For her doctorate, Kaye studied molecular chaperone assisted protein folding in thermophilic bacteria under the supervision of Prof. Robert Scopes. In 1999, shortly after obtaining her PhD, she was awarded an Alexander von Humboldt Research Fellowship to examine the protein import machinery in mitochondria of yeast and was hosted by Prof. Nikolaus Pfanner (Institute for Biochemistry and Molecular Biology, Freiburg, Germany). In 2001 Kaye was promoted to group leader within the Pfanner lab where she continued her studies on the molecular mechanisms of mitochondrial protein translocation. In 2004 she was awarded a QEII Fellowship by the Australian Research Council to study protein degradation by AAA+ proteases in bacteria and mitochondria. In 2009 Kaye was awarded an ARC Future Fellowship to extend her research in the area of mitochondrial protein homeostasis focusing on the role of AAA+ proteases in protein quality control and the mitochondrial unfolded protein response. Kaye is currently a Senior Lecturer and is examining mitochondrial protein biogenesis pathways and protein homeostasis networks in relation to human health and disease.