Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion Academic Article uri icon

abstract

  • Key Points BAK/BAX depletion in murine platelets reveals that intrinsic apoptosis is not required for the development of the platelet storage lesion. Restriction of platelet life span by intrinsic apoptosis is pivotal to maintain a functional, hemostatically reactive platelet population.

authors

  • Pleines, I
  • Lebois, M
  • Gangatirkar, P
  • Au, AE
  • Lane, RM
  • Henley, KJ
  • Kauppi, M
  • Corbin, J
  • Cannon, P
  • Bernardini, J
  • Alwis, I
  • Jarman, KE
  • Ellis, Sarah
  • Metcalf, D
  • Jackson, SP
  • Schoenwaelder, SM
  • Kile, BT
  • Josefsson, EC

publication date

  • 2018

published in