selected publications
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academic article
- Sakthianandeswaren AParsons MJMouradov DMacKinnon RNCatimel BLiu SPalmieri MLove CJorissen RNLi SWhitehead LPutoczki TLPreaudet ATsui CNowell CJWard RLHawkins NJDesai JGibbs PErnst MStreet IBuchert MSieber OM. MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors . Cancer Discovery. 8:988-1005. 2018
- Ziegler PKBollrath JPallangyo CKMatsutani TCanli ÖDe Oliveira TDiamanti MAMüller NGamrekelashvili JPutoczki THorst DMankan AKÖner MGMüller SMüller-Höcker JKirchner TSlotta-Huspenina JTaketo MMReinheckel TDröse SLarner ACWels WSErnst MGreten TFArkan MCKorn TWirth DGreten FR. Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis. Cell. 174:88-101.e16. 2018
- Eissmann MFDijkstra CWouters MABaloyan DMouradov DNguyen PMDavalos-Salas MPutoczki TLSieber OMMariadason JMErnst MMasson F. Interleukin 33 Signaling Restrains Sporadic Colon Cancer in an Interferon-γ–Dependent Manner. Cancer immunology research. 6:409-421. 2018
- Schmidt SSchumacher NSchwarz JTangermann SKenner LSchlederer MSibilia MLinder MAltendorf-Hofmann AKnösel TGruber ESOberhuber GBolik JRehman ASinha ALokau JArnold PCabron ASZunke FBecker-Pauly CPreaudet ANguyen PHuynh JAfshar-Sterle SChand ALWestermann JDempsey PJGarbers CSchmidt-Arras DRosenstiel PPutoczki TErnst MRose-John S. ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling. Journal of Experimental Medicine. 215:1205-1225. 2018
- Deswaerte VNguyen PWest ABrowning AFYu LRuwanpura SMBalic JLivis TGirard CPreaudet AOshima HFung KYTye HNajdovska MErnst MOshima MGabay CPutoczki TJenkins BJ. Inflammasome adaptor ASC suppresses apoptosis of gastric cancer cells by an IL18-mediated inflammation-independent mechanism. Cancer Research. 78:1293-1307. 2018
- O’Reilly LAPutoczki TLMielke LALow JTLin APreaudet AHerold MJYaprianto KTai LKueh APacini GFerrero RLGugasyan RHu YChristie MWilcox SGrumont RGriffin MDWO’Connor LSmyth GKErnst MWaring PGerondakis SStrasser A. Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner. Immunity. 48:570-583.e8. 2018
- Poh ARErnst M. Targeting Macrophages in Cancer: From Bench to Bedside. Frontiers in Oncology. 8:1-16. 2018
- Morrow RJEtemadi NYeo BErnst M. Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast Cancer. Mediators of Inflammation. 2017:1-15. 2017
- Alorro MGPierce TPEissmann MFDijkstra CDickins RAErnst MBuchert MMasson F. Generation of an inducible mouse model to reversibly silence Stat3. Genesis. 55:1-10. 2017
- Poh ARLove CGMasson FPreaudet ATsui CWhitehead LMonard SKhakham YBurstroem LLessene GSieber OLowell CPutoczki TLO'Donoghue RJJErnst M. Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression. Cancer Cell. 31:563-575.e5. 2017
- Ahmed AUYim HCHAlorro MErnst MWilliams BRG. Integrin-Linked Kinase Expression in Myeloid Cells Promotes Inflammatory Signaling during Experimental Colitis. Journal of Immunology. 199:2128-2139. 2017
- Flanagan DJBarker NNowell CClevers HErnst MPhesse TJVincan E. Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo. Disease Models and Mechanisms. 10:971-980. 2017
- Huynh JEtemadi NHollande FErnst MBuchert M. The JAK/STAT3 axis: A comprehensive drug target for solid malignancies. Seminars in Cancer Biology. 45:13-22. 2017
- Coulson RLiew SHConnelly AAYee NSDeb SKumar BVargas ACO’Toole SAParslow ACPoh APutoczki TMorrow RJAlorro MLazarus KAYeap EFWWalton KLHarrison CAHannan NJGeorge AJClyne CDErnst MAllen AMChand AL. The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma. Oncotarget. 8:18640-18656. 2017
- Xin AMasson FLiao YPreston SGuan TGloury ROlshansky MLin JXSpeed TPSmyth GKErnst MLeonard WJPellegrini MKaech SNutt SShi WBelz GKallies A. A combinatorial threshold model for effector differentiation of CD8+ T cells mediated by Blimp-1 and T-bet. Nature Immunology. 17:422-432. 2016
- Xin AMasson FLiao YPreston SGuan TGloury ROlshansky MLin J-XLi PSpeed TPSmyth GKErnst MLeonard WJPellegrini MKaech SMNutt SLShi WBelz GTKallies A. A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet. Nature Immunology. 17:422-432. 2016
- Eissmann MAtapattu LSaha NChheang CEissman MFXu KVail MEHii LLlerena CLiu ZHorvay KAbud HEKusebauch UMoritz RLDing B-SCao ZRafii SErnst MScott AMNikolov DBLackmann MJanes PW. An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth. Journal of Experimental Medicine. 213:1741-1757. 2016
