A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands Academic Article uri icon

abstract

  • Described is the structure-based design and synthesis of a series of tris-triazole G-quadruplex binding ligands utilising the copper catalysed azide-alkyne 'click' reaction. The results of G-quadruplex stabilisation by the ligands are reported and discussed.

authors

  • Moses, John E
  • Ritson, Dougal J
  • Zhang, Fengzhi
  • Lombardo, Caterina Maria
  • Haider, Shozeb
  • Oldham, Neil
  • Neidle, Stephen

publication date

  • 2010