selected publications
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academic article
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KaurStallmannSchanzeLaumannHegerSteinfurtStachonPeterBodeMoserAhrensDuerschmiedHortmann. Extracellular HtrA2 Induces Apoptosis in Human Umbilical Vein Endothelial Cells.
International Journal of Molecular Sciences.
20:5446-5446.
2019
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Yap MLMcFadyen JDWang XZiegler MChen YCWillcox ANowell CJScott AMSloan EKHogarth PMPietersz GAPeter K. Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases.
Theranostics.
9:1154-1169.
2019
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Michel TLink AAbraham M-KSchlensak CPeter KWendel H-PWang XKrajewski S. Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA.
Journal of Visualized Experiments.
144.
2019
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Heger LAHortmann MAlbrecht MColberg CPeter KWitsch TStallmann DZirlik ABode CDuerschmied DAhrens I. Inflammation in acute coronary syndrome: Expression of TLR2 mRNA is increased in platelets of patients with ACS.
PLoS ONE.
14.
2019
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Diehl PNienaber FZaldivia MTKStamm JSiegel PMMellett NAWessinger MWang XMcFadyen JDBassler NPuetz GHtun NMBraig DHabersberger JHelbing TEisenhardt SUFuller MBode CMeikle PJChen YCPeter K. Lysophosphatidylcholine is a Major Component of Platelet Microvesicles Promoting Platelet Activation and Reporting Atherosclerotic Plaque Instability.
Thrombosis and Haemostasis.
119:1295-1310.
2019
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Palasubramaniam JWang XPeter K. Myocardial Infarction-From Atherosclerosis to Thrombosis Uncovering New Diagnostic and Therapeutic Approaches.
Arteriosclerosis, Thrombosis and Vascular Biology.
39:E176-E185.
2019
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McFadyen JDFernando HPeter K. Off-target drug effects on platelet function: protecting an Achilles heel of drug development.
Current Opinion in Toxicology.
17:9-17.
2019
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Koh JQSFernando HPeter KStub D. Opioids and ST Elevation Myocardial Infarction: A Systematic Review.
Heart Lung and Circulation.
28:697-706.
2019
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Antonipillai JRigby SBassler NPeter KBernard O. Pharmacological inhibition of LIM kinase pathway impairs platelets functionality and facilitates thrombolysis.
Experimental Cell Research.
382.
2019
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Krishnan SMLing YHHuuskes BMFerens DSaini NChan CTDiep HKett MMSamuel CSKemp-Harper BKRobertson AABCooper MAPeter KLatz EMansell ASobey CGDrummond GRVinh A. Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage and dysfunction in salt-sensitive hypertension..
Cardiovascular Research.
115:776-787.
2019
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Kocovski PJiang XD'Souza CLi ZDang PWang XChen WPeter KHale MOrian J. Platelet depletion is effective in ameloirating anxiety-like behavior and reducing the pro-inflammatory environment in the hippocampus in murine experimental autoimmune encephalomyelitis.
Journal of Clinical Medicine.
8.
2019
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Ziegler MWang XPeter K. Platelets in cardiac ischaemia/reperfusion injury: a promising therapeutic target.
Cardiovascular Research.
115:1178-1188.
2019
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Pearce HAQian HConnell TUHuang DGottstein CDonnelly PSPeter KGregorevic PHagemeyer CE. Site-Specific Glycation and Chemo-enzymatic Antibody Sortagging for the Retargeting of rAAV6 to Inflamed Endothelium.
Molecular Therapy - Methods and Clinical Development.
14:261-269.
2019
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Mohammed MThurgood PGilliam CNguyen NPirogova EPeter KKhoshmanesh KBaratchi S. Studying the Response of Aortic Endothelial Cells under Pulsatile Flow Using a Compact Microfluidic System.
Analytical Chemistry.
91:12077-12084.
2019
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Zaldivia MTKHering DMarusic PSata YLee REsler MDHtun NMDuval JHammond LFlierl UWang XDrummond GRWalton AGardiner EEAndrews RKSchlaich MPPeter K. Successful Renal Denervation Decreases the Platelet Activation Status in Hypertensive Patients..
Cardiovascular Research.
2019
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Granja TKörner AGlück CHohmann JDWang XKöhler DStreißenberger ANandurkar HHMirakaj VRosenberger PPeter KStraub A. Targeting CD39 Toward Activated Platelets Reduces Systemic Inflammation and Improves Survival in Sepsis.
Critical Care Medicine.
47:e420-e427.
2019
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Ziegler MHaigh KNguyen TWang XLim BYap MLEddy EMHaigh JJPeter K. The pulmonary microvasculature entraps induced vascular progenitor cells (iVPCs) systemically delivered after cardiac ischemia-reperfusion injury: Indication for preservation of heart function via paracrine effects beyond engraftment.
Microcirculation.
26.
2019
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Wallert MBauer JKluge SSchmölz LChen YCZiegler MSearle AKMaxones ASchubert MThürmer MPein HKoeberle AWerz OBirringer MPeter KLorkowski S. The vitamin E derivative garcinoic acid from Garcinia kola nut seeds attenuates the inflammatory response.
Redox Biology.
24.
2019
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Ranasinghe MPPeter KMcFadyen JD. Thromboembolic and bleeding complications in transcatheter aortic valve implantation: insights on mechanisms, prophylaxis and therapy.
Journal of Clinical Medicine.
8.
2019
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Wallert MZiegler MWang XMaluenda AXu XYap MLWitt RGiles CKluge SHortmann MZhang JMeikle PLorkowski SPeter K. α-Tocopherol preserves cardiac function by reducing oxidative stress and inflammation in ischemia/reperfusion injury.
Redox Biology.
26.
2019
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Thiele JRZeller JKiefer JBraig DKreuzaler SLenz YPotempa LAGrahammer FHuber TBHuber-Lang MBannasch HStark GBPeter KEisenhardt SU. A Conformational Change in C-Reactive Protein Enhances Leukocyte Recruitment and Reactive Oxygen Species Generation in Ischemia/Reperfusion Injury.
Frontiers in Immunology.
9.
2018
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Wolf DAnto-Michel NBlankenbach HWiedemann ABuscher KHohmann JDLim BBäuml MMarki AMauler MDuerschmied DFan ZWinkels HSidler DDiehl PZajonc DMHilgendorf IStachon PMarchini TWillecke FSchell MSommer Bvon zur Muhlen CReinöhl JGerhardt TPlow EFYakubenko VLibby PBode CLey KPeter KZirlik A. A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense.
Nature Communications.
9.
2018
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Ziegler MHohmann JDSearle AKAbraham M-KNandurkar HHWang XPeter K. A single-chain antibody-CD39 fusion protein targeting activated platelets protects from cardiac ischaemia/reperfusion injury.
European Heart Journal.
39:111-116.
2018
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Sata YHering DHead GAWalton ASPeter KMarusic PDuval JLee RHammond LJLambert EALambert GWEsler MDSchlaich MP. Ambulatory arterial stiffness index as a predictor of blood pressure response to renal denervation*.
Journal of Hypertension.
36:1414-1422.
2018
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Hosseini HYi LKanellakis PCao ATay CPeter KBobik AToh BHKyaw T. Anti‐TIM‐1 Monoclonal Antibody (RMT1‐10) Attenuates Atherosclerosis By Expanding IgM‐producing B1a Cells.
Journal of the American Heart Association.
7.
2018
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Samudra ANDwyer KMSelan CFreddi SMurray-Segal LNikpour MHickey MJPeter KRobson SCSashindranath MCowan PJNandurkar HH. CD39 and CD73 activity are protective in a mouse model of antiphospholipid antibody-induced miscarriages.
Journal of Autoimmunity.
88:131-138.
2018
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Robinson SFollo MHaenel DMauler MStallmann DHeger LAHelbing TDuerschmied DPeter KBode CAhrens IHortmann M. Chip-based digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction patients.
Acta Pharmacologica Sinica.
39:1217-1227.
2018
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McFadyen JDSchaff MPeter K. Current and future antiplatelet therapies: emphasis on preserving haemostasis.
Nature Reviews Cardiology.
15:181-191.
2018
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McFadyen JDKiefer JBraig DLoseff-Silver JPotempa LAEisenhardt SUPeter K. Dissociation of C-Reactive Protein Localizes and Amplifies Inflammation: Evidence for a Direct Biological Role of C-Reactive Protein and Its Conformational Changes.
Frontiers in Immunology.
9.
2018
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Robinson SFollo MHaenel DMauler MStallmann DTewari MDuerschmied DPeter KBode CAhrens IHortmann M. Droplet digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction.
International Journal of Cardiology.
257:247-254.
2018
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Wang XSearle AKHohmann JDLiu ALAbraham M-KPalasubramaniam JLim BYao YWallert MYu EChen Y-CPeter K. Dual-Targeted Theranostic Delivery of miRs Arrests Abdominal Aortic Aneurysm Development.
Molecular Therapy.
26:1056-1065.
2018
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Rashid IMaghzal GJChen YCCheng DTalib JNewington DRen MVajandar SKSearle AMaluenda ALindstedt ELJabbour AKettle AJBongers APower CMichaëlsson EPeter KStocker R. Myeloperoxidase is a potential molecular imaging and therapeutic target for the identification and stabilization of high-risk atherosclerotic plaque.
European Heart Journal.
39:3301-3310.
2018
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Hanjaya-Putra DHaller CWang XDai ELim BLiu LJaminet PYao JSearle ABonnard THagemeyer CEPeter KChaikof EL. Platelet-targeted dual pathway antithrombotic inhibits thrombosis with preserved hemostasis.
JCI insight.
3:1-18.
2018
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D'Souza CSLi ZMaxwell DLTrusler OMurphy MCrewther SPeter KOrian JM. Platelets drive neuroinflammation and target grey matter and the retina in autoimmune-mediated encephalomyelitis.
Journal of Neuropathology and Experimental Neurology.
77:567-576.
2018
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Flierl UNero TLLim BAndrews RKParker MWGardiner EEPeter K. Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: comment.
Journal of Thrombosis and Haemostasis.
16:181-185.
2018
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Carnagarin RMatthews VZaldivia MTKPeter KSchlaich MP. The bidirectional interaction between the sympathetic nervous system and immune mechanisms in the pathogenesis of hypertension.
British Journal of Pharmacology.
176:1839-1852.
2018
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Diehl PGaul DSSogl JFlierl UHenstridge DPahla JBugger HEmmert MYRuschitzka FBode CLüscher TFMoser MMatter CMPeter KWinnik S. The effect of oxygen in Sirt3-mediated myocardial protection: a proof-of-concept study in cultured cardiomyoblasts.
Journal of Thrombosis and Thrombolysis.
46:102-112.
2018
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Ta HTTruong NPWhittaker AKDavis TPPeter K. The effects of particle size, shape, density and flow characteristics on particle margination to vascular walls in cardiovascular diseases.
Expert Opinion on Drug Delivery.
15:33-45.
2018
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Pietersz GAWang XYap MLLim BPeter K. Therapeutic targeting in nanomedicine: The future lies in recombinant antibodies.
Nanomedicine.
12:1873-1889.
2017
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Lim BYao YHuang AL-IYap MLFlierl UPalasubramaniam JZaldivia MTKWang XPeter K. A Unique Recombinant Fluoroprobe Targeting Activated Platelets Allows In Vivo Detection of Arterial Thrombosis and Pulmonary Embolism Using a Novel Three-Dimensional Fluorescence Emission Computed Tomography (FLECT) Technology.
Theranostics.
7:1047-1061.
2017
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Maier APlaza-Heck PMeixner FGuenther FKaufmann BAKramer MHeidt TZirlik AHilgendorf IReinöhl JStachon PBronsert PBirkemeyer RNeudorfer IPeter KBode Cvon zur Mühlen C. A molecular intravascular ultrasound contrast agent allows detection of activated platelets on the surface of symptomatic human plaques.
Atherosclerosis.
267:68-77.
2017
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Michel TLuft DAbraham M-KReinhardt SSalinas Medina MLKurz JSchaller MAvci-Adali MSchlensak CPeter KWendel HPWang XKrajewski S. Cationic Nanoliposomes Meet mRNA: Efficient Delivery of Modified mRNA Using Hemocompatible and Stable Vectors for Therapeutic Applications.
Molecular Therapy - Nucleic Acids.
8:459-468.
2017
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Hortmann MRobinson SMohr MHaenel DMauler MStallmann DReinoehl JDuerschmied DPeter KBode CAhrens I. Circulating HtrA2 as a novel biomarker for mitochondrial induced cardiomyocyte apoptosis and ischemia-reperfusion injury in ST-segment elevation myocardial infarction.
International Journal of Cardiology.
243:485-491.
2017
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Kyaw TPeter KLi YTipping PToh B-HBobik A. Cytotoxic lymphocytes and atherosclerosis: Significance, mechanisms and therapeutic challenges.
British Journal of Pharmacology.
174:3956-3972.
2017
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Sashindranath MDwyer KMDezfouli SSelan CCrikis SLu BYuan YHickey MJPeter KRobson SCCowan PJNandurkar HH. Development of a novel strategy to target CD39 antithrombotic activity to the endothelial-platelet microenvironment in kidney ischemia–reperfusion injury.
Purinergic Signalling.
13:259-265.
2017
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Günther FHeidt TKramer MKhanicheh EKlibanov ALGeibel-Zehender AFerrante EAHilgendorf IWolf DZirlik AReinöhl JBode CPeter KKaufmann BAMühlen CVZ. Dual targeting improves capture of ultrasound microbubbles towards activated platelets but yields no additional benefit for imaging of arterial thrombosis.
Scientific Reports.
7.