- Patel ODai WMentzel MGriffin MDWSerindoux JGay YFischer SSterle SKropp ABurns CJErnst MBuchert MLucet IS. Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1. Structure. 24:1550-1561. 2016
- Duan MSteinfort DPSmallwood DHew MChen WErnst MIrving LBAnderson GPHibbs ML. CD11b immunophenotyping identifies inflammatory profiles in the mouse and human lungs. Mucosal Immunology. 9:550-563. 2016
- Thiem SEissmann MFStuart EElzer JJonas ABuchert MErnst M. Inducible gene modification in the gastric epithelium of Tff1-CreERT2, Tff2-rtTA, Tff3-luc mice. Genesis. 54:626-635. 2016
- Malaterre JPereira LPutoczki TMillen RPaquet-Fifield SGermann MLiu JCheasley DSampurno SStacker SAAchen MGWard RLWaring PMantamadiotis TErnst MRamsay RG. Intestinal-specific activatable Myb initiates colon tumorigenesis in mice. Oncogene. 35:2475-2484. 2016
- Poh ARO'Donoghue RJJErnst MPutoczki TL. Mouse models for gastric cancer: Matching models to biological questions. Journal of Gastroenterology and Hepatology. 31:1257-1272. 2016
- Thiem SEissmann MFElzer JJonas APutoczki TLPoh ANguyen PPreaudet AFlanagan DVincan EWaring PBuchert MJarnicki AErnst M. Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model. Cancer Research. 76:2277-2287. 2016
- Buchert MBurns CJErnst M. Targeting JAK kinase in solid tumors: emerging opportunities and challenges. Oncogene. 35:939-951. 2016
- Etemadi NChopin MAnderton HTanzer MCRickard JAAbeysekera WHall CSpall SKWang BXiong YHla TPitson SMBonder CSWong WW-LErnst MSmyth GKVaux DLNutt SLNachbur USilke J. TRAF2 regulates TNF and NF-kappa B signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1. eLife. 4:1-27. 2015
- Buchert MRohde FEissmann MTebbutt NWilliams BTan CWOwen AHirokawa YGnann AOrend GOrner GDashwood RHHeath JKErnst MJanssen K-P. A hypermorphic epithelial beta-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations. Disease Models and Mechanisms. 8:1361-1373. 2015
- Johnstone CNChand APutoczki TLErnst M. Emerging roles for IL-11 signaling in cancer development and progression: Focus on breast cancer. Cytokine and Growth Factor Reviews. 26:489-498. 2015
- Flanagan DJPhesse TJBarker NSchwab RHMAmin NMalaterre JStange DENowell CJCurrie SASaw JTSBeuchert ERamsay RGSansom OJErnst MClevers HVincan E. Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells. Stem Cell Reports. 4:759-767. 2015
- Williams BBTebbutt NCBuchert MPutoczki TLDoggett KBao SJohnstone CNMasson FHollande FBurgess AWScott AMErnst MHeath JK. Glycoprotein A33 deficiency: A new mouse model of impaired intestinal epithelial barrier function and inflammatory disease. Disease Models and Mechanisms. 8:805-815. 2015
- Poh ARO'Donoghue RJJErnst M. Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells. Oncotarget. 6:15752-15771. 2015
- Putoczki TLErnst M. IL-11 signaling as a therapeutic target for cancer. Immunotherapy. 7:441-453. 2015
- Ernst MPreaudet APutoczki T. Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice. Journal of Visualized Experiments. 2015. 2015
- Nguyen PMPutoczki TLErnst M. STAT3-activating cytokines: A therapeutic opportunity for inflammatory bowel disease?. Journal of Interferon and Cytokine Research. 35:340-350. 2015
- Pearson HBMcGlinn EPhesse TJSchlueter HSrikumar AGoedde NJWoelwer CBRyan APhillips WAErnst MKaur PHumbert P. The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis. Molecular Cancer. 14:1-16. 2015
- Rickard JO’Donnell JEvans JLalaoui NPoh ARogers TVince JLawlor KNinnis RAnderton HHall CSpall SPhesse TAbud HCengia LCorbin JMifsud SDi Rago LMetcalf DErnst MDewson GRoberts AAlexander WMurphy JEkert PMasters SVaux DCroker BGerlic MSilke J. RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis. Cell. 157:1175-1188. 2014
- Kennedy CLNajdovska MTye HMcLeod LYu LJarnicki ABhathal PSPutoczki TErnst MJenkins BJ. Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis. Oncogene. 33:2540-2546. 2014
- Ernst MThiem SNguyen PMEissmann MPutoczki TL. Epithelial gp130/Stat3 functions: An intestinal signaling node in health and disease. Seminars in Immunology. 26:29-37. 2014
- Humphries JMPenno MASWeiland FKlingler-Hoffmann MZuber ABoussioutas AErnst MHoffmann P. Identification and validation of novel candidate protein biomarkers for the detection of human gastric cancer. BBA: Proteins and Proteomics. 1844:1051-1058. 2014
