Journal of Medicinal Chemistry
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Overview
publication venue for
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Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiLX)
2020
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Heterodimeric Analogues of the Potent Y1R Antagonist 1229U91, Lacking One of the Pharmacophoric C-Terminal Structures, Retain Potent Y1R Affinity and Show Improved Selectivity over Y4R.
63:5274-5286.
2020
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Aggregation-induced emission photosensitizers: From molecular design to photodynamic therapy.
63.
2020
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Substituted Pyridazin-3(2H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists.
62:5242-5248.
2019
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Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.
60:9349-9359.
2017
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Optically pure, structural, and fluorescent analogues of a dimeric Y 4 receptor agonist derived by an olefin metathesis approach.
59:6059-6069.
2016
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Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion.
59:10994-11005.
2016
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Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.
58:7707-7718.
2015
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Synthesis and in Vivo Evaluation of [¹²³I]Melanin-Targeted Agents.
58:6214-6224.
2015
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De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-XL: Synthesis, Structural and Biochemical Characterization.
57:1323-1343.
2014
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Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies.
57:3666-3677.
2014
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Ligand-Induced Conformational Change of Plasmodium falciparum AMA1 Detected Using F-19 NMR.
57:6419-6427.
2014
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Transition State Mimetics of the Plasmodium Export Element Are Potent Inhibitors of Plasmepsin V from P-falciparum and P-vivax.
57:7644-7662.
2014
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Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.
56:5514-5540.
2013
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Lactam-Stabilized Helical Analogues of the Analgesic μ-Conotoxin KIIIA.
54:7558-7566.
2011
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Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity.
54:1914-1926.
2011
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Radiosynthesis and Biological Evaluation ofl- andd-S-(3-[18F]Fluoropropyl)homocysteine for Tumor Imaging Using Positron Emission Tomography.
54:1860-1870.
2011
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Binding Inhibitors of the Bacterial Sliding Clamp by Design.
54:4831-4838.
2011
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Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[ b ]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
54:6014-6027.
2011
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Tripeptide Motifs in Biology: Targets for Peptidomimetic Design.
54:1111-1125.
2011
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New Anthracenedione Derivatives with Improved Biological Activity by Virtue of Stable Drug−DNA Adduct Formation.
53:6851-6866.
2010
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Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): A Novel Antibacterial Peptide Optimized against Gram-Negative Human Pathogens.
53:5240-5247.
2010
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Discovery of [18F]N-(2-(Diethylamino)ethyl)-6-fluoronicotinamide: A Melanoma Positron Emission Tomography Imaging Radiotracer with High Tumor to Body Contrast Ratio and Rapid Renal Clearance.
52:5299-5302.
2009
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A New Class of Blockers of the Voltage-Gated Potassium Channel Kv1.3 via Modification of the 4- or 7-Position of Khellinone.
49:1433-1441.
2006
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Structure of Aldehyde Reductase Holoenzyme in Complex with the Potent Aldose Reductase Inhibitor Fidarestat: Implications for Inhibitor Binding and Selectivity.
48:5536-5542.
2005
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The Role of Intracellularly Released Formaldehyde and Butyric Acid in the Anticancer Activity of Acyloxyalkyl Esters.
48:1042-1054.
2005
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Broad-Based Quantitative Structure−Activity Relationship Modeling of Potency and Selectivity of Farnesyltransferase Inhibitors Using a Bayesian Regularized Neural Network.
47:6230-6238.
2004
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Rapid Prediction of Chemical Metabolism by Human UDP-glucuronosyltransferase Isoforms Using Quantum Chemical Descriptors Derived with the Electronegativity Equalization Method.
47:5311-5317.
2004
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High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor.
47:4530-4537.
2004
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Synthesis and Cytotoxic Activity of Carboxamide Derivatives of Benzo[b][1,6]naphthyridines.
46:1049-1054.
2003
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Structural Studies of the Resistance of Influenza Virus Neuramindase to Inhibitors.
45:2207-2212.
2002
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Synthesis and Cytotoxic Activity of 7-Oxo-7H-dibenz[f,ij]isoquinoline and 7-Oxo-7H-benzo[e]perimidine Derivatives.
44:2004-2014.
2001
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Inhibition of Heme Detoxification Processes Underlies the Antimalarial Activity of Terpene Isonitrile Compounds from Marine Sponges.
44:873-885.
2001
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New 1-Aryl-3-(4-arylpiperazin-1-yl)propane Derivatives, with Dual Action at 5-HT1ASerotonin Receptors and Serotonin Transporter, as a New Class of Antidepressants.
44:418-428.
2001
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Robust QSAR Models Using Bayesian Regularized Neural Networks.
42:3183-3187.
1999
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Matrix Metalloproteinase Inhibitors: A Structure−Activity Study.
41:199-223.
1998
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Synthesis and Antitumor Properties ofN-[2-(Dimethylamino)ethyl]carboxamide Derivatives of Fused Tetracyclic Quinolines and Quinoxalines: A New Class of Putative Topoisomerase Inhibitors.
40:2040-2046.
1997
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Molecular Modeling Studies of “Flap Up” Mannosyl Cation Mimics.
39:4332-4334.
1996
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Synthesis and Activity of Some Antimalarial Bisquinolines.
38:204-206.
1995
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Electron-Deficient DNA Intercalating Agents as Antitumor Drugs: Aza Analogs of the Experimental Clinical Agent N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide.
37:593-597.
1994
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Design of potential anti-HIV agents. 1. Mannosidase inhibitors.
32:2084-2089.
1989
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Conformational energy calculations and electrostatic potentials of dihydrofolate reductase ligands: relevance to mode of binding and species specificity.
29:698-708.
1986
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N.alpha.-(O,O'-Diphenoxyphosphoryl)-L-alanyl-L-proline, N.alpha.-[O,O'-bis(4-nitrophenoxy)phosphoryl]-L-alanyl-L-proline and N.alpha.-[P-(2-phenylethyl)-O-phenoxyphosphoryl]-L-alanyl-L-proline: releasers of potent inhibitors of angiotensin converting enzyme at physiological pH and temperature.
28:1422-1427.
1985
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Structure-activity relations of convulsant and anticonvulsant barbiturates: a computer-graphic-based pattern-recognition analysis.
26:1223-1229.
1983
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Conformational analysis of the ergot alkaloids ergotamine and ergotaminine.
25:937-942.
1982
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