2017
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Ying Y-LChen YCJandeleit-Dahm KPeter K. GLP-1 receptor agonists: An example of the challenge for animal models to predict plaque instability/rupture and cardiovascular outcomes.
Atherosclerosis.
265:250-252.
2017
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Wolf DBukosza NEnge DPoggi MJehle FMichel NAChen YCColberg CHoppe NDufner BBoon LBlankenbach HHilgendorf IMuhlen CVZReinoehl JSommer BMarchini TFebbraio MAWeber CBode CPeter KLutgens EZirlik A. Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11b/CD18) in diet-induced obesity (DIO).
Thrombosis and Haemostasis.
117:325-338.
2017
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Baratchi SKhoshmanesh KWoodman OLPotocnik SPeter KMcIntyre P. Molecular Sensors of Blood Flow in Endothelial Cells.
Trends in Molecular Medicine.
23:850-868.
2017
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Ta HTLi ZHagemeyer CECowin GZhang SPalasubramaniam JAlt KWang XPeter KWhittaker AK. Molecular imaging of activated platelets via antibody-targeted ultra-small iron oxide nanoparticles displaying unique dual MRI contrast.
Biomaterials.
134:31-42.
2017
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Wang XPeter K. Molecular imaging of atherothrombotic diseases: Seeing is believing.
Arteriosclerosis, Thrombosis and Vascular Biology.
37:1029-1040.
2017
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Abraham M-KPeter KMichel TWendel HPKrajewski SWang X. Nanoliposomes for safe and efficient therapeutic mRNA delivery: A step toward nanotheranostics in inflammatory and cardiovascular diseases as well as cancer.
Nanotheranostics.
1:154-165.
2017
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Htun NMChen YCLim BSchiller TMaghzal GJHuang ALElgass KDRivera JSchneider HGWood BRStocker RPeter K. Near-infrared autofluorescence induced by intraplaque hemorrhage and heme degradation as marker for high-risk atherosclerotic plaques.
Nature Communications.
8.
2017
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McFadyen JDPeter K. Novel Antithrombotic Drugs on the Horizon.
Circulation Research.
121:1133-1135.
2017
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Bonnard TTennant ZNiego BKanojia RAlt KJagdale SLaw LSRigby SMedcalf RLPeter KHagemeyer CE. Novel Thrombolytic Drug Based on Thrombin Cleavable Microplasminogen Coupled to a Single‐Chain Antibody Specific for Activated GPIIb/IIIa.
Journal of the American Heart Association.
6.
2017
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Jamasbi JAyabe KGoto SNieswandt BPeter KSiess W. Platelet receptors as therapeutic targets: Past, present and future.
Thrombosis and Haemostasis.
117:1249-1257.
2017
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Zaldivia MTKMcFadyen JDLim BWang XPeter K. Platelet-derived microvesicles in cardiovascular diseases.
Frontiers in Cardiovascular Medicine.
4.
2017
Full text if available -
Ziegler MWang XLim BLeitner EKlingberg FChing VYao YHuang DGao X-MKiriazis HDu X-JHaigh JJBobik AHagemeyer CEAhrens IPeter K. Platelet-targeted delivery of peripheral blood mononuclear cells to the ischemic heart restores cardiac function after ischemia-reperfusion injury.
Theranostics.
7:3192-3206.
2017
Full text if available -
Htun NMMagliano DJZhang Z-YLyons JPetit TNkuipou-Kenfack ERamirez-Torres Avon zur Muhlen CMaahs DSchanstra JPPontillo CPejchinovski MSnell-Bergeon JKDelles CMischak HStaessen JAShaw JEKoeck TPeter K. Prediction of acute coronary syndromes by urinary proteome analysis.
PLoS ONE.
12.
2017
Full text if available -
Zaldivia MTKRivera JHering DMarusic PSata YLim BEikelis NLee RLambert GWEsler MDHtun NMDuval JHammond LEisenhardt SUFlierl USchlaich MPPeter K. Renal Denervation Reduces Monocyte Activation and Monocyte–Platelet Aggregate Formation.
Hypertension.
69:323-331.
2017
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Molloy CPYao YKammoun HBonnard THoefer TAlt KTovar-Lopez FRosengarten GRamsland PAvan der Meer ADvan den Berg AMurphy AJHagemeyer CEPeter KWestein E. Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation.
Journal of Thrombosis and Haemostasis.
15:972-982.
2017
Full text if available -
Yap MLMcFadyen JDWang XZia NAHohmann JDZiegler MYao YPham AHarris MDonnelly PSHogarth PMPietersz GALim BPeter K. Targeting activated platelets: A unique and potentially universal approach for cancer imaging.
Theranostics.
7:2565-2574.
2017
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Hortmann MRobinson SMohr MMauler MStallmann DReinöhl JDuerschmied DPeter KCarr JGibson CMBode CAhrens I. The mitochondria-targeting peptide elamipretide diminishes circulating HtrA2 in ST-segment elevation myocardial infarction.
European Heart Journal: Acute Cardiovascular Care.
2017
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Braig DNero TLKoch H-GKaiser BWang XThiele JRMorton CJZeller JKiefer JPotempa LAMellett NAMiles LADu X-JMeikle PJHuber-Lang MStark GBParker MWPeter KEisenhardt SU. Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites.
Nature Communications.
8.
2017
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McFadyen JPeter K. Forget about thrombosis: Platelets and Alzheimer’s disease, yet another sticky situation.
Science Signaling.
9.
2016
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Hohmann JDPeter K. Activated-platelet targeting of CD39 as a potential way forward: The quest for efficient antithrombotic therapy without associated bleeding complications.
Hamostaseologie.
36:17-25.
2016
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Chen YCHuang ALKyaw TSBobik APeter K. Atherosclerotic Plaque Rupture.
Arteriosclerosis, Thrombosis and Vascular Biology.
36:e63-e72.
2016
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Tay CLiu Y-HHosseini HKanellakis PCao APeter KTipping PBobik AToh B-HKyaw T. B-cell-specific depletion of tumour necrosis factor alpha inhibits atherosclerosis development and plaque vulnerability to rupture by reducing cell death and inflammation.
Cardiovascular Research.
111:385-397.
2016
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Yudi MBClark DJFarouque OEccleston DAndrianopoulos NDuffy SJBrennan ALefkovits JRamchand JYip TOqueli EReid CMAjani AEAndrianopoulos NClark DNew GHiew COqueli EShaw JAWalton ADart ABroughton AFederman JKeighley CHengel CPeter KO’Brien JBala HSelkrig LVandernet RHuntington RFarouque OHorrigan MJohns JOliver LBrennan JChan RProimos GDortimer TChan BNadurata VHuq RFernando DCharter KBrown LAlFiadh ASugumar SSpencer RScott POqueli ERyan NBarry CRoberts LFreeman MTeh ARowe MProimos GCheong YGoods CBaradi AJackson DSajeev JLew RSzto GTeperman RSebastian MMok MRankin KMachado CDyson JMcDonald BDuff LKrum HReid CChand VDinh DYan BPWarren RIyer RGurvitch RWilson WBrooks MBiswas SYeoh JCheshire CGaikwad N. Clopidogrel, prasugrel or ticagrelor in patients with acute coronary syndromes undergoing percutaneous coronary intervention.
Internal Medicine Journal.
46:559-565.
2016
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Cabrera-Fuentes HAAragones JBernhagen JBoening ABoisvert WABøtker HEBulluck HCook SDi Lisa FEngel FBEngelmann BFerrazzi FFerdinandy PFong AFleming IGnaiger EHernández-Reséndiz SKalkhoran SBKim MHLecour SLiehn EAMarber MSMayr MMiura TOng S-BPeter KSedding DSingh MKSuleiman MSSchnittler HJSchulz RShim WTello DVogel C-WWalker MLi QOYYellon DMHausenloy DJPreissner KT. From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on “New frontiers in cardiovascular research”.
Basic Research in Cardiology.
111.
2016
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Ziegler MAlt KPaterson BMKanellakis PBobik ADonnelly PSHagemeyer CEPeter K. Highly Sensitive Detection of Minimal Cardiac Ischemia using Positron Emission Tomography Imaging of Activated Platelets.
Scientific Reports.
6.
2016
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Heidt TEhrismann SHövener J-BNeudorfer IHilgendorf IReisert MHagemeyer CEZirlik AReinöhl JBode CPeter Kvon Elverfeldt Dvon zur Muhlen C. Molecular Imaging of Activated Platelets Allows the Detection of Pulmonary Embolism with Magnetic Resonance Imaging.
Scientific Reports.
6.
2016
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Chen YCRivera JFitzgerald MHausding CYing Y-LWang XTodorova KHayrabedyan SBarnea ERPeter K. PreImplantation factor prevents atherosclerosis via its immunomodulatory effects without affecting serum lipids.
Thrombosis and Haemostasis.
115:1010-1024.
2016
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Hering DMarusic PWalton ASDuval JLee RSata YKrum HLambert EPeter KHead GLambert GEsler MDSchlaich MP. Renal artery anatomy affects the blood pressure response to renal denervation in patients with resistant hypertension.
International Journal of Cardiology.
202:388-393.
2016
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Weber CShantsila EHristov MCaligiuri GGuzik THeine GHHoefer IEMonaco CPeter KRainger ESiegbahn ASteffens SWojta JLip GYH. Role and analysis of monocyte subsets in cardiovascular disease Joint consensus document of the European Society of Cardiology (ESC) Working Groups "Atherosclerosis & Vascular Biology" and "Thrombosis".
Thrombosis and Haemostasis.
116:626-637.
2016
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Bei J-JLiu CPeng SLiu C-HZhao W-BQu X-LChen QZhou ZYu Z-PPeter KHu H-Y. Staphylococcal SSL5-induced platelet microparticles provoke proinflammatory responses via the CD40/TRAF6/NF kappa B signalling pathway in monocytes.
Thrombosis and Haemostasis.
115:632-645.
2016
Full text if available -
Wang XGkanatsas YPalasubramaniam JHohmann JDChen YCLim BHagemeyer CEPeter K. Thrombus-Targeted Theranostic Microbubbles: A New Technology towards Concurrent Rapid Ultrasound Diagnosis and Bleeding-free Fibrinolytic Treatment of Thrombosis.
Theranostics.
6:726-738.
2016
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Hosseini HLi YKanellakis PTay CCao ALiu EPeter KTipping PToh BBobik AKyaw T. Toll‐like receptor (TLR)4 and MyD88 are essential for atheroprotection by peritoneal B1a B cells.
Journal of the American Heart Association.
5.
2016
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von zur Mühlen CKoeck TSchiffer ESackmann CZürbig PHilgendorf IReinöhl JRivera JZirlik AHehrlein CMischak HBode CPeter K. Urine proteome analysis as a discovery tool in patients with deep vein thrombosis and pulmonary embolism.
Proteomics.
10:574-584.
2016
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Alt KPaterson BMWestein ERudd SEPoniger SSJagdale SArdipradja KConnell TUKrippner GYNair AKNWang XTochon-Danguy HJDonnelly PSPeter KHagemeyer CE. A Versatile Approach for the Site-Specific Modification of Recombinant Antibodies Using a Combination of Enzyme-Mediated Bioconjugation and Click Chemistry.
Angewandte Chemie International Edition.
54:7515-7519.
2015
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Cui JDe Rose RAlt KAlcantara SPaterson BMLiang KHu MRichardson JJYan YJeffery CMPrice RIPeter KHagemeyer CEDonnelly PSKent SJCaruso F. Engineering Poly(ethylene glycol) Particles for Improved Biodistribution.
ACS Nano.
9:1571-1580.
2015
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Bode MHaenel DHagemeyer CESeeba HDuerschmied DBassler NJandeleit-Dahm KASweet MJAgrotis ABobik APeter KAhrens IChen Y-CTopcic D. HMGB1 binds to activated platelets via the receptor for advanced glycation end products and is present in platelet rich human coronary artery thrombi.
Thrombosis and Haemostasis.
114:994-1003.
2015
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Meier SPütz GMassing UHagemeyer CEvon Elverfeldt DMeißner MArdipradja KBarnert SPeter KBode CSchubert Rvon zur Muhlen C. Immuno-magnetoliposomes targeting activated platelets as a potentially human-compatible MRI contrast agent for targeting atherothrombosis.
Biomaterials.
53:137-148.
2015
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Abraham M-KNolte AReus RBehring AZengerle DAvci-Adali MHohmann JDPeter KSchlensak CWendel HPKrajewski S. In vitro Study of a Novel Stent Coating Using Modified CD39 Messenger RNA to Potentially Reduce Stent Angioplasty-Associated Complications.
PLoS ONE.
10.
2015
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Gunawan STKempe KBonnard TCui JAlt KLaw LSWang XWestein ESuch GKPeter KHagemeyer CECaruso F. Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets.
Advanced Materials.
27:5153-5157.
2015
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Guo JWang XHenstridge DCRichardson JJCui JSharma AFebbraio MAPeter Kde Haan JBHagemeyer CECaruso F. Nanoporous Metal-Phenolic Particles as Ultrasound Imaging Probes for Hydrogen Peroxide.
Journal of Interconnection Networks.
4:2170-2175.
2015
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Chan CTSobey CGLieu MFerens DKett MMDiep HKim HAKrishnan SMLewis CVSalimova ETipping PVinh ASamuel CSPeter KGuzik TJKyaw TSToh B-HBobik ADrummond GR. Obligatory role for B cells in the development of angiotensin II-dependent hypertension.
Hypertension.
66:1023-1033.
2015
Full text if available -
Hagemeyer CEAlt KJohnston APRSuch GKTa HTLeung MKMPrabhu SWang XCaruso FPeter K. Particle generation, functionalization and sortase A–mediated modification with targeting of single-chain antibodies for diagnostic and therapeutic use.