- Ernst MPutoczki TL. Molecular pathways: IL11 as a tumor-promoting cytokine-translational implications for cancers. Clinical Cancer Research. 20:5579-5588. 2014
- Phesse TJBuchert MStuart EFlanagan DJFaux MAfshar-Sterle SWalker FZhang HHNowell CJJorissen RTan CWHirokawa YEissmann MFPoh ARMalaterre JPearson HBKirsch DGProvero PPoli VRamsay RGSieber OBurgess AWHuszar DVincan EErnst M. Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration. Science Signaling. 7:1-12. 2014
- Hare LMPhesse TJWaring PMMontgomery KGKinross KMMills KRoh VHeath JKRamsay RGErnst MPhillips WA. Physiological expression of the PI3K-activating mutation Pik3ca H1047R combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice. Biochemical Journal. 458:251-258. 2014
- Ciprotti MChong GGan HKChan AMurone CMacGregor DLee FTJohns TGHeath JKErnst MBurgess AWScott AM. Quantitative intratumoural microdistribution and kinetics of 131I-huA33 antibody in patients with colorectal carcinoma. EJNMMI Research. 4:1-10. 2014
- Elsum IAYates LLPearson HBPhesse TJLong FO'Donoghue RErnst MCullinane CHumbert PO. Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo. Oncogene. 33:5523-5533. 2014
- Infantino SJones SAWalker JAMaxwell MJLight AO'Donnell KTsantikos EPeperzak VPhesse TErnst MMackay FHibbs MLFairfax KATarlinton DM. The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice. Science Signaling. 7:1-10. 2014
- Stuart EBuchert MPutoczki TThiem SFarid RElzer JHuszar DWaring PMPhesse TJErnst M. Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice. Molecular Cancer Therapeutics. 13:468-474. 2014
- Carow BReuschl AKGavier-Widén DJenkins BJErnst MYoshimura AChambers BJRottenberg ME. Critical and Independent Role for SOCS3 in Either Myeloid or T Cells in Resistance to Mycobacterium tuberculosis. PLoS Pathogens. 9:1-20. 2013
- Putoczki TLThiem SLoving ABusuttil RAWilson NJZiegler PKNguyen PMPreaudet AFarid REdwards KMBoglev YLuwor RBJarnicki AHorst DBoussioutas AHeath JKSieber OMPleines IKile BTNash AGreten FRMcKenzie BSErnst M. Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell. 24:257-271. 2013
- Tsantikos EMaxwell MJPutoczki TErnst MRose-John STarlinton DMHibbs ML. Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice. Arthritis and Rheumatism. 65:2691-2702. 2013
- Thiem SPierce TPPalmieri MPutoczki TLBuchert MPreaudet AFarid ROLove CCatimel BLei ZRozen SGopalakrishnan VSchaper FHallek MBoussioutas ATan PJarnicki AErnst M. mTORC1 inhibition restricts infammation-associated gastrointestinal tumorigenesis in mice. Journal of Clinical Investigation. 123:767-781. 2013
- Penno MASKlingler-Hoffmann MBrazzatti JABoussioutas APutoczki TErnst MHoffmann P. 2D-DIGE analysis of sera from transgenic mouse models reveals novel candidate protein biomarkers for human gastric cancer. Journal of Proteomics. 77:40-58. 2012
- Ernst MRamsay RG. Colorectal cancer mouse models: integrating inflammation and the stroma. Journal of Gastroenterology and Hepatology. 27:39-50. 2012
- Penno MErnst MHoffmann P. Comparative 2D DIGE analysis of the depleted serum proteome for biomarker discovery. Methods in Molecular Biology. 854:207-220. 2012
- Malaterre JMcPherson CSDenoyer DLai EHagekyriakou JLightowler SShudo KErnst MAshley DMShort JLWheeler GRamsay RG. Enhanced lithium-induced brain recovery following cranial irradiation is not impeded by inflammation. Stem cells translational medicine. 1:469-479. 2012
- O'Donoghue RJJKnight DARichards CDPrêle CMLau HLJarnicki AGJones JBozinovski SVlahos RThiem SMcKenzie BSWang BStumbles PLaurent GJMcAnulty RJRose-John SZhu HJAnderson GPErnst MRMutsaers SE. Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis. EMBO Molecular Medicine. 4:939-951. 2012
- Traum DTimothee PSilver JRose-John SErnst MLaRosa DF. IL-10-induced gp130 expression in mouse mast cells permits IL-6 trans-signaling. Journal of Leukocyte Biology. 91:427-435. 2012
- Nishina TKomazawa-Sakon SYanaka SPiao XZheng DMPiao JHKojima YYamashina SSano EPutoczki TDoi TUeno TEzaki JUshio HErnst MTsumoto KOkumura KNakano H. Interleukin-11 links oxidative stress and compensatory proliferation. Science Signaling. 5. 2012
- Greenhill CJGould JErnst MJarnicki AHertzog PJMansell AJenkins BJ. LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling. Immunology and Cell Biology. 90:559-563. 2012
