Detection of Malignant Tumors Using Tc-99m Labeled Fab' Fragments From a Monoclonal Antibody With Specificity for D-Dimer of Cross-Linked Fibrin Academic Article uri icon

abstract

  • The authors present the case studies of two patients whose malignant tumors were detected with a Tc-99m labeled antifibrin monoclonal antibody (DD-3B6/22), which is specific for cross-linked fibrin. The first case was a malignant fibrous histiocytoma involving the proximal aspect of the left thigh, whereas in the second case, the patient was receiving treatment for a squamous cell carcinoma of the right mainstem bronchus. The results highlight the potential of this anti-D-dimer radiopharmaceutical for noninvasive detection of malignant tumors.

authors

  • ANGELIDES, SOCRATES
  • LEE, FOOKT
  • BASTEN, ANTHONY
  • LAMBRECHT, RICHARDM
  • WALKER, KARENZ
  • BUNDESEN, PETERG
  • BAUTOVICH, GEORGEJ

publication date

  • March 1996