Thrombo-inflammation in cardiovascular disease: an expert consensus document from the Third Maastricht Consensus Conference on Thrombosis Academic Article uri icon

abstract

  • AbstractThrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.

authors

  • D'Alessandro, E
  • Becker, C
  • Bergmeier, W
  • Bode, C
  • Bourne, JH
  • Brown, H
  • Buller, HR
  • Ten Cate-Hoek, AJ
  • Ten Cate, V
  • Van Cauteren, YJM
  • Cheung, YFH
  • Cleuren, A
  • Coenen, D
  • Crijns, HJGM
  • De Simone, I
  • Dolleman, SC
  • Klein, CE
  • Fernandez, DI
  • Granneman, L
  • Van T Hof, A
  • Henke, P
  • Henskens, YMC
  • Huang, J
  • Jennings, LK
  • Jooss, N
  • Karel, M
  • Van Den Kerkhof, D
  • Klok, FA
  • Kremers, B
  • Lämmle, B
  • Leader, A
  • Lundstrom, A
  • Mackman, N
  • Mannucci, PM
  • Maqsood, Z
  • Van Der Meijden, PEJ
  • Van Moorsel, M
  • Moran, LA
  • Morser, J
  • Van Mourik, M
  • Navarro, S
  • Neagoe, RAI
  • Olie, RH
  • Van Paridon, P
  • Posma, J
  • Provenzale, I
  • Reitsma, PH
  • Scaf, B
  • Schurgers, L
  • Seelig, J
  • Siegbahn, A
  • Siegerink, B
  • Soehnlein, O
  • Soriano, EM
  • Sowa, MA
  • Spronk, HMH
  • Storey, RF
  • Tantiwong, C
  • Veninga, A
  • Wang, X
  • Watson, SP
  • Weitz, J
  • Zeerleder, SS
  • Ten Cate, H
  • Lina, B
  • Christoph, B
  • Marc, H
  • Peter, Karlheinz
  • Rory, K
  • Gregory, L
  • Steffen, M
  • Philipp, VH
  • Christian, W
  • Johann, W

publication date

  • 2020