Background:Improved function, through balance and mobility, has been demonstrated in individuals with an acquired brain injury (ABI) following various exercise interventions; however, the feasibility of implementing "McGill's Big 3" exercises, typically prescribed for people with back pain, to improve function in people with ABI requires investigation. Objective:The aim of this case report was to determine the feasibility of implementing "McGill's Big 3" exercises on balance and mobility when prescribed to an individual with an ABI who ambulates independently. Methods and Materials:A 40-year-old female with an ABI completed an 8-week exercise intervention consisting of "McGill's Big 3" exercises. Balance and mobility testing were completed pre and post intervention, including, heel-to-toe standing; the foot tap test; forward reach test; pick-up test; stand-to-floor test; and three-meter timed up-and-go. Results:The results demonstrated improvement across all tests. Conclusions:These findings support the use of "McGill's Big 3" exercises in a rehabilitation program, for individuals with neurological impairments such as an ABI.