- Ernst MPutoczki TL. Stat3: Linking inflammation to (gastrointestinal) tumourigenesis. Clinical and Experimental Pharmacology and Physiology. 39:711-718. 2012
- Greenhill CJRose-John SLissilaa RFerlin WErnst MHertzog PJMansell AJenkins BJ. IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3. Journal of Immunology. 186:1199-1208. 2011
- Cao YDepinho RAErnst MVousden K. Cancer research: Past, present and future. Nature Reviews: Cancer. 11:749-754. 2011
- Haroon FDrögemüller KHändel UBrunn AReinhold DNishanth GMueller WTrautwein CErnst MDeckert MSchlüter D. Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation. Journal of Immunology. 186:6521-6531. 2011
- Silver JSStumhofer JSPassos SErnst MHunter CA. IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondii. Journal of Immunology. 187:350-360. 2011
- Ruwanpura SMMcLeod LMiller AJones JBozinovski SVlahos RErnst MArmes JBardin PGAnderson GPJenkins BJ. Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice. American Journal of Respiratory Cell and Molecular Biology. 45:720-730. 2011
- Sakthianandeswaren AChristie MD'Andreti CTsui CJorissen RNLi SFleming NIGibbs PLipton LMalaterre JRamsay RGPhesse TJErnst MJeffery REPoulsom RLeedham SJSegditsas STomlinson IPMBernhard OKSimpson RJWalker FFaux MCChurch NCatimel BFlanagan DJVincan ESieber OM. PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis. Cancer Research. 71:3709-3719. 2011
- Itman CWong CHunyadi BErnst MJans DALoveland KL. SMAD3 dosage determines androgen responsiveness and sets the pace of postnatal testis development. Endocrinology. 152:2076-2089. 2011
- Putoczki TErnst M. More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer. Journal of Leukocyte Biology. 88:1109-1117. 2010
- Hilfiker-Kleiner DShukla PKlein GSchaefer AStapel BHoch MMuller WScherr MTheilmeier GErnst MHilfiker ADrexler H. Continuous Glycoprotein-130-Mediated Signal Transducer and Activator of Transcription-3 Activation Promotes Inflammation, Left Ventricular Rupture, and Adverse Outcome in Subacute Myocardial Infarction. Circulation. 122:145-155. 2010
- Kirsch MTrautmann NErnst MHofmann H-D. Involvement of gp130-associated cytokine signaling in Müller cell activation following optic nerve lesion. Glia. 58:768-779. 2010
- Pereira-Fantini PMJudd LMKalantzis APeterson AErnst MHeath JKGiraud AS. A33 antigen-deficient mice have defective colonic mucosal repair. Inflammatory Bowel Diseases. 16:604-612. 2010
- Mejías-Luque RLindén SKGarrido MTye HNajdovska MJenkins BJIglesias MErnst Mde Bolós C. Inflammation modulates the expression of the intestinal mucins MUC2 and MUC4 in gastric tumors. Oncogene. 29:1753-1762. 2010
- Buchert MAthineos DAbud HEBurke ZDFaux MCSamuel MSJarnicki AGWinbanks CENewton IPMeniel VSSuzuki HStacker SANäthke ISTosh DHuelsken JClarke ARHeath JKSansom OJErnst M. Genetic Dissection of Differential Signaling Threshold Requirements for the Wnt/β-Catenin Pathway In Vivo. PLoS Genetics. 6:e1000816-e1000816. 2010
- Jarnicki APutoczki TErnst M. Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?. Cell Division. 5:14-14. 2010
- Ciznadija DTothill RWaterman MLZhao LHuynh DYu RMErnst MIshii SMantamadiotis TGonda TJRamsay RGMalaterre J. Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling. Cell Death and Differentiation. 16:1530-1538. 2009
- Penno MASErnst MHoffmann P. Optimal preparation methods for automated matrix-assisted laser desorption/ionization time-of-flight mass spectrometry profiling of low molecular weight proteins and peptides. Rapid Communications in Mass Spectrometry. 23:2656-2662. 2009
- Samuel MSSuzuki HBuchert MPutoczki TLTebbutt NCLundgren–May TChristou AInglese MToyota MHeath JKWard RLWaring PMErnst M. Elevated Dnmt3a Activity Promotes Polyposis in ApcMin Mice by Relaxing Extracellular Restraints on Wnt Signaling. Gastroenterology. 137:902-913.e11. 2009
- Steinberg GRWatt MJErnst MBirnbaum MJKemp BEJorgensen SB. Ciliary Neurotrophic Factor Stimulates Muscle Glucose Uptake by a PI3-Kinase-Dependent Pathway That Is Impaired With Obesity. Diabetes. 58:829-839. 2009
- Howlett MGiraud ASLescesen HJackson CBKalantzis AVan Driel IRRobb LVan der Hoek MErnst MMinamoto TBoussioutas AOshima HOshima MJudd LM. The Interleukin-6 Family Cytokine Interleukin-11 Regulates Homeostatic Epithelial Cell Turnover and Promotes Gastric Tumor Development. Gastroenterology. 136:967-977.e3. 2009
