. 2009
The Receptor Tyrosine Kinase EPHB4 Has Tumor Suppressor Activities in Intestinal Tumorigenesis. 69:7430-7438. 2009
Transcriptional Output of the Salvador/Warts/Hippo Pathway Is Controlled in Distinct Fashions in Drosophila melanogaster and Mammalian Cell Lines. 69:6033-6041. 2009
Breast Cancer Lung Metastasis Requires Expression of Chemokine Receptor CCR4 and Regulatory T Cells. 69:5996-6004. 2009
Correction: Article on Vaccination Reveals a Long Dominant CTL Epitope. 69:4553-4553. 2009
ABT-737 overcomes Bcl-2 mediated resistance to doxorubicin-DNA adduct forming treatments in HL-60 cells. 69. 2009
Bmp4 controls breast cancer metastasis by modulating CD11b(+)Gr1(+) cells in vivo. 69. 2009
The role of c-Myb in tumorigenesis and mammary gland development. 69. 2009
A Long, Naturally Presented Immunodominant Epitope from NY-ESO-1 Tumor Antigen: Implications for Cancer Vaccine Design. 69:1046-1054. 2009
Bone Morphogenetic Protein-7 Inhibits Telomerase Activity, Telomere Maintenance, and Cervical Tumor Growth. 68:9157-9166. 2008
Correction: Prediction of Response to Cetuximab. 68:6859-6859. 2008
Defective Claudin-7 Regulation by Tcf-4 and Sox-9 Disrupts the Polarity and Increases the Tumorigenicity of Colorectal Cancer Cells. 68:4258-4268. 2008
The Regulatory T Cell-Associated Transcription Factor FoxP3 Is Expressed by Tumor Cells. 68:3001-3009. 2008
PIK3CA Mutation/PTEN Expression Status Predicts Response of Colon Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Cetuximab. 68:1953-1961. 2008
TRAIL Induces Receptor-Interacting Protein 1–Dependent and Caspase-Dependent Necrosis-Like Cell Death under Acidic Extracellular Conditions. 67:218-226. 2007
HOXB7, a Homeodomain Protein, Is Overexpressed in Breast Cancer and Confers Epithelial-Mesenchymal Transition. 66:9527-9534. 2006
EPHB4 and Survival of Colorectal Cancer Patients. 66:8943-8948. 2006
Transduction of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand into Hematopoietic Cells Leads to Inhibition of Syngeneic Tumor Growth In vivo. 66:6304-6311. 2006
Doxorubicin-DNA Adducts Induce a Non-Topoisomerase II–Mediated Form of Cell Death. 66:4863-4871. 2006
Papillomavirus E2 Protein Induces Expression of the Matrix Metalloproteinase-9 via the Extracellular Signal-Regulated Kinase/Activator Protein-1 Signaling Pathway. 65:11613-11621. 2005
Mechanisms of Inactivation of the Receptor Tyrosine Kinase EPHB2 in Colorectal Tumors. 65:10170-10173. 2005
Apoptin Nuclear Accumulation Is Modulated by a CRM1-Recognized Nuclear Export Signal that Is Active in Normal but not in Tumor Cells. 65:7059-7064. 2005
Concurrent Binding of Anti-EphA3 Antibody and Ephrin-A5 Amplifies EphA3 Signaling and Downstream Responses: Potential as EphA3-Specific Tumor-Targeting Reagents. 65:6745-6754. 2005
OncogenicK-RASIs Required to Maintain Changes in Cytoskeletal Organization, Adhesion, and Motility in Colon Cancer Cells. 65:1244-1250. 2005
Correction. 64:8794-8794. 2004
Alterations in Vascular Gene Expression in Invasive Breast Carcinoma. 64:7857-7866. 2004
The Phosphoprotein StarD10 Is Overexpressed in Breast Cancer and Cooperates with ErbB Receptors in Cellular Transformation. 64:3538-3544. 2004
Gene Expression Profiling-Based Prediction of Response of Colon Carcinoma Cells to 5-Fluorouracil and Camptothecin. 63:8791-8812. 2003
TR3/Nur77 in colon cancer cell apoptosis. 63:5401-5407. 2003
The direct mapping of the uptake of platinum anticancer agents in individual human ovarian adenocarcinoma cells using a hard x-ray microprobe. 63:1776-1779. 2003
AACR special meeting in cancer research: colon cancer--genetics to prevention. 62:6779-6783. 2002
A gene expression profile that defines colon cell maturation in vitro. 62:4791-4804. 2002
Molecular basis for the synergistic interaction of Adriamycin with the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate (AN-9). 61:8194-8202. 2001
