The oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (Ovis aries) Academic Article uri icon

abstract

  • Galectins are a family of glycan-binding molecules with a characteristic affinity for ß-D-glycosides that mediate a variety of important cellular functions, including immune and inflammatory responses. Galectin-11 (LGALS-11) has been recently identified as a mediator induced specifically in animals against gastrointestinal nematodes and can interfere with parasite growth and development. Here, we report that at least two natural genetic variants of LGALS-11 exist in sheep, and demonstrate fundamental differences in anti-parasitic activity, correlated with their ability to dimerise. This study improves our understanding of the role of galectins in the host immune and inflammatory responses against parasitic nematodes and provides a basis for genetic studies toward selective breeding of animals for resistance to parasites.

authors

  • Sakthivel, Dhanasekaran
  • Preston, Sarah
  • Gasser, Robin B
  • Costa, Tatiana P Soares da
  • Hernandez, Julia N
  • Shahine, Adam
  • Shakif-Azam, MD
  • Lock, Peter
  • Rossjohn, Jamie
  • González, Jorge Francisco
  • Perugini, Matthew A
  • Meeusen, Els
  • Piedrafita, David
  • Beddoe, Travis

publication date

  • 2020