Stabilization of G-Quadruplex DNA by Highly Selective Ligands via Click Chemistry Academic Article uri icon

abstract

  • A series of G-quadruplex stabilizing compounds have been prepared via click chemistry employing the Cu(I)-catalyzed Huisgen reaction. These compounds were shown to bind tightly to G-quadruplex DNA even in the presence of competing high concentrations of duplex DNA. Furthermore, a modified TRAP assay has shown that some of these compounds also inhibit telomerase at low micromolar concentration.

authors

  • Moorhouse, Adam D
  • Santos, Ana Mafalda
  • Gunaratnam, Mekala
  • Moore, Michael
  • Neidle, Stephen
  • Moses, John E

publication date

  • December 2006