Anterior cingulate activation in antipsychotic-naïve first-episode schizophrenia Academic Article uri icon


  • Anterior cingulate (ACC) hypo-activity is commonly observed in chronically ill schizophrenia patients. However, it is unclear whether this is secondary to persistent illness and/or medication. METHOD: We examined eight antipsychotic-naïve first-episode patients and matched healthy controls undergoing PET scanning while performing the Stroop task. RESULTS: Group-averaged and single-subject analyses showed ACC activation in both controls and patients, albeit in different sub-regions (paracingulate and cingulate respectively). A direct comparison revealed relative under-activity of the left paracingulate cortex in patients. CONCLUSION: These findings suggest that the more pervasive hypo-activation observed in chronic patients may be secondary to persistent illness and/or medication.


  • Yücel, M
  • Brewer, WJ
  • Harrison, BJ
  • Fornito, A
  • O'Keefe, GJ
  • Olver, J
  • Scott, AM
  • Egan, GF
  • Velakoulis, D
  • McGorry, PD
  • Pantelis, C

publication date

  • February 2007