The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin Academic Article uri icon

abstract

  • Tissue-resident memory T cells (T(RM) cells) provide superior protection against infection in extralymphoid tissues. Here we found that CD103(+)CD8(+) T(RM) cells developed in the skin from epithelium-infiltrating precursor cells that lacked expression of the effector-cell marker KLRG1. A combination of entry into the epithelium plus local signaling by interleukin 15 (IL-15) and transforming growth factor-β (TGF-β) was required for the formation of these long-lived memory cells. Notably, differentiation into T(RM) cells resulted in the progressive acquisition of a unique transcriptional profile that differed from that of circulating memory cells and other types of T cells that permanently reside in skin epithelium. We provide a comprehensive molecular framework for the local differentiation of a distinct peripheral population of memory cells that forms a first-line immunological defense system in barrier tissues.

authors

  • Mackay, Laura K
  • Rahimpour, Azad
  • Ma, Joel Z
  • Collins, Nicholas
  • Stock, Angus T
  • Hafon, Ming-Li
  • Vega-Ramos, Javier
  • Lauzurica, Pilar
  • Mueller, Scott N
  • Stefanovic, Tijana
  • Tscharke, David C
  • Heath, William R
  • Inouye, Michael
  • Carbone, Francis R
  • Gebhardt, Thomas

publication date

  • 2013

has subject area