c-Myb Is Required for Neural Progenitor Cell Proliferation and Maintenance of the Neural Stem Cell Niche in Adult Brain Academic Article uri icon

abstract

  • Ongoing production of neurons in adult brain is restricted to specialized neurogenic niches. Deregulated expression of genes controlling homeostasis of neural progenitor cell division and/or their microenvironment underpins a spectrum of brain pathologies. Using conditional gene deletion, we show that the proto-oncogene c-myb regulates neural progenitor cell proliferation and maintains ependymal cell integrity in mice. These two cellular compartments constitute the neurogenic niche in the adult brain. Brains devoid of c-Myb showed enlarged ventricular spaces, ependymal cell abnormalities, and reduced neurogenesis. Neural progenitor cells lacking c-Myb showed a reduced intrinsic proliferative capacity and reduction of Sox-2 and Pax-6 expression. These data point to an important role for c-Myb in the neurogenic niche of the adult brain.

authors

  • Malaterre, Jordane
  • Mantamadiotis, Theo
  • Dworkin, Sebastian
  • Lightowler, Sally
  • Yang, Qing
  • Ransome, Mark I
  • Turnley, Ann M
  • Nichols, Nancy R
  • Emambokus, Nikla R
  • Frampton, Jon
  • Ramsay, Robert G

publication date

  • January 2008

has subject area