- Bollrath JPhesse TJvon Burstin VAPutoczki TBennecke MBateman TNebelsiek TLundgren-May TCanli ÖSchwitalla SMatthews VSchmid RMKirchner TArkan MCErnst MGreten FR. gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis. Cancer Cell. 15:91-102. 2009
- Nowell MAWilliams ASCarty SAScheller JHayes AJJones GWRichards PJSlinn SErnst MJenkins BJTopley NRose-John SJones SA. Therapeutic Targeting of IL-6 Trans Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis. Journal of Immunology. 182:613-622. 2009
- Fielding CAMcLoughlin RMMcLeod LColmont CSNajdovska MGrail DErnst MJones SATopley NJenkins BJ. IL-6 Regulates Neutrophil Trafficking during Acute Inflammation via STAT3. Journal of Immunology. 181:2189-2195. 2008
- Ernst MNajdovska MGrail DLundgren-May TBuchert MTye HMatthews VBArmes JBhathal PSHughes NRMarcusson EGKarras JGNa SSedgwick JDHertzog PJJenkins BJ. STAT3 and STAT1 mediate IL-11–dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. Journal of Clinical Investigation. 118:1727-1738. 2008
- Dierssen UBeraza NLutz HHLiedtke CErnst MWasmuth HETrautwein C. Molecular Dissection of gp130-dependent Pathways in Hepatocytes during Liver Regeneration. Journal of Biological Chemistry. 283:9886-9895. 2008
- Walker FZhang H-HMatthews VWeinstock JNice ECErnst MRose-John SBurgess AW. IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice. Blood. 111:3978-3985. 2008
- Stumhofer JSSilver JSLaurence APorrett PMHarris THTurka LAErnst MSaris CJMO'Shea JJHunter CA. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nature Immunology. 8:1363-1371. 2007
- Brender CTannahill GMJenkins BJFletcher JColumbus RSaris CJMErnst MNicola NAHilton DJAlexander WSStarr R. Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27. Blood. 110:2528-2536. 2007
- Flentjar NChu PNg AYJohnstone CNHeath JKErnst MHertzog PJPritchard MA. TGF-βRII Rescues Development of Small Intestinal Epithelial Cells in Elf3-Deficient Mice. Gastroenterology. 132:1410-1419. 2007
- Jenkins BJRoberts AWGreenhill CJNajdovska MLundgren-May TRobb LGrail DErnst M. Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis. Blood. 109:2380-2388. 2007
- Malaterre JCarpinelli MErnst MAlexander WCooke MSutton SDworkin SHeath JKFrampton JMcArthur GClevers HHilton DMantamadiotis TRamsay RG. c-Myb is required for progenitor cell homeostasis in colonic crypts. Proceedings of the National Academy of Sciences of USA. 104:3829-3834. 2007
- Boireau SBuchert MSamuel MSPannequin JRyan JLChoquet AChapuis HRebillard XAvancès CErnst MJoubert DMottet NHollande F. DNA-methylation-dependent alterations of claudin-4 expression in human bladder carcinoma. Carcinogenesis. 28:246-258. 2007
- Yeoh GCTErnst MRose-John SAkhurst BPayne CLong SAlexander WCroker BGrail DMatthews VB. Opposing roles of gp130-mediated STAT-3 and ERK-1/2 signaling in liver progenitor cell migration and proliferation. Hepatology. 45:486-494. 2007
- Samuel MSSamuel MSLundgren-May TErnst M. Identification of putative targets of DNA (cytosine-5) methylation-mediated transcriptional silencing using a novel conditionally active form of DNA methyltransferase 3a. Growth Factors. 25:426-436. 2007
- Kiu HHilton DJNicola NAErnst MMarquez RAlexander WSRoberts AWMcmanus EJ. Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFα. Growth Factors. 25:319-328. 2007
- Pietrangelo ADierssen UValli LGaruti CRump ACorradini EErnst MKlein CTrautwein C. STAT3 Is Required for IL-6-gp130–Dependent Activation of Hepcidin In Vivo. Gastroenterology. 132:294-300. 2007
- El Kasmi KCHolst JCoffre MMielke Lde Pauw ALhocine NSmith AMRutschman RKaushal DShen YSuda TDonnelly RPMyers MGAlexander WVignali DAAWatowich SSErnst MHilton DJMurray PJ. General Nature of the STAT3-Activated Anti-Inflammatory Response. Journal of Immunology. 177:7880-7888. 2006
- Judd LMBredin KKalantzis AJenkins BJErnst MGiraud AS. STAT3 Activation Regulates Growth, Inflammation, and Vascularization in a Mouse Model of Gastric Tumorigenesis. Gastroenterology. 131:1073-1085. 2006
- Stumhofer JSLaurence AWilson EHHuang ETato CMJohnson LMVillarino AVHuang QYoshimura ASehy DSaris CJMO'Shea JJHennighausen LErnst MHunter CA. Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system. Nature Immunology. 7:937-945. 2006
