CAR-T cells are serial killers Academic Article uri icon

abstract

  • Chimeric antigen receptor (CAR) T cells have enjoyed unprecedented clinical success against haematological malignancies in recent years. However, several aspects of CAR T cell biology remain unknown. We recently compared CAR and T cell receptor (TCR)-based killing in the same effector cell and showed that CAR T cells can not only efficiently kill single tumor targets, they can also kill multiple tumor targets in a sequential manner. Single and serial killing events were not sustained long term due to CAR down-regulation after 20┬áhours.

authors

  • Davenport, AJ
  • Jenkins, MR
  • Ritchie, DS
  • Prince, HM
  • Trapani, JA
  • Kershaw, MH
  • Darcy, PK
  • Neeson, PJ

publication date

  • 2015