A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(ii) complex that binds to amyloid-β plaques Academic Article uri icon

abstract

  • A bis(thiosemicarbazonato)copper(ii) complex with an appended stilbene functional group binds to amyloid-beta plaques that are associated with Alzheimer's disease. The complex has the potential to be of use as a copper-64 radiopharmaceutical to assist in the diagnosis of Alzheimer's disease by positron emission tomography.

authors

  • Lim, SinChun
  • Paterson, Brett M
  • Fodero-Tavoletti, Michelle T
  • O'Keefe, Graeme J
  • Cappai, Roberto
  • Barnham, Kevin J
  • Villemagne, Victor L
  • Donnelly, Paul S

publication date

  • 2010