Limited stage grade 3 follicular lymphoma patients can experience favorable outcomes with combined modality therapy Academic Article uri icon


  • Controversy exists regarding the optimal management of limited stage grade 3 follicular lymphoma (FL3). We assessed the treatment outcomes of 190 consecutive patients with stage I-II FL. Fifty two patients had FL3 disease, in whom the median age was 55 years. At a median follow-up of 65 months, 5-year progression-free survival (PFS) and overall survival (OS) rates were 76.6% and 87.6%, respectively. Patients receiving systemic therapy followed by radiation therapy (RT) had a significantly better PFS (p=.003) than those treated with RT alone, but similar OS (p = .476). Patients treated with RT had 100% local control. Compared to 132 patients with grade 1-2 FL, those with FL3 had similar PFS (p = .493) and OS (p  =  .330). Patients with FL3 can experience favorable outcomes when treated with a combination of systemic therapy and RT, comparable to low grade FL.


  • Ayoub, Zeina
  • Andraos, Therese
  • Milgrom, Sarah A
  • Pinnix, Chelsea C
  • Dabaja, Bouthaina S
  • Ng, Sweet Ping
  • Gunther, Jillian R
  • Khoury, Joseph D
  • Fowler, Nathan H
  • Neelapu, Satva S
  • Samaniego, Felipe
  • Fayad, Luis E
  • Nastoupil, Loretta J

publication date

  • August 24, 2019