Adherence therapy for people with schizophrenia Academic Article uri icon


  • BackgroundThere is equivocal evidence of the effectiveness of adherence therapy in improving treatment adherence and clinical outcomes for people with schizophrenia.AimsTo evaluate the effectiveness of adherence therapy in improving quality of life for people with schizophrenia.MethodA 52-week, single-blind, multicentre randomised controlled trial of the effectiveness of adherence therapy. Participants were individually randomised to receive eight sessions of adherence therapy or health education. Assessments were undertaken at baseline and at 52-week follow-up.ResultsAdherence therapy was no more effective than health education in improving quality of life.ConclusionsThis effectiveness trial provides evidence for the lack of effect of adherence therapy in people with schizophrenia with recent clinical instability, treated in ordinary clinical settings.


  • Gray, Richard
  • Leese, Morven
  • Bindman, Jonathan
  • Becker, Thomas
  • Burti, Lorenzo
  • David, Anthony
  • Gournay, Kevin
  • Kikkert, Martijn
  • Koeter, Maarten
  • Puschner, Bernd
  • Schene, Aart
  • Thornicroft, Graham
  • Tansella, Michele

publication date

  • December 2006