Structure-based design of selective high-affinity telomeric quadruplex-binding ligands Academic Article uri icon

abstract

  • A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.

authors

  • Lombardo, Caterina Maria
  • Martínez, Iria Sánchez
  • Haider, Shozeb
  • Gabelica, Valérie
  • De Pauw, Edwin
  • Moses, John E
  • Neidle, Stephen

publication date

  • 2010