p21^WAF1/cip1 is an important determinant of intestinal cell response to sulindac in vitro and in vivo. 61:6297-6302. 2001
Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor. 61:5349-5354. 2001
Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR. 61:5355-5361. 2001
Specific localization, gamma camera imaging, and intracellular trafficking of radiolabelled chimeric anti-GD3 ganglioside monoclonal antibody KM871 in SK-MEL-28 melanoma xenografts. 61:4474-4482. 2001
Down-regulation of β-catenin TCF signaling is linked to colonic epithelial cell differentiation. 61:3465-3471. 2001
Nitric oxide synthase II gene disruption: Implications for tumor growth and vascular endothelial growth factor production. 61:3182-3187. 2001
Bcl-2 delays and alters hepatic carcinogenesis induced by transforming growth factor. 61:594-601. 2001
Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. 60:6818-6821. 2000
Dissociation of staurosporine-induced apoptosis from G2-M arrest in SW620 human colonic carcinoma cells: Initiation of the apoptotic cascade is associated with elevation of the mitochondrial membrane potential (Δψ(m)). 60:6704-6713. 2000
In vivo biodistribution of a humanized anti-Lewis Y monoclonal antibody (hu3s193) in MCF-7 xenografted BALB/c nude mice. 60:4804-4811. 2000
Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: Comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer. 60:4561-4572. 2000
Construction, production, and characterization of humanized anti-Lewis Y monoclonal antibody 3S193 for targeted immunotherapy of solid tumors. 60:3254-3261. 2000
Insights from Bcl-2 and Myc: Malignancy Involves Abrogation of Apoptosis as well as Sustained Proliferation. 59:1685S-1692S. 1999
Methylation of the BRCA1 gene in sporadic breast cancer. 57:3347-3350. 1997
Transformation of Astrocytes in Transgenic Mice Expressing SV40 T Antigen under the Transcriptional Control of the Glial Fibrillary Acidic Protein Promoter. 55:4302-4310. 1995
Inhibition of Angiogenesis by the Matrix Metalloprotease Inhibitor N-[2R-2-(Hydroxamidocarbonymethyl)-4-methylpentanoyl)-L-tryptophan Methylamide. 54:4715-4718. 1994
Immunobead-PCR: A Technique for the Detection of Circulating Tumor Cells Using Immunomagnetic Beads and the Polymerase Chain Reaction. 53:3455-3458. 1993
THERMOTOLERANCE IN THE ABSENCE OF INDUCED HEAT-SHOCK PROTEINS IN A MURINE LYMPHOMA. 52:2854-2861. 1992
LOSS OF THE INTRINSIC HEAT-RESISTANCE OF HUMAN-CELLS AND CHANGES IN MR 70,000 HEAT-SHOCK PROTEIN EXPRESSION IN HUMAN X HAMSTER HYBRIDS. 51:2636-2641. 1991
erba-related sequence coding for dna-binding hormone receptor localized to chromosome 3p21-3p25 and deleted in small cell lung carcinoma. 48:682-685. 1988
Effects of Sodium Butyrate on the Synthesis and Methylation of DNA in Normal Cells and Their Transformed Counterparts. 46:713-716. 1986
Measurements of drinking patterns in the general population and possible applications in studies of the role of alcohol in cancer. 39:2830-2833. 1979
MEASUREMENTS OF DRINKING PATTERNS IN THE GENERAL-POPULATION AND POSSIBLE APPLICATIONS IN STUDIES OF THE ROLE OF ALCOHOL IN CANCER. 39:2830-2833. 1979
Abstract 2962: LRH-1 expression in breast cancer tissue and its association with phenotype and DNA methylation [Abstract] 2015
Abstract 76: Liver receptor homologue-1 increases incidence of DMBA-induced mammary tumors 2014
The HDAC inhibitory prodrug AN-7 reduces the toxicity of doxorubicin, anti-Her2 and radiation while augmenting their anticancer efficacy [Abstrat] 2011
Cellular responses to doxorubicin-DNA adducts. Is cytotoxicity independent of p53 status? 2009
Abstract GS2-03: The androgen receptor is a tumour suppressor in estrogen receptor positive breast cancer 2020
Abstract P3-01-10: Ndrg1-egfr axis in inflammatory breast cancer tumorigenesis and brain metastasis 2020
