Bis (thiosemicarbazonato) Cu-64 Complexes for Positron Emission Tomography Imaging of Alzheimer's Disease Academic Article uri icon

abstract

  • A bis (thiosemicarbazonato) complex radiolabeled with positron emitting Cu-64 can be used for a new and alternative method for the non-invasive diagnosis of Alzheimer's disease using positron emission tomography (PET). Most imaging agents being investigated for the diagnosis of Alzheimer's disease target amyloid-beta plaque burden but our new approach highlights altered copper homeostasis. This approach has the potential to offer complementary information to other diagnostic procedures that elucidate plaque burden.

authors

  • Fodero-Tavoletti, Michelle T
  • Villemagne, Victor L
  • Paterson, Brett M
  • White, Anthony R
  • Li, Qiao-Xin
  • Camakaris, James
  • O'Keefe, Graeme
  • Cappai, Roberto
  • Barnham, Kevin J
  • Donnelly, Paul S

publication date

  • March 24, 2010