Effect of Salicylic Acid on Articular Cartilage in Organ Culture Academic Article uri icon

abstract

  • An organ culture system was used to study the metabolic effects of exposure of articular cartilage to increasing concentrations of salicylic acid. It was shown that concentration of salicylate above 1 mM inhibited the incorporation of 35S-sulphate into proteoglycans and at concentrations above 2.5 mM inhibited the incorporation of 3H-proline into collagen. Long-term exposure of the cartilage to salicylic acid at concentrations above 1 mM had a toxic effect on both proteoglycan and collagen synthesis.

publication date

  • 1978