Professor Nick HoogenraadProfessor (Research), Biochemistry
Nick Hoogenraad was trained as an agricultural scientist in the mid 1960s after which he completed a PhD in Biochemistry in 1969. He commenced his life long interest in medical research when he joined the Pediatric department at Stanford in 1970.
Over his long career in science Nick Hoogenraad's work has focussed on mitochondrial biogenesis and on the role of molecular chaperones in protein targeting and folding in mammalian cells. His research led to the discovery of the mitochondrial stress response (mtUPR) and the role of HSP90 in the targeting and import of proteins into mitochondria of mammalian cells. He has also been active in translational research as part of the Cooperative Research Centres for Diagnostic Technologies, the CRC for Diagnostics and the CRC for Biomarker Translation (2007). With funding from the CRC his laboratory was responsible for the discovery of a receptor which when expressed in tumours in mice, caused cachexia, characterised by severe muscle wasting, fat loss and ultimately death. His group developed monoclonal antibodies which were effective in blocking this cachexia. This work, which was awarded patents in the US and Australia and was recently accepted for publication in Cell is now the subject of further work to humanise antibodies for use in human clinical trials. He has won many major awards for his research and has served on many committees. In 2010 he established the La Trobe Institute for Molecular Science and in 2011 was awarded funding from the Commonwealth government to build the LIMS facility which houses the School of Molecular Sciences and LIMS.
In his spare time Nick and his family runs a vineyard in the Diamond Valley which produces award winning Pinot Noir.