- Stuhlmann-Laeisz CLang SChalaris AKrzysztof PEnge SEichler JKlingmüller USamuel MErnst MRose-John SScheller J. Forced Dimerization of gp130 Leads to Constitutive STAT3 Activation, Cytokine-independent Growth, and Blockade of Differentiation of Embryonic Stem Cells. Molecular Biology of the Cell. 17:2986-2995. 2006
- Watt MJDzamko NThomas WGRose-John SErnst MCarling DKemp BEFebbraio MASteinberg GR. CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nature Medicine. 12:541-548. 2006
- Emery BMerson TDSnell CYoung KMErnst MKilpatrick TJ. SOCS3 negatively regulates LIF signaling in neural precursor cells. Molecular and Cellular Neuroscience. 31:739-747. 2006
- Vlahos RBozinovski SGualano RCErnst MAnderson GP. Modelling COPD in mice. Pulmonary Pharmacology and Therapeutics. 19:12-17. 2006
- Howlett MJudd LMJenkins BLa Gruta NLGrail DErnst MGiraud AS. Differential Regulation of Gastric Tumor Growth by Cytokines That Signal Exclusively Through the Coreceptor gp130. Gastroenterology. 129:1005-1018. 2005
- Jenkins BJGrail DNheu TNajdovska MWang BWaring PInglese MMcLoughlin RMJones SATopley NBaumann HJudd LMGiraud ASBoussioutas AZhu H-JErnst M. Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling. Nature Medicine. 11:845-852. 2005
- McLoughlin RMJenkins BJGrail DWilliams ASFielding CAParker CRErnst MTopley NJones SA. IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation. Proceedings of the National Academy of Sciences of USA. 102:9589-9594. 2005
- Sims NAJenkins BJNakamura AQuinn JMLi RGillespie MTErnst MRobb LMartin TJ. Interleukin-11 Receptor Signaling Is Required for Normal Bone Remodeling. Journal of Bone and Mineral Research. 20:1093-1102. 2005
- Ernst MWJenkins BJ. The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis. Blood. 105:3512-3520. 2005
- Klein CWüstefeld TAssmus URoskams TRose-John SMüller MManns MPErnst MTrautwein C. The IL-6–gp130–STAT3 pathway in hepatocytes triggers liver protection in T cell–mediated liver injury. Journal of Clinical Investigation. 115:860-869. 2005
- Palmer JErnst MHammacher AHertzog PJ. Constitutive activation of gp130 leads to neuroendocrine differentiation in vitro and in vivo. The Prostate. 62:282-289. 2005
- O Donoghue RJJAnderson GPBozinovski SJones JErnst MKnight DAMutsaers SE. Directed Gp130-Mediated Signaling Dissociates Inflammation from Fibrosis in Bleomycin Induced Lung Injury. Inflammation Research. 54:S215-S216. 2005
- Zhao LHart SCheng JMelenhorst JJBierie BErnst MStewart CSchaper FHeinrich PCUllrich ARobinson GWHennighausen L. Mammary Gland Remodeling Depends on gp130 Signaling through Stat3 and MAPK. Journal of Biological Chemistry. 279:44093-44100. 2004
- Jenkins BJGrail DInglese MQuilici CBozinovski SWong PErnst M. Imbalanced gp130-Dependent Signaling in Macrophages Alters Macrophage Colony-Stimulating Factor Responsiveness via Regulation of c-fms Expression. Molecular and Cellular Biology. 24:1453-1463. 2004
- Sims NAJenkins BJQuinn JMWNakamura AGlatt MGillespie MTErnst MMartin TJ. Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways. Journal of Clinical Investigation. 113:379-389. 2004
- Ernst M. Acquiring signalling specificity from the cytokine receptor gp130. Trends in Genetics. 20:23-32. 2004
- Judd LMAlderman BMHowlett MShulkes ADow CMoverley JGrail DJenkins BJErnst MGiraud AS. Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130. Gastroenterology. 126:196-207. 2004
- Ernst MWKaczmarczyk S. Threshold effects of glucose transporter-4 (GLUT4) deficiency on cardiac glucose uptake and development of hypertrophy. Journal of Molecular Endocrinology. 31:449-459. 2003
- Knight DAErnst MAnderson GPMoodley YPMutsaers SE. The role of gp130/IL-6 cytokines in the development of pulmonary fibrosis: critical determinants of disease susceptibility and progression?. Pharmacology and Therapeutics. 99:327-338. 2003
- Wong PKKCampbell IKEgan PJErnst MWicks IP. The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover. Arthritis and Rheumatism. 48:1177-1189. 2003
- Ernst MWJenkins B. Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling. Experimental Hematology. 30:1248-1256. 2002
- Tebbutt NCGiraud ASInglese MJenkins BWaring PClay FJMalki SAlderman BMGrail DHollande FHeath JKErnst M. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nature Medicine. 8:1089-1097. 2002