Nature Protocols.
10:90-105.
2015
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Flierl UNero TLLim BArthur JFYao YJung SMGitz EPollitt AYZaldivia MTKJandrot-Perrus MSchäfer ANieswandt BAndrews RKParker MWGardiner EEPeter K. Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators.
Journal of Experimental Medicine.
212:129-137.
2015
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McLellan AJASchlaich MPTaylor AJPrabhu SHering DHammond LMarusic PDuval JSata YEllims AEsler MPeter KShaw JWalton AKalman JMKistler PM. Reverse cardiac remodeling after renal denervation: Atrial electrophysiologic and structural changes associated with blood pressure lowering.
Heart Rhythm.
12:982-990.
2015
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Kim WHaller CDai EWang XHagemeyer CELiu DRPeter KChaikof EL. Targeted Antithrombotic Protein Micelles.
Angewandte Chemie International Edition.
54:1461-1465.
2015
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Thiele JRZeller JBannasch HStark GBPeter KEisenhardt SU. Targeting C-Reactive Protein in Inflammatory Disease by Preventing Conformational Changes.
Mediators of Inflammation.
2015:1-9.
2015
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Braig DKaiser BThiele JRBannasch HPeter KStark GBKoch H-GEisenhardt SU. A conformational change of C-reactive protein in burn wounds unmasks its proinflammatory properties.
International Immunology.
26:467-478.
2014
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Liu JPeter KShi DZhang LDong GZhang DBreiteneder HBauer RJakowitsch JMa Y. Anti-Inflammatory Effects of the Chinese Herbal Formula Sini Tang in Myocardial Infarction Rats.
Evidence-Based Complementary and Alternative Medicine.
2014:1-10.
2014
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Wolf DJehle FMichel NABukosza ENRivera JChen YCHoppe NDufner BRodriguez AOColberg CNieto LRupprecht BWiedemann ASchulte LPeikert ABassler NLozhkin AHergeth SPStachon PHilgendorf IWillecke Fvon zur Mühlen Cvon Elverfeldt DBinder CJAichele PVaro NFebbraio MALibby PBode CPeter KZirlik A. Coinhibitory suppression of T cell activation by CD40 protects against obesity and adipose tissue inflammation in mice.
Circulation.
129:2414-2425.
2014
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Ardipradja KYeoh SDAlt KO'Keefe GRigopoulos AHowells DWScott AMPeter KAckerman UHagemeyer CE. Detection of activated platelets in a mouse model of carotid artery thrombosis with 18F-labeled single-chain antibodies.
Nuclear Medicine and Biology.
41:229-237.
2014
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Thiele JRHabersberger JBraig DSchmidt YGoerendt KMaurer VBannasch HScheichl AWoollard KJvon Dobschütz EKolodgie FVirmani RStark GBPeter KEisenhardt SU. Dissociation of pentameric to monomeric C-Reactive protein localizes and aggravates inflammation.
Circulation.
130:35-50.
2014
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von Elverfeldt DMaier ADuerschmied DBraig MWitsch TWang XMauler MNeudorfer IMenza MIdzko MZirlik AHeidt TBronsert PBode CPeter Kvon zur Muhlen C. Dual-contrast molecular imaging allows noninvasive characterization of myocardial ischemia/reperfusion injury after coronary vessel occlusion in mice by magnetic resonance imaging.
Circulation.
130:676-687.
2014
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Guo JPing YEjima HAlt KMeissner MRichardson JJYan YPeter Kvon Elverfeldt DHagemeyer CECaruso F. Engineering multifunctional capsules through the assembly of metal-phenolic networks.
Angewandte Chemie International Edition.
53:5546-5551.
2014
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Paterson BMAlt KJeffery CMPrice RIJagdale SRigby SWilliams CCPeter KHagemeyer CEDonnelly PS. Enzyme-mediated site-specific bioconjugation of metal complexes to proteins: sortase-mediated coupling of copper-64 to a single-chain antibody.
Angewandte Chemie International Edition.
53:6115-6119.
2014
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Rupprecht BWolf DHergeth SHoppe NDufner BSchulte LMichel NBukosza NMarchini TJäckel MStachon PHilgendorf IZeschky KSchleicher RLanger HFvon zur Muhlen CBode CPeter KWillecke FTiwari SZirlik A. Interruption of classic CD40L-CD40 signalling but not of the novel CD40L-Mac-1 interaction limits arterial neointima formation in mice.
Thrombosis and Haemostasis.
112:379-389.
2014
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Koulis CChen YCHausding CAhrens IKyaw TSTay CAllen TJandeleit-Dahm KSweet MJAkira SBobik APeter KAgrotis A. Protective role for toll-like receptor-9 in the development of atherosclerosis in apolipoprotein E–deficient mice.
Arteriosclerosis, Thrombosis and Vascular Biology.
34:516-525.
2014
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Alt KPaterson BMArdipradja KSchieber CBuncic GLim BPoniger SSJakoby BWang XOkeefe GJTochon-Danguy HJScott AMAckermann UPeter KDonnelly PSHagemeyer CE. Single-Chain antibody conjugated to a cage amine chelator and labeled with positron-emitting copper-64 for diagnostic imaging of activated platelets.
Molecular Pharmaceutics.
11:2855-2863.
2014
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Wang XPalasubramaniam JGkanatsas YHohmann JDWestein EKanojia RAlt KHuang DJia FAhrens IMedcalf RLPeter KHagemeyer CE. Towards effective and safe thrombolysis and thromboprophylaxis.
Circulation Research.
114:1083-1093.
2014
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Chen YCBui AVDiesch JManasseh RHausding CRivera JHaviv IAgrotis AHtun NMJowett JHagemeyer CEHannan RDBobik APeter K. A novel mouse model of atherosclerotic plaque Instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling.
Circulation Research.
113:252-265.
2013
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Hohmann JDWang XKrajewski SSelan CHaller CAStraub AChaikof ELNandurkar HHHagemeyer CEPeter K. Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?.
Blood.
121:3067-3075.
2013
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Westein EFlierl UHagemeyer CEPeter K. Destination known: targeted drug delivery in atherosclerosis and thrombosis.
Drug Development Research.
74:460-471.
2013
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Fink KBusch H-JBourgeois NSchwarz MWolf DZirlik APeter KBode Cvon zur Muhlen C. Mac-1 directly binds to the endothelial protein C-receptor: a link between the protein C anticoagulant pathway and inflammation?.
PLoS ONE.
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2013
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Schmid EKrajewski SBachmann DKurz JWendel HPRosenberger PBalkau BPeter KUnertl KStraub A. Inhibition of inflammatory events during extracorporeal circulation: Anti-inflammatory effects of the volatile anesthetic sevoflurane.
Applied Cardiopulmonary Pathophysiology: the interface between laboratory and clinical practice.
16:349.
2012
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Krajewski SKurz JNeumann BGreiner TOStolz ABalkau BPeter KWendel HPUnertl KRosenberger PStraub A. Protection against coagulopathy and inflammation during extracorporeal circulation and hypothermia - short-acting P2Y12 blockade as novel pharmacological strategy.
Applied Cardiopulmonary Pathophysiology: the interface between laboratory and clinical practice.
16:335.
2012
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ARMSTRONG PCJHU HRIVERA JRIGBY SCHEN Y-CHOWDEN BPGARDINER EPETER K. Staphylococcal superantigen-like protein 5 induces thrombotic and bleeding complicationsin vivo: inhibition by an anti-SSL5 antibody and the glycan Bimosiamose.
Journal of Thrombosis and Haemostasis.
10:2607-2609.
2012
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Habersberger JStrang FScheichl AHtun NBassler NMerivirta R-MDiehl PKrippner GMeikle PEisenhardt SUMeredith IPeter K. Circulating microparticles generate and transport monomeric C-reactive protein in patients with myocardial infarction.
Cardiovascular Research.
96:64-72.
2012
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Eisenhardt SUStarke JThiele JRMurphy ABjörn Stark GBassler NSviridov DWinkler KPeter K. Pentameric CRP attenuates inflammatory effects of mmLDL by inhibiting mmLDL–monocyte interactions.
Atherosclerosis.
224:384-393.
2012
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Schmid EKrajewski SBachmann DKurz JWendel HPRosenberger PBalkau BPeter KUnertl KStraub A. The volatile anesthetic sevoflurane inhibits activation of neutrophil granulocytes during simulated extracorporeal circulation.
International Immunopharmacology.
14:202-208.
2012
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von Elverfeldt Dvon zur Muhlen CWiens KNeudorfer IZirlik AMeissner MTilly PCharles A-LBode CPeter KFabre J-E. In Vivo Detection of Activated Platelets Allows Characterizing Rupture of Atherosclerotic Plaques with Molecular Magnetic Resonance Imaging in Mice.
PLoS ONE.
7:e45008-e45008.
2012
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Mischak HIoannidis JPAArgiles AAttwood TKBongcam-Rudloff EBroenstrup MCharonis AChrousos GPDelles CDominiczak ADylag TEhrich JEgido JFindeisen PJankowski JJohnson RWJulien BALankisch TLeung HYMaahs DMagni FManns MPManolis EMayer GNavis GNovak JOrtiz APersson FPeter KRiese HHRossing PSattar NSpasovski GThongboonkerd VVanholder RSchanstra JPVlahou A. Implementation of proteomic biomarkers: making it work.
European Journal of Clinical Investigation.
42:1027-1036.
2012
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Patko ZCsaszar AAcsady GPeter KSchwarz M. Roles of Mac-1 and glycoprotein IIb/IIIa integrins in leukocyte–platelet aggregate formation: Stabilization by Mac-1 and inhibition by GpIIb/IIIa blockers.
Platelets (London).
23:368-375.
2012
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Leung MKMHagemeyer CEJohnston APRGonzales CKamphuis MMJArdipradja KSuch GKPeter KCaruso F. Bio-Click Chemistry: Enzymatic Functionalization of PEGylated Capsules for Targeting Applications.
Angewandte Chemie International Edition.
51:7132-7136.
2012
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von zur Muhlen CSchiffer ESackmann CZürbig PNeudorfer IZirlik AHtun NIphöfer AJänsch LMischak HBode CChen YCPeter K. Urine Proteome Analysis Reflects Atherosclerotic Disease in an ApoE−/−Mouse Model and Allows the Discovery of New Candidate Biomarkers in Mouse and Human Atherosclerosis.
Molecular and Cellular Proteomics.
11:M111.013847-M111.013847.
2012
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Wang XHagemeyer CEHohmann JDLeitner EArmstrong PCJia FOlschewski MNeedles APeter KAhrens I. Novel Single-Chain Antibody-Targeted Microbubbles for Molecular Ultrasound Imaging of Thrombosis.
Circulation.
125:3117-3126.
2012
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Krajewski SKurz JGeisler TPeter KWendel HPStraub A. Combined Blockade of ADP Receptors and PI3-Kinase p110β Fully Prevents Platelet and Leukocyte Activation during Hypothermic Extracorporeal Circulation.
PLoS ONE.
7:e38455-e38455.
2012
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Krajewski SKurz JNeumann BGreiner TOStolz ABalkau BPeter KUnertl KWendel HPStraub A. Short-acting P 2 Y 12 blockade to reduce platelet dysfunction and coagulopathy during experimental extracorporeal circulation and hypothermia.
British Journal of Anaesthesia.
108:912-921.
2012
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Strang FScheichl AChen Y-CWang XHtun N-MBassler NEisenhardt SUHabersberger JPeter K. Amyloid Plaques Dissociate Pentameric to Monomeric C-Reactive Protein: A Novel Pathomechanism Driving Cortical Inflammation in Alzheimer's Disease?.
Brain Pathology.
22:337-346.
2012
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Ta HTPeter KHagemeyer CE. Enzymatic Antibody Tagging: Toward a Universal Biocompatible Targeting Tool.
Trends in Cardiovascular Medicine.
22:105-111.
2012
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Peter KBobik A. HMGB1 signals danger in acute coronary syndrome: Emergence of a new risk marker for cardiovascular death?.
Atherosclerosis.
221:317-318.
2012
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Diehl PFricke ASander LStamm JBassler NHtun NZiemann MHelbing TEl-Osta AJowett JBMPeter K. Microparticles: major transport vehicles for distinct microRNAs in circulation.
Cardiovascular Research.
93:633-644.
2012
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Wolf DJehle FOrtiz Rodriguez ADufner BHoppe NColberg CLozhkin ABassler NRupprecht BWiedemann AHilgendorf IStachon PWillecke FFebbraio MBinder CJBode CZirlik APeter K. CD40L Deficiency Attenuates Diet-Induced Adipose Tissue Inflammation by Impairing Immune Cell Accumulation and Production of Pathogenic IgG-Antibodies.
PLoS ONE.
7:e33026-e33026.
2012
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von Elverfeldt DMeißner MPeter KPaul DMeixner FNeudorfer IMerkle AHarloff AZirlik ASchöllhorn JMarkl MHennig JBode Cvon zur Muhlen C. An approach towards molecular imaging of activated platelets allows imaging of symptomatic human carotid plaques in a new model of a tissue flow chamber.
Contrast Media and Molecular Imaging.
7:204-213.
2012
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Ahrens IPeter KLip GYHBode C. Development and clinical applications of novel oral anticoagulants. Part I. Clinically approved drugs..
Discovery medicine.
13:433-443.
2012
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Ahrens IPeter KLip GYHBode C. Development and clinical applications of novel oral anticoagulants. Part II. Drugs under clinical investigation..
Discovery medicine.
13:445-450.
