Ethynyldiisopropylsilyl: A New Alkynylsilane Protecting Group and “Click” Linker Academic Article uri icon

abstract

  • A new silyl-based reagent has been developed for "catch and release" immobilization, combining click chemistry with silyl protection. The traditional "all carbon" attachment to solid supports in a silyl type linker was substituted with a stable triazole, easily assembled using the CuAAC reaction. The methodology introduces a novel ethynyldiiospropylchlorosilane reagent (EDIPS-Cl) as a functionalized protecting group linker.

publication date

  • June 18, 2010