Three-step two-pot automated production of NCA [18F]FDOPA with FlexLab module Academic Article uri icon

abstract

  • Automated three-step two-pot production of no-carrier-added (NCA) [18F]FDOPA was first implemented in the iPHASE FlexLab module. Decay-corrected radiochemical yield (RCY) of [18F]FDOPA synthesized by this method was 10~14% (n = 7) with a synthesis time of ~110 min [18F]FDOPA was obtained in > 95% of radiochemical purity with a molar activity of ~431 GBq/μmol. With the method successfully implementing on the commercial FlexLab module and its built-in step-by-step activity monitoring, further processes optimization would be achieved.

authors

  • Huang, YY
  • Poniger, S
  • Tsai, CL
  • Tochon-Danguy, HJ
  • Ackerman, Uwe
  • Yen, RF

publication date

  • 2020