2012
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Armstrong PCPeter K. GPIIb/IIIa inhibitors: From bench to bedside and back to bench again.
Thrombosis and Haemostasis.
107:808-814.
2012
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Wolf DHohmann J-DWiedemann ABledzka KBlankenbach HMarchini TGutte KZeschky KBassler NHoppe NRodriguez AOHerr NHilgendorf IStachon PWillecke FDuerschmied Dvon zur Muhlen CSoloviev DAZhang LBode CPlow EFLibby PPeter KZirlik A. Binding of CD40L to Mac-1's I-Domain Involves the EQLKKSKTL Motif and Mediates Leukocyte Recruitment and Atherosclerosis—But Does Not Affect Immunity and Thrombosis in Mice.
Circulation Research.
109:1269-1279.
2011
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Ahrens IHabersberger JBaumlin NQian HSmith BKStasch J-PBode CSchmidt HHHWPeter K. Measuring oxidative burden and predicting pharmacological response in coronary artery disease patients with a novel direct activator of haem-free/oxidised sGC.
Atherosclerosis.
218:431-434.
2011
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Duerschmied DMeiner MPeter KNeudorfer IRoming FZirlik ABode Cvon Elverfeldt Dvon zur Muhlen C. Molecular Magnetic Resonance Imaging Allows the Detection of Activated Platelets in a New Mouse Model of Coronary Artery Thrombosis.
Investigative Radiology.
46:618-623.
2011
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Topcic DKim WHolien JKJia FArmstrong PCHohmann JDStraub AKrippner GHaller CADomeij HHagemeyer CEParker MWChaikof ELPeter K. An Activation-Specific Platelet Inhibitor That Can Be Turned On/Off by Medically Used Hypothermia.
Arteriosclerosis, Thrombosis and Vascular Biology.
31:2015-2023.
2011
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Ahrens IDomeij HEisenhardt SUTopcic DAlbrecht MLeitner EViitaniemi KJowett JBLappas MBode CHaviv IPeter K. Opposing effects of monomeric and pentameric C-reactive protein on endothelial progenitor cells.
Basic Research in Cardiology.
106:879-895.
2011
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Ahrens IDomeij HTopcic DHaviv IMerivirta R-MAgrotis ALeitner EJowett JBBode CLappas MPeter K. Successful In Vitro Expansion and Differentiation of Cord Blood Derived CD34+ Cells into Early Endothelial Progenitor Cells Reveals Highly Differential Gene Expression.
PLoS ONE.
6:e23210-e23210.
2011
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Ta HTPrabhu SLeitner EJia Fvon Elverfeldt DJackson KEHeidt TNair AKNPearce Hvon zur Muhlen CWang XPeter KHagemeyer CE. Enzymatic Single-Chain Antibody Tagging.
Circulation Research.
109:365-373.
2011
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FERNANDO HBASSLER NHABERSBERGER JSHEFFIELD LJSHARMA RDART AMPETER KHSHAW JA. Randomized double-blind placebo-controlled crossover study to determine the effects of esomeprazole on inhibition of platelet function by clopidogrel.
Journal of Thrombosis and Haemostasis.
9:1582-1589.
2011
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Straub AKrajewski SHohmann JDWestein EJia FBassler NSelan CKurz JWendel HPDezfouli SYuan YNandurkar HJackson SHickey MJPeter K. Evidence of Platelet Activation at Medically Used Hypothermia and Mechanistic Data Indicating ADP as a Key Mediator and Therapeutic Target.
Arteriosclerosis, Thrombosis and Vascular Biology.
31:1607-1616.
2011
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Hu HArmstrong PCJKhalil EChen Y-CStraub ALi MSoosairajah JHagemeyer CEBassler NHuang DAhrens IKrippner GGardiner EPeter K. GPVI and GPIbα Mediate Staphylococcal Superantigen-Like Protein 5 (SSL5) Induced Platelet Activation and Direct toward Glycans as Potential Inhibitors.
PLoS ONE.
6:e19190-e19190.
2011
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Heidt TDeininger FPeter KGoldschmidt JPethe AHagemeyer CENeudorfer IZirlik AWeber WABode CMeyer PTBehe Mvon zur Mühlen C. Activated Platelets in Carotid Artery Thrombosis in Mice Can Be Selectively Targeted with a Radiolabeled Single-Chain Antibody.
PLoS ONE.
6:e18446-e18446.
2011
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Kanellakis PAgrotis AKyaw TSKoulis CAhrens IMori STakahashi HKLiu KPeter KNishibori MBobik A. High-Mobility Group Box Protein 1 Neutralization Reduces Development of Diet-Induced Atherosclerosis in Apolipoprotein E–Deficient Mice.
Arteriosclerosis, Thrombosis and Vascular Biology.
31:313-319.
2011
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Eisenhardt SUHabersberger JOliva KLancaster GIAyhan MWoollard KJBannasch HRice GEPeter K. A proteomic analysis of C-reactive protein stimulated THP-1 monocytes.
Proteome Science.
9:1-1.
2011
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Myles PPeter K. Perioperative antiplatelet therapy: A knife-edged choice between thrombosis and bleeding still based on consensus rather than evidence.
Thrombosis and Haemostasis.
105:750-751.
2011
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Fernando HDart APeter KShaw J. Proton pump inhibitors, genetic polymorphisms and response to clopidogrel therapy.
Thrombosis and Haemostasis.
105:933-944.
2011
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Lip GPeter KAhrens I. What do the RE-LY, AVERROES and ROCKET-AF trials tell us for stroke prevention in atrial fibrillation?.
Thrombosis and Haemostasis.
105:574-578.
2011
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E. Hagemeyer CPeter K. Targeting the Platelet Integrin GPIIb/IIIa.
Current Pharmaceutical Design.
16:4119-4133.
2010
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Good DMZürbig PArgilés ÀBauer HWBehrens GCoon JJDakna MDecramer SDelles CDominiczak AFEhrich JHHEitner FFliser DFrommberger MGanser AGirolami MAGolovko IGwinner WHaubitz MHerget-Rosenthal SJankowski JJahn HJerums GJulian BAKellmann MKliem VKolch WKrolewski ASLuppi MMassy ZMelter MNeusüss CNovak JPeter KRossing KRupprecht HSchanstra JPSchiffer EStolzenburg J-UTarnow LTheodorescu DThongboonkerd VVanholder RWeissinger EMMischak HSchmitt-Kopplin P. Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease.
Molecular and Cellular Proteomics.
9:2424-2437.
2010
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Delles CSchiffer Evon zur Muhlen CPeter KRossing PParving H-HDymott JANeisius UZimmerli LUSnell-Bergeon JKMaahs DMSchmieder REMischak HDominiczak AF. Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals.
Journal of Hypertension.
28:2316-2322.
2010
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von zur Muhlen CFink-Petri ASalaklang JPaul DNeudorfer IBerti VMerkle APeter KBode Cvon Elverfeldt D. Imaging monocytes with iron oxide nanoparticles targeted towards the monocyte integrin MAC-1 (CD11b/CD18) does not result in improved atherosclerotic plaque detection by in vivo MRI.
Contrast Media and Molecular Imaging.
5:268-275.
2010
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Mischak HAllmaier GApweiler RAttwood TBaumann MBenigni ABennett SEBischoff RBongcam-Rudloff ECapasso GCoon JJD'Haese PDominiczak AFDakna MDihazi HEhrich JHFernandez-Llama PFliser DFrokiaer JGarin JGirolami MHancock WSHaubitz MHochstrasser DHolman RRIoannidis JPAJankowski JJulian BAKlein JBKolch WLuider TMassy ZMattes WBMolina FMonsarrat BNovak JPeter KRossing PSanchez-Carbayo MSchanstra JPSemmes OJSpasovski GTheodorescu DThongboonkerd VVanholder RVeenstra TDWeissinger EYamamoto TVlahou A. Recommendations for Biomarker Identification and Qualification in Clinical Proteomics.
Science Translational Medicine.
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2010
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Peter K. Proteomics unravels platelet function.
Blood.
115:4008-4009.
2010
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Habersberger JEisenhardt SPeter K. C-reactive protein measurement and cardiovascular disease.
Lancet.
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2010
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Smolich Jd‘Udekem YBrizard CStraub APeter KHorton S. Activation of platelets in young infants during cardiopulmonary bypass.
Thrombosis and Haemostasis.
103:466-469.
2010
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Lip GPeter K. Changing the scope of preventative and therapeutic approaches in atherothrombosis.
Thrombosis and Haemostasis.
103:487-488.
2010
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Hagemeyer CEAhrens IBassler NDschachutaschwili NChen YCEisenhardt SUBode CPeter K. Genetic transfer of fusion proteins effectively inhibits VCAM-1-mediated cell adhesion and transmigration via inhibition of cytoskeletal anchorage.
Journal of Cell and Molecular Medicine.
14:290-302.
2010
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Lip GPeter KAhrens I. New oral anticoagulant drugs in cardiovascular disease.
Thrombosis and Haemostasis.
104:49-60.
2010
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Lip GPeter K. Thrombosis and cardiovascular disease: Exciting perspectives in cardiovascular prevention and therapy.
Thrombosis and Haemostasis.
103:875-876.
2010
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Eisenhardt SUThiele JRBannasch HStark GBPeter K. C-reactive protein: How conformational changes influence inflammatory properties.
Cell Cycle.
8:3885-3892.
2009
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Eisenhardt SUHabersberger JPeter K. Monomeric C-Reactive Protein Generation on Activated Platelets: The Missing Link Between Inflammation and Atherothrombotic Risk.
Trends in Cardiovascular Medicine.
19:232-237.
2009
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Hu HStraub ATian ZBassler NCheng JPeter K. Celastrol, a Triterpene Extracted From Tripterygium wilfordii Hook F, Inhibits Platelet Activation.
Journal of Cardiovascular Pharmacology.
54:240-245.
2009
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Ahrens IPeter K. FX-06, a fibrin-derived Bβ15-42 peptide for the potential treatment of reperfusion injury following myocardial infarction.
Current Opinion in Investigational Drugs.
10:997-1003.
2009
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Eisenhardt SUHabersberger JMurphy AChen Y-CWoollard KJBassler NQian Hvon zur Muhlen CHagemeyer CEAhrens IChin-Dusting JBobik APeter K. Dissociation of Pentameric to Monomeric C-Reactive Protein on Activated Platelets Localizes Inflammation to Atherosclerotic Plaques.
Circulation Research.
105:128-137.
2009
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Löffler CStraub ABassler NPernice KBeyersdorf FBode CSiegenthaler MPPeter K. Evaluation of platelet activation in patients supported by the Jarvik 2000∗ high–rotational speed impeller ventricular assist device.
Journal of Thoracic and Cardiovascular Surgery.
137:736-741.
2009
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von zur Muhlen CSchiffer EZuerbig PKellmann MBrasse MMeert NVanholder RCDominiczak AFChen YCMischak HBode CPeter K. Evaluation of Urine Proteome Pattern Analysis for Its Potential To Reflect Coronary Artery Atherosclerosis in Symptomatic Patients.
Journal of Proteome Research.
8:335-345.
2009
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Hagemeyer CEPeter K. Ex-vivo thrombolytic gene therapy for vein graft patency: The frontier for development of selective, localised therapeutic approaches.
Thrombosis and Haemostasis.
102:03-04.
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Peter KBerndt MKhachigian L. Recent advances in vascular biology: Selected highlights from IVBM 2008.
Thrombosis and Haemostasis.
101:997-998.
2009
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von zur Muhlen CPeter KAli ZASchneider JUREMcAteer MANeubauer SChannon KMBode CChoudhury RP. Visualization of Activated Platelets by Targeted Magnetic Resonance Imaging Utilizing Conformation-Specific Antibodies against Glycoprotein IIb/IIIa.
Journal of Vascular Research.
46:6-14.
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Woollard KJSuhartoyo AHarris EEEisenhardt SUJackson SPPeter KDart AMHickey MJChin-Dusting JPF. Pathophysiological Levels of Soluble P-Selectin Mediate Adhesion of Leukocytes to the Endothelium Through Mac-1 Activation.
Circulation Research.
103:1128-1138.
2008
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von zur Muhlen Cvon Elverfeldt DMoeller JAChoudhury RPPaul DHagemeyer CEOlschewski MBecker ANeudorfer IBassler NSchwarz MBode CPeter K. Magnetic Resonance Imaging Contrast Agent Targeted Toward Activated Platelets Allows In Vivo Detection of Thrombosis and Monitoring of Thrombolysis.
Circulation.
118:258-267.
2008
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Ahrens IEllwanger CSmith BKBassler NChen YCNeudorfer ILudwig ABode CPeter K. Selenium supplementation induces metalloproteinase-dependent L-selectin shedding from monocytes.
Journal of Leukocyte Biology.
83:1388-1395.
2008
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von zur Muhlen CSibson NRPeter KCampbell SJWilainam PGrau GEBode CChoudhury RPAnthony DC. A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI.
Journal of Clinical Investigation.
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2008
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von zur Mühlen Cvon Elverfeldt DChoudhury RPEnder JAhrens ISchwarz MHennig JBode CPeter K. Functionalized Magnetic Resonance Contrast Agent Selectively Binds to Glycoprotein IIb/IIIa on Activated Human Platelets under Flow Conditions and Is Detectable at Clinically Relevant Field Strengths.
Molecular Imaging.
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Zimmerli LUSchiffer EZürbig PGood DMKellmann MMouls LPitt ARCoon JJSchmieder REPeter KHMischak HKolch WDelles CDominiczak AF. Urinary Proteomic Biomarkers in Coronary Artery Disease.
Molecular and Cellular Proteomics.
