The Use of Tripeptides for Lead Discovery of 5-HT4 Receptor Ligands Academic Article uri icon


  • A series of 30 tripeptides were synthesized and tested as novel 5-HT4 receptor ligands. Receptor binding assays showed that a subset of compounds had reasonable potency relative to the agonists serotonin and 5-methoxytryptamine. Structure-activity analyses and molecular docking have highlighted avenues for further synthetic work.


  • Hanna-Elias, A
  • Thompson, P
  • Manallack, D
  • Irving, H
  • Coupar, I
  • Berque-Bestel, I
  • Iskander, M

publication date

  • July 1, 2009