Abstract P5-08-04: Physical activity, sedentary behaviour, and risk of breast cancer: Results from the SUN (‘Seguimiento Universidad de Navarra’) project 2020
Abstract 2492: BRAF inhibitors synergize with BH3 mimetics to induce apoptosis inBRAFmutant colorectal cancer cells 2019
Abstract 823: A case-control study of constitutionalBRCA1methylation in a mammographically screened cohort 2019
Abstract 840: Identification of novel colorectal tumor suppressor genes through genome-wide promoter hypermethylation analysis 2019
Abstract CT063: Preliminary findings of a Phase I safety and bioimaging trial of KB004 (ifabotuzumab) in patients with glioblastoma 2019
Abstract CT167: A Phase Ib study to assess safety, tolerability, pharmacokinetics, and preliminary antitumor activity of sitravatinib in combination with tislelizumab in patients with advanced solid tumors 2019
Abstract LB-135: Targeting the myeloid-cell specific SRC-kinase HCK improves anti-tumor immunity 2019
Abstract P1-19-02: Innovation in diagnosis and treatment of brain metastases using multifunctional nanomedicines 2019
Abstract P5-08-05: The interplay between stromal density, epithelial mesenchymal transition and chemoresistance in breast cancer 2019
Characterization of high TIL breast cancers reveals a prognostic and functionally distinct tissue-resident memory subpopulation 2019
Long-term exposure (LTE) to Tislelizumab, an investigational anti-PD-1 antibody, in a first-in-human Phase I study 2019
Repurposing bazedoxifene to suppress gastrointestinal cancer growth 2019
Abstract 5885: Loss of RAD51C promoter hypermethylation confers PARP inhibitor resistance 2018
Abstract LB-183: Investigating the role of polarity protein, SCRIB, in hematopoiesis 2018
BMP4 suppresses the progression of breast cancer through altered expression of metastasis regulating genes 2018
Classification of molecular subtypes of triple-negative breast cancer cell lines using two models 2018
EphA2: An emerging target in triple-negative breast cancer 2018
A novel approach to overcome resistance to HER2 targeted therapy in a new syngeneic model of breast cancer brain metastasis 2018
ABT-806-derived antibody-drug conjugates (ADCs) inhibit growth of malignant mesothelioma in vivo 2018
Analysis of angiogenic and stromal biomarkers in a large malignant mesothelioma cohort 2018
Development of small-molecule mTORC1 radiotracers for evaluation of targeted therapy resistance using PET 2018
Exploring the germ-line contribution to exceptional response to PD-1/PD-L1 inhibition in patients with metastatic non-small-cell lung cancer by whole genome sequencing 2018
IL-11 as a therapeutic target to treat colorectal cancer 2018
Acquired chemotherapeutic drug resistance in colorectal cancer is regulated by epithelial-to-mesenchymal transition and altered cellular pathways 2017
Double somatic mutations as a cause of tumor mismatch repair-deficiency in population-based colorectal and endometrial cancer with Lynch-like syndrome 2017
Dual role of p120ctn in cancer: epithelial vs mesenchymal 2017
Abstract P1-05-03: Predictive value of de novo and induced epithelial-mesenchymal transition in locally advanced breast cancer treated with neoadjuvant chemotherapy 2016
Abstract B04: A role for EphA3 in angiogenesis, in vivo and in vitro exploration 2016
The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma 2016
Abstract 1078: TGF-β and TNF-α activate gene transcription programs associated with poor breast cancer prognosis 2015
Abstract 3543: Ligand-directed and transcription-based molecular imaging and treatment of cancer 2015
Abstract CT238: Phase I safety and biodistribution study of 124I-PEG-AVP0458 diabody in patients with TAG-72 positive ovarian and prostate cancer 2015
Abstract 2058: RHOA inactivation enhances Wnt signaling and promotes colorectal cancer 2015
Excessive activation of the Src-kinase HCK in the tumor stroma promotes progression of solid tumors 2015