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2008
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Ahrens IPeter K. Humanizing mouse thrombi.
Nature Biotechnology.
26:62-63.
2008
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Wendel HDietz KSchiebold DPeter KSchoenwaelder SZiemer GStraub A. Selective inhibition of the platelet phosphoinositide 3-kinase p110β as promising new strategy for platelet protection during extracorporeal circulation.
Thrombosis and Haemostasis.
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2008
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Ahrens IPeter K. Therapeutic integrin inhibition: Allosteric and activation-specific inhibition strategies may surpass the initial ligand-mimetic strategies.
Thrombosis and Haemostasis.
99:803-804.
2008
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Eisenhardt SUSchwarz MBassler NPeter K. Subtractive single-chain antibody (scFv) phage-display: tailoring phage-display for high specificity against function-specific conformations of cell membrane molecules.
Nature Protocols.
2:3063-3073.
2007
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Ahrens IPeter KBode C. Literatur zum Artikel: Bigalke, Lindemann, Gawaz.
Hamostaseologie.
27:328-328.
2007
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Ahrens ISmith BKBode CPeter K. Direct thrombin inhibition with bivalirudin as an antithrombotic strategy in general and interventional cardiology.
Expert Opinion on Drug Metabolism and Toxicology.
3:609-620.
2007
Full text if available -
von zur Muhlen Cvon Elverfeldt DBassler NNeudorfer ISteitz BPetri-Fink AHofmann HBode CPeter K. Superparamagnetic iron oxide binding and uptake as imaged by magnetic resonance is mediated by the integrin receptor Mac-1 (CD11b/CD18): Implications on imaging of atherosclerotic plaques.
Atherosclerosis.
193:102-111.
2007
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Stoll PBassler NHagemeyer CEEisenhardt SUChen YCSchmidt RSchwarz MAhrens IKatagiri YPannen BBode CPeter K. Targeting Ligand-Induced Binding Sites on GPIIb/IIIa via Single-Chain Antibody Allows Effective Anticoagulation Without Bleeding Time Prolongation.
Arteriosclerosis, Thrombosis and Vascular Biology.
27:1206-1212.
2007
Full text if available -
Eisenhardt SUSchwarz MSchallner NSoosairajah JBassler NHuang DBode CPeter K. Generation of activation-specific human anti-αMβ2 single-chain antibodies as potential diagnostic tools and therapeutic agents.
Blood.
109:3521-3528.
2007
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Zirlik AMaier CGerdes NMacFarlane LSoosairajah JBavendiek UAhrens IErnst SBassler NMissiou APatko ZAikawa MSchönbeck UBode CLibby PPeter K. CD40 Ligand Mediates Inflammation Independently of CD40 by Interaction With Mac-1.
Circulation.
115:1571-1580.
2007
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Bassler NLoeffler CMangin PYuan YSchwarz MHagemeyer CEEisenhardt SUAhrens IBode CJackson SPPeter K. A Mechanistic Model for Paradoxical Platelet Activation by Ligand-Mimetic α
IIb
β
3
(GPIIb/IIIa) Antagonists.
Arteriosclerosis, Thrombosis and Vascular Biology.
27:E9-E15.
2007
Full text if available -
Hagemeyer CSchwarz MPeter K. Single-Chain Antibodies as New Antithrombotic Drugs.
Seminars in Thrombosis and Hemostasis.
33:185-195.
2007
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Mischak HApweiler RBanks REConaway MCoon JDominiczak AEhrich JHHFliser DGirolami MHermjakob HHochstrasser DJankowski JJulian BAKolch WMassy ZANeusuess CNovak JPeter KRossing KSchanstra JSemmes OJTheodorescu DThongboonkerd VWeissinger EMVan Eyk JEYamamoto T. Clinical proteomics: A need to define the field and to begin to set adequate standards.
Proteomics: Clinical Applications.
1:148-156.
2007
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Breuer MWendel HPeter KDietz KZiemer GStraub A. Critical temperature ranges of hypothermia-induced platelet activation: Possible implications for cooling patients in cardiac surgery.
Thrombosis and Haemostasis.
97:608-616.
2007
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Schwarz MHagemeyer CEPeter KBode C. Literatur zum Artikel: Schwarz.
Hamostaseologie.
27:360-360.
2007
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Ahrens ISchwarz MPeter KBode C. Therapeutic Inhibitors of Platelet Aggregation – from Aspirin to Integrin Blockersf.
Transfusion Medicine and Hemotherapy.
34:44-54.
2007
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Mühlen CVZPeter KSpreer JBeyersdorf FPache GBode CHandke M. Evidence of a Steal Phenomenon by a Thoracic Side Branch of an Internal Mammary Artery Bypass.
Journal of Vascular and Interventional Radiology.
17:1714-1715.
2006
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Schwarz MMeade GStoll PYlanne JBassler NChen YCHagemeyer CEAhrens IMoran NKenny DFitzgerald DBode CPeter K. Conformation-Specific Blockade of the Integrin GPIIb/IIIa.
Circulation Research.
99:25-33.
2006
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Ahrens IGMoran NAylward KMeade GMoser MAssefa DFitzgerald DJBode CPeter K. Evidence for a differential functional regulation of the two β3-integrins αVβ3 and αIIbβ3.
Experimental Cell Research.
312:925-937.
2006
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Ahrens IBode CPeter K. Inhibition of platelet activation and aggregation.
Handbook of Experimental Pharmacology.
170:443-462.
2005
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Huber RNauck MBasler NHaas BMattern MLüdtke RPeter K. Effects of subtotal fasting on plasmatic coagulation, fibrinolytic status and platelet activation: A controlled pilot study in healthy subjects.
Nutrition Metabolism and Cardiovascular Diseases.
15:212-218.
2005
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Peter KBode C. Pharmacotherapy in cardiovascular diseases and vascular interventions.
Thrombosis and Haemostasis.
92:1172-1174.
2004
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Kanse SMMatz RLPreissner KTPeter K. Promotion of Leukocyte Adhesion by a Novel Interaction Between Vitronectin and the β
2
Integrin Mac-1 (α
M
β
2
, CD11b/CD18).
Arteriosclerosis, Thrombosis and Vascular Biology.
24:2251-2256.
2004
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Peter KAhrens ISchwarz MBode CYlänne J. Distinct roles of ligand affinity and cytoskeletal anchorage in αIIbβ3(GP IIb/IIIa)-mediated cell aggregation and adhesion.
Platelets (London).
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2004
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SCHWARZ MEIKERÖTTGEN PETERTAKADA YOSHIAZUKULE GALL FABRICEKNACKMUSS STEFANBASSLER NICOLEBÜTTNER CLAUDIALITTLE MELVYNBODE CHRISTOPHPETER KARLHEINZ. Single-chain antibodies for the conformation-specific blockade of activated platelet integrin αIIbβ3 designed by subtractive selection from naive human phage libraries.
The FASEB Journal.
18:1704-1706.
2004
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Grotz WSiebig SOlschewski MStrey CWPeter K. LOW-DOSE ASPIRIN THERAPY IS ASSOCIATED WITH IMPROVED ALLOGRAFT FUNCTION AND PROLONGED ALLOGRAFT SURVIVAL AFTER KIDNEY TRANSPLANTATION.
Transplantation.
77:1848-1853.
2004
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Hagemeyer CETomic IWeirich UGraeber JNordt TRunge MSBode CPeter K. Construction and characterization of a recombinant plasminogen activator composed of an anti-fibrin single-chain antibody and low-molecular-weight urokinase.
Journal of Thrombosis and Haemostasis.
2:797-803.
2004
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Schwarz MKatagiri YKotani MBassler NLoeffler CBode CPeter K. Reversibility versus Persistence of GPIIb/IIIa Blocker-Induced Conformational Change of GPIIb/IIIa (αIIbβ3, CD41/CD61).
Journal of Pharmacology and Experimental Therapeutics.
308:1002-1011.
2004
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Weirich UBassler NSchwarz MRunge MBode CHagemeyer CTomic IJaminet PPeter K. Fibrin-targeted direct factor Xa inhibition: construction and characterization of a recombinant factor Xa inhibitor composed of an anti-fibrin single-chain antibody and tick anticoagulant peptide.
Thrombosis and Haemostasis.
92:47-53.
2004
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Jacobin MJRobert RPouns OLaroche-Traineau JNurden APeter KLittle MClofent-Sanchez G. Improving selection of αIIbβ3-binding phage antibodies with increased reactivity derived from immunized donors.
Clinical Immunology.
108:199-210.
2003
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Peter KGupta ANordt TBauer SRunge MSBode C. Construction and In Vitro Testing of a Novel Fab-Hirudin–Based Fusion Protein That Targets Fibrin and Inhibits Thrombin in a Factor Xa–Dependent Manner.
Journal of Cardiovascular Pharmacology.
42:237-244.
2003
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Ahrens IPeter KBode C. Use of GPIIb/IIIa inhibitors in cardiovascular medicine.
Expert Review of Cardiovascular Therapy.
1:233-242.
2003
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Moser MBertram UPeter KBode CRuef J. Abciximab, Eptifibatide, and Tirofiban Exhibit Dose-dependent Potencies to Dissolve Platelet Aggregates.
Journal of Cardiovascular Pharmacology.
41:586-592.
2003
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Schuler PAssefa DYlänne JBasler NOlschewski MAhrens INordt TBode CPeter K. Adhesion of Monocytes to Medical Steel as Used for Vascular Stents is Mediated by the Integrin Receptor Mac-1 (CD11b/CD18; α M β 2 ) and Can be Inhibited by Semiconductor Coating.
Cell Communication and Adhesion (Print Edition).
10:17-26.
2003
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Eschenfelder EPeter KSobel BBode CNordt T. Independence of growth factor induced plasminogen activator inhibitor type-1 (PAI-1) expression from the 4G/5G polymorphism of the PAI-1 gene.
Thrombosis and Haemostasis.
90:36-42.
2003
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Schwarz MNordt TBode CPeter K. The GP IIb/IIIa inhibitor abciximab (c7E3) inhibits the binding of various ligands to the leukocyte integrin Mac-1 (CD11b/CD18, αMβ2).
Thrombosis Research: vascular obstruction, hemorrhage and hemostasis.
107:121-128.
2002
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Peter KSchwarz MBode C. Activating Effects of GPIIb/IIIa Blockers: An Intrinsic Consequence of Ligand- Mimetic Properties.
Circulation.
105:E180-E180.
2002
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Jacobin M-JLaroche-Traineau JLittle MKeller APeter KWelschof MNurden AClofent-Sanchez G. Human IgG Monoclonal Anti-αIIbβ3-Binding Fragments Derived from Immunized Donors Using Phage Display.
Journal of Immunology.
168:2035-2045.
2002
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Bertram UMoser MPeter KKuecherer HFBekeredjian RStraub ANordt TKBode CRuef J. Effects of different thrombolytic treatment regimen with abciximab and tirofiban on platelet aggregation and platelet-leukocyte interactions: A subgroup analysis from the GUSTO V and FASTER trials.
Journal of Thrombosis and Thrombolysis.
14:197-203.
2002
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Peter KSchwarz MNordt TBode C. Intrinsic Activating Properties of GP IIb/IIIa Blockers.
Thrombosis Research: vascular obstruction, hemorrhage and hemostasis.
103:S21-S27.
2001
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Nordt TKPeter KBode C. GPIIb/IIIa-Blockade zur Optimierung der Thrombolyse bei aktuem Myokardinfarkt.
Herz: kardiovaskulaere Erkraenkungen.
26:S42-S45.
2001
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Lutzi SRuef JPeter KKlar EKübler WSobel BBode CNordt T. Attenuation by Fibrates of Plasminogen Activator Inhibitor Type-1 Expression in Human Arterial Smooth Muscle Cells.
Thrombosis and Haemostasis.
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2001
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Peter KMoser MD MRuef MD JPeter MD KKohler MD BGulba MD DCPaterna MD NNordt MD TKu¨bler MD WBode MD C. Ecarin clotting time but not aPTT correlates with PEG-hirudin plasma activity.
Journal of Thrombosis and Thrombolysis.
12:165-169.
2001
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Nordt TKPeter KBode CSobel BE. Differential regulation by troglitazone of plasminogen activator inhibitor type 1 in human hepatic and vascular cells.
Journal of Clinical Endocrinology and Metabolism.
85:1563-1568.
2000
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Peter KSchwarz MNordt TBode CConradt CMoser MKubler W. Heparin also interacts with selectins and modulates the cell adhesion process - Response.
Circulation.
102:E169-E169.
2000
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Peter KNordt TBode C. Therapeutische Inhibition von Thrombozyten im akuten Koronarsyndrom und bei Koronarintervention: Mechanismen und klinische Ergebnisse.
Clinical Research in Cardiology.
89:VII60-VII69.
2000
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Peter KNordt TBode C. Therapeutische Inhibition von Thrombozyten im akuten Koronarsyndrom und bei Koronarintervention: Mechanismen und klinische Ergebnisse.
Clinical Research in Cardiology.
89:60-69.
2000
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Peter KKohler BStraub ARuef JMoser MNordt TOlschewski MOhman MEKübler WBode C. Flow Cytometric Monitoring of Glycoprotein IIb/IIIa Blockade and Platelet Function in Patients With Acute Myocardial Infarction Receiving Reteplase, Abciximab, and Ticlopidine.
Circulation.
102:1490-1496.
2000
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Peter KGraeber JKipriyanov SZewe-Welschof MRunge MSKübler WLittle MBode C. Construction and Functional Evaluation of a Single-Chain Antibody Fusion Protein With Fibrin Targeting and Thrombin Inhibition After Activation by Factor Xa.
Circulation.