- Johnstone CNWhite SJTebbutt NCClay FJErnst MBiggs WHViars CSCzekay SArden KCHeath JK. Analysis of the Regulation of the A33 Antigen Gene Reveals Intestine-specific Mechanisms of Gene Expression. Journal of Biological Chemistry. 277:34531-34539. 2002
- Ernst MInglese MScholz GMHarder KWClay FJBozinovski SWaring PDarwiche RKay TSly PCollins RTurner DHibbs MLAnderson GPDunn AR. Constitutive Activation of the Src Family Kinase Hck Results in Spontaneous Pulmonary Inflammation and an Enhanced Innate Immune Response. Journal of Experimental Medicine. 196:589-604. 2002
- Orner GADashwood W-MBlum CADı́az GLi QAl-Fageeh MTebbutt NHeath JKErnst MDashwood RH. Response of Apcmin and A33ΔNβ-cat mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Mutation Research. 506-507:121-127. 2002
- Butzkueven HZhang J-GSoilu-Hanninen MHochrein HChionh FShipham KAEmery BTurnley AMPetratos SErnst MBartlett PFKilpatrick TJ. LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival. Nature Medicine. 8:613-619. 2002
- Ernst MInglese MWaring PCampbell IKBao SClay FJAlexander WSWicks IPTarlinton DMNovak UHeath JKDunn AR. Defective Gp130-Mediated Signal Transducer and Activator of Transcription (Stat) Signaling Results in Degenerative Joint Disease, Gastrointestinal Ulceration, and Failure of Uterine Implantation. Journal of Experimental Medicine. 194:189-204. 2001
- Lafage-Proust MHWesolowski GErnst MRodan GARodan SB. Retinoic acid effects on an SV-40 large T antigen immortalized adult rat bone cell line. Journal of Cellular Physiology. 179:267-275. 1999
- Ernst MNovak UNicholson SELayton JEDunn AR. The Carboxyl-terminal Domains of gp130-related Cytokine Receptors Are Necessary for Suppressing Embryonic Stem Cell Differentiation. Journal of Biological Chemistry. 274:9729-9737. 1999
- Clay FJErnst MRTrueman JWFlegg RDunn AR. The mouse Plk gene: structural characterization, chromosomal localization and identification of a processed Plk pseudogene. Gene. 198:329-339. 1997
- Starr RNovak UWillson TAInglese MMurphy VAlexander WSMetcalf DNicola NAHilton DJErnst M. Distinct Roles for Leukemia Inhibitory Factor Receptor α-Chain and gp130 in Cell Type-specific Signal Transduction. Journal of Biological Chemistry. 272:19982-19986. 1997
- Gendall ARDunn ARErnst M. Isolation and characterization of a leukemia inhibitory factor-independent embryonic stem cell line. The International Journal of Biochemistry and Cell Biology. 29:829-840. 1997
- Ernst MOates ADunn AR. gp130-mediated Signal Transduction in Embryonic Stem Cells Involves Activation of Jak and Ras/Mitogen-activated Protein Kinase Pathways. Journal of Biological Chemistry. 271:30136-30143. 1996
- Ernst MGearing DPDunn AR. Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells. The EMBO Journal. 13:1574-1584. 1994
- Ernst MParker MGRodan GA. Functional Estrogen Receptors in Osteoblastic Cells Demonstrated by Transfection with a Reporter Gene Containing an Estrogen Response Element. Molecular Endocrinology. 5:1597-1606. 1991
- Ernst MRodan GA. Estradiol Regulation of Insulin-Like Growth Factor-I Expression in Osteoblastic Cells: Evidence for Transcriptional Control. Molecular Endocrinology. 5:1081-1089. 1991
- Suva LJErnst MRodan GA. Retinoic acid increases zif268 early gene expression in rat preosteoblastic cells.. Molecular and Cellular Biology. 11:2503-2510. 1991
- ERNST MRODAN GA. Increased Activity of Insulin-Like Growth Factor (IGF) in Osteoblastic Cells in the Presence of Growth Hormone (GH): Positive Correlation with the Presence of the GHInduced IGF-Binding Protein BP-3. Endocrinology. 127:807-814. 1990
- Ernst MSchmid CFroesch E. Phenol red mimics biological actions of estradiol: Enhancement of osteoblast proliferation in vitro and of type I collagen gene expression in bone and uterus of rats in vivo. Journal of Steroid Biochemistry. 33:907-914. 1989
- ERNST MHEATH JKRODAN GA. Estradiol Effects on Proliferation, Messenger Ribonucleic Acid for Collagen and Insulin-like Growth Factor-I, and Parathyroid Hormone-Stimulated Adenylate Cyclase Activity in Osteoblastic Cells from Calvariae and Long Bones. Endocrinology. 125:825-833. 1989
- Schmid CErnst MZapf JFroesch ER. Release of insulin-like growth factor carrier proteins by osteoblasts: Stimulation by estradiol and growth hormone. Biochemical and Biophysical Research Communications. 160:788-794. 1989