Phase I studies of a selective cMet inhibitor AZD6094 (HMPL504/volitinib) in patients with advanced solid tumors 2015
Abstract 2015: Thrombospondin-1 is a targetable marker of invasive, mesenchymal- like melanoma cells 2014
Abstract 2339: Transcriptional basis for loss of cellular differentiation in colon cancer 2014
Abstract 2835: Telomere length: A novel biomarker for anti-EGFR therapy in colorectal cancer 2014
Abstract 290: Constitutional BRCA1 methylation is a major predisposition factor for high-grade serous ovarian cancer 2014
Abstract 383: Is loss of MGMT a therapeutic target in lung cancer 2014
Abstract 5112: Histone deacetylase and proteasome inhibitors synergistically induce apoptosis in colon cancer, multiple myeloma and CTCL cells through induction of the immediate early genes ATF3 and JUN 2014
Abstract 5172: Whole exome mutation landscape of 70 commonly used colorectal cancer cell lines 2014
Estrogen receptor alpha drives proliferation of prostate cancer through PI3K and MAPK signaling 2014
Mobilization of tumor cells into the circulation during radiation therapy for lung cancer 2014
Receptor occupancy and tumor penetration by antibodies, peptides, and antibody fragments: Molecular simulation of imaging assessment 2014
The SMAC-mimetic birinapant regulates autocrine TNF production by caspase-8:RIPK1 complex via p38MAPK pathway 2014
Abstract P6-12-11: Celecoxib inhibits the growth of IBC tumors by suppressing the regulation of cancer stem-like cells by nodal 2013
Excessive Wnt activity is insufficient for intestinal tumor growth or regeneration without gp130/Jak2/Stat3 signaling. 2013
Targeting BCL-2 with the BH3 mimetic ABT-199 in ER-positive breast cancer 2013
Abstract 1486: The contribution of stromal caveolin-1 to breast cancer metastasis 2012
Abstract 2903: Therapeutic targeting of leukemia and lymphoma with a neuropilin-1 binding pro-apoptotic peptide 2012
Defining the role of the cellular polarity regulator Scrib in epithelial tumorigenesis 2012
Abstract 1690: Definition of dose-limiting toxicity in phase I cancer clinical trials of molecularly targeted agents 2011
Abstract 2629: Sustained immediate-early gene induction is linked to histone deacetylase inhibitor-induced apoptosis in multiple tumour types 2011
Abstract 5318: Optimizing pharmacokinetics and targeting properties of recombinant anti-Lewis Y antibody hu3S193 in A431 tumor-bearing mice 2011
Abstract 636: C-Met antibodies with distinctive characteristics including induction of receptor degradation without activation and tumor specificity 2011
Abstract 3108: Functional delineation of structural domains in Yorkie/Yes-associated protein 2010
The Role of microRNA Genes in Breast Cancer Progression and Metastasis. 2009
An integrated geneome-wide profiling strategy for the identification of potential epigenetically regulated loci in colon cancer. 2009
Aspirin inhibits camptothecin-induced p21(CIP1) protein levels in breast cancer cells: implications for chemotherapy 2009
Contribution of specific Inhibitor of Apoptosis Proteins in distinct apoptotic pathways 2009
Homology modeling based site-directed mutagenesis of anti-Le(y) antibody hu3S193 Fc:FcRn interactions 2009
Humoral immune responses in patients vaccinated with HER2 protein complexed with a novel antigen delivery system of cholesteryl pullulan(CHP-HER2) 2006
Inhibition of solid tumor growth by intravenous administration of cG250-TNF immunocytokine 2006
The synergistic interaction of mitoxantrone and herceptin 2006
Transduction of TNF-related apoptosis inducing ligand (TRAIL) into hematopoietic cells leads to inhibition of syngeneic tumor growth in vivo 2006
AACR special meeting in cancer research: Colon cancer-genetics to prevention 2002
Insights from bcl-2 and myc: Malignancy involves abrogation of apoptosis as well as sustained proliferation 1999

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