Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10 Academic Article uri icon

abstract

  • Interleukin 10 (IL-10) has a prominent function in regulating the balance between protective and pathological T cell responses. Consistent with that activity, many sources of this cytokine are found in vivo, including from myeloid cells and a variety of T cell subsets. However, although there are many pathways that regulate innate production of IL-10, the factors that govern its synthesis by the adaptive response are poorly understood. Here we report that IL-27 and IL-6 induced T helper type 1 and type 2 cells, as well as T helper cells that produce IL-17, to secrete IL-10. This effect was dependent on the transcription factors STAT1 and STAT3 for IL-27 and on STAT3 for IL-6. Our studies identify a previously unknown pathway that allows the immune system to temper inflammatory responses.

authors

  • Stumhofer, Jason S
  • Silver, Jonathan S
  • Laurence, Arian
  • Porrett, Paige M
  • Harris, Tajie H
  • Turka, Laurence A
  • Ernst, Matthias
  • Saris, Christiaan JM
  • O'Shea, John J
  • Hunter, Christopher A

publication date

  • December 2007