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2000
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Moser MNordt TPeter KRuef JKohler BSchmittner MSmalling RKübler WBode C. Platelet Function During and After Thrombolytic Therapy for Acute Myocardial Infarction With Reteplase, Alteplase, or Streptokinase.
Circulation.
100:1858-1864.
1999
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Peter KSchwarz MConradt CNordt TMoser MKübler WBode C. Heparin Inhibits Ligand Binding to the Leukocyte Integrin Mac-1 (CD11b/CD18).
Circulation.
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1999
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Peter KStraub AKohler BVolkmann MSchwarz MKübler WBode C. Platelet activation as a potential mechanism of GP IIb/IIIa inhibitor-induced thrombocytopenia.
American Journal of Cardiology.
84:519-524.
1999
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Kääpä APeter KYlänne J. Effects of Mutations in the Cytoplasmic Domain of Integrin β1 to Talin Binding and Cell Spreading.
Experimental Cell Research.
250:524-534.
1999
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Ruef JNordt TKPeter KRunge MSKubler WBode C. A bispecific antifibrin-antiplatelet urokinase conjugate (BAAUC) induces enhanced clot lysis and inhibits platelet aggregation.
Thrombosis and Haemostasis.
82:109-114.
1999
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Gries ABode CGross SPeter KBohrer HMartin E. The Effect of Intravenously Administered Magnesium on Platelet Function in Patients After Cardiac Surgery.
Anesthesia and Analgesia.
88:1213-1219.
1999
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Ruef JNordt TPeter KRunge MKübler WBode C. A Bispecific Antifibrin-antiplatelet Urokinase Conjugate (BAAUC) Induces Enhanced Clot Lysis and Inhibits Platelet Aggregation.
Thrombosis and Haemostasis.
82:109-114.
1999
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Ruef JPeter KNordt TKKubler WBode C. Is oxidative stress an important factor in atherogenesis?.
Zeitschrift f�r Kardiovaskulare Medizin.
3:4-12.
1999
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Peter KSchwarz MNordt TKohler BMoser MRuef JKübler WBode C. P13 Various GP IIb/IIIa (α
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Nordt TKLutzi SPeter KKübler WBode C. P53 Gemfibrozil inhibits specifically the expression of plasminogen activator inhibitor type 1 in adult arterial smooth muscle cells.
Fibrinolysis and Proteolysis.
12:108.
1998
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Peter KSchwarz MYlänne JKohler BMoser MNordt TSalbach PKübler WBode C. Induction of Fibrinogen Binding and Platelet Aggregation as a Potential Intrinsic Property of Various Glycoprotein IIb/IIIa (IIbβ3) Inhibitors.
Blood.
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1998
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Christ FMoser CPeter KMeßmer K. Veränderungen der Flüssigkeitsfiltrationskapazität und des Blutflusses nach Tourniquet bei Knieoperationen in Spinalanästhesie.
Der Anaesthesist: Zeitschrift fuer Anaesthesie, Intensivmedizin, Notfall- und Katastrophenmedizin, Schmerzmedizin.
47:460-468.
1998
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Gries ABode CPeter KHerr ABöhrer HMotsch JMartin E. Inhaled Nitric Oxide Inhibits Human Platelet Aggregation, P-Selectin Expression, and Fibrinogen Binding In Vitro and In Vivo.
Circulation.
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1998
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Moser MKohler BRuef JPeter KKübler WBode CNordt T. Augmented Platelet Aggregation as Predictor of Reocclusion after Thrombolysis in Acute Myocardial Infarction.
Thrombosis and Haemostasis.
80:881-886.
1998
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Peter KNordt TBode C. Construction of an activated, high-affinity GP IIb/IIIa (αIIbβ3) integrin receptor and its use for the determination of the role of affinity and cytoskeletal anchorage in cell adhesion, cell migration and fibronectin matrix assembly.
Fibrinolysis.
11:193-196.
1997
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Peter KNawroth PConradt CNordt TWeiss TBoehme MWunsch AAllenberg JKübler WBode C. Circulating Vascular Cell Adhesion Molecule-1 Correlates With the Extent of Human Atherosclerosis in Contrast to Circulating Intercellular Adhesion Molecule-1, E-Selectin, P-Selectin, and Thrombomodulin.
Arteriosclerosis, Thrombosis and Vascular Biology.
17:505-512.
1997
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Nordt TKKornas KPeter KFujii SSobel BEKu¨bler WBode C. Attenuation by Gemfibrozil of Expression of Plasminogen Activator Inhibitor Type 1 Induced by Insulin and its Precursors.
Circulation.
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1997
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Peter KBode C. Clinical studies with reteplase.
Drugs of Today.
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1997
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Bode CNordt TKPeter KSmalling RWRunge MSKübler W. Patency Trials With Reteplase (r-PA): What Do They Tell Us?.
American Journal of Cardiology.
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1996
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Peter KBode C. A deletion in the ?? subunit locks platelet integrin ??IIb??3 into a high affinity state.
Blood Coagulation and Fibrinolysis: international journal in haemostasis and thrombosis.
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1996
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Peter K. Modulation of cell adhesion by changes in alpha L beta 2 (LFA-1, CD11a/CD18) cytoplasmic domain/cytoskeleton interaction.
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1995
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Peter KO'Toole TE. Integrin cytoplasmic domains mediate inside-out signal transduction.
The Journal of Cell Biology.
124:1047-1059.
1994
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Bode CPeter KKubler WKatus HA. Aggressive thrombolysis in acute myocardial infarction: Limitations and possibilities.
Clinical Research in Cardiology.
83:393-403.
1994
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KaurStallmannSchanzeLaumannHegerSteinfurtStachonPeterBodeMoserAhrensDuerschmiedHortmann. Extracellular HtrA2 Induces Apoptosis in Human Umbilical Vein Endothelial Cells.
International Journal of Molecular Sciences.
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Methods in Molecular Biology.
333-338.
2015
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Prabhu SSharma RPeter KFitridge RThompson M. Platelets in the pathogenesis of vascular disease and their role as a therapeutic target.
201-226.
2011
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Eisenhardt SUPeter K. Phage Display and Subtractive Selection on Cells.
165-182.
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Chen YCRivera JPeter K. Tandem Stenosis to Induce Atherosclerotic Plaque Instability in the Mouse.
Methods in Molecular Biology.
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comment
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Yap MLWang XPietersz GAPeter K. Mesoscale nanoparticles: An unexpected means for selective therapeutic targeting of kidney diseases!.
Hypertension.
61-63.
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McFadyen JDPeter K. Platelet lipidomics and function: Joining the dots.
Blood.
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Htun NMPeter K. Biomarkers for AAA: Encouraging steps but clinical relevance still to be delivered.
Proteomics: Clinical Applications.
732-734.
2014
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Peter K. Isoform-specific effects of protein phosphatase 1 on outside-in signalling of integrin αIIbβ3: A story told by genetic manipulation of platelet surrogate cells.
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2013
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Yap MLWang XPietersz GAPeter K. Mesoscale nanoparticles: An unexpected means for selective therapeutic targeting of kidney diseases!.
Hypertension.
61-63.
2018
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conference paper
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Wang XSearle APeter K. Targeted Drug Therapy To Provide Effective And Localised Anticoagulation Without Impairing Haemostasis.
Atherosclerosis.
e33-e33.
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Wallert MZiegler MWang XMaluenda ALorkowski SPeter K. Boost of vitamin E metabolism as a novel treatment strategy for myocardial infarction.
Free Radical Biology and Medicine.
S25-S25.
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Wang XAbraham M-KPeter KMichel TWendel HKrajewski S. Nanoliposomes for safe and efficient therapeutic CD39 MRNA delivery: prevention and treatment of inflammatory and cardiovascular diseases.
Atherosclerosis Supplements.
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Pearce HQian HPeter KGregorevic PHagemeyer CE. Re-targeting RAAV6 towards inflamed Endothelial Cells.
Journal of Gene Medicine.
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Wang XZiegler MHohmann JDSearle AKAbraham M-KNandurkar HPeter K. Restoring of heart function after myocardial infarction using activated platelets targeted drugs.
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Chen YCHtun NMMaghzal GJSchneider HStocker RPeter KWang X. Shining and light on plaque instability: Near infrared autofluorescence as characteristic of unstable, high risk atherosclerotic plaques.
Atherosclerosis Supplements.
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Wang XSearle AKChen YCPeter K. Targeted microbubbles loaded with microrna for a theranostic approach of abdominal aortic aneurysms.
Atherosclerosis Supplements.
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Wang XSearle AKChen YCPeter K. Downregulation of vascular cell adhesion molecule-1 using targeted microbubbles for the delivery of microRNA-126: treatment and prevention of abdominal aortic aneurysm.
European Heart Journal.
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Wallert MHeise JChen YCKluge SSchmolz LSchubert MSearle AKKoeberle AGalli FWerz OBirringer MLorkowski SPeter K. Garcinia kola - African ethno medication with anti-atherosclerotic effects?.
Free Radical Biology and Medicine.
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Wolf DMichel NABlankenbach HBode CPeter KZirlik A. Leukocyte mobilization through CD40L/Mac-1 drives cardiovascular inflammation.
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Circulation.
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Chen YCHtun NLim BSchneider HStocker RPeter K. Near infrared autofluorescence is a unique feature of vulnerable atherosclerotic plaques.
European Heart Journal.
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Wang XGkanatsas YPalasubramaniam JHohmann JDHagemeyer CPeter K. Novel targeted-theranostic microbubbles for simultaneous diagnosis, treatment and monitoring via ultrasound technology.
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Cheng DChen YCStanley CTalib JRashid ILindstedt E-LKettle AJMichaelsson EPeter KMaghzal GJStocker R. Pharmacological Inhibition of Myeloperoxidase Improves Endothelial Function and Stabilizes Atherosclerotic Lesions in a Mouse Model of Vulnerable Plaque.
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Zaldivia MTKRivera JHering DMarusic PSata YEikelis NLee RLambert GWHtun NMDuval JHammond LEisenhardt SFlierl USchlaich MPPeter K. Renal Denervation reduces monocyte activation: an anti-inflammatory effect relevant for cardiovascular risk.
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D'Souza CPeter KOrian JM. Platelets drive neuroinflammation in the C57Bl/6 variant of the Experimental Autoimmune Encephalomyelitis (EAE) model of Multiple Sclerosis (MS).
Multiple Sclerosis.
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Wolf DMichel NANora BEngel DPoggi MWeber CBode CPeter KLutgens EZirlik A. Inflammation, but not recruitment, of adipose tissue macrophages requires signaling through mac-1 in diet-induced obesity (DIO).
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Maier ADuerschmied DVon Elverfeldt DMauler MMoritz MWitsch TNeudorfer IPeter KBode CVon Zur Muehlen C. P2Y12-receptor knockout leads to reduced myocardial ischemia/reperfusion injury in mice.
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Westein EMolloy CYao JPeter K. Site specific inhibition of thrombus formation using shear sensitive anti-thrombotic nanoparticles.
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Alt KPaterson BArdipradja KPoniger SAckermann UPeter KTochon-Danguy HScott ADonnelly PHagemeyer C. Site-specific enzymatic and click chemistry bioconjugation of metal complexes to single-chain antibodies for PET/CT imaging of activated platelets.
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Ta HPrabhu SLeitner EJia FPutnam KBassler NPeter KHagemeyer C. Targeted molecular imaging and cell homing in cardiovascular disease via antibody-sortagging.
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Chen Y-CPeter K. A novel mouse model that reflects human atherosclerotic plaque instability is a unique tool for drug testing and mechanistic discoveries.
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Peter K. Introduction of a mouse model that reflects human atherosclerotic plaque instability and rupture: a unique tool for discovery of strategies towards plaque pacification and ultimately prevention of myocardial infarction.
Cardiology: international journal of cardiovascular medicine, surgery and pathology.
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Flierl UNero TLLim BArthur JFNieswandt BAndrews RKParker MWGardiner EEPeter K. Phosphorothioate oligonucleotides are potent platelet activators.
European Heart Journal.
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Meier ADuerschmied DVon Elverfeldt DHeidt TPeter KBode CVon Zur Muhlen C. Simultaneous molecular imaging of activated platelets and myocardial necrosis allows in vivo evaluation of ischemia-reperfusion injury in mice by magnetic resonance imaging.
European Heart Journal.
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Flierl UYao JBassler NPeter K. Phosphorothioate oligodeoxynucleotides are potent platelet activators acting toll-like receptor 9 independently.
Journal of Thrombosis and Haemostasis.
897-897.
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Peter K. A novel haemodynamic model of plaque instability in mice that truly reflects the endstage of human atherosclerosis.
Cardiology: international journal of cardiovascular medicine, surgery and pathology.
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Maier ADuerschmied Dvon Elverfedlt DBraig MHeidt TNeudorfer IPeter KBode Cvon zur Muhlen C. Abstract 10322: Molecular magnetic resonance imaging allows in vivo evaluation of ischemia-reperfusion injury by simultaneous targeting of activated platelets and myocardial necrosis in mice..
Circulation.
2013
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Hohmann JDWang XKrajewski SStraub AHagemeyer CPeter K. Delayed targeting of CD39 to thrombus with an activated-platelet antibody allows for effective antithrombotic treatment without prolonging bleeding times.
Journal of Thrombosis and Haemostasis.
107-108.
2013
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Krohn-Grimberghe MVon Elverfeldt DNeudorfer IPeter KGawaz MBode CHMuehlen CVZ. Development of a novel triple-target imaging strategy for the characterization of plaque inflammation in ApoE-/- mice.
European Heart Journal.
