selected publications
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academic article
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Miles MAHawkins CJ. In vitro analysis reveals necroptotic signaling does not provoke DNA damage or HPRT mutations.
Cell Death and Disease.
11:680.
2020
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Miles MACaruso SBaxter AAPoon IKHHawkins CJ. Smac mimetics can provoke lytic cell death that is neither apoptotic nor necroptotic.
Apoptosis: an international journal on programmed cell death.
25:500-518.
2020
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Harris MAHawkins CJMiles MA. Tetrazolium reduction assays under-report cell death provoked by clinically relevant concentrations of proteasome inhibitors.
Molecular Biology Reports: an international journal on molecular and cellular biology.
47:1-8.
2020
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Harris MAMiles MAShekhar TMCerra CGeorgy SRRyan SDCannon CMHawkins CJ. The proteasome inhibitor ixazomib inhibits the formation and growth of pulmonary and abdominal osteosarcoma metastases in mice.
Cancers.
12:1-18.
2020
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Harris MShekhar TCoupland LAMiles MHawkins C. Transient NK cell depletion facilitates pulmonary osteosarcoma metastases after intravenous inoculation in athymic mice.
Journal of Adolescent and Young Adult Oncology.
2020
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Bloomer DTKitevska-Ilioski TPantaki DJi YMiles MAHeras BHawkins CJ. CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently produces caspase-1-specific variants.
Biochemical Journal.
476:1335-1357.
2019
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Atkin-Smith GKMiles MATixeira RLay FTDuan MHawkins CJPhan TKPaone SMathivanan SHulett MDChen WPoon IKH. Plexin B2 is a regulator of monocyte apoptotic cell disassembly.
Cell Reports.
29:1821-1831.e3.
2019
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Miles MAHarris MAHawkins CJ. Proteasome inhibitors trigger mutations via activation of caspases and CAD, but mutagenesis provoked by the HDAC inhibitors vorinostat and romidepsin is caspase/CAD-independent.
Apoptosis: an international journal on programmed cell death.
24:404-413.
2019
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Miles MAHawkins CJ. Mutagenic assessment of chemotherapy and Smac mimetic drugs in cells with defective DNA damage response pathways.
Scientific Reports.
8:1-14.
2018
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Miles MAHawkins CJ. Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine.
Cell Death and Disease.
8:1-13.
2017
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Shekhar TMMiles MAGupte ATaylor STascone BWalkley CRHawkins CJ. IAP antagonists sensitize murine osteosarcoma cells to killing by TNF alpha.
Oncotarget.
7:33866-33886.
2016
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Miles MAShekhar TMHall NEHawkins CJ. TRAIL causes deletions at the HPRT and TK1 loci of clonogenically competent cells.
Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis.
787:15-31.
2016
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Shekhar TMGreen MMRayner DMMiles MACutts SMHawkins CJ. Inhibition of Bcl-2 or IAP proteins does not provoke mutations in surviving cells.
Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis.
777:23-32.
2015
Full text if available
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Miles MAHawkins CJ. In vitro analysis reveals necroptotic signaling does not provoke DNA damage or HPRT mutations.
Cell Death and Disease.
11:680.
2020
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chapter
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Miles MAKitevska-Ilioski THawkins CJ. Old and Novel Functions of Caspase-2.
International Review of Cell and Molecular Biology.
155-212.
2017
Full text if available
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Miles MAKitevska-Ilioski THawkins CJ. Old and Novel Functions of Caspase-2.
International Review of Cell and Molecular Biology.
155-212.
2017