- Ernst MHeath JKSchmid CFroesch RERodan GA. Evidence for a direct effect of estrogen on bone cells in vitro. Journal of Steroid Biochemistry. 34:279-284. 1989
- Ernst MSchmid CFroesch ER. Enhanced osteoblast proliferation and collagen gene expression by estradiol.. Proceedings of the National Academy of Sciences of USA. 85:2307-2310. 1988
- Ernst MFroesch ER. Growth hormone dependent stimulation of osteoblast-like cells in serum-free cultures via local synthesis of insulin-like growth factor I. Biochemical and Biophysical Research Communications. 151:142-147. 1988
- Ernst MFroesch ER. Triiodothyronine stimulates proliferation of osteoblast-like cells in serum-free culture. FEBS Letters. 220:163-166. 1987
- Ernst MFroesch ER. Osteoblastlike cells in a serum-free methylcellulose medium form colonies: Effects of insulin and insulinlike growth factor I. Calcified Tissue International. 40:27-34. 1987
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conference paper
- Prele CPearce DMiles TO'Donoghue RLucas AFear MErnst MLaurent GKnight DHoyne GMcanulty RMutsaers S. PLASMA CELL AND REGULATORY B CELL-INFILTRATION IN THE LUNGS OF BLEOMYCIN-TREATED MICE. Respirology. 70-70. 2018
- Masson FXin ALiao YPreston SGuan TGloury ROlshansky MLin J-XLi PSpeed TPSmyth GKErnst MLeonard WJPellegrini MKaech SNutt SLShi WBelz GTKallies A. A combinatorial threshold model for effector differentiation of CD8(+) T cells mediated by Blimp-1 and T-bet. European Journal of Immunology. 5-5. 2016
- Duan MSteinfort DSmallwood DHew MErnst MAnderson GIrving LHibbs MChen W. CD11b alveolar macrophage upregulation is a hallmark of acute and chronic inflammatory lung diseases. European Journal of Immunology. 432-433. 2016
- O'Donoghue RJarnicki APoh AMasson FFaux MNowell CBozinovski SAnderson GErnst M. Haemtopoietic cell kinase promotes myeloid endotypes underpinning the development of COPD and tumour progression in mice. European Journal of Immunology. 1026-1026. 2016
- Lau MTsantiskos EMaxwell MDuan EErnst MHibbs M. Increased Src kinase activity leads to chronic obstructive pulmonary disease (COPD) and lung cancer. European Journal of Immunology. 82-83. 2016
- Coulson RSDeb SErnst MAllen AChand AL. Abstract LB-257: The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma. Cancer Research. LB-257-LB-257. 2016
- Prele CIosifidis TMcAnulty RBadrian BJamieson SPearce DErnst MThompson PLaurent GKnight DAMutsaers S. Socs-Regulation Of Jak/stat Signalling In Idiopathic Pulmonary Fibrosis (ipf). American Journal of Respiratory and Critical Care Medicine. 2016
- Pereira-Fantini PMJudd LMKalantzis APeterson AJHeath JKErnst MGiraud AS. A33 antigen-deficient mice are unable to resolve mucosal damage caused by TNBS colitis. Gastroenterology. A355-A356. 2008
- Johnstone CNChang LMErnst M. AACR special meeting in cancer research: Colon cancer-genetics to prevention. Cancer Research. 6779-6783. 2002
- Ernst MHeath JKRodan GA. Estradiol enhances insulin-like growth factor I mRNA and has anabolic effects in osteoblastic cells from rat calvariae and long bones. Calcium regulation and bone metabolism. Basic and clinical aspects: proceedings of the 10th International Conference on calcium regulating hormones and bone metabolism. ICS886. 395-399. 1990
- Schmid CZapf JMeier PBoeni MErnst MFroesch ER. Hormonal regulation of insulin-like growth factor binding proteins from culturd rat hepatocytes and osteoblasts. Insuline-like Growth Factor binding proteins: proceedings of a workshop on Insuline-like Growth Factor binding proteins. ICS881. 267-274. 1989
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editorial article
- Ernst MO'Donoghue RPoh A. Targeting H(i)ck education for cancer therapy. Oncoscience. 4:11-12. 2017
- Ernst MPutoczki TL. Targeting IL-11 signaling in colon cancer. Oncotarget. 4:1860-1861. 2013
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erratum
- Etemadi NChopin MAnderton HTanzer MCRickard JAAbeysekera WHall CSpall SKWang BXiong YHla TPitson SMBonder CSWong WW-LErnst MSmyth GKVaux DLNutt SLNachbur USilke J. Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1. eLife. 1-4. 2017
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other publication
- Ernst MPutoczki T. IL-17 Cuts to the Chase in Colon Cancer. Immunity. 880-882. 2014