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2013
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Wolf DJehle FBukosza NMichel NAStachon PVaro NBode CLibby PPeter KZirlik A. Immunotherapy with an agonistic anti-CD40 antibody limits adipose tissue inflammation and protects from pre-established metabolic disease in mice.
European Heart Journal.
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2013
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Wang XHagemeyer CHohmann JDAhrens IPeter K. In vivo molecular ultrasound imaging for monitoring and efficacy testing of thrombolytic drugs using platelet-targeted microbubbles.
Journal of Thrombosis and Haemostasis.
248-248.
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Meier SPuetz GMassing UHagemeyer CMutscher ALArdipradja KMeissner Mvon Elverfeldt DSchubert RPeter Kvon zur Muhlen CBode C. Molecular MRI of activated platelets using anti-libs-magnetoliposomes as a new strategy for timely detection of unstable plaques.
Circulation.
2013
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Duerschmied DCanault MKoch PPeter KAlessie M-CBode CAhrens I. Platelet-mediated innate immunity via toll-like receptor 2 stimulation and subsequent serotonin release.
Journal of Thrombosis and Haemostasis.
438-438.
2013
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Albrecht MDuerschmied DColberg CZirlik APeter KBode CAhrens I. Quantitative PCR of platelet specific mRNA reveals significant upregulation of TLR-2 in patients with non-ST elevation myocardial infarction.
Journal of Thrombosis and Haemostasis.
635-636.
2013
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Habersberger JScheichl AStrang FEisenhardt SUHtun NMPeter K. The dissociation of pentameric to monomeric c-reactive protein (CRP) on microparticles drives inflammation in patients with myocardial infarction.
Cardiology: international journal of cardiovascular medicine, surgery and pathology.
383-383.
2013
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Wolf DJehle FBukosza ENWillecke FHilgendorf IStachon PVaro NBode CLibby PPeter KZirlik A. CD40 is Associated with Obesity in Humans and Stimulation of CD40 Signaling Limits Progression of Pre-Established Metabolic Disease in Mice.
Circulation.
2012
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Guenther FKaufmann BAKlibanov ALHeidt TKramer MKhanicheh EFerrante EANeudorfer IYasuhiro KPeter KBode Cvon zur Muhlent C. Dual Microbubble Targeting Improves in vitro Capture Efficiency of Ultrasound Micro-Bubbles Targeted to Selectins and Activated Platelets Although not Providing Additional Signal Effect for in vivo Imaging of Arterial Thrombosis.
Circulation.
2012
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Wolf DBukosza ENJehle FWillecke FHilgendorf IStachon PBode CPeter KZirlik A. Genetic Absence of the Leukocyte Integrin Mac-1 Potentiates Adipose Tissue Inflammation by Enhancing Immune Cell Infiltration.
Circulation.
2012
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Willecke FTiwari SRupprecht BWolf DHoppe NDufner BStachon PHilgendorf IPeter KLibby PBode CZirlik A. Interruption of Classic CD4oL-CD4o Signaling But Not of the Novel CC4oL-Mac-1 Interaction Limits Arterial Neointima Formation in Mice.
Circulation.
2012
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Diehl PBassler NSteiner DFricke APeter K. Phage Display of Designed Ankyrin Repeat Proteins (DARPins) against the I Domain Of Mac-1 Results in Novel Diagnostic and Therapeutic Agents Specifically Acting on Activated Monocytes.
Circulation.
2012
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Wang XHohmann JDLeitner EHagemeyer CEPeter K. Platelet-Targeted Microbubbles Allow Monitoring and Efficacy Testing of Thrombolytic Drugs in Molecular Ultrasound Imaging.
Circulation.
2012
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Von Zur Muhlen CSchiffer ESackmann CChen YCZurbig PMischak HBode CPeter K. Urine Proteome Analysis Allows Establishment of Polypeptide Patterns non-Invasively Reflecting Drug-Mediated Regression of Atherosclerosis in ApoE-/--Mice.
Circulation.
2012
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Ardipradja KYeoh SDO'Keefe GHowells DPeter KTochon-Danguy HAckermann UHagemeyer C. DETECTION OF ACTIVATED PLATELETS IN CAROTID ARTERY THROMBOSIS IN MICE WITH RADIOLABELED SINGLE CHAIN ANTIBODIES FOR PET.
Internal Medicine Journal.
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Wolf DJehle FStachon PWillecke FBode CPeter KZirlik A. CD40L deficiency ameliorates diet-induced adipose tissue inflammation, but does not protect from insulin resistance and hepatic steatosis in mice.
European Heart Journal.
880-880.
2012
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Wolf DJehle FStachon PWillecke FBode CPeter KZirlik A. Genetic deficiency of CD40 aggravates adipose tissue inflammation in mice by increasing inflammatory cell recruitment.
European Heart Journal.
356-356.
2012
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Ahrens IAgrotis ATopcic DBassler NChen YCBobik ABode CPeter K. HMGB1 binds to activated platelets via platelet-expressed receptor for advanced glycation end products (RAGE) and is highly expressed in platelet rich coronary artery thrombi.
European Heart Journal.
278-278.
2012
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Von Zur Muhlen CVon Elverfeldt DWiens KMeissner MCharles APeter KBode CFabre JE. In vivo detection of activated platelets allows characterizing rupture of atherosclerotic plaques with molecular magnetic resonance imaging in mice.
European Heart Journal.
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2012
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Meier SPuetz GMassing UElverfeldt DVBarnert SPeter KSchubert RBode CMuehlen CVZ. Magnetoliposomes for targeting activated platelets: development of a human compatible MRI contrast agent for detection of unstable atherosclerotic plaques.
European Heart Journal.
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2012
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Hagemeyer CEWang XHohmann J-DHuang DJia FPeter K. A Novel Antibody-Targeted Recombinant Plasminogen Activator Directed to Activated Platelets Allows Efficient Antithrombotic Prophylaxis.
Circulation.
2011
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Wolf DJehle FLozhkin AHilgendorf IBode CPeter KZirlik A. CD40 Deficiency Aggravates Diet-Induced Obesity, Adipose Tissue Inflammation, and Insulin Resistance in Mice.
Circulation.
2011
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Hohmann JDKrajewski SWang XSelan CStraub ANandurkar HHagemeyer CPeter K. Clot-targeting Of CD39 Through Genetic Fusion To An Activated-platelet Specific Single-chain Antibody Provides Efficient Inhibition Of ADP Receptor-mediated Platelet Activation Without Systemic Platelet Inhibition.
Circulation.
2011
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Wolf DJehle FHilgendorf IStachon PBinder CJBode CZirlik APeter K. Genetic Deficiency of CD40L Attenuates Diet-Induced Adipose Tissue Inflammation - but Does Not Protect From Insulin Resistance and Hepatic Steatosis in Mice.
Circulation.
2011
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Ahrens IAgrotis ATopcic DBassler NChen Y-CBobik ABode CPeter K. The Pro-Atherogenic DNA-Binding Cytokine HMGB1 Binds to Activated Platelets via the Receptor for Advanced Glycation End Products (RAGE) and Toll-Like Receptor 2 (TLR 2).
Circulation.
2011
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Heidt TDeininger FPeter KHGoldschmidt JNeudorfer IWeber WMeyer PBode CBehe MVon Zur Muehlen C. Activated platelets in carotid artery thrombosis in mice can be selectively targeted in vivo with SPECT-CT using a radiolabeled single chain antibody.
European Heart Journal.
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Peter KWang XHagemeyer CJia FLeitner EAhrens I. Antibody-coupling and targeting of microbubbles to activated platelets allows molecular imaging of thrombosis and monitoring of success or failure of thrombolysis using non-invasive ultrasound.
European Heart Journal.
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Duerschmied DMeissner MNeudorfer IRoming FPeter KBode CVon Elverfeldt DVon Zur Muhlen C. Molecular magnetic resonance imaging allows the detection of activated platelets in a new mouse model of coronary artery thrombosis.
European Heart Journal.
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Fernando HBassler NHabersberger JSheffield LDart APeter KShaw J. Randomised double blind placebo controlled crossover study to determine the effects of esomeprazole on the inhibition of platelet function by clopidogrel.
European Heart Journal.
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Wolf DWiedemann AHohmann JHilgendorf IStachon PWillecke FLibby PBode CPeter KZirlik A. Selective disruption of the CD40L/Mac-1 interaction by a small peptide inhibitor mimicking the EQLKKSKTL motif attenuates inflammation and atherogenesis in mice.
European Heart Journal.
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2011
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Von Zur Muhlen CSchiffer ESackmann CChen YCZuerbig PMischak HBode CPeter K. Urine proteome analysis reflects atherosclerotic disease in an ApoE-/- mouse model and allows the discovery of new biomarkers and mediators of atherosclerosis.
European Heart Journal.
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2011
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Ahrens IHagemeyer CKlingberg FLeitner EViitaniemi KJia FBassler NBode CPeter K. Augmenting the homing of progenitor cells with bispecific single chain antibodies targeting Sca-1 and the activated GPIIb/IIIa receptor on platelets.
Journal of Thrombosis and Haemostasis.
276-276.
2011
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Ahrens IDomeij HEisenhardt SAlbrecht MTopcic DLeitner EJowett JLappas MHaviv IBode CPeter K. Monomeric C-reactive protein impairs endothelial progenitor cell function and differentiation via up-regulation of interferon alpha responsive genes.
Journal of Thrombosis and Haemostasis.
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2011
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Wang XHagemeyer CEJia FLeitner EAhrens IPeter K. Novel single-chain antibody-targeted microbubbles for detection of arterial thrombosis via contrast enhanced ultrasound.
Journal of Thrombosis and Haemostasis.
503-503.
2011
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Ahrens IAlbrecht MBode CPeter K. Quantification of platelet mRNA from highly purified platelets reveals significant expression of components of the innate immune system in platelets.
Journal of Thrombosis and Haemostasis.
535-536.
2011
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Zirlik AWolf DWiedemann AHohmann JDBassler NLibby PPeter KBode C. Selective disruption of the CD40L/MAC-1 interaction by a small peptide inhibitor mimicking the EQLKKSKTL motif attenuates inflammation and atherogenesis in mice.
Journal of Thrombosis and Haemostasis.
484-484.
2011
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Wang XHagemeyer CEJia FLeitner EAhrens IPeter K. 40 NON-INVASIVE MOLECULAR IMAGING USING CONTRAST ENHANCED ULTRASOUND FOR DETECTION OF ARTERIAL THROMBOSIS VIA SINGLE-CHAIN ANTIBODY-TARGETED MICROBUBBLES.
Atherosclerosis Supplements.
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2011
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Deininger FTimo HGoldschmidt JPethe APeter KWeber WBode CMeyer Pvon zur Muehlen CBehe M. Molecular imaging of specific glycoprotein IIb/IIIa-receptor binding sites to detect activated platelets in an arterial thrombosis mouse model.
Journal of Nuclear Medicine.
2011
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Duerschmied DMeissner MNeudorfer IPeter KBode Cvon Elverfeldt Dvon zur Muehlen C. A Platelet-specific Magnetic Resonance Imaging Contrast Agent Allows Detection of Thrombosis in a New Mouse Model of Coronary Artery Thrombosis.
Circulation.
2010
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Ahrens IHagemeyer CEKlingberg FLeitner EViitaniemi KJia FBassler NBode CPeter K. Bispecific Anti-GPIIb/IIIa Single Chain Antibodies for Stem Cell Homing.
Circulation.
2010
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Topcic DHaller CAWookhyun KStraub AJia FChaikoff ELPeter K. The Design of an Activation-Specific Platelet Inhibitor that Can Be Turned On/Off at Medically Employed Hypothermia.
Arteriosclerosis, Thrombosis and Vascular Biology.
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Delles CSchiffer Evon zur Muehlen CPeter KRossing PParving HHDymott JANeisius UZimmerli LUSnell-Bergeon JKMaahs DMSchmieder REMischak HDominiczak AF. Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 subjects.
Journal of Human Hypertension.
698-698.
2010
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Ahrens IKlingberg FLeitner EJia FBassler NBode CHagemeyer CPeter K. Development of bispecific single chain antibodies for stem cell homing to the sites of vascular injury.
European Heart Journal.
395-395.
2010
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Von Zur Muhlen CFink ASalaklang JVon Elverfeldt DPaul DNeudorfer IBerti VBode CPeter K. Imaging monocytes with iron oxide nanoparticles targeted towards the monocyte integrin MAC-1 does not result in improved atherosclerotic plaque detection by in vivo MRI.
European Heart Journal.
295-295.
2010
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Heidt TDeininger FNeudorfer IPeter KMeyer PBehe MBode CVon Zur Muhlen C. Labelling of an activation-specific glycoprotein IIb/IIIa-receptor antibody with Indium-111 allows imaging of activated platelets in carotid artery thrombosis in mice.
European Heart Journal.
611-611.
2010
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Ahrens IDomeiji HTopcic DMerivirta RBode CLappas MPeter K. Successful in vitro expansion and differentiation of cord blood derived CD34+cells into functionally active endothelial progenitor cells.
European Heart Journal.
396-396.
2010
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Ahrens IHabersberger JQian HStasch J-PBode CSchmidt HPeter K. MS396 DETERMINING THE OXIDATIVE BURDEN IN PATIENTS WITH CORONARY ARTERY DISEASE USING A NOVEL DIRECT ACTIVATOR OF HEME-FREE/OXIDIZED SGC.
Atherosclerosis Supplements.
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Delles CSchiffer EMuhlen CVZPeter KHRossing PParving HHDymott JANeisius UZimmerli LUSnell-Bergeon JKMaahs DMSchmieder REMischak HDominiczak AF. URINARY PROTEOMIC DIAGNOSIS OF CORONARY ARTERY DISEASE: IDENTIFICATION AND CLINICAL VALIDATION IN 623 SUBJECTS.
