Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes Academic Article uri icon

abstract

  • Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptional regulator has not been identified. Here, we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of tissue-resident lymphocytes, including natural killer T (NKT) cells and liver-resident NK cells, all of which share a common transcriptional program. Our results identify Hobit and Blimp1 as central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations.

authors

  • Mackay, LK
  • Minnich, M
  • Kragten, NAM
  • Liao, Yang
  • Nota, B
  • Seillet, C
  • Zaid, A
  • Man, K
  • Preston, S
  • Freestone, D
  • Braun, A
  • Wynne-Jones, E
  • Behr, FM
  • Stark, R
  • Pellicci, DG
  • Godfrey, DI
  • Belz, GT
  • Pellegrini, M
  • Gebhardt, T
  • Busslinger, M
  • Shi, Wei
  • Carbone, FR
  • Van Lier, RAW
  • Kallies, A
  • Van Gisbergen, KPJM

publication date

  • 2016