The effect of N-methylation on transition state mimetic inhibitors of the Plasmodium protease, plasmepsin V Academic Article uri icon

abstract

  • An N-methylation strategy has been applied to transition state mimetics that are potent inhibitors of plasmepsin V to improve their physical characteristics and their ability to reduce the viability of Plasmodium parasites in culture.

authors

  • Gazdik, M
  • O'Neill, MT
  • Lopaticki, S
  • Lowes, KN
  • Smith, BJ
  • Cowman, AF
  • Boddey, JA
  • Sleebs, BE

publication date

  • 2015