A Lysosome-Targeting AIEgen for Autophagy Visualization Academic Article uri icon

abstract

  • In this work, a morpholine-functionalized aggregation-induced emission luminogen (AIEgen), AIE-LysoY, is reported for lysosomal imaging and autophagy visualization. To attain outstanding imaging contrast, AIE-LysoY is equipped with excited state intramolecular proton transfer (ESIPT) characteristic. AIE-LysoY provides a new platform for lysosome visualization with good biocompatibility, large Stokes shift, superior signal-to-noise ratio, and high photostability.

authors

  • Leung, CWT
  • Wang, Z
  • Zhao, E
  • Hong, Y
  • Chen, S
  • Kwok, RTK
  • Leung, ACS
  • Wen, R
  • Li, B
  • Lam, JWY
  • Tang, BZ

publication date

  • 2016