The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells Academic Article uri icon

abstract

  • Ets-related gene (ERG), which encodes a member of the Ets family of transcription factors, is a potent oncogene. Chromosomal rearrangements involving ERG are found in acute myeloid leukemia, acute lymphoblastic leukemia, Ewing's sarcoma and more than half of all prostate cancers; however, the normal physiological function of Erg is unknown. We did a sensitized genetic screen of the mouse for regulators of hematopoietic stem cell function and report here a germline mutation of Erg. We show that Erg is required for definitive hematopoiesis, adult hematopoietic stem cell function and the maintenance of normal peripheral blood platelet numbers.

authors

  • Loughran, Stephen J
  • Kruse, Elizabeth A
  • Hacking, Douglas F
  • de Graaf, Carolyn A
  • Hyland, Craig D
  • Willson, Tracy A
  • Henley, Katya J
  • Ellis, Sarah
  • Voss, Anne K
  • Metcalf, Donald
  • Hilton, Douglas J
  • Alexander, Warren S
  • Kile, Benjamin T

publication date

  • July 2008