Clinical comparison of radiolocalization of two monoclonal antibodies (mAbs) against the TAG-72 antigen Academic Article uri icon

abstract

  • Ten patients with colorectal cancer metastases received 125I-B72.3 and 131I-CC49 prior to laparotomy (five patients received 1 mg, and five 20 mg of each mAb). Tumor:serum ratios of 131I-CC49 were better than those of 125I-B72.3 (P < 0.01 at 1 mg; P = 0.05 at 20 mg; P < 0.01 at both doses). All known lesions > or = 1 cm in diameter were visualized at the 20 mg dose. There was no difference in absolute tumor uptake of 125I-B72.3 or 131I-CC49. We conclude that mAb CC49 has better relative uptake in colorectal cancers than mAb B72.3.

authors

  • Divgi, CR
  • Scott, AM
  • McDermott, K
  • Fallone, PS
  • Hilton, S
  • Siler, K
  • Carmichael, N
  • Daghighian, F
  • Finn, RD
  • Cohen, AM
  • Schlom, J
  • Larson, SM

publication date

  • January 1994