Cytotoxicity of Paclitaxel or Cisplatin on Carcinoma Cell Lines is not Inhibited by Leukemia Inhibitory Factor (LIF) Academic Article uri icon

abstract

  • We have established a reliable, reproducible and objective growth assay to measure whether leukemia inhibitory factor (LIF) was able to protect tumour-derived cell lines from toxic effects of the chemotherapy agents, cisplatin and paclitaxel. Using this assay, we demonstrated that LIF did not alter the cytotoxic action of these drugs, on a panel of seven cancer cell lines. This was not because of the inactivity of the LIF or because the cell lines did not express components of the LIF receptor. These findings suggest that the potential clinical use of LIF, as a neuroprotective agent, in conjunction with chemotherapy will not interfere with the anti-tumour treatment.

authors

  • O'Flaherty, E
  • Cook, W
  • Boyd, J
  • Grant, SL
  • Kurek, J
  • Begley, CG

publication date

  • January 2002

has subject area