An overview of the serpin superfamily Academic Article uri icon

abstract

  • Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways. Serpins are conformationally labile and many of the disease-linked mutations of serpins result in misfolding or in pathogenic, inactive polymers.

authors

  • Law, RHP
  • Zhang, Q
  • McGowan, S
  • Buckle, AM
  • Silverman, GA
  • Wong, W
  • Rosado, CJ
  • Langendorf, CG
  • Pike, RN
  • Bird, PI
  • Whisstock, JC

publication date

  • May 30, 2006