New Synthesis of 1-Substituted-1H-indazoles via 1,3-Dipolar Cycloaddition ofin situGenerated Nitrile Imines and Benzyne Academic Article uri icon

abstract

  • A new synthesis of 1-substituted-1H-indazoles via 1,3-dipolar cycloaddition of nitrile imines to benzyne is described. The reaction is completed within 5 min, affording the corresponding N(1)-C(3) disubstituted indazoles in moderate to excellent yields.

publication date

  • August 6, 2010