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Bobik AKanellakis PAgrotis AKoulis CAhrens IPeter KMori STakahashi NKLiu KNishibori M. A Proatherogenic Role for HMGB1 in Atherosclerosis.
Circulation.
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2009
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Hu HKhalil EChen YCStraub ALi MJia FBassler NHuang DAhrens IGardiner EPeter K. Staphylococcal Superantigen-like 5 Induces Platelet Activation and Thrombosis via Binding to GPIb alpha and GPVI.
Circulation.
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Peter KVlahou AAllmaier GAttwood TBongcam-Rudloff ECharonis AFrokiaer JMischak HSchanstra JSpasovski G. 2nd Combined Working Group and Management Committee Meeting of Urine and Kidney Proteomics COST Action 29-30 March 2009, Nafplio, Greece.
Proteomics: Clinical Applications.
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Von Zur Muhlen CPaul DVon Elverfeldt DMeixner FNeudorfer IBode CPeter K. Targeted specific magnetic resonance imaging allows detection of activated platelets in symptomatic human carotid artery endarterectomy specimens ex vivo.
European Heart Journal.
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von zur Muehlen CSchiffer EZuerbig PMischak HBode CPeter K. Urine Proteome Patterns Can Identify Atherosclerosis and in Particular Coronary Artery Disease.
Arteriosclerosis, Thrombosis and Vascular Biology.
E39-E39.
2009
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Eisenhardt SUThiele JRWoollard KJvon Dobschuetz ESommer OPeter KBannasch HStark GB. A causal role of C-reactive protein (CRP) in inflammation: Conformational rearrangement in C-reactive protein is required for enhanced pro-inflammatory leukocyte activation and leukocyte adhesion.
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Muhlen CVZElverfeldt DVPeter KHagemeyer C. Single-chain antibodies as diagnostic tools and therapeutic agents.
Thrombosis and Haemostasis.
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von Zur Muehlen CElverfeldt DMoeller JChoudhury RHagemeyer CSchwarz MBode CPeter K. A Magnetic Resonance Imaging Contrast Agent Targeted Towards Activated Platelets Allows In Vivo Detection of Thrombosis and Monitoring of Thrombolysis.
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Straub AWestein EBassler NJia FYuan YJackson SHickey MJPeter K. Mechanisms of Cold-Induced Platelet Dysfunction: P2Y12 Receptor Blockade Protects Platelets during Hypothermia as Employed in Clinical Settings.
Circulation.
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Ahrens IEllwanger CChen YCNicole BSmith BNeudorfer ILudwig ABode CPeter K. Selenium supplementation downregulates monocyte rolling and adhesion via metalloproteinase-dependent L-selectin shedding from monocytes.
Arteriosclerosis, Thrombosis and Vascular Biology.
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Schwarz MRakemus ABassler NBode CPeter K. Design of activation-specific GPIlb/Illa inhibiting peptides.
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Hagemeyer CEEisenhardt SUBassler NStoll PSchwarz MChen YCAhrens IBode CPeter K. Simultaneous clot-largeted factor Xa inhibition and selective blockade of activated GPIlb/IIIa on platelets results in delayed but potent antithrombotic effects without bleeding time prolongation.
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Zirlik AMaier CGerdes NBavendiek UErnst SSchoenbeck UBode CLibby PPeter K. Mac-1 mediates CD40L-induced inflammation independently from CD40.
European Heart Journal.
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European Heart Journal.
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Arteriosclerosis, Thrombosis and Vascular Biology.
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Bassler NLoeffler CMangin PYuan YSchwarz MHagemeyer CEEisenhardt SUAhrens IBode CJackson SPPeter K. Mechanism of paradoxical platelet activation induced by blockers of platelet integrin alpha(IIb)beta(3) (GPIIb/IIIa).
Arteriosclerosis, Thrombosis and Vascular Biology.
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von zur Muehlen CAli ZSchneider JMcAteer MChannon KBode CPeter KChoudhury R. Activated platelets canLiblilla be imaged by activation-specific glycoprotein IIb/IIIa antibodies conjugated to iron oxide microparticles in an ex vivo magnetic resonance imaging mouse model.
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Schwarz MSchallner NPeter K. Generation of activation-specific human anti mac-1 (alpha M beta 2, CD 11b/CD18) single-chain antibodies as potential diagnostic tools and therapeutic agents.
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Von Zur Muhlen CElverfeldt DBassler NNeudorfer IBode CPeter K. MAC-1 mediates Superparamagnetic Iron Oxide Uptake into human monocytes as quantified by MRI and flow cytometry.
European Heart Journal.
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Ahrens IGEllwanger CNeudorfer IBode CBassler NPeter K. ISOLATED MONOCYTES EXPOSED TO SELENIUM EXHIBIT DECREASED ADHESION UNDER SHEAR STRESS THROUGH MMP DEPENDENT L-SELECTIN (CD62L) SHEDDING..
Critical Care Medicine.
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Ahrens IGMoran NMeade GMoser MPlenzig SFitzgerald DJBode CPeter K. The crucial role of the alpha-cytoplasmic tail for integrin alphaVbeta(3) dependent adhesion, cytoskeleton organisation and spreading under shear stress.
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Conzen PFFischer SDetter CPeter K. Sevoflurane Provides Greater Protection of the Myocardium than Propofol in Patients Undergoing Off-pump Coronary Artery Bypass Surgery.
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Decker MWeirich UNordt TBauer SKreuzer JBode CPeter K. Transfection with DNA of soluble VCAM-1 causes monocyte chemotaxis and increased endothelial cell staining: A new gene-therapeutic approach for angiogenesis?.
Journal of the American College of Cardiology.
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Marheineke SPeter K. Gene transfer of a fusion protein confers a specific functional blockade of vascular cell adhesion molecule-1 (VCAM-1; CD106) and results in a decreased recruitment of monocytes.
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Zirlik ALaugers APeter KNordt TK. Inhibition of plasminogen activator inhibitor type-1 expression in human adipose tissue - A new pleiotropic effect of selected glitazones.
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Peter KTovic IGraeber JWeirich UBauer SRuef JNordt TLittle MBode C. Construction and functional evaluation of a new fibrin-targeted fibrinolytic: A recombinant fusion protein with an anti-fibrin single-chain antibody and a low molecular weight form single-chain urokinase.
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Bertram UMoser MNordt TPeter KRuef J. Effects of different thrombolytic treatment regimen with abciximab and tirofiban on platelet aggregation and platelet-leukocyte interaction.
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Nordt TKEschenfelder EPeter KSobel BEBode C. Attenuation of PAI-1 synthesis by troglitazone in human arterial smooth muscle cells is affected by the 4g/5g polymorphism in the promoter of the PAI-1 gene.
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Ruef JMoser MSchwarz MPeter KNordt TKKubler WBode C. Induction of endothelin-1 expression by oxidative stress in vascular smooth muscle cells.
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Peter KAssefa DYianne JMahreineke SNordt TRuef JBode C. Immobilized heparin mediates cell adhesion by its binding to the leukocyte integrin Mac-1.
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1997
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Nordt TWeckesser SPeter KFuji SBode C. Differential regulation of insulin-induced expression of 2.2 kb and 3.2 kb PAI-1 mRNA by gemfibrozil.
Circulation.
3045-3045.
1997
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Peter KYlanne JNordt TLKohler BMoser MBode C. Distinct roles of ligand affinity and cytoskeletal anchorage in GP IIb/IIIa (alpha IIb beta 3)-mediated cell aggregation and adhesion.
Circulation.
11-11.
1997
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Peter KSchwarz MYlanne JNordt TLKohler BBode C. Induction of fibrinogen binding and platelet aggregation as an intrinsic property of various GP IIb/IIIa (allbb3) inhibitors.
Circulation.
3714-3714.
1997
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Bode CMoser MKohler BSchmittner MPeter KNordt TLSmalling RW. Platelet function during and after thrombolytic therapy for acute myocardial infarction with reteplase, alteplase, or streptokinase.
Circulation.
2997-2997.
1997
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Bode CPeter KNordt TKRuef JSmalling RWKübler W. Pharmacology and clinical efficacy of reteplase.
Fibrinolysis.
29-33.
1997
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Nordt TKPeter KKübler WBode C. Regulation of the synthesis of plasminogen activator inhibitor type 1 (PAI-1): pathogenetic mechanism of atherosclerosis in diabetes mellitus?.
Fibrinolysis.
141-147.
1997
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Bode CNordt TKPeter KRuef JRunge MSKübler W. Targeting of thrombolytic and antithrombotic agents.
Fibrinolysis.
63-70.
1997
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Bode CPeter KNordt TKohler BMoser MRuef JRunge MS. New developments in thrombolytic therapy.
Fibrinolysis.
109-114.
1997
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Nordt TKMoser MKohler BPeter KBode C. Attenuated success rate of thrombolysis for acute myocardial infarction by reduced endogenous fibrinolysis.
Journal of the American College of Cardiology.
96291-96291.
1997
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Nordt TKMoser MPeter KKohler BBode C. Increased platelet aggregation during coronary thrombolysis as a predictor for early and late reocclusion.
Journal of the American College of Cardiology.
79115-79115.
1997
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Peter KSchwarz MMajer PKohler BNordt TBode C. The antibody fragment c7E3 (ReoPro(R)) binds to activated and nonactivated Mac-1 on granulo- and monocytes and blocks Mac-1-mediated cell adhesion and aggregation.
Journal of the American College of Cardiology.
97487-97487.
1997
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Peter KHaller CMajer PLee YSNordt TKreuzer JBode C. The construction of a fusion protein for the inhibition of integrin mediated cell adhesion.
Circulation.
3030-3030.
1996
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PETER KOTOOLE TE. A DELETION IN THE ALPHA-SUBUNIT LOCKS INTEGRIN ALPHA(IIB) BETA-3 IN A HIGH-AFFINITY STATE.
Circulation.
346-346.
1994
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PETER KGUPTA ARUEF JRUNGE MBODE C. A RECOMBINANT MOLECULE WITH HIGH-AFFINITY FOR FIBRIN EXHIBITS ANTITHROMBIN ACTIVITY AFTER CLEAVAGE BY FACTOR-XA.
Circulation.
348-348.
1994
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BODE CKOHLER BNORDT TPETER KRUEF JVONHODENBERG ESMALLING RW. THROMBIN ACTIVITY DURING AND AFTER THROMBOLYSIS WITH RETEPLASE OR ALTEPLASE IN PATIENTS WITH ACUTE MYOCARDIAL-INFARCTION.
Circulation.
563-563.
1994
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Wang XSearle APeter K. Targeted Drug Therapy To Provide Effective And Localised Anticoagulation Without Impairing Haemostasis.
Atherosclerosis.
e33-e33.
2019
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editorial article
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Wang XPeter K. Mending the failing heart.
Aging.
11:1605-1606.
2019
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Yap MLPeter K. Molecular Positron Emission Tomography in Cardiac Ischemia/Reperfusion Providing a Path to Personalized Medicine!.
Circulation Research.
124:827-829.
2019
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Bienvenu LAWang XPeter K. Prime time viewing of the ischaemic heart: new technologies allow imaging and flow assessment of the microvasculature in the beating heart.
Cardiovascular Research.
115.
2019
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Guzik TJAntoniades CBaker AHHarrison DGLoughrey CMMaffia PMurphy ENicklin SAPeter KPearson JCasadei B. What matters in Cardiovascular Research? Scientific discovery driving clinical delivery.
Cardiovascular Research.
114:1565-1568.
2018
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Huang ALBosco JJPeter K. Mast Cell.
Circulation Research.
121:899-901.
2017
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McFadyen JDMeikle PJPeter K. Platelet lipidomics: a window of opportunity to assess cardiovascular risk?.
European Heart Journal.
38:2006-2008.
2017
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Santos-Gallego CGWallert MPeter K. Myocardial infarction caused by surgery: Blame inflammation not the surgeon.
Atherosclerosis.
255:113-116.
2016
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Chen YCPeter K. Determining the characteristics of human atherosclerosis: A difficult but indispensable task providing the direction and proof of concept for pioneering atherosclerosis research in animal models.
Atherosclerosis.
241:595-596.
2015
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Htun NMPeter K. Non-vitamin K antagonist oral anticoagulants (NOACs) in the cardiac catherisation laboratory: Friends or foes?.
Thrombosis and Haemostasis.
114:214-216.
2015
Full text if available
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Wang XPeter K. Mending the failing heart.
Aging.
11:1605-1606.
2019
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letter
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Hortmann MRobinson SMohr MHaenel DMauler MLaumann RStallmann DReinoehl JDuerschmied DPeter KBode CAhrens I. Circulating HtrA2 after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: A potential novel biomarker for mitochondrial induced cardiomyocyte apoptosis and ischemia-reperfusion injury.
International Journal of Cardiology.
437-437.
2017
Full text if available
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Hortmann MRobinson SMohr MHaenel DMauler MLaumann RStallmann DReinoehl JDuerschmied DPeter KBode CAhrens I. Circulating HtrA2 after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: A potential novel biomarker for mitochondrial induced cardiomyocyte apoptosis and ischemia-reperfusion injury.
International Journal of Cardiology.
437-437.
2017
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other publication
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Htun NMPeter K. Coagulation disorders and aortic stenosis: a chicken and egg question?.
Journal of Thrombosis and Haemostasis.
731-732.
2013
Full text if available
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Htun NMPeter K. Coagulation disorders and aortic stenosis: a chicken and egg question?.
Journal of Thrombosis and Haemostasis.
731-732.
2013