Chronic Helicobacter pylori Infection Does Not Significantly Alter the Microbiota of the Murine Stomach Academic Article uri icon

abstract

  • We examined the impact of Helicobacter pylori infection on the murine gastric microbiota by culture and terminal-restriction fragment length polymorphism and found that neither acute nor chronic H. pylori infection substantially affected the gastric microbial composition. Interestingly, the total H. pylori burden detected by real-time PCR was significantly higher than that revealed by viable counts, suggesting that the antigenic load sustaining H. pylori-induced gastritis could be considerably higher than previously believed.

authors

  • Tan, MP
  • Kaparakis, M
  • Galic, M
  • Pedersen, J
  • Pearse, M
  • Wijburg, OLC
  • Janssen, PH
  • Strugnell, RA

publication date

  • February 1, 2007