Clinical studies with granulocyte colony stimulating factor (G-CSF) in patients receiving cytotoxic chemotherapy Academic Article uri icon


  • Bacterially synthesised human granulocyte colony-stimulating factor (G-CSF) was administered to patients with advanced cancer. The immediate effect of G-CSF was a fall in the level of circulating neutrophils followed by a rise after 4 hours that was sustained during G-CSF administration. The rise in neutrophil level was less in patients who had been treated previously with chemotherapy and/or radiotherapy. G-CSF was also administered to patients following melphalan and this resulted in a reduction in the duration of the neutropenia that invariably follows melphalan. G-CSF was well tolerated and did not have to be stopped in any patient.


  • Morstyn, G
  • Campbell, L
  • Duhrsen, U
  • Souza, LM
  • Alton, NK
  • Villeval, JL
  • Nicola, NA
  • Boyd, AW
  • Kannourakis, G
  • Cebon, J
  • Thomas, R
  • Boyd, J
  • Keech, J
  • Green, M
  • Sheridan, W
  • Metcalf, D
  • Fox, R

publication